HIT-result

ID: C0337	Common name: Puerarin
IUPAC: 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one	CAS: CAS:3681-99-0
Chembl ID: CHEMBL486386	Pubchem ID: CID:5281807
Formula: C21H20O9	TCM-ID: TCMC1965
Smiles: OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)c1c(O)ccc2c1occ(c2=O)c1ccc(cc1)O
Alias: Puerarin; 8-β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Daidzein 8-C-glucoside; Kakonein; NPI 031G	Structure:

Target id	Protein Name	Gene Symbol	Uniprot ID	Target Level	No.of Literature Evidence
T06RMZ	Nuclear factor NF-kappa-B p105 subunit	NFKB1	P19838	A	2 Reference(s)
T85U8U	Caspase-3	CASP3	P42574	A	2 Reference(s)
T23P74	Caspase-9	CASP9	P55211	A	1 Reference(s)
T71BDH	Mitogen-activated protein kinase 14	MAPK14	Q16539	A	2 Reference(s)
T28ULC	NA	MIR22	NA	A	1 Reference(s)
T49TDM	Matrix metalloproteinase-9	MMP9	P14780	A	1 Reference(s)
T11BI7	Toll-like receptor 4	TLR4	O00206	A	1 Reference(s)
T16MRU	NACHT, LRR and PYD domains-containing protein 3	NLRP3	Q96P20	A	1 Reference(s)
T88TDZ	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	A	1 Reference(s)
T16A2X	Catalase	CAT	P04040	A	1 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	A	1 Reference(s)
T65JYL	C-X-C motif chemokine 2	CXCL2	P19875	A	1 Reference(s)
T53AOE	Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide	TGFB1	P01137	A	1 Reference(s)
T02QBS	Cytochrome P450 1A2	CYP1A2	P05177	B	1 Reference(s)
T79TJS	Caveolin-3	CAV3	P56539	B	1 Reference(s)
T09H2Z	Nitric oxide synthase, inducible	NOS2	P35228	B	1 Reference(s)
T17E95	Protein kinase C gamma type	PRKCG	P05129	B	1 Reference(s)
T92FAW	Dual specificity protein phosphatase 1	DUSP1	P28562	C	1 Reference(s)
T71K92	Apoptosis regulator Bcl-2	BCL2	P10415	C	1 Reference(s)
T83YZD	Acetylcholinesterase	ACHE	P22303	C	1 Reference(s)
T73LPO	Poly [ADP-ribose] polymerase 1	PARP1	P09874	C	2 Reference(s)
T51WML	Glutamate receptor 1	GRIA1	P42261	C	1 Reference(s)
T54G8J	Protein kinase C delta type	PRKCD	Q05655	C	1 Reference(s)
T30D9G	Superoxide dismutase [Cu-Zn]	SOD1	P00441	C	1 Reference(s)
T90XYZ	C-reactive protein	CRP	P02741	C	1 Reference(s)
T05O6O	Estrogen receptor beta	ESR2	Q92731	C	1 Reference(s)
T13QI6	Aldo-keto reductase family 1 member A1	AKR1A1	P14550	C	1 Reference(s)
T33OSQ	Sterol regulatory element-binding protein 1	SREBF1	P36956	C	1 Reference(s)
T71GZE	UDP-glucuronosyltransferase 2B28	UGT2B28	Q9BY64	C	1 Reference(s)
T01QLH	Estrogen receptor	ESR1	P03372	C	1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0665	Chai Hu Shao	柴胡梢	Chinese thorowax	Bupleurum chinense
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0650	Chai Hu	柴胡	Chinese thorowax	Bupleurum chinense
H0714	Yan Tai Chai Hu	烟台柴胡	Chinese thorowax	Bupleurum chinense
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0659	Chai Hu Jin Gao	柴胡浸膏	Chinese thorowax	Bupleurum chinense
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1037	Fen Ge	粉葛	Thomson kudzuvine	Pueraria thomsonii
H0685	Xuan Cao Gen	萱草根	Orange daylily	Hemerocallis fulva

Compound Description

Related Targets (Total: 30)

Related Herbs (Total: 16)