HIT-result

Target Description

Type	Detail
Target ID	T98OJA
Protein Name	Mothers against decapentaplegic homolog 7
Uniprot ID	O15105
Protein Name Alias	MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7
Gene ID	4092
Gene Symbol	SMAD7
Gene Alias	MADH7; MADH8
TTD	T94695: Clinical Trial target
Pfam	PF03165 ; PF03166
GO	0005813:centrosome 0060389:pathway-restricted SMAD protein phosphorylation 0032991:protein-containing complex 0008013:beta-catenin binding 0031625:ubiquitin protein ligase binding 0048185:activin binding 0034616:response to laminar fluid shear stress 0055117:regulation of cardiac muscle contraction 0060373:regulation of ventricular cardiac muscle cell membrane depolarization 0016579:protein deubiquitination 0030279:negative regulation of ossification 0010944:negative regulation of transcription by competitive promoter binding 1902731:negative regulation of chondrocyte proliferation 0060395:SMAD protein signal transduction 0030336:negative regulation of cell migration 0002725:negative regulation of T cell cytokine production 0030512:negative regulation of transforming growth factor beta receptor signaling pathway 0031397:negative regulation of protein ubiquitination 0046872:metal ion binding 0005829:cytosol 0034629:cellular protein-containing complex localization 0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process 0001657:ureteric bud development 0030154:cell differentiation 2000317:negative regulation of T-helper 17 type immune response 0050821:protein stabilization 0060394:negative regulation of pathway-restricted SMAD protein phosphorylation 1903043:positive regulation of chondrocyte hypertrophy 0005886:plasma membrane 0043433:negative regulation of DNA-binding transcription factor activity 0033137:negative regulation of peptidyl-serine phosphorylation 0051444:negative regulation of ubiquitin-protein transferase activity 0032925:regulation of activin receptor signaling pathway 0030514:negative regulation of BMP signaling pathway 0005654:nucleoplasm 0005737:cytoplasm 0003677:DNA binding 0031398:positive regulation of protein ubiquitination 0034713:type I transforming growth factor beta receptor binding 2000320:negative regulation of T-helper 17 cell differentiation 0005518:collagen binding 0045944:positive regulation of transcription by RNA polymerase II 0055010:ventricular cardiac muscle tissue morphogenesis 0034333:adherens junction assembly 1990830:cellular response to leukemia inhibitory factor 0009653:anatomical structure morphogenesis 0005634:nucleus 0022409:positive regulation of cell-cell adhesion 0010717:regulation of epithelial to mesenchymal transition 0010801:negative regulation of peptidyl-threonine phosphorylation 0071144:heteromeric SMAD protein complex 0048844:artery morphogenesis 0060412:ventricular septum morphogenesis 0007179:transforming growth factor beta receptor signaling pathway 0071560:cellular response to transforming growth factor beta stimulus 0030509:BMP signaling pathway 0001650:fibrillar center 0140416:transcription regulator inhibitor activity 0000785:chromatin 0017015:regulation of transforming growth factor beta receptor signaling pathway 0000122:negative regulation of transcription by RNA polymerase II 0070411:I-SMAD binding 0010719:negative regulation of epithelial to mesenchymal transition
PDB	2LTY ; 2LTW ; 2DJY ; 2KXQ ; 2LTV ; 2LTZ ; 2LTX
Drugbank	NA
KEGG	hsa:4092

Type

Detail

Target ID

T98OJA

Protein Name

Mothers against decapentaplegic homolog 7

Uniprot ID

O15105

Protein Name Alias

MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7

Gene ID

4092

Gene Symbol

SMAD7

Gene Alias

MADH7; MADH8

TTD

T94695: Clinical Trial target

Pfam

PF03165 ; PF03166

0005813:centrosome

0060389:pathway-restricted SMAD protein phosphorylation

0032991:protein-containing complex

0008013:beta-catenin binding

0031625:ubiquitin protein ligase binding

0048185:activin binding

0034616:response to laminar fluid shear stress

0055117:regulation of cardiac muscle contraction

0060373:regulation of ventricular cardiac muscle cell membrane depolarization

0016579:protein deubiquitination

0030279:negative regulation of ossification

0010944:negative regulation of transcription by competitive promoter binding

1902731:negative regulation of chondrocyte proliferation

0060395:SMAD protein signal transduction

0030336:negative regulation of cell migration

0002725:negative regulation of T cell cytokine production

0030512:negative regulation of transforming growth factor beta receptor signaling pathway

0031397:negative regulation of protein ubiquitination

0046872:metal ion binding

0005829:cytosol

0034629:cellular protein-containing complex localization

0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process

0001657:ureteric bud development

0030154:cell differentiation

2000317:negative regulation of T-helper 17 type immune response

0050821:protein stabilization

0060394:negative regulation of pathway-restricted SMAD protein phosphorylation

1903043:positive regulation of chondrocyte hypertrophy

0005886:plasma membrane

0043433:negative regulation of DNA-binding transcription factor activity

0033137:negative regulation of peptidyl-serine phosphorylation

0051444:negative regulation of ubiquitin-protein transferase activity

0032925:regulation of activin receptor signaling pathway

0030514:negative regulation of BMP signaling pathway

0005654:nucleoplasm

0005737:cytoplasm

0003677:DNA binding

0031398:positive regulation of protein ubiquitination

0034713:type I transforming growth factor beta receptor binding

2000320:negative regulation of T-helper 17 cell differentiation

0005518:collagen binding

0045944:positive regulation of transcription by RNA polymerase II

0055010:ventricular cardiac muscle tissue morphogenesis

0034333:adherens junction assembly

1990830:cellular response to leukemia inhibitory factor

0009653:anatomical structure morphogenesis

0005634:nucleus

0022409:positive regulation of cell-cell adhesion

0010717:regulation of epithelial to mesenchymal transition

0010801:negative regulation of peptidyl-threonine phosphorylation

0071144:heteromeric SMAD protein complex

0048844:artery morphogenesis

0060412:ventricular septum morphogenesis

0007179:transforming growth factor beta receptor signaling pathway

0071560:cellular response to transforming growth factor beta stimulus

0030509:BMP signaling pathway

0001650:fibrillar center

0140416:transcription regulator inhibitor activity

0000785:chromatin

0017015:regulation of transforming growth factor beta receptor signaling pathway

0000122:negative regulation of transcription by RNA polymerase II

0070411:I-SMAD binding

0010719:negative regulation of epithelial to mesenchymal transition

PDB

2LTY ; 2LTW ; 2DJY ; 2KXQ ; 2LTV ; 2LTZ ; 2LTX

Drugbank

KEGG

hsa:4092

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0427	Shan Zhu Yu	山茱萸	Asiatic cornelian cherry	Cornus officinalis
H0469	Shi Yan	食盐	Salt	Sal
H0341	Qing Feng Teng	青风藤	Orientvine	Sinomenium acutum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H1033	Fang Ji	防己	Fourstamen stephania	Stephania tetrandra
H0938	Da Suan	大蒜	Garlic	Allium sativum
H1125	Guang Ming Yan	光明盐	Salt	Sal
H0289	Niu Bang Zi	牛蒡子	Great burdock fruit	Arctium lappa
H1214	Hua Jiao	花椒	Bunge pricklyash	Zanthoxylum bungeanum
H0085	Jiu Yu Rou	酒萸肉	Asiatic cornelian cherry	Cornus officinalis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0205	Ma Wei Lian	马尾连	Manyleaf meadowrue	Thalictrum foliolosum
H0936	Da Qing Yan	大青盐	NA	Halitum
H0167	Long Xian Xiang	龙涎香	Ammbergris	Physeter catodon
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0228	Mang Xiao	芒硝	Sodium sulfate	Natrii sulfas
H0077	Jiu	酒	Ethanol	Vinum

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 19)