Target Description

Type Detail
Target ID T80R6A
Protein Name Insulin-like growth factor I
Uniprot ID P05019
Protein Name Alias IGF-I;  Mechano growth factor;  MGF;  Somatomedin-C
Gene ID 3479
Gene Symbol IGF1
Gene Alias IBP1
TTD T60930: Clinical Trial target
Pfam PF00049
GO
0005178:integrin binding

0046579:positive regulation of Ras protein signal transduction

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0042104:positive regulation of activated T cell proliferation

0070371:ERK1 and ERK2 cascade

0010629:negative regulation of gene expression

0032720:negative regulation of tumor necrosis factor production

0044267:cellular protein metabolic process

0048009:insulin-like growth factor receptor signaling pathway

0035867:alphav-beta3 integrin-IGF-1-IGF1R complex

0040014:regulation of multicellular organism growth

0043568:positive regulation of insulin-like growth factor receptor signaling pathway

0005576:extracellular region

2001237:negative regulation of extrinsic apoptotic signaling pathway

2000679:positive regulation of transcription regulatory region DNA binding

0042567:insulin-like growth factor ternary complex

0060283:negative regulation of oocyte development

0042060:wound healing

0000187:activation of MAPK activity

0043388:positive regulation of DNA binding

0008283:cell population proliferation

0001775:cell activation

0043410:positive regulation of MAPK cascade

0014911:positive regulation of smooth muscle cell migration

0050679:positive regulation of epithelial cell proliferation

0043066:negative regulation of apoptotic process

0045725:positive regulation of glycogen biosynthetic process

0050714:positive regulation of protein secretion

0002576:platelet degranulation

1904707:positive regulation of vascular associated smooth muscle cell proliferation

0008083:growth factor activity

0050821:protein stabilization

0035630:bone mineralization involved in bone maturation

0070886:positive regulation of calcineurin-NFAT signaling cascade

0009408:response to heat

0014904:myotube cell development

0014065:phosphatidylinositol 3-kinase signaling

0008284:positive regulation of cell population proliferation

0032148:activation of protein kinase B activity

0005159:insulin-like growth factor receptor binding

0045821:positive regulation of glycolytic process

0045445:myoblast differentiation

1904646:cellular response to amyloid-beta

1905460:negative regulation of vascular associated smooth muscle cell apoptotic process

0045669:positive regulation of osteoblast differentiation

0048146:positive regulation of fibroblast proliferation

0043491:protein kinase B signaling

0034392:negative regulation of smooth muscle cell apoptotic process

0010468:regulation of gene expression

0010560:positive regulation of glycoprotein biosynthetic process

1904075:positive regulation of trophectodermal cell proliferation

0009441:glycolate metabolic process

0031093:platelet alpha granule lumen

0048661:positive regulation of smooth muscle cell proliferation

0016942:insulin-like growth factor binding protein complex

0014834:skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0030166:proteoglycan biosynthetic process

0045944:positive regulation of transcription by RNA polymerase II

0046326:positive regulation of glucose import

0010628:positive regulation of gene expression

0005158:insulin receptor binding

0014896:muscle hypertrophy

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

1902430:negative regulation of amyloid-beta formation

0007165:signal transduction

0051450:myoblast proliferation

0005615:extracellular space

0150079:negative regulation of neuroinflammatory response

0010613:positive regulation of cardiac muscle hypertrophy

0007265:Ras protein signal transduction

0045840:positive regulation of mitotic nuclear division

0001501:skeletal system development

0061051:positive regulation of cell growth involved in cardiac muscle cell development

0090201:negative regulation of release of cytochrome c from mitochondria

0045893:positive regulation of transcription, DNA-templated

0030335:positive regulation of cell migration

0048015:phosphatidylinositol-mediated signaling

0007517:muscle organ development

0070382:exocytic vesicle

0005179:hormone activity

0032691:negative regulation of interleukin-1 beta production

PDB 1PMX ; 1WQJ ; 1H59 ; 1GF1 ; 1B9G ; 1H02 ; 1IMX ; 6PYH ; 6RVA ; 6FF3 ; 2DSQ ; 2DSR ; 4XSS ; 1BQT ; 1GZY ; 1GZZ ; 3GF1 ; 2DSP ; 1GZR ; 3LRI ; 1TGR ; 5U8Q ; 2GF1
Drugbank DB02643 ; DB01890
KEGG hsa:3479

Related Compounds  (Total: 10)

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C0055
Name: Estradiol
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C0158
Name: Isotretinoin
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C0282
Name: Paeoniflorin
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C0348
Name: Pyridoxine
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C0363
Name: Resveratrol


Related Herbs  (Total: 56)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0763 Yu Mi Xu玉米须 Maize styleZea mays
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0416 Shan Shen山参 NAPanax ginseng
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0244 Mi La蜜蜡 Bee waxApis cerana
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1088 Gan Zhe甘蔗 Sweetcane culmSaccharum sinensis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1162 Hang Shao杭芍 White peony rootPaeonia albiflora
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0253 Mian Hua Gen棉花根 Levant cotton rootGossypium herbaceum
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0077 Jiu EthanolVinum
H0938 Da Suan大蒜 GarlicAllium sativum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0023 Bai Shao Gan Jin Gao白芍干浸膏 Common peonyPaeonia lactiflora
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1036 Fen Dan Pi粉丹皮 Tree peony barkPaeonia suffruticosa
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0021 Bai Shao白芍 Common peonyPaeonia lactiflora
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0257 Mo Gu蘑菇 MushroomAgaricus campestris
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H1040 Feng Mi蜂蜜 HoneyApis cerana
H0357 Ren Shen人参 GinsengPanax ginseng
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H1087 Gan Sui甘遂 Kansui euphorbiaEuphorbia kansui