Target Description

Type Detail
Target ID T47HTN
Protein Name Prostaglandin E synthase
Uniprot ID O14684
Protein Name Alias EC 5.3.99.3;  Glutathione peroxidase PTGES;  EC 1.11.1.-;  Glutathione transferase PTGES;  EC 2.5.1.18;  Microsomal glutathione S-transferase 1-like 1;  MGST1-L1;  Microsomal prostaglandin E synthase 1;  MPGES-1;  p53-induced gene 12 protein
Gene ID 9536
Gene Symbol PTGES
Gene Alias MGST1L1;  MPGES1;  PGES;  PIG12
TTD T02562: Clinical Trial target
Pfam PF01124
GO
0004667:prostaglandin-D synthase activity

0050220:prostaglandin-E synthase activity

0005641:nuclear envelope lumen

0016021:integral component of membrane

0002526:acute inflammatory response

0016020:membrane

0002544:chronic inflammatory response

0031620:regulation of fever generation

0032496:response to lipopolysaccharide

0008285:negative regulation of cell population proliferation

0051592:response to calcium ion

0004364:glutathione transferase activity

0043295:glutathione binding

0004602:glutathione peroxidase activity

0034097:response to cytokine

0014070:response to organic cyclic compound

0048471:perinuclear region of cytoplasm

0019233:sensory perception of pain

0005789:endoplasmic reticulum membrane

0019371:cyclooxygenase pathway

0032526:response to retinoic acid

0006693:prostaglandin metabolic process

0007165:signal transduction

0001516:prostaglandin biosynthetic process

0032308:positive regulation of prostaglandin secretion

0050727:regulation of inflammatory response

PDB 5BQG ; 4BPM ; 5BQH ; 5T36 ; 4AL1 ; 5K0I ; 6VL4 ; 5BQI ; 5TL9 ; 4YL3 ; 4WAB ; 4YK5 ; 3DWW ; 4AL0 ; 4YL0 ; 5T37 ; 4YL1
Drugbank NA
KEGG hsa:9536

Related Compounds  (Total: 8)

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C0040
Name: Embelin
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C0055
Name: Estradiol
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C0199
Name: Luteolin
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C0363
Name: Resveratrol
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C0456
Name: Tretinoin


Related Herbs  (Total: 195)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0695 Ya Dan Zi鸦胆子 Java bruceaBrucea javanica
H0832 Zhu Sha Gen朱砂根 Coral ardisiaArdisia crenata
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0357 Ren Shen人参 GinsengPanax ginseng
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H1219 Hua Sheng Mi花生米 NAArachis hypogaea
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0727 Ye Gan Cao野甘草 Sweet broomwortScoparia dulcis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0142 Liang Jiang良姜 NAAlpinia officinarum
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0183 Luo Hua Sheng Zhi Ye落花生枝叶 Peanut branch-leafArachis hypogaea
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0590 Wei Ling威灵 Chinese clematisClematis chinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0901 Chun Gen Teng春根藤 Twig and leaf of creeping psychotriaPsychotria serpens
H0247 Mi Meng Hua密蒙花 Pale butterflybushBuddleja officinalis
H0045 Jin Fei Cao金沸草 Japanese inulaInula japonica
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1218 Hua Sheng花生 NAArachis hypogaea
H0668 Xiao Ye Huang Yang小叶黄杨 Small-leaved boxBuxus microphylla
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0592 Wei Ling Xian威灵仙 Chinese clematisClematis chinensis
H0329 Qian Niu Zi牵牛子 Lobedleaf pharbitis seedPharbitis nil
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H1160 Han Xin Cao韩信草 Indian skullcapScutellaria indica
H0077 Jiu EthanolVinum
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0848 Zi Jin Niu紫金牛 Japanese ardisiaArdisia japonica
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0010 Ji Guan Hua鸡冠花 Common cockscomb flowerCelosia cristata
H0218 Man Jiu Jie蔓九节 Creeping ninenodePsychotria serpens
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H0730 Ye Ma Zhui野马追 NAEupatorium lindleyanum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H0524 Tan Xiang檀香 SandalwoodSantalum album
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H0379 Bian Xu萹蓄 Common knotgrassPolygonum aviculare
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0416 Shan Shen山参 NAPanax ginseng
H0919 Cui Yun Cao翠云草 Hooked spikemossSelaginella uncinata
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H0204 Ma Ren麻仁 NACannabis sativa