Compound Description

ID:   C0055 Common name:   Estradiol
IUPAC:  (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol CAS:  CAS:50-28-2
Chembl ID:   CHEMBL135 Pubchem ID:   CID:5757
Formula:  C18H24O2 TCM-ID:  TCMC1133
Smiles:  CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
Alias:

Estradiol;

(17β)-Estra-1,3,5(10)-triene-3,17-diol;

(+)-3,17β-Estradiol;

13β-Methyl-1,3,5(10)-gonatriene-3,17β-ol;

17β-Estradiol;

17β-Estradiol E2;

17β-Oestradiol;

3,17-Epidihydroxyestratriene;

3,17β-Dihydroxyestra-1,3,5(10)-triene;

3,17β-Estradiol;

Absorlent Matrix;

Aerodiol;

Alora;

Altrad;

Aquadiol;

Bardiol;

Benzogynestry;

Beta-estradiol;

Bio-E Gel;

Climaderm;

Climara;

Compudose;

Compudose 100;

Compudose 200;

Compudose 365;

Compudose 400;

Corpagen;

Dermestril;

Destradiol;

Dihydrofollicular hormone;

Dihydrofolliculin;

Dihydromenformon;

Dihydrotheelin;

Dihydroxyestrin;

Dimenformon;

Diogyn;

Diogynets;

Divigel;

E 2;

Elestrim;

Encore;

Epiestriol 50;

Estasorb;

Estra-1,3,5(10)-triene-3,17-diol, (17β)-;

Estra-1,3,5(10)-triene-3,17β-diol;

Estrace;

Estraderm;

Estraderm MX;

Estraderm TTS;

Estraderm TTS 100;

Estraderm TTS 50;

Estradiol-17β;

Estradot;

Estraldine;

Estrapatch;

Estredox;

Estreva;

Estring;

Estring Vaginal Ring;

Estroclim;

Estroclim 50;

Estrogel;

Estrogel HBF;

Estropause;

Estrovite;

Evamist;

Evorel;

FemSeven;

Femanest;

Femestral;

Femogen;

Fempatch;

Follicyclin;

Gelestra;

Ginosedol;

Gynergon;

Gynodiol;

Gynoestryl;

IMVEXXY;

Innofem;

Lamdiol;

Macrodiol;

Menorest;

Menostar;

NSC 9895;

Nordicol;

Oesclim;

Oestergon;

Oestra-1,3,5(10)-triene-3,17β-diol;

Oestradiol;

Oestrogel;

Oestroglandol;

Ovahormon;

Ovasterol;

Ovastevol;

Ovocyclin;

Ovocylin;

Perlatanol;

Primofol;

Profoliol;

Profoliol B;

Progynon;

Progynon DH;

Sandrena 1;

Sprediol;

Syndiol;

Systen;

TX 004HR;

Theelin, dihydro-;

Vagifem;

Vivelle;

Vivelle-Dot;

Zesteem;

Zumenon;

β-Estradiol
Structure:

Related Targets  (Total: 152)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T80PUR Caspase-7CASP7 P55210
A 1 Reference(s)
T25NS3 Caspase-6CASP6 P55212
A 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
A 3 Reference(s)
T38T1U Caspase-8CASP8 Q14790
A 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
A 6 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 2 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
A 1 Reference(s)
T86CQC Glutamate receptor ionotropic, NMDA 1GRIN1 Q05586
A 1 Reference(s)
T57MP0 ChymaseCMA1 P23946
A 1 Reference(s)
T86YQL ProlactinPRL P01236
A 1 Reference(s)
T61NZN Progonadoliberin-1GNRH1 P01148
A 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
A 1 Reference(s)
T91MKC Runt-related transcription factor 2RUNX2 Q13950
A 1 Reference(s)
T70HTD Cytochrome P450 2E1CYP2E1 P05181
A 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
A 2 Reference(s)
T73LXA Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1BHSPA1A;HSPA1B P0DMV8;P0DMV9
A 1 Reference(s)
T23K1O CalmodulinCALM3;CALML2;CAM3;CAMC;CAMIII P62158
B 1 Reference(s)
T32P8F Serine/threonine-protein phosphatase 5PPP5C P53041
B 1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
B 1 Reference(s)
T47HTN Prostaglandin E synthasePTGES O14684
B 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
B 2 Reference(s)
T32YAJ G-protein coupled estrogen receptor 1GPER1 Q99527
B 1 Reference(s)
T11OU8 Progesterone receptorPGR P06401
B 1 Reference(s)
T94FQR Fibroblast growth factor 7FGF7 P21781
B 1 Reference(s)
T47OCS Fibroblast growth factor 10FGF10 O15520
B 1 Reference(s)
T22JG3 Fibroblast growth factor receptor 2FGFR2 P21802
B 2 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
B 4 Reference(s)
T64UH1 Nitric oxide synthase, endothelialNOS3 P29474
B 2 Reference(s)
T32IXS Integrin alpha-MITGAM P11215
B 1 Reference(s)
T04OY0 Granulocyte colony-stimulating factor receptorCSF3R Q99062
B 1 Reference(s)
T16A2X CatalaseCAT P04040
B 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
B 3 Reference(s)
T64X48 C-X-C chemokine receptor type 4CXCR4 P61073
B 1 Reference(s)
T45KYV Stromal cell-derived factor 1CXCL12 P48061
B 1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
B 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
B 1 Reference(s)
T46AQJ Glutathione S-transferase PGSTP1 P09211
B 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
B 1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
B 1 Reference(s)
T04WT7 FibronectinFN1 P02751
B 2 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
B 1 Reference(s)
T50FHQ TGF-beta receptor type-2TGFBR2 P37173
B 1 Reference(s)
T62P0D Collagenase 3MMP13 P45452
B 1 Reference(s)
T83QHM Beta-nerve growth factorNGF P01138
B 1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
B 1 Reference(s)
T16K98 Protein jagged-1JAG1 P78504
B 1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
B 1 Reference(s)
T13KGH TyrosinaseTYR P14679
B 1 Reference(s)
T67JR8 Heat shock factor protein 1HSF1 Q00613
B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
B 2 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
B 2 Reference(s)
T44S1A Apolipoprotein A-IAPOA1 P02647
B 1 Reference(s)
T58D39 OsteocalcinBGLAP P02818
B 1 Reference(s)
T29PSX Receptor of activated protein C kinase 1RACK1 P63244
B 1 Reference(s)
T24U57 E-selectinSELE P16581
B 2 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
B 2 Reference(s)
T54G8J Protein kinase C delta typePRKCD Q05655
B 1 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
B 1 Reference(s)
T64W2K Cyclin-dependent kinase inhibitor 1CDKN1A P38936
B 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
B 1 Reference(s)
T37VLU Interferon gammaIFNG P01579
B 1 Reference(s)
T11AJ4 WW domain-containing oxidoreductaseWWOX Q9NZC7
B 1 Reference(s)
T77TY2 Protein disulfide-isomeraseP4HB P07237
B 1 Reference(s)
T84W8G Aryl hydrocarbon receptorAHR P35869
B 2 Reference(s)
T89L4V InsulinINS P01308
B 1 Reference(s)
T35R2F PR domain zinc finger protein 2PRDM2 Q13029
B 1 Reference(s)
T61OY3 UDP-glucuronosyltransferase 1A1UGT1A1 P22309
B 1 Reference(s)
T57YL7 Sex hormone-binding globulinSHBG P04278
B 1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
C 1 Reference(s)
T78O6C Mothers against decapentaplegic homolog 3SMAD3 P84022
C 1 Reference(s)
T61J7T Mothers against decapentaplegic homolog 2SMAD2 Q15796
C 1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
C 1 Reference(s)
T61HH0 Prostate-specific antigenKLK3 P07288
C 1 Reference(s)
T68NCI Aldo-keto reductase family 1 member B1AKR1B1 P15121
C 1 Reference(s)
T29NEF ResistinRETN Q9HD89
C 1 Reference(s)
T45WII Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptideTGFB3 P10600
C 1 Reference(s)
T47X6Y Thyrotropin subunit betaTSHB P01222
C 1 Reference(s)
T21TC9 Kallikrein-10KLK10 O43240
C 1 Reference(s)
T28HOM LeptinLEP P41159
C 1 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
C 1 Reference(s)
T52FC6 Protein NDRG2NDRG2 Q9UN36
C 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
C 2 Reference(s)
T76EHP Glutathione S-transferase A1GSTA1 P08263
C 2 Reference(s)
T58N83 Serine/threonine-protein kinase STK11STK11 Q15831
C 1 Reference(s)
T69NNS PRKC apoptosis WT1 regulator proteinPAWR Q96IZ0
C 2 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
C 1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
C 2 Reference(s)
T63VZZ Metastasis-suppressor KiSS-1KISS1 Q15726
C 2 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
C 1 Reference(s)
T00EP2 Tissue-type plasminogen activatorPLAT P00750
C 1 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
C 1 Reference(s)
T80MG0 Growth hormone secretagogue receptor type 1GHSR Q92847
C 2 Reference(s)
T98Z62 NAMIR144 NA
C 1 Reference(s)
T15N66 Myosin regulatory light polypeptide 9MYL9 P24844
C 1 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
C 1 Reference(s)
T82LND Myoblast determination protein 1MYOD1 P15172
C 1 Reference(s)
T95K0K Interferon alpha-1/13IFNA1; IFNA13 P01562
C 1 Reference(s)
T06JXV CD44 antigenCD44 P16070
C 1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
C 1 Reference(s)
T51EKP Apolipoprotein MAPOM O95445
C 1 Reference(s)
T47WWK C-C chemokine receptor type 1CCR1 P32246
C 1 Reference(s)
T46PRA Excitatory amino acid transporter 3SLC1A1 P43005
C 1 Reference(s)
T11GHO Transforming protein RhoARHOA P61586
C 1 Reference(s)
T62G0S Cofilin-1CFL1 P23528
C 1 Reference(s)
T82N70 Interleukin-21IL21 Q9HBE4
C 1 Reference(s)
T43QZ3 SclerostinSOST Q9BQB4
C 1 Reference(s)
T77YFO Voltage-dependent L-type calcium channel subunit alpha-1CCACNA1C Q13936
C 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
C 1 Reference(s)
T80R6A Insulin-like growth factor IIGF1 P05019
C 2 Reference(s)
T87TVN Toll-like receptor 5TLR5 O60602
C 1 Reference(s)
T38IRL Interferon-stimulated gene 20 kDa proteinISG20 Q96AZ6
C 1 Reference(s)
T10RBK Atrial natriuretic peptide receptor 2NPR2 P20594
C 1 Reference(s)
T28K6X Insulin receptor substrate 1IRS1 P35568
C 1 Reference(s)
T23RWU Type-1 angiotensin II receptorAGTR1 P30556
C 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
C 1 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
C 1 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
C 1 Reference(s)
T42LAP NAMIR190B NA
C 1 Reference(s)
T50HUJ MerlinNF2 P35240
C 1 Reference(s)
T71HD9 NAMIR148A NA
C 1 Reference(s)
T52HO1 HLA class I histocompatibility antigen, alpha chain GHLA-G P17693
C 1 Reference(s)
T47T27 C-C motif chemokine 24CCL24 O00175
C 1 Reference(s)
T31SX8 Bone morphogenetic protein 2BMP2 P12643
C 1 Reference(s)
T62L0I Pro-FMRFamide-related neuropeptide VF [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVFNPVF Q9HCQ7
C 1 Reference(s)
T51NKF Alpha-2-antiplasminSERPINF2 P08697
C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
C 1 Reference(s)
T06MXL NeprilysinMME P08473
C 1 Reference(s)
T94FK3 Progonadoliberin-2GNRH2 O43555
C 1 Reference(s)
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
C 1 Reference(s)
T43BVC BasiginBSG P35613
C 1 Reference(s)
T87DEX Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenaseXDH P47989
C 1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
C 1 Reference(s)
T76ZOF Apolipoprotein A-IVAPOA4 P06727
C 1 Reference(s)
T73PZA Vesicular inhibitory amino acid transporterSLC32A1 Q9H598
C 1 Reference(s)
T47G3X Glucocorticoid receptorNR3C1 P04150
C 1 Reference(s)
T73ND5 MyocilinMYOC Q99972
C 1 Reference(s)
T40MAR Cadherin-11CDH11 P55287
C 1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
C 1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
C 1 Reference(s)
T04YQC Homeobox protein SIX6SIX6 O95475
C 1 Reference(s)
T06PVX E3 ubiquitin-protein ligase Mdm2MDM2 Q00987
C 1 Reference(s)
T56RMM DNADNMT3A Q9Y6K1
C 1 Reference(s)
T60WNX Vasopressin-neurophysin 2-copeptinAVP P01185
C 1 Reference(s)
T02GD4 Tumor necrosis factor ligand superfamily member 6FASLG P48023
C 1 Reference(s)
T53FD0 Leptin receptorLEPR P48357
C 1 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
C 1 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
C 1 Reference(s)
T91MLF Alpha-1-antitrypsinSERPINA1 P01009
C 1 Reference(s)
T46TBY Prostaglandin E2 receptor EP2 subtypePTGER2 P43116
C 1 Reference(s)
T68O49 Prostaglandin E2 receptor EP4 subtypePTGER4 P35408
C 1 Reference(s)
T35YGY Prostaglandin F2-alpha receptorPTGFR P43088
C 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 17)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0077 Jiu EthanolVinum