Herb Description
| Herb ID: H0461 | Chinese Character: 使君子仁 |
| English Name: NA | Latin Name: Combretum indicum |
| Chinese Pin Yin : Shi Jun Zi Ren | TCM-ID: TCMH1939 |
| Therapeutic Function in Chinese : NA | Therapeutic Function in English: NA |
| Herb Function: NA | |
Related Targets (Total: 205)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
4 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
7 Reference(s) |
| T74P7I | G-protein coupled bile acid receptor 1 | GPBAR1 |
Q8TDU6 |
2 Reference(s) |
| T02O3F | Endothelial lipase | LIPG |
Q9Y5X9 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
4 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
5 Reference(s) |
| T36HAE | D-amino-acid oxidase | DAO |
P14920 |
1 Reference(s) |
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
| T89GFN | Macrophage migration inhibitory factor | MIF |
P14174 |
1 Reference(s) |
| T16X77 | Solute carrier family 15 member 1 | SLC15A1 |
P46059 |
1 Reference(s) |
| T97VA2 | Transient receptor potential cation channel subfamily V member 4 | TRPV4 |
Q9HBA0 |
1 Reference(s) |
| T71B0A | Cytosolic phospholipase A2 | PLA2G4A |
P47712 |
2 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
6 Reference(s) |
| T60XJI | Transient receptor potential cation channel subfamily M member 8 | TRPM8 |
Q7Z2W7 |
1 Reference(s) |
| T59DDI | Liver carboxylesterase 1 | CES1 |
P23141 |
1 Reference(s) |
| T41WA8 | Ephrin type-A receptor 2 | EPHA2 |
P29317 |
1 Reference(s) |
| T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
1 Reference(s) |
| T08Q1T | Amiloride-sensitive sodium channel subunit alpha | SCNN1A |
P37088 |
1 Reference(s) |
| T80GST | Acid-sensing ion channel 3 | ASIC3 |
Q9UHC3 |
1 Reference(s) |
| T40EUL | Transient receptor potential cation channel subfamily V member 4 | TRPV4 |
Q9HBA0 |
1 Reference(s) |
| T70U24 | Sigma non-opioid intracellular receptor 1 | SIGMAR1 |
Q99720 |
1 Reference(s) |
| T95Y0K | Sphingosine kinase 1 | SPHK1 |
Q9NYA1 |
1 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
1 Reference(s) |
| T21K0F | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | ATP2A3 |
Q93084 |
1 Reference(s) |
| T92X7D | Nucleoside diphosphate kinase A | NME1 |
P15531 |
1 Reference(s) |
| T14AON | Nucleoside diphosphate kinase, mitochondrial | NME4 |
O00746 |
1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
1 Reference(s) |
| T77ERW | Protein disulfide-isomerase A3 | PDIA3 |
P30101 |
1 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
3 Reference(s) |
| T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
1 Reference(s) |
| T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
2 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
5 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T06VX0 | MAP/microtubule affinity-regulating kinase 4 | MARK4 |
Q96L34 |
1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
1 Reference(s) |
| T20IHC | Diacylglycerol O-acyltransferase 1 | DGAT1 |
O75907 |
2 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
1 Reference(s) |
| T16UZ4 | Dipeptidyl peptidase 4 | DPP4 |
P27487 |
1 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
2 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
3 Reference(s) |
| T74WWP | Peroxisome proliferator-activated receptor delta | PPARD |
Q03181 |
1 Reference(s) |
| T14JSX | Plasminogen | PLG |
P00747 |
1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
3 Reference(s) |
| T67LRH | RNA-binding protein Musashi homolog 1 | MSI1 |
O43347 |
1 Reference(s) |
| T37G49 | Platelet-activating factor acetylhydrolase | PLA2G7 |
Q13093 |
1 Reference(s) |
| T38N54 | Fumarate hydratase, mitochondrial | FH |
P07954 |
1 Reference(s) |
| T18VDI | Apoptosis-inducing factor 1, mitochondrial | AIFM1 |
O95831 |
1 Reference(s) |
| T62KUY | Endonuclease G, mitochondrial | ENDOG |
Q14249 |
1 Reference(s) |
| T90ADC | BH3-interacting domain death agonist | BID |
P55957 |
1 Reference(s) |
| T86J48 | Sodium/glucose cotransporter 1 | SLC5A1 |
P13866 |
1 Reference(s) |
| T77PFO | Histone deacetylase 6 | HDAC6 |
Q9UBN7 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
6 Reference(s) |
| T43G0N | Cytochrome P450 2C8 | CYP2C8 |
P10632 |
1 Reference(s) |
| T69XEM | Tyrosine-protein kinase SYK | SYK |
P43405 |
1 Reference(s) |
| T70HTD | Cytochrome P450 2E1 | CYP2E1 |
P05181 |
1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
2 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
2 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
2 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
2 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
2 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
| T53FF1 | S-phase kinase-associated protein 2 | SKP2 |
Q13309 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
2 Reference(s) |
| T75NEV | Aquaporin-1 | AQP1 |
P29972 |
1 Reference(s) |
| T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
2 Reference(s) |
| T53SLQ | Aquaporin-9 | AQP9 |
O43315 |
2 Reference(s) |
| T89EW0 | Aquaporin-8 | AQP8 |
O94778 |
1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
2 Reference(s) |
| T41A4Y | Lamin-B1 | LMNB1 |
P20700 |
1 Reference(s) |
| T19JEU | Beta-galactosidase | GLB1 |
P16278 |
1 Reference(s) |
| T32OC4 | Aldehyde dehydrogenase, mitochondrial | ALDH2 |
P05091 |
1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
2 Reference(s) |
| T34ZZ0 | Potassium channel subfamily K member 2 | KCNK2 |
O95069 |
1 Reference(s) |
| T58TOI | Apolipoprotein D | APOD |
P05090 |
1 Reference(s) |
| T14AV3 | Potassium channel subfamily K member 10 | KCNK10 |
P57789 |
1 Reference(s) |
| T07NML | P-selectin | SELP |
P16109 |
1 Reference(s) |
| T16KVU | Tumor necrosis factor receptor superfamily member 1A | TNFRSF1A |
P19438 |
1 Reference(s) |
| T05ZBL | Tumor necrosis factor receptor superfamily member 1B | TNFRSF1B |
P20333 |
1 Reference(s) |
| T47HTN | Prostaglandin E synthase | PTGES |
O14684 |
1 Reference(s) |
| T44OPR | Aldehyde dehydrogenase, dimeric NADP-preferring | ALDH3A1 |
P30838 |
1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
2 Reference(s) |
| T32P8F | Serine/threonine-protein phosphatase 5 | PPP5C |
P53041 |
1 Reference(s) |
| T72BXP | Platelet endothelial cell adhesion molecule | PECAM1 |
P16284 |
1 Reference(s) |
| T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
1 Reference(s) |
| T84AR4 | Smoothened homolog | SMO |
Q99835 |
1 Reference(s) |
| T56OUM | 14-3-3 protein zeta/delta | YWHAZ |
P63104 |
2 Reference(s) |
| T30TYH | Phospholipase A2 | PLA2G1B |
P04054 |
1 Reference(s) |
| T68XO1 | Indoleamine 2,3-dioxygenase 1 | IDO1 |
P14902 |
1 Reference(s) |
| T10OBQ | Endophilin-A1 | SH3GL2 |
Q99962 |
1 Reference(s) |
| T76EHP | Glutathione S-transferase A1 | GSTA1 |
P08263 |
1 Reference(s) |
| T48XM4 | Glutathione S-transferase Mu 2 | GSTM2 |
P28161 |
1 Reference(s) |
| T87WYU | Glutathione S-transferase Mu 1 | GSTM1 |
P09488 |
1 Reference(s) |
| T24CYX | Chitin synthase 2 | CHS2 |
P14180 |
1 Reference(s) |
| T46AQJ | Glutathione S-transferase P | GSTP1 |
P09211 |
1 Reference(s) |
| T62F1Y | Glutathione S-transferase A2 | GSTA2 |
P09210 |
1 Reference(s) |
| T10KMJ | Insulin-like growth factor II | IGF2 |
P01344 |
1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
2 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
3 Reference(s) |
| T97KL5 | Microsomal glutathione S-transferase 1 | MGST1 |
P10620 |
2 Reference(s) |
| T81BH5 | Sulfotransferase 1A1 | SULT1A1 |
P50225 |
2 Reference(s) |
| T32SPJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | PIK3CG |
P48736 |
1 Reference(s) |
| T39YFG | Trypsin-1 | PRSS1 |
P07477 |
1 Reference(s) |
| T54WR0 | Fatty acid-binding protein 5 | FABP5 |
Q01469 |
1 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
2 Reference(s) |
| T07S0E | BDNF/NT-3 growth factors receptor | NTRK2 |
Q16620 |
1 Reference(s) |
| T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
| T51WGR | Pancreas/duodenum homeobox protein 1 | PDX1 |
P52945 |
1 Reference(s) |
| T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
1 Reference(s) |
| T89L4V | Insulin | INS |
P01308 |
1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
| T23YZF | Peptidyl-glycine alpha-amidating monooxygenase | PAM |
P19021 |
1 Reference(s) |
| T77FOL | Neuromodulin | GAP43 |
P17677 |
1 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
2 Reference(s) |
| T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
1 Reference(s) |
| T02DEN | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide | GCG |
P01275 |
1 Reference(s) |
| T48UT8 | Cholesteryl ester transfer protein | CETP |
P11597 |
2 Reference(s) |
| T32HPO | Aspartyl aminopeptidase | DNPEP |
Q9ULA0 |
1 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
| T02YLA | Alpha-lactalbumin | LALBA |
P00709 |
1 Reference(s) |
| T76TED | Pro-opiomelanocortin | POMC |
P01189 |
1 Reference(s) |
| T37JN5 | Neutrophil gelatinase-associated lipocalin | LCN2 |
P80188 |
1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
3 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
2 Reference(s) |
| T31SX8 | Bone morphogenetic protein 2 | BMP2 |
P12643 |
1 Reference(s) |
| T23EWB | Transcriptional repressor protein YY1 | YY1 |
P25490 |
1 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
2 Reference(s) |
| T61DYZ | Phospholipid-transporting ATPase ABCA1 | ABCA1 |
O95477 |
1 Reference(s) |
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
| T69VYP | ATP-binding cassette sub-family G member 1 | ABCG1 |
P45844 |
1 Reference(s) |
| T87UKX | Glucose-6-phosphate 1-dehydrogenase | G6PD |
P11413 |
1 Reference(s) |
| T21EGX | Multidrug resistance-associated protein 1 | ABCC1 |
P33527 |
1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
1 Reference(s) |
| T29NEF | Resistin | RETN |
Q9HD89 |
1 Reference(s) |
| T67RBZ | Mitochondrial uncoupling protein 2 | UCP2 |
P55851 |
2 Reference(s) |
| T32ECR | Collagen alpha-2(I) chain | COL1A2 |
P08123 |
1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
2 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
2 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
1 Reference(s) |
| T09KPZ | Vimentin | VIM |
P08670 |
1 Reference(s) |
| T16DCZ | Twist-related protein 1 | TWIST1 |
Q15672 |
1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T42FMQ | Mitogen-activated protein kinase kinase kinase 1 | MAP3K1 |
Q13233 |
1 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
1 Reference(s) |
| T51EKP | Apolipoprotein M | APOM |
O95445 |
1 Reference(s) |
| T07VV7 | Guanylin | GUCA2A |
Q02747 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
5 Reference(s) |
| T80WPU | Protein ABHD15 | ABHD15 |
Q6UXT9 |
1 Reference(s) |
| T24YWQ | Insulin-degrading enzyme | IDE |
P14735 |
1 Reference(s) |
| T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
1 Reference(s) |
| T08B2M | M-phase inducer phosphatase 1 | CDC25A |
P30304 |
1 Reference(s) |
| T33UEM | Lactoperoxidase | LPO |
P22079 |
1 Reference(s) |
| T03TJ0 | Interleukin-33 | IL33 |
O95760 |
1 Reference(s) |
| T40G6B | Prostaglandin reductase 1 | PTGR1 |
Q14914 |
1 Reference(s) |
| T31VDH | Myeloid differentiation primary response protein MyD88 | MYD88 |
Q99836 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
1 Reference(s) |
| T67HYX | Mitochondrial uncoupling protein 3 | UCP3 |
P55916 |
1 Reference(s) |
| T19EKF | Cholecystokinin | CCK |
P06307 |
1 Reference(s) |
| T19XSL | Fatty acid-binding protein, liver | FABP1 |
P07148 |
1 Reference(s) |
| T23APZ | Retinol-binding protein 2 | RBP2 |
P50120 |
1 Reference(s) |
| T03NWF | Sterol O-acyltransferase 1 | SOAT1 |
P35610 |
1 Reference(s) |
| T75EH8 | Glucagon-like peptide 1 receptor | GLP1R |
P43220 |
1 Reference(s) |
| T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
1 Reference(s) |
| T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
2 Reference(s) |
| T98DNG | Natriuretic peptides A | NPPA |
P01160 |
1 Reference(s) |
| T78ILO | Stearoyl-CoA desaturase | SCD |
O00767 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
2 Reference(s) |
| T68IZC | Natriuretic peptides B | NPPB |
P16860 |
1 Reference(s) |
| T02H9U | Nuclear factor of activated T-cells, cytoplasmic 4 | NFATC4 |
Q14934 |
1 Reference(s) |
| T76AZQ | Histidine decarboxylase | HDC |
P19113 |
1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
| T04V7K | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | ENPP7 |
Q6UWV6 |
1 Reference(s) |
| T51U9M | Carnitine O-palmitoyltransferase 1, muscle isoform | CPT1B |
Q92523 |
1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
1 Reference(s) |
| T33KFW | Matrilysin | MMP7 |
P09237 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
| T36ZU3 | Ras GTPase-activating-like protein IQGAP2 | IQGAP2 |
Q13576 |
1 Reference(s) |
| T82G3R | Integrin beta-3 | ITGB3 |
P05106 |
1 Reference(s) |
| T92CLX | Calcitonin receptor | CALCR |
P30988 |
1 Reference(s) |
| T81I6O | Nucleophosmin | NPM1 |
P06748 |
1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T34E5V | Endothelin-1 receptor | EDNRA |
P25101 |
1 Reference(s) |
| T90ZS8 | Endothelin-converting enzyme 1 | ECE1 |
P42892 |
1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
1 Reference(s) |
| T67LQK | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | MAPK11 |
Q15759 |
1 Reference(s) |
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
1 Reference(s) |
Related Compounds (Total: 18)
C1180
Name: Betulinic Acid
C1166
Name: Benzoic Acid
C0917
Name: Arachidonic Acid
C0231
Name: Myristic Acid
C0039
Name: Ellagic Acid
key description of the interaction between compound and target