HIT-result

Type	Detail
Target ID	T92FAW
Protein Name	Dual specificity protein phosphatase 1
Uniprot ID	P28562
Protein Name Alias	EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100
Gene ID	1843
Gene Symbol	DUSP1
Gene Alias	CL100; MKP1; PTPN10; VH1
TTD	T35194: Clinical Trial target
Pfam	PF00581
GO	0033574:response to testosterone 0019838:growth factor binding 0005634:nucleus 0051592:response to calcium ion 0001706:endoderm formation 0090266:regulation of mitotic cell cycle spindle assembly checkpoint 1990869:cellular response to chemokine 0051591:response to cAMP 0106306:protein serine phosphatase activity 0004722:protein serine/threonine phosphatase activity 0004725:protein tyrosine phosphatase activity 0043066:negative regulation of apoptotic process 0009416:response to light stimulus 0017017:MAP kinase tyrosine/serine/threonine phosphatase activity 0008330:protein tyrosine/threonine phosphatase activity 0032870:cellular response to hormone stimulus 1903753:negative regulation of p38MAPK cascade 0035970:peptidyl-threonine dephosphorylation 0051384:response to glucocorticoid 0032526:response to retinoic acid 0043407:negative regulation of MAP kinase activity 0035556:intracellular signal transduction 2000279:negative regulation of DNA biosynthetic process 0051019:mitogen-activated protein kinase binding 0043409:negative regulation of MAPK cascade 0090027:negative regulation of monocyte chemotaxis 0008138:protein tyrosine/serine/threonine phosphatase activity 0004721:phosphoprotein phosphatase activity 0035335:peptidyl-tyrosine dephosphorylation 0070262:peptidyl-serine dephosphorylation 0000188:inactivation of MAPK activity 0042542:response to hydrogen peroxide 0043065:positive regulation of apoptotic process 0006470:protein dephosphorylation 0051447:negative regulation of meiotic cell cycle 0071850:mitotic cell cycle arrest 0106307:protein threonine phosphatase activity 0032355:response to estradiol 0007162:negative regulation of cell adhesion 0070373:negative regulation of ERK1 and ERK2 cascade 0005737:cytoplasm
PDB	6APX ; 6D67 ; 6D65 ; 6D66
Drugbank	NA
KEGG	hsa:1843

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H0714	Yan Tai Chai Hu	烟台柴胡	Chinese thorowax	Bupleurum chinense
H1165	He Shi	鹤虱	Common carpesium fruit	Fructus carpesii
H0685	Xuan Cao Gen	萱草根	Orange daylily	Hemerocallis fulva
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H1037	Fen Ge	粉葛	Thomson kudzuvine	Pueraria thomsonii
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0650	Chai Hu	柴胡	Chinese thorowax	Bupleurum chinense
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0659	Chai Hu Jin Gao	柴胡浸膏	Chinese thorowax	Bupleurum chinense
H0769	Yuan Zhi	远志	Thinleaf milkwort	Polygala tenuifolia
H0301	Ou	藕	Hindu lotus large rhizome	Nelumbo nucifera
H1188	Hong Hua	红花	Safflower	Carthamus tinctorius
H0304	Ou Pian	藕片	Hindu lotus large rhizome	Nelumbo nucifera
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0699	Chang Pu	菖蒲	rhizome of grassleaf sweetflag.	Acorus calamus
H0118	Kun Ming Shan Hai Tang	昆明山海棠	Glaucousback threewingnut	Tripterygium hypoglaucum
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H1164	He Geng	荷梗	Hindu lotus petiole	Nelumbo nucifera
H0302	Ou Fen	藕粉	Hindu lotus large rhizome	Nelumbo nucifera
H0233	Mao Liang Mian Zhen	毛两面针	NA	Zanthoxylum nitidum
H0452	Shi Chang Pu Qing Gao	石菖蒲清膏	Grassleaved sweetflag	Acorus tatarinowii
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H0140	Lian Zi	莲子	Hindu lotus seed	Nelumbo nucifera
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0105	Ku Di Ding	苦地丁	Bunge corydalis	Corydalis bungeana
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H1090	Gao Ben	藁本	Chinese ligusticum	Ligusticum sinense
H0483	Shui Chang Pu	水菖蒲	Calamus	Acorus calamus var. angustatus
H1169	He Ye	荷叶	Hindu lotus leaf	Nelumbo nucifera
H0665	Chai Hu Shao	柴胡梢	Chinese thorowax	Bupleurum chinense
H0141	Lian Zi Xin	莲子心	Hindu lotus plumule	Nelumbo nucifera
H0450	Shi Chang Pu	石菖蒲	Grassleaved sweetflag	Acorus tatarinowii
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0966	Di Ding	地丁	All - grass of tokyo violet	Corydalis bungeana
H0505	Cang Chang Pu	藏菖蒲	Sweet flag	Acorus calamus
H0771	Yuan Zhi Liu Jin Gao	远志流浸膏	Thinleaf milkwort	Polygala tenuifolia
H0770	Yuan Zhi Jin Gao	远志浸膏	Thinleaf milkwort	Polygala tenuifolia
H0451	Shi Chang Pu Jin Gao	石菖蒲浸膏	Grassleaved sweetflag	Acorus tatarinowii
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis

Target Description

Related Compounds (Total: 7)

Related Herbs (Total: 52)