Compound Description

ID:   C0337 Common name:   Puerarin
IUPAC:  7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one CAS:  CAS:3681-99-0
Chembl ID:   CHEMBL486386 Pubchem ID:   CID:5281807
Formula:  C21H20O9 TCM-ID:  TCMC1965
Smiles:  OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)c1c(O)ccc2c1occ(c2=O)c1ccc(cc1)O
Alias:

Puerarin;

8-β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;

Daidzein 8-C-glucoside;

Kakonein;

NPI 031G
Structure:

Related Targets  (Total: 30)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 2 Reference(s)
T85U8U Caspase-3CASP3 P42574
A 2 Reference(s)
T23P74 Caspase-9CASP9 P55211
A 1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
A 2 Reference(s)
T28ULC NAMIR22 NA
A 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
A 1 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
A 1 Reference(s)
T16MRU NACHT, LRR and PYD domains-containing protein 3NLRP3 Q96P20
A 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
A 1 Reference(s)
T16A2X CatalaseCAT P04040
A 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
A 1 Reference(s)
T65JYL C-X-C motif chemokine 2CXCL2 P19875
A 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
A 1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
B 1 Reference(s)
T79TJS Caveolin-3CAV3 P56539
B 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
B 1 Reference(s)
T17E95 Protein kinase C gamma typePRKCG P05129
B 1 Reference(s)
T92FAW Dual specificity protein phosphatase 1DUSP1 P28562
C 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
C 1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
C 1 Reference(s)
T73LPO Poly [ADP-ribose] polymerase 1PARP1 P09874
C 2 Reference(s)
T51WML Glutamate receptor 1GRIA1 P42261
C 1 Reference(s)
T54G8J Protein kinase C delta typePRKCD Q05655
C 1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
C 1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
C 1 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
C 1 Reference(s)
T13QI6 Aldo-keto reductase family 1 member A1AKR1A1 P14550
C 1 Reference(s)
T33OSQ Sterol regulatory element-binding protein 1SREBF1 P36956
C 1 Reference(s)
T71GZE UDP-glucuronosyltransferase 2B28UGT2B28 Q9BY64
C 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 16)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0685 Xuan Cao Gen萱草根 Orange daylilyHemerocallis fulva
H1037 Fen Ge粉葛 Thomson kudzuvinePueraria thomsonii
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata