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Compound Description

ID:   C0325 Common name:   Progesterone
IUPAC:  (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one CAS:  CAS:57-83-0
Chembl ID:   CHEMBL103 Pubchem ID:   CID:5994
Formula:  C21H30O2 TCM-ID:  TCMC1940
Smiles:  CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Alias:

Progesterone;

4-Pregnene-3,20-dione;

Agolutin;

Bio-luton;

CIDR;

Corlutin;

Corlutina;

Corluvite;

Corporin;

Corpus luteum hormone;

Crinone;

Cue-Mate;

Cyclogest;

Duraprogen;

EAZI-BREED CIDR;

Endometrin;

Estima;

Flavolutan;

Fologenon;

Gesterol;

Gestiron;

Gestone;

Gestormone;

Gestron;

Glanducorpin;

Gynlutin;

Gynolutone;

Hormoflaveine;

Hormoluton;

Lipo-Lutin;

Lucorteum Sol;

Lugesteron;

Lugesterone;

Luteal Hormone;

Luteinique;

Luteocrin normale;

Luteodyn;

Luteogan;

Luteohormone;

Luteol;

Luteopur;

Luteosan;

Luteostab;

Luteosterone;

Luteovis;

Luteum;

Lutex;

Lutidon;

Lutin;

Lutinus;

Lutociclina;

Lutocuclin M;

Lutocyclin;

Lutocyclin M;

Lutocylin;

Lutoform;

Lutogyl;

Lutren;

Lutromone;

Microgest;

Minagest;

NSC 64377;

NSC 9704;

Nalutron;

Percutacrine Luteinique;

Piaponon;

Primolut;

Prochieve;

Progeffik;

Progeffik 200;

Progekan;

Progestan;

Progestasert;

Progesterol;

Progestin;

Progestogel;

Progestol;

Progeston;

Progestone;

Progestron;

Prolets;

Prolidon;

Proluton;

Prometrium;

Prontogest;

Protormone;

Sincrogest;

Syngesterone;

Syngestrets;

Syntolutan;

U 3672;

Utrogest;

Utrogestan;

Vitarrine;

Δ4-Pregnene-3,20-dione
Structure:

Related Targets  (Total: 145)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T92E71 Corticosteroid 11-beta-dehydrogenase isozyme 2HSD11B2 P80365
 A 1 Reference(s)
T82W6S Toll-like receptor 3TLR3 O15455
 A 1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
 A 1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
 A 2 Reference(s)
T06UTD Transcription factor Sp6SP6 Q3SY56
 A 1 Reference(s)
T15UBS Suppressor of cytokine signaling 1SOCS1 O15524
 A 1 Reference(s)
T32YAJ G-protein coupled estrogen receptor 1GPER1 Q99527
 A 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
 A 2 Reference(s)
T61NZN Progonadoliberin-1GNRH1 P01148
 A 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
 A 2 Reference(s)
T18B9T Tubulinyl-Tyr carboxypeptidase 1VASH1 Q7L8A9
 A 1 Reference(s)
T77RFX Alpha-2A adrenergic receptorADRA2A P08913
 A 1 Reference(s)
T70U24 Sigma non-opioid intracellular receptor 1SIGMAR1 Q99720
 A 1 Reference(s)
T79STG Cation channel sperm-associated protein 1CATSPER1 Q8NEC5
 A 1 Reference(s)
T89VFL Alpha-crystallin B chainCRYAB P02511
 A 1 Reference(s)
T68XO1 Indoleamine 2,3-dioxygenase 1IDO1 P14902
 A 2 Reference(s)
T11RHZ Reticulon-4RTN4 Q9NQC3
 A 1 Reference(s)
T89L4V InsulinINS P01308
 A 1 Reference(s)
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
 A 1 Reference(s)
T60A9R NACYP3A NA
 A 1 Reference(s)
T73A8T High mobility group nucleosome-binding domain-containing protein 3HMGN3 Q15651
 A 1 Reference(s)
T24C0P Bile acid receptorNR1H4 Q96RI1
 A 1 Reference(s)
T25M2J Anoctamin-1ANO1 Q5XXA6
 A 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
 A 3 Reference(s)
T52VL6 Signal transducer and activator of transcription 5ASTAT5A P42229
 A 1 Reference(s)
T19K8W Signal transducer and activator of transcription 5BSTAT5B P51692
 A 1 Reference(s)
T36H6L UTP--glucose-1-phosphate uridylyltransferaseUGP2 Q16851
 A 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
 A 1 Reference(s)
T01S8U Metalloproteinase inhibitor 2TIMP2 P16035
 A 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
 A 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
 A 3 Reference(s)
T31SR7 Integrin alpha-3ITGA3 P26006
 B 1 Reference(s)
T52CKD Pro-epidermal growth factorEGF P01133
 B 1 Reference(s)
T50VJF OsteopontinSPP1 P10451
 B 1 Reference(s)
T95F6I Cerebellar degeneration-related antigen 1CDR1 P51861
 B 1 Reference(s)
T58C7Q Myelin protein P0MPZ P25189
 B 1 Reference(s)
T01FNJ Cadherin-6CDH6 P55285
 B 1 Reference(s)
T15VAS Integrin beta-1ITGB1 P05556
 B 1 Reference(s)
T50BY8 Interleukin-13 receptor subunit alpha-2IL13RA2 Q14627
 B 1 Reference(s)
T82G3R Integrin beta-3ITGB3 P05106
 B 1 Reference(s)
T83VW4 Myelin basic proteinMBP P02686
 B 1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
 B 2 Reference(s)
T75H3W Cyclin-dependent kinase 2CDK2 P24941
 B 1 Reference(s)
T13KGH TyrosinaseTYR P14679
 B 1 Reference(s)
T55TEP Steroidogenic acute regulatory protein, mitochondrialSTAR P49675
 B 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
 B 1 Reference(s)
T02GD4 Tumor necrosis factor ligand superfamily member 6FASLG P48023
 B 2 Reference(s)
T24LXT G2/mitotic-specific cyclin-B1CCNB1 P14635
 B 2 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
 B 1 Reference(s)
T82SSI GlycodelinPAEP P09466
 B 1 Reference(s)
T08BOH CCN family member 5CCN5 O76076
 B 1 Reference(s)
T64F54 Mineralocorticoid receptorNR3C2 P08235
 B 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
 B 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
 B 2 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
 B 1 Reference(s)
T11OU8 Progesterone receptorPGR P06401
 B 1 Reference(s)
T04WT7 FibronectinFN1 P02751
 B 1 Reference(s)
T24GGY Glutamyl aminopeptidaseENPEP Q07075
 B 1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
 B 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
 B 4 Reference(s)
T75IW3 Matrix metalloproteinase-14MMP14 P50281
 B 2 Reference(s)
T66NVP Fatty-acid amide hydrolase 1FAAH O00519
 B 2 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
 B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
 B 2 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
 B 1 Reference(s)
T06LRM Insulin-like growth factor-binding protein 2IGFBP2 P18065
 B 1 Reference(s)
T93WPH Insulin-like growth factor-binding protein 5IGFBP5 P24593
 B 2 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
 B 2 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
 B 1 Reference(s)
T64X48 C-X-C chemokine receptor type 4CXCR4 P61073
 B 1 Reference(s)
T62P0D Collagenase 3MMP13 P45452
 B 1 Reference(s)
T53ZQH Growth/differentiation factor 8MSTN O14793
 B 1 Reference(s)
T71V6E Serine/threonine-protein kinase PAK 1PAK1 Q13153
 B 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
 B 1 Reference(s)
T22CPR Cyclin-G1CCNG1 P51959
 B 1 Reference(s)
T92HNO High mobility group protein B1HMGB1 P09429
 B 1 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
 B 2 Reference(s)
T30VOZ Epithelial membrane protein 2EMP2 P54851
 B 1 Reference(s)
T04MBA Vascular endothelial growth factor receptor 2KDR P35968
 B 1 Reference(s)
T57B8N Homeobox protein MSX-2MSX2 P35548
 B 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
 B 2 Reference(s)
T95Y0K Sphingosine kinase 1SPHK1 Q9NYA1
 B 1 Reference(s)
T93LMN Microtubule-associated protein tauMAPT P10636
 B 1 Reference(s)
T82ALJ Glycogen synthase kinase-3 betaGSK3B P49841
 B 2 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
 B 1 Reference(s)
T18SKL C-C motif chemokine 5CCL5 P13501
 B 1 Reference(s)
T68OE2 Pro-neuregulin-1, membrane-bound isoformNRG1 Q02297
 B 1 Reference(s)
T05ZAI Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragmentAGRN O00468
 B 1 Reference(s)
T56OMG Fibulin-1FBLN1 P23142
 B 2 Reference(s)
T17CZC Tissue factorF3 P13726
 B 1 Reference(s)
T20H9F Stromelysin-1MMP3 P08254
 B 1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
 B 1 Reference(s)
T58D39 OsteocalcinBGLAP P02818
 B 1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
 B 1 Reference(s)
T28V82 Wilms tumor proteinWT1 P19544
 B 1 Reference(s)
T88QEV Transient receptor potential cation channel subfamily M member 3TRPM3 Q9HCF6
 B 1 Reference(s)
T88CW3 Membrane-associated progesterone receptor component 1PGRMC1 O00264
 B 3 Reference(s)
T85K8L Forkhead box protein O1FOXO1 Q12778
 B 2 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
 B 1 Reference(s)
T37ADS Early growth response protein 1EGR1 P18146
 B 1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
 B 1 Reference(s)
T34ON0 Endothelin-2EDN2 P20800
 B 1 Reference(s)
T91CUJ Endothelin-3EDN3 P14138
 B 1 Reference(s)
T09YEF Keratin, type II cytoskeletal 5KRT5 P13647
 B 1 Reference(s)
T05P7L Signal transducer and activator of transcription 4STAT4 Q14765
 B 1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
 B 1 Reference(s)
T45KYV Stromal cell-derived factor 1CXCL12 P48061
 B 1 Reference(s)
T06U3P Claudin-3CLDN3 O15551
 B 1 Reference(s)
T72BXP Platelet endothelial cell adhesion moleculePECAM1 P16284
 B 1 Reference(s)
T97FEH Homeobox protein Hox-A11HOXA11 P31270
 C 1 Reference(s)
T33KEM Kallikrein-4KLK4 Q9Y5K2
 C 1 Reference(s)
T63EMC Interleukin-18IL18 Q14116
 C 1 Reference(s)
T03CZ8 Catechol O-methyltransferaseCOMT P21964
 C 1 Reference(s)
T13I7C Transforming growth factor beta-2 proproteinTGFB2 P61812
 C 1 Reference(s)
T45WII Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptideTGFB3 P10600
 C 1 Reference(s)
T50TQS Fibulin-2FBLN2 P98095
 C 1 Reference(s)
T97KL5 Microsomal glutathione S-transferase 1MGST1 P10620
 C 1 Reference(s)
T95V8S FumarylacetoacetaseFAH P16930
 C 1 Reference(s)
T00T9M Thrombospondin-1THBS1 P07996
 C 1 Reference(s)
T41XLQ E3 SUMO-protein ligase EGR2EGR2 P11161
 C 2 Reference(s)
T22JG3 Fibroblast growth factor receptor 2FGFR2 P21802
 C 1 Reference(s)
T76AZQ Histidine decarboxylaseHDC P19113
 C 1 Reference(s)
T94HUW Pituitary adenylate cyclase-activating polypeptideADCYAP1 P18509
 C 1 Reference(s)
T94WHJ Retinol-binding protein 4RBP4 P02753
 C 1 Reference(s)
T87TVN Toll-like receptor 5TLR5 O60602
 C 1 Reference(s)
T48J2C Transient receptor potential cation channel subfamily M member 7TRPM7 Q96QT4
 C 1 Reference(s)
T48J1U Aldo-keto reductase family 1 member C1AKR1C1 Q04828
 C 1 Reference(s)
T70P4F Cysteine-rich secretory protein LCCL domain-containing 2CRISPLD2 Q9H0B8
 C 1 Reference(s)
T15JRW Interferon alpha-inducible protein 27, mitochondrialIFI27 P40305
 C 1 Reference(s)
T02IOG Cyclin-dependent kinase inhibitor 1BCDKN1B P46527
 C 1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
 C 1 Reference(s)
T92FAW Dual specificity protein phosphatase 1DUSP1 P28562
 C 1 Reference(s)
T47OQP Serine palmitoyltransferase 2SPTLC2 O15270
 C 1 Reference(s)
T66T67 Gamma-aminobutyric acid receptor subunit alpha-4GABRA4 P48169
 C 1 Reference(s)
T97FJG High mobility group nucleosome-binding domain-containing protein 5HMGN5 P82970
 C 1 Reference(s)
T85JI5 Vitamin D3 receptorVDR P11473
 C 1 Reference(s)
T40VB1 Non-histone chromosomal protein HMG-14HMGN1 P05114
 C 1 Reference(s)
T73AR5 Complement decay-accelerating factorCD55 P08174
 C 1 Reference(s)
T07TRP Short transient receptor potential channel 5TRPC5 Q9UL62
 C 1 Reference(s)
T05WU9 Serine/threonine-protein phosphatase 2A activatorPTPA Q15257
 C 1 Reference(s)
T63VZZ Metastasis-suppressor KiSS-1KISS1 Q15726
 C 1 Reference(s)
T85S9Z Cholesterol side-chain cleavage enzyme, mitochondrialCYP11A1 P05108
 C 1 Reference(s)
T21XA6 Leukemia inhibitory factorLIF P15018
 C 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
 C 1 Reference(s)
T86YQL ProlactinPRL P01236
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 8)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum

Ckey description of the interaction between compound and target


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