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Compound Description

ID:   C0210 Common name:   Melatonin
IUPAC:  N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide CAS:  CAS:73-31-4
Chembl ID:   CHEMBL45 Pubchem ID:   CID:896
Formula:  C13H16N2O2 TCM-ID:  TCMC1541
Smiles:  COc1ccc2c(c1)c(CCN=C(O)C)c[nH]2
Alias:

Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-;

N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide;

3-(2-Acetamidoethyl)-5-methoxyindole;

5-Methoxy-N-acetyltryptamine;

Circadin;

Melatol;

Melatonin;

Melatonine;

Melaxen;

Melovine;

N-Acetyl-5-methoxytryptamine;

N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide;

NSC 113928;

NSC 56423;

Regulin
Structure:

Related Targets  (Total: 62)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T30VNV MyeloperoxidaseMPO P05164
 A 2 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
 A 3 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
 A 2 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
 A 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
 A 1 Reference(s)
T70MCF Cyclic AMP-dependent transcription factor ATF-6 alphaATF6 P18850
 A 1 Reference(s)
T43LYL X-box-binding protein 1XBP1 P17861
 A 1 Reference(s)
T69XEM Tyrosine-protein kinase SYKSYK P43405
 A 1 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
 A 1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
 A 1 Reference(s)
T74RBE Inositol 1,4,5-trisphosphate receptor type 1ITPR1 Q14643
 B 1 Reference(s)
T63VZZ Metastasis-suppressor KiSS-1KISS1 Q15726
 B 1 Reference(s)
T58K2N Calmodulin-3;Calmodulin-1;Calmodulin-2CALM3;CALM1;CALM2 P0DP25;P0DP23;P0DP24
 B 2 Reference(s)
T28K6X Insulin receptor substrate 1IRS1 P35568
 B 1 Reference(s)
T31RG4 NAMIR98 NA
 B 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
 C 2 Reference(s)
T62Z4P Sarcoplasmic/endoplasmic reticulum calcium ATPase 2ATP2A2 P16615
 C 1 Reference(s)
T32BH6 cGMP-specific 3',5'-cyclic phosphodiesterasePDE5A O76074
 C 1 Reference(s)
T35XJB Period circadian protein homolog 1PER1 O15534
 C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
 C 2 Reference(s)
T16A2X CatalaseCAT P04040
 C 2 Reference(s)
T67MQU AntileukoproteinaseSLPI P03973
 C 1 Reference(s)
T87QBF Alkaline phosphatase, tissue-nonspecific isozymeALPL P05186
 C 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
 C 1 Reference(s)
T10IWJ Bone morphogenetic protein receptor type-2BMPR2 Q13873
 C 1 Reference(s)
T16SLA Mothers against decapentaplegic homolog 6SMAD6 O43541
 C 1 Reference(s)
T98OJA Mothers against decapentaplegic homolog 7SMAD7 O15105
 C 1 Reference(s)
T95IYZ AdiponectinADIPOQ Q15848
 C 1 Reference(s)
T35V03 Eyes absent homolog 3EYA3 Q99504
 C 1 Reference(s)
T05PKX Steroid 17-alpha-hydroxylase/17,20 lyaseCYP17A1 P05093
 C 1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
 C 1 Reference(s)
T67GDP Aryl hydrocarbon receptor nuclear translocator-like protein 1ARNTL O00327
 C 1 Reference(s)
T20OEM Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1PIN1 Q13526
 C 1 Reference(s)
T06UK9 Homeobox protein Hox-C13HOXC13 P31276
 C 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
 C 1 Reference(s)
T06URY Transcription factor Sp1SP1 P08047
 C 1 Reference(s)
T15UBS Suppressor of cytokine signaling 1SOCS1 O15524
 C 1 Reference(s)
T74J8E Synaptic vesicular amine transporterSLC18A2 Q05940
 C 1 Reference(s)
T60DK9 Rho-associated protein kinase 1ROCK1 Q13464
 C 2 Reference(s)
T02GD4 Tumor necrosis factor ligand superfamily member 6FASLG P48023
 C 1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
 C 1 Reference(s)
T80OP0 Alternative prion protein;Major prion proteinPRNP F7VJQ1;P04156
 C 1 Reference(s)
T28HOM LeptinLEP P41159
 C 1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
 C 1 Reference(s)
T82S9G DNA repair protein RAD51 homolog 1RAD51 Q06609
 C 1 Reference(s)
T15C1D NestinNES P48681
 C 1 Reference(s)
T13DHC Disintegrin and metalloproteinase domain-containing protein 10ADAM10 O14672
 C 1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
 C 1 Reference(s)
T55DO8 NALOC102724197 NA
 C 1 Reference(s)
T13YN2 Bcl-2-like protein 1Bcl2l1 Q64373
 C 1 Reference(s)
T23P74 Caspase-9CASP9 P55211
 C 1 Reference(s)
T12W63 Rho-associated protein kinase 2ROCK2 O75116
 C 1 Reference(s)
T19BRL Interferon-induced helicase C domain-containing protein 1IFIH1 Q9BYX4
 C 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
 C 1 Reference(s)
T84WE9 Vascular endothelial growth factor receptor 1FLT1 P17948
 C 1 Reference(s)
T06VYG Dentin sialophosphoprotein [Cleaved into: Dentin phosphoproteinDSPP Q9NZW4
 C 1 Reference(s)
T97TLX Activin receptor type-1ACVR1 Q04771
 C 1 Reference(s)
T06CBM ELAV-like protein 4ELAVL4 P26378
 C 1 Reference(s)
T20E5P Cytochrome b-245 heavy chainCYBB P04839
 C 1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
 C 2 Reference(s)
T57HGP Tumor necrosis factor receptor superfamily member 6FAS P25445
 C 1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 3)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens

Ckey description of the interaction between compound and target


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