Target Description

Type Detail
Target ID T45WII
Protein Name Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide
Uniprot ID P10600
Protein Name Alias LAP;  TGF-beta-3
Gene ID 7043
Gene Symbol TGFB3
Gene Alias NA
TTD T22978: Clinical Trial target
Pfam PF00019 ; PF00688
GO
0042127:regulation of cell population proliferation

0005634:nucleus

0032967:positive regulation of collagen biosynthetic process

0031093:platelet alpha granule lumen

0050714:positive regulation of protein secretion

0009986:cell surface

0000187:activation of MAPK activity

0034616:response to laminar fluid shear stress

0005114:type II transforming growth factor beta receptor binding

1904706:negative regulation of vascular associated smooth muscle cell proliferation

0051496:positive regulation of stress fiber assembly

0008083:growth factor activity

0034713:type I transforming growth factor beta receptor binding

0060364:frontal suture morphogenesis

0043524:negative regulation of neuron apoptotic process

0043231:intracellular membrane-bounded organelle

0002576:platelet degranulation

0062023:collagen-containing extracellular matrix

0010718:positive regulation of epithelial to mesenchymal transition

1905075:positive regulation of tight junction disassembly

0043627:response to estrogen

0042802:identical protein binding

0005615:extracellular space

0030512:negative regulation of transforming growth factor beta receptor signaling pathway

0005125:cytokine activity

0045893:positive regulation of transcription, DNA-templated

0060395:SMAD protein signal transduction

0045944:positive regulation of transcription by RNA polymerase II

0042704:uterine wall breakdown

0045216:cell-cell junction organization

0044877:protein-containing complex binding

0051491:positive regulation of filopodium assembly

0034714:type III transforming growth factor beta receptor binding

0010936:negative regulation of macrophage cytokine production

0050431:transforming growth factor beta binding

0001666:response to hypoxia

0048839:inner ear development

0001701:in utero embryonic development

0008285:negative regulation of cell population proliferation

0048702:embryonic neurocranium morphogenesis

0062009:secondary palate development

0032570:response to progesterone

0043932:ossification involved in bone remodeling

0043065:positive regulation of apoptotic process

0005576:extracellular region

0030315:T-tubule

0043025:neuronal cell body

0005886:plasma membrane

0030879:mammary gland development

0048565:digestive tract development

0060391:positive regulation of SMAD protein signal transduction

0030509:BMP signaling pathway

0007435:salivary gland morphogenesis

0042060:wound healing

0007565:female pregnancy

0042476:odontogenesis

0007179:transforming growth factor beta receptor signaling pathway

0007568:aging

0070483:detection of hypoxia

0008284:positive regulation of cell population proliferation

0048286:lung alveolus development

0030501:positive regulation of bone mineralization

0010862:positive regulation of pathway-restricted SMAD protein phosphorylation

0051781:positive regulation of cell division

0060325:face morphogenesis

PDB 2PJY ; 1TGJ ; 4UM9 ; 1TGK ; 3EO1 ; 1KTZ
Drugbank DB03316
KEGG hsa:7043

Related Compounds  (Total: 3)

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C0055
Name: Estradiol
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C0325
Name: Progesterone
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C0419
Name: Styrene


Related Herbs  (Total: 52)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0077 Jiu EthanolVinum
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0788 Zhang Nao Zi樟脑子 CamphorarCinnamomum camphora
H0366 Rou Gui肉桂 CassiabarktreeCinnamomum cassia
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0790 Zhang Shu Zi樟树子 Camphor treeCinnamomum camphora
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0789 Zhang Shu Gen樟树根 Camphor treeCinnamomum camphora
H1022 E Zhu莪术 Zedoray rhizomeCurcuma aeruginosa
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0307 Peng E Zhu蓬莪术 Zedoray rhizomeRhizoma curcumae
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H0747 An Xi Xiang安息香 Sumatra snowbelStyrax benzoin
H0787 Zhang Nao樟脑 CamphorarCinnamomum camphora
H0510 Su He Xiang苏合香 Oriental sweetgum resinLiquidambar orientalis
H0367 Rou Gui Ye肉桂叶 Cassia bark oilOleum cinnamomi
H1129 Guang Xi E Zhu广西莪术 rhizome of kwangsi turmericRhizoma curcumae
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H1139 Gui Zhi桂枝 Cassiabarktree twigCinnamomum cassia
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H0368 Rou Gui Zi肉桂子 CassiabarktreeCinnamomum cassia
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H1114 Guan Gui官桂 CassiabarktreeCinnamomum cassia
H0786 Zhang Mu樟木 Ligum cinmamomi camphoraeCinnamomum camphora
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0903 Ci Cai荠菜 ShepherdspurseCapsella bursa-pastoris