Target Description

Type Detail
Target ID T50FHQ
Protein Name TGF-beta receptor type-2
Uniprot ID P37173
Protein Name Alias TGFR-2;  EC 2.7.11.30;  TGF-beta type II receptor;  Transforming growth factor-beta receptor type II;  TGF-beta receptor type II;  TbetaR-II
Gene ID 7048
Gene Symbol TGFBR2
Gene Alias NA
TTD T49989: Clinical Trial target
Pfam PF08917 ; PF07714
GO
0016021:integral component of membrane

0032147:activation of protein kinase activity

0007420:brain development

0002666:positive regulation of T cell tolerance induction

0007182:common-partner SMAD protein phosphorylation

0031435:mitogen-activated protein kinase kinase kinase binding

0060463:lung lobe morphogenesis

1905317:inferior endocardial cushion morphogenesis

0043011:myeloid dendritic cell differentiation

0005901:caveola

0007219:Notch signaling pathway

0034714:type III transforming growth factor beta receptor binding

0010718:positive regulation of epithelial to mesenchymal transition

0001947:heart looping

0010634:positive regulation of epithelial cell migration

0002663:positive regulation of B cell tolerance induction

0071363:cellular response to growth factor stimulus

0060412:ventricular septum morphogenesis

0007179:transforming growth factor beta receptor signaling pathway

0042060:wound healing

0003148:outflow tract septum morphogenesis

0002053:positive regulation of mesenchymal cell proliferation

0050431:transforming growth factor beta binding

0004674:protein serine/threonine kinase activity

0005024:transforming growth factor beta-activated receptor activity

0005524:ATP binding

0018107:peptidyl-threonine phosphorylation

0048185:activin binding

1905007:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

0001666:response to hypoxia

0007566:embryo implantation

0003274:endocardial cushion fusion

0043415:positive regulation of skeletal muscle tissue regeneration

0001569:branching involved in blood vessel morphogenesis

0046872:metal ion binding

0006915:apoptotic process

0001570:vasculogenesis

0035162:embryonic hemopoiesis

0002088:lens development in camera-type eye

0004675:transmembrane receptor protein serine/threonine kinase activity

0034713:type I transforming growth factor beta receptor binding

0005539:glycosaminoglycan binding

0003214:cardiac left ventricle morphogenesis

0060440:trachea formation

0008284:positive regulation of cell population proliferation

0003430:growth plate cartilage chondrocyte growth

0002651:positive regulation of tolerance induction to self antigen

0007224:smoothened signaling pathway

0048701:embryonic cranial skeleton morphogenesis

0003149:membranous septum morphogenesis

0042493:response to drug

2000563:positive regulation of CD4-positive, alpha-beta T cell proliferation

0051138:positive regulation of NK T cell differentiation

0007507:heart development

0043627:response to estrogen

0010468:regulation of gene expression

0062009:secondary palate development

0017002:activin-activated receptor activity

0048565:digestive tract development

0006898:receptor-mediated endocytosis

0005886:plasma membrane

0003181:atrioventricular valve morphogenesis

0048661:positive regulation of smooth muscle cell proliferation

1990428:miRNA transport

0048545:response to steroid hormone

0060443:mammary gland morphogenesis

0003151:outflow tract morphogenesis

0042127:regulation of cell population proliferation

0007568:aging

0007369:gastrulation

2000379:positive regulation of reactive oxygen species metabolic process

0060389:pathway-restricted SMAD protein phosphorylation

0003186:tricuspid valve morphogenesis

0060434:bronchus morphogenesis

1990086:lens fiber cell apoptotic process

0060044:negative regulation of cardiac muscle cell proliferation

0046332:SMAD binding

0006468:protein phosphorylation

0001568:blood vessel development

0007584:response to nutrient

0018105:peptidyl-serine phosphorylation

0030512:negative regulation of transforming growth factor beta receptor signaling pathway

0005829:cytosol

0009897:external side of plasma membrane

0001701:in utero embryonic development

0005887:integral component of plasma membrane

0043235:receptor complex

0045766:positive regulation of angiogenesis

0009612:response to mechanical stimulus

0009749:response to glucose

0045121:membrane raft

0031100:animal organ regeneration

0070723:response to cholesterol

0005026:transforming growth factor beta receptor activity, type II

PDB 1M9Z ; 4XJJ ; 5E91 ; 3KFD ; 5QIN ; 5TX4 ; 1KTZ ; 1PLO ; 5E92 ; 5TY4 ; 5E8Y ; 4P7U ; 2PJY ; 5E8V
Drugbank DB12010 ; DB10770 ; DB10772
KEGG hsa:7048

Related Compounds  (Total: 3)

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C0055
Name: Estradiol
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C0406
Name: Simvastatin
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C1170
Name: Berbamine


Related Herbs  (Total: 18)

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H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0077 Jiu EthanolVinum
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng