Herb Description

Herb ID:   H0809 Chinese Character:   知母
English Name:  Common anemarrhena Latin Name:  Anemarrhena asphodeloides
Chinese Pin Yin :  Zhi Mu TCM-ID:  TCMH2624
Therapeutic Function in Chinese :  清热 Therapeutic Function in English:  Heat clearence
Herb Function:  Remove heat and quench fire, and promote the production of body fluid and relieve dryness syndromes

Related Targets  (Total: 218)

Target idProtein NameGene SymbolUniprot IDNo.of Literature Evidence
T02O3F Endothelial lipaseLIPG Q9Y5X9
1 Reference(s)
T05OGW Melanoma-associated antigen C3MAGEC3 Q8TD91
1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
2 Reference(s)
T92HNO High mobility group protein B1HMGB1 P09429
1 Reference(s)
T32JN2 Beta-glucuronidaseGUSB P08236
1 Reference(s)
T16MRU NACHT, LRR and PYD domains-containing protein 3NLRP3 Q96P20
1 Reference(s)
T75H3W Cyclin-dependent kinase 2CDK2 P24941
1 Reference(s)
T22NX4 Toll-like receptor 2TLR2 O60603
1 Reference(s)
T76QBQ CREB-regulated transcription coactivator 2CRTC2 Q53ET0
1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
31 Reference(s)
T86MX7 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1CD38 P28907
2 Reference(s)
T41BXR NAD-dependent protein deacetylase sirtuin-3, mitochondrialSIRT3 Q9NTG7
3 Reference(s)
T40DE5 Tryptophan 2,3-dioxygenaseTDO2 P48775
1 Reference(s)
T73LPO Poly [ADP-ribose] polymerase 1PARP1 P09874
3 Reference(s)
T21PEZ NAD(+) hydrolase SARM1SARM1 Q6SZW1
1 Reference(s)
T28PHS Angiotensin-converting enzymeACE P12821
2 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
4 Reference(s)
T69CTT Acetyl-CoA acetyltransferase, mitochondrialACAT1 P24752
1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
1 Reference(s)
T61M4P Nuclear receptor ROR-alphaRORA P35398
1 Reference(s)
T77VME ATP-binding cassette sub-family F member 3ABCF3 Q9NUQ8
1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
3 Reference(s)
T93AZS NAECB2 NA
1 Reference(s)
T38OH4 Caspase-1CASP1 P29466
1 Reference(s)
T63KO8 NAMIR33A NA
1 Reference(s)
T68OIU CREB-regulated transcription coactivator 1CRTC1 Q6UUV9
1 Reference(s)
T67OMA Ryanodine receptor 2RYR2 Q92736
1 Reference(s)
T98OJA Mothers against decapentaplegic homolog 7SMAD7 O15105
1 Reference(s)
T76PKX Mast/stem cell growth factor receptor KitKIT P10721
1 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
1 Reference(s)
T54VET Protein tyrosine phosphatase type IVA 3PTP4A3 O75365
1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
3 Reference(s)
T37ADS Early growth response protein 1EGR1 P18146
1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
5 Reference(s)
T20JZ2 Androgen receptorAR P10275
1 Reference(s)
T12RJE Casein kinase II subunit alpha'CSNK2A2 P19784
1 Reference(s)
T47C6A Phosphoglycerate mutase 1PGAM1 P18669
1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
2 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
2 Reference(s)
T65S3S Tyrosine-protein kinase JAK2JAK2 O60674
2 Reference(s)
T58XLK Tyrosine-protein phosphatase non-receptor type 1PTPN1 P18031
3 Reference(s)
T77PFO Histone deacetylase 6HDAC6 Q9UBN7
1 Reference(s)
T52VL6 Signal transducer and activator of transcription 5ASTAT5A P42229
1 Reference(s)
T19K8W Signal transducer and activator of transcription 5BSTAT5B P51692
1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
1 Reference(s)
T16UZ4 Dipeptidyl peptidase 4DPP4 P27487
1 Reference(s)
T85U8U Caspase-3CASP3 P42574
2 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
2 Reference(s)
T73S71 Apolipoprotein B-100APOB P04114
5 Reference(s)
T99EYH Lipoprotein lipaseLPL P06858
2 Reference(s)
T80O6V Hydroxycarboxylic acid receptor 2HCAR2 Q8TDS4
1 Reference(s)
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
1 Reference(s)
T24U57 E-selectinSELE P16581
1 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
2 Reference(s)
T13KGH TyrosinaseTYR P14679
1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
2 Reference(s)
T75HMM Induced myeloid leukemia cell differentiation protein Mcl-1MCL1 Q07820
1 Reference(s)
T00RU5 Histone H1.0H1-0 P07305
1 Reference(s)
T37V37 Prostaglandin-H2 D-isomerasePTGDS P41222
1 Reference(s)
T09DI4 Lysine-specific histone demethylase 1AKDM1A O60341
1 Reference(s)
T78VUO RAF proto-oncogene serine/threonine-protein kinaseRAF1 P04049
1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
3 Reference(s)
T75ZQD Myelin proteolipid proteinPLP1 P60201
2 Reference(s)
T67U3B Translocator proteinTSPO P30536
4 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
2 Reference(s)
T44AEN NPC intracellular cholesterol transporter 1NPC1 O15118
2 Reference(s)
T01E8J Amyloid-beta precursor proteinAPP P05067
2 Reference(s)
T50V79 Interleukin-4IL4 P05112
1 Reference(s)
T13DVU Conserved oligomeric Golgi complex subunit 2COG2 Q14746
1 Reference(s)
T37I8W NAMIR33B NA
1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
1 Reference(s)
T56FPY CD81 antigenCD81 P60033
1 Reference(s)
T89EW0 Aquaporin-8AQP8 O94778
1 Reference(s)
T21K0F Sarcoplasmic/endoplasmic reticulum calcium ATPase 3ATP2A3 Q93084
1 Reference(s)
T92MGC Phosphatidylcholine:ceramide cholinephosphotransferase 2SGMS2 Q8NHU3
1 Reference(s)
T81DYL Cysteine-rich secretory protein 2CRISP2 P16562
1 Reference(s)
T90K33 ATP-binding cassette sub-family G member 5ABCG5 Q9H222
2 Reference(s)
T75NEV Aquaporin-1AQP1 P29972
2 Reference(s)
T91X8E Sterol carrier protein 2SCP2 P22307
1 Reference(s)
T07VO1 Steroid hormone receptor ERR1ESRRA P11474
1 Reference(s)
T47RAK NAMIR145 NA
2 Reference(s)
T15ZAV Lymphocyte antigen 96LY96 Q9Y6Y9
1 Reference(s)
T38WWN Serum paraoxonase/arylesterase 1PON1 P27169
1 Reference(s)
T84AR4 Smoothened homologSMO Q99835
1 Reference(s)
T44GAO 55 kDa erythrocyte membrane proteinMPP1 Q00013
1 Reference(s)
T08VQQ Proprotein convertase subtilisin/kexin type 9PCSK9 Q8NBP7
1 Reference(s)
T04H8Y Beta-secretase 1BACE1 P56817
1 Reference(s)
T75SPS Fibroblast growth factor 1FGF1 P05230
1 Reference(s)
T58CPZ G-protein coupled receptor 55GPR55 Q9Y2T6
1 Reference(s)
T16CFE Lysosome-associated membrane glycoprotein 1LAMP1 P11279
1 Reference(s)
T02GMU Lysosome-associated membrane glycoprotein 2LAMP2 P13473
1 Reference(s)
T44X5B Cholesterol 24-hydroxylaseCYP46A1 Q9Y6A2
2 Reference(s)
T35OPL Sonic hedgehog proteinSHH Q15465
1 Reference(s)
T59L1E Sterol regulatory element-binding protein cleavage-activating proteinSCAP Q12770
1 Reference(s)
T55TEP Steroidogenic acute regulatory protein, mitochondrialSTAR P49675
1 Reference(s)
T92MFC Phosphomannomutase 2PMM2 O15305
1 Reference(s)
T07NML P-selectinSELP P16109
1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
6 Reference(s)
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
3 Reference(s)
T33OPP Interleukin-6IL6 P05231
1 Reference(s)
T36BW3 Cathepsin GCTSG P08311
1 Reference(s)
T57MP0 ChymaseCMA1 P23946
1 Reference(s)
T31P1D Metalloproteinase inhibitor 1TIMP1 P01033
1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
2 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
2 Reference(s)
T16A2X CatalaseCAT P04040
3 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
5 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
3 Reference(s)
T33VZN Retinoic acid receptor betaRARB P10826
1 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
1 Reference(s)
T58FWN Tyrosine-protein kinase BTKBTK Q06187
1 Reference(s)
T06Q1R Amine oxidase [flavin-containing] BMAOB P27338
1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
3 Reference(s)
T01QLH Estrogen receptorESR1 P03372
1 Reference(s)
T27U96 Granulocyte-macrophage colony-stimulating factorCSF2 P04141
1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
2 Reference(s)
T84WE9 Vascular endothelial growth factor receptor 1FLT1 P17948
1 Reference(s)
T04MBA Vascular endothelial growth factor receptor 2KDR P35968
1 Reference(s)
T29JZ3 Vascular endothelial growth factor receptor 3FLT4 P35916
1 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
2 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
1 Reference(s)
T32UNL Lens fiber major intrinsic proteinMIP P30301
1 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
2 Reference(s)
T27F5B Interleukin-1 receptor-associated kinase 1IRAK1 P51617
1 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
1 Reference(s)
T71B0A Cytosolic phospholipase A2PLA2G4A P47712
1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
2 Reference(s)
T52UTG HaptoglobinHP P00738
1 Reference(s)
T64UH1 Nitric oxide synthase, endothelialNOS3 P29474
1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
1 Reference(s)
T95IYZ AdiponectinADIPOQ Q15848
3 Reference(s)
T48UT8 Cholesteryl ester transfer proteinCETP P11597
1 Reference(s)
T55IIP CDGSH iron-sulfur domain-containing protein 1CISD1 Q9NZ45
1 Reference(s)
T54SZZ Endoplasmic reticulum chaperone BiPHSPA5 P11021
2 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
2 Reference(s)
T97XMW NAMIR374A NA
1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
1 Reference(s)
T51EKP Apolipoprotein MAPOM O95445
1 Reference(s)
T07VV7 GuanylinGUCA2A Q02747
1 Reference(s)
T80WPU Protein ABHD15ABHD15 Q6UXT9
1 Reference(s)
T56OUM 14-3-3 protein zeta/deltaYWHAZ P63104
1 Reference(s)
T24YWQ Insulin-degrading enzymeIDE P14735
1 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
1 Reference(s)
T16O4B CCAAT/enhancer-binding protein epsilonCEBPE Q15744
1 Reference(s)
T10WEJ Betaine--homocysteine S-methyltransferase 1BHMT Q93088
1 Reference(s)
T99HGY Ubiquitin-protein ligase E3AUBE3A Q05086
1 Reference(s)
T80SD7 Sterol regulatory element-binding protein 2SREBF2 Q12772
1 Reference(s)
T50MQN NPC1-like intracellular cholesterol transporter 1NPC1L1 Q9UHC9
2 Reference(s)
T61DYZ Phospholipid-transporting ATPase ABCA1ABCA1 O95477
1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
1 Reference(s)
T79UHV Prolow-density lipoprotein receptor-related protein 1LRP1 Q07954
1 Reference(s)
T25H22 Protein kinase C beta typePRKCB P05771
2 Reference(s)
T47HOW NAMIR185 NA
1 Reference(s)
T90IQF NAHULC NA
1 Reference(s)
T86TYE Dehydrodolichyl diphosphate synthase complex subunit NUS1NUS1 Q96E22
1 Reference(s)
T26CFB DNA damage-inducible transcript 3 proteinDDIT3 P35638;P0DPQ6
2 Reference(s)
T30C1L Sorting nexin-8SNX8 Q9Y5X2
1 Reference(s)
T17T4P NAMIR122 NA
1 Reference(s)
T79TJS Caveolin-3CAV3 P56539
1 Reference(s)
T66IUC Homeobox protein Nkx-2.5NKX2-5 P52952
1 Reference(s)
T95EU5 ATP-binding cassette sub-family G member 8ABCG8 Q9H221
1 Reference(s)
T49PL1 Low-density lipoprotein receptorLDLR P01130
1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
2 Reference(s)
T51P5Q DNA replication factor Cdt1CDT1 Q9H211
1 Reference(s)
T26UPI Collagen alpha-1(VII) chainCOL7A1 Q02388
1 Reference(s)
T17FIA AngiotensinogenAGT P01019
1 Reference(s)
T65DBI Beta-galactoside alpha-2,6-sialyltransferase 2ST6GAL2 Q96JF0
1 Reference(s)
T39WPZ Mitogen-activated protein kinase 9MAPK9 P45984
1 Reference(s)
T05JUS Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalinPENK P01210
1 Reference(s)
T43DMF Kappa-type opioid receptorOPRK1 P41145
1 Reference(s)
T76TED Pro-opiomelanocortinPOMC P01189
1 Reference(s)
T36I66 Metallothionein-2MT2A P02795
1 Reference(s)
T01S8U Metalloproteinase inhibitor 2TIMP2 P16035
1 Reference(s)
T26PDJ CUGBP Elav-like family member 1CELF1 Q92879
1 Reference(s)
T77UWH CCAAT/enhancer-binding protein betaCEBPB P17676
1 Reference(s)
T30VA7 Stromelysin-3MMP11 P24347
1 Reference(s)
T94S85 Collagen alpha-1(I) chainCOL1A1 P02452
2 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
1 Reference(s)
T10S5F Cyclin-dependent kinase 4CDK4 P11802
1 Reference(s)
T04WT7 FibronectinFN1 P02751
1 Reference(s)
T32ECR Collagen alpha-2(I) chainCOL1A2 P08123
1 Reference(s)
T48K08 Procathepsin LCTSL P07711
1 Reference(s)
T49M04 Rap guanine nucleotide exchange factor 4RAPGEF4 Q8WZA2
1 Reference(s)
T02HZD Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6JMJD6 Q6NYC1
1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
1 Reference(s)
T90W59 Histone deacetylase 11HDAC11 Q96DB2
1 Reference(s)
T52CKD Pro-epidermal growth factorEGF P01133
1 Reference(s)
T42PUG Solute carrier family 2, facilitated glucose transporter member 1SLC2A1 P11166
1 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
1 Reference(s)
T95K0K Interferon alpha-1/13IFNA1; IFNA13 P01562
1 Reference(s)
T64LKA Bile salt export pumpABCB11 O95342
2 Reference(s)
T78O6C Mothers against decapentaplegic homolog 3SMAD3 P84022
1 Reference(s)
T84CEG Claudin-5CLDN5 O00501
1 Reference(s)
T30AEN Aquaporin-5AQP5 P55064
1 Reference(s)
T02GD4 Tumor necrosis factor ligand superfamily member 6FASLG P48023
1 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
1 Reference(s)
T37SV3 OccludinOCLN Q16625
1 Reference(s)
T69F5W Forkhead box protein D3FOXD3 Q9UJU5
1 Reference(s)
T13I7C Transforming growth factor beta-2 proproteinTGFB2 P61812
1 Reference(s)
T44EUX Fragile X mental retardation syndrome-related protein 1FXR1 P51114
1 Reference(s)
T92LK2 Tumor necrosis factor ligand superfamily member 10TNFSF10 P50591
1 Reference(s)
T64X48 C-X-C chemokine receptor type 4CXCR4 P61073
1 Reference(s)
T04V7K Ectonucleotide pyrophosphatase/phosphodiesterase family member 7ENPP7 Q6UWV6
1 Reference(s)
T51U9M Carnitine O-palmitoyltransferase 1, muscle isoformCPT1B Q92523
1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
1 Reference(s)
T20W8R NAMIR182 NA
1 Reference(s)
T13YN2 Bcl-2-like protein 1Bcl2l1 Q64373
1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
1 Reference(s)

Related Compounds  (Total: 14)

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C0245
Name: Niacin
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C0152
Name: Isoliquiritigenin
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C0285
Name: Palmitic Acid
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C0246
Name: Niacinamide
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C1234
Name: Cholesterol