Target Description

Type Detail
Target ID T69XEM
Protein Name Tyrosine-protein kinase SYK
Uniprot ID P43405
Protein Name Alias EC 2.7.10.2;  Spleen tyrosine kinase;  p72-Syk
Gene ID 6850
Gene Symbol SYK
Gene Alias NA
TTD T62431: Successful target
Pfam PF00017 ; PF07714
GO
0005178:integrin binding

0032991:protein-containing complex

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0050853:B cell receptor signaling pathway

0002862:negative regulation of inflammatory response to antigenic stimulus

0006606:protein import into nucleus

0019815:B cell receptor complex

0002283:neutrophil activation involved in immune response

0071639:positive regulation of monocyte chemotactic protein-1 production

0005102:signaling receptor binding

0001525:angiogenesis

0032009:early phagosome

0046777:protein autophosphorylation

0090237:regulation of arachidonic acid secretion

0002250:adaptive immune response

0002366:leukocyte activation involved in immune response

0001784:phosphotyrosine residue binding

0045087:innate immune response

0007257:activation of JUN kinase activity

0051090:regulation of DNA-binding transcription factor activity

0042101:T cell receptor complex

0001945:lymph vessel development

0019221:cytokine-mediated signaling pathway

0038110:interleukin-2-mediated signaling pathway

0002092:positive regulation of receptor internalization

0033630:positive regulation of cell adhesion mediated by integrin

0030593:neutrophil chemotaxis

0032481:positive regulation of type I interferon production

0031234:extrinsic component of cytoplasmic side of plasma membrane

0004674:protein serine/threonine kinase activity

0004713:protein tyrosine kinase activity

0038156:interleukin-3-mediated signaling pathway

0005524:ATP binding

0007229:integrin-mediated signaling pathway

0032755:positive regulation of interleukin-6 production

0032760:positive regulation of tumor necrosis factor production

0038095:Fc-epsilon receptor signaling pathway

0002223:stimulatory C-type lectin receptor signaling pathway

0042742:defense response to bacterium

0030154:cell differentiation

0032753:positive regulation of interleukin-4 production

0042169:SH2 domain binding

0045588:positive regulation of gamma-delta T cell differentiation

0004672:protein kinase activity

0043306:positive regulation of mast cell degranulation

0048514:blood vessel morphogenesis

0031334:positive regulation of protein-containing complex assembly

0019370:leukotriene biosynthetic process

0031623:receptor internalization

0010803:regulation of tumor necrosis factor-mediated signaling pathway

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0004715:non-membrane spanning protein tyrosine kinase activity

0045780:positive regulation of bone resorption

0043313:regulation of neutrophil degranulation

0051712:positive regulation of killing of cells of other organism

0050850:positive regulation of calcium-mediated signaling

0046638:positive regulation of alpha-beta T cell differentiation

0032733:positive regulation of interleukin-10 production

0016170:interleukin-15 receptor binding

0071404:cellular response to low-density lipoprotein particle stimulus

0005886:plasma membrane

0045579:positive regulation of B cell differentiation

0043366:beta selection

0046641:positive regulation of alpha-beta T cell proliferation

0005634:nucleus

0019901:protein kinase binding

0070372:regulation of ERK1 and ERK2 cascade

0032735:positive regulation of interleukin-12 production

0030168:platelet activation

0032928:regulation of superoxide anion generation

0050764:regulation of phagocytosis

0019902:phosphatase binding

0032725:positive regulation of granulocyte macrophage colony-stimulating factor production

0002554:serotonin secretion by platelet

0035325:Toll-like receptor binding

0038096:Fc-gamma receptor signaling pathway involved in phagocytosis

0120162:positive regulation of cold-induced thermogenesis

0018108:peptidyl-tyrosine phosphorylation

0006468:protein phosphorylation

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0032757:positive regulation of interleukin-8 production

0018105:peptidyl-serine phosphorylation

0002281:macrophage activation involved in immune response

0005829:cytosol

0007159:leukocyte cell-cell adhesion

0005737:cytoplasm

0071226:cellular response to molecule of fungal origin

0010543:regulation of platelet activation

0032930:positive regulation of superoxide anion generation

0009887:animal organ morphogenesis

0038063:collagen-activated tyrosine kinase receptor signaling pathway

0032752:positive regulation of interleukin-3 production

0090330:regulation of platelet aggregation

0016032:viral process

0004714:transmembrane receptor protein tyrosine kinase activity

PDB 4XG2 ; 4XG9 ; 4FL1 ; 4GFG ; 4XG6 ; 5Y5T ; 6HM7 ; 6VOV ; 5LMB ; 4FL2 ; 4XG8 ; 4XG7 ; 3TUB ; 4YJP ; 4FZ7 ; 5CXH ; 4RX9 ; 5Y5U ; 4RX7 ; 4PX6 ; 4FL3 ; 4YJT ; 5CXZ ; 3BUW ; 5CY3 ; 4I0S ; 3EMG ; 4XG4 ; 1XBA ; 4YJO ; 4RSS ; 4FYN ; 4YJU ; 5LMA ; 5GHV ; 4DFL ; 4DFN ; 5T68 ; 5TR6 ; 5TT7 ; 4YJV ; 5C26 ; 3TUD ; 4PUZ ; 5TIU ; 6SSB ; 1XBC ; 3FQE ; 1A81 ; 3FQH ; 3TUC ; 3VF9 ; 3FQS ; 4YJS ; 6HM6 ; 4YJQ ; 1CSY ; 4PV0 ; 4I0R ; 1CSZ ; 4XG3 ; 5C27 ; 4FZ6 ; 4WNM ; 3VF8 ; 1XBB ; 4FYO ; 4F4P ; 4I0T ; 3SRV ; 4RX8 ; 4YJR
Drugbank DB07194 ; DB06834 ; DB08361 ; DB07159 ; DB08846 ; DB12010 ; DB02010
KEGG hsa:6850

Related Compounds  (Total: 5)

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C0101
Name: Genistein
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C0210
Name: Melatonin
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C0308
Name: Piceatannol
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C0427
Name: Tanshinone I
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C0739
Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione


Related Herbs  (Total: 69)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H1227 Huai Zhi槐枝 NASophora japonica
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0357 Ren Shen人参 GinsengPanax ginseng
H1186 Hong Gen Cao红根草 Hispid sageSalvia prionitis
H0845 Zi Dan Shen紫丹参 Manchurian sageSalvia przewalskii var. mandarinorum
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H1007 Dou You豆油 Soybean oilGlycine max
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0472 Shu Da Huang熟大黄 NARheum palmatum
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0026 Jiang Soybean pasteGlycine max
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H1229 Bai Mu Xiang白木香 Chinese eaglewoodAquilaria sinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0323 Qian Hu前胡 Common hogfennelAngelica decursiva
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1225 Huai Mi槐米 NASophora japonica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0416 Shan Shen山参 NAPanax ginseng
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis