Herb ID: H0809 | Chinese Character: 知母 |
English Name: Common anemarrhena | Latin Name: Anemarrhena asphodeloides |
Chinese Pin Yin : Zhi Mu | TCM-ID: TCMH2624 |
Therapeutic Function in Chinese : 清热 | Therapeutic Function in English: Heat clearence |
Herb Function: Remove heat and quench fire, and promote the production of body fluid and relieve dryness syndromes |
Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
---|---|---|---|---|
T02O3F | Endothelial lipase | LIPG |
Q9Y5X9 |
1 Reference(s) |
T05OGW | Melanoma-associated antigen C3 | MAGEC3 |
Q8TD91 |
1 Reference(s) |
T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
2 Reference(s) |
T92HNO | High mobility group protein B1 | HMGB1 |
P09429 |
1 Reference(s) |
T32JN2 | Beta-glucuronidase | GUSB |
P08236 |
1 Reference(s) |
T16MRU | NACHT, LRR and PYD domains-containing protein 3 | NLRP3 |
Q96P20 |
1 Reference(s) |
T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
1 Reference(s) |
T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
31 Reference(s) |
T86MX7 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | CD38 |
P28907 |
2 Reference(s) |
T41BXR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | SIRT3 |
Q9NTG7 |
3 Reference(s) |
T40DE5 | Tryptophan 2,3-dioxygenase | TDO2 |
P48775 |
1 Reference(s) |
T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
3 Reference(s) |
T21PEZ | NAD(+) hydrolase SARM1 | SARM1 |
Q6SZW1 |
1 Reference(s) |
T28PHS | Angiotensin-converting enzyme | ACE |
P12821 |
2 Reference(s) |
T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
4 Reference(s) |
T69CTT | Acetyl-CoA acetyltransferase, mitochondrial | ACAT1 |
P24752 |
1 Reference(s) |
T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
1 Reference(s) |
T61M4P | Nuclear receptor ROR-alpha | RORA |
P35398 |
1 Reference(s) |
T77VME | ATP-binding cassette sub-family F member 3 | ABCF3 |
Q9NUQ8 |
1 Reference(s) |
T80XW6 | Scavenger receptor class B member 1 | SCARB1 |
Q8WTV0 |
1 Reference(s) |
T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
3 Reference(s) |
T93AZS | NA | ECB2 |
NA |
1 Reference(s) |
T38OH4 | Caspase-1 | CASP1 |
P29466 |
1 Reference(s) |
T63KO8 | NA | MIR33A |
NA |
1 Reference(s) |
T68OIU | CREB-regulated transcription coactivator 1 | CRTC1 |
Q6UUV9 |
1 Reference(s) |
T67OMA | Ryanodine receptor 2 | RYR2 |
Q92736 |
1 Reference(s) |
T98OJA | Mothers against decapentaplegic homolog 7 | SMAD7 |
O15105 |
1 Reference(s) |
T76PKX | Mast/stem cell growth factor receptor Kit | KIT |
P10721 |
1 Reference(s) |
T40DIM | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 |
P28845 |
1 Reference(s) |
T54VET | Protein tyrosine phosphatase type IVA 3 | PTP4A3 |
O75365 |
1 Reference(s) |
T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
3 Reference(s) |
T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
1 Reference(s) |
T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
5 Reference(s) |
T20JZ2 | Androgen receptor | AR |
P10275 |
1 Reference(s) |
T12RJE | Casein kinase II subunit alpha' | CSNK2A2 |
P19784 |
1 Reference(s) |
T47C6A | Phosphoglycerate mutase 1 | PGAM1 |
P18669 |
1 Reference(s) |
T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
2 Reference(s) |
T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
2 Reference(s) |
T65S3S | Tyrosine-protein kinase JAK2 | JAK2 |
O60674 |
2 Reference(s) |
T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
3 Reference(s) |
T77PFO | Histone deacetylase 6 | HDAC6 |
Q9UBN7 |
1 Reference(s) |
T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
1 Reference(s) |
T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
1 Reference(s) |
T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
1 Reference(s) |
T16UZ4 | Dipeptidyl peptidase 4 | DPP4 |
P27487 |
1 Reference(s) |
T85U8U | Caspase-3 | CASP3 |
P42574 |
2 Reference(s) |
T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
2 Reference(s) |
T73S71 | Apolipoprotein B-100 | APOB |
P04114 |
5 Reference(s) |
T99EYH | Lipoprotein lipase | LPL |
P06858 |
2 Reference(s) |
T80O6V | Hydroxycarboxylic acid receptor 2 | HCAR2 |
Q8TDS4 |
1 Reference(s) |
T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
1 Reference(s) |
T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
2 Reference(s) |
T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
2 Reference(s) |
T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
T00RU5 | Histone H1.0 | H1-0 |
P07305 |
1 Reference(s) |
T37V37 | Prostaglandin-H2 D-isomerase | PTGDS |
P41222 |
1 Reference(s) |
T09DI4 | Lysine-specific histone demethylase 1A | KDM1A |
O60341 |
1 Reference(s) |
T78VUO | RAF proto-oncogene serine/threonine-protein kinase | RAF1 |
P04049 |
1 Reference(s) |
T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
2 Reference(s) |
T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
3 Reference(s) |
T75ZQD | Myelin proteolipid protein | PLP1 |
P60201 |
2 Reference(s) |
T67U3B | Translocator protein | TSPO |
P30536 |
4 Reference(s) |
T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
2 Reference(s) |
T44AEN | NPC intracellular cholesterol transporter 1 | NPC1 |
O15118 |
2 Reference(s) |
T01E8J | Amyloid-beta precursor protein | APP |
P05067 |
2 Reference(s) |
T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
T13DVU | Conserved oligomeric Golgi complex subunit 2 | COG2 |
Q14746 |
1 Reference(s) |
T37I8W | NA | MIR33B |
NA |
1 Reference(s) |
T63YAO | Caveolin-1 | CAV1 |
Q03135 |
1 Reference(s) |
T56FPY | CD81 antigen | CD81 |
P60033 |
1 Reference(s) |
T89EW0 | Aquaporin-8 | AQP8 |
O94778 |
1 Reference(s) |
T21K0F | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | ATP2A3 |
Q93084 |
1 Reference(s) |
T92MGC | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SGMS2 |
Q8NHU3 |
1 Reference(s) |
T81DYL | Cysteine-rich secretory protein 2 | CRISP2 |
P16562 |
1 Reference(s) |
T90K33 | ATP-binding cassette sub-family G member 5 | ABCG5 |
Q9H222 |
2 Reference(s) |
T75NEV | Aquaporin-1 | AQP1 |
P29972 |
2 Reference(s) |
T91X8E | Sterol carrier protein 2 | SCP2 |
P22307 |
1 Reference(s) |
T07VO1 | Steroid hormone receptor ERR1 | ESRRA |
P11474 |
1 Reference(s) |
T47RAK | NA | MIR145 |
NA |
2 Reference(s) |
T15ZAV | Lymphocyte antigen 96 | LY96 |
Q9Y6Y9 |
1 Reference(s) |
T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
T84AR4 | Smoothened homolog | SMO |
Q99835 |
1 Reference(s) |
T44GAO | 55 kDa erythrocyte membrane protein | MPP1 |
Q00013 |
1 Reference(s) |
T08VQQ | Proprotein convertase subtilisin/kexin type 9 | PCSK9 |
Q8NBP7 |
1 Reference(s) |
T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
T75SPS | Fibroblast growth factor 1 | FGF1 |
P05230 |
1 Reference(s) |
T58CPZ | G-protein coupled receptor 55 | GPR55 |
Q9Y2T6 |
1 Reference(s) |
T16CFE | Lysosome-associated membrane glycoprotein 1 | LAMP1 |
P11279 |
1 Reference(s) |
T02GMU | Lysosome-associated membrane glycoprotein 2 | LAMP2 |
P13473 |
1 Reference(s) |
T44X5B | Cholesterol 24-hydroxylase | CYP46A1 |
Q9Y6A2 |
2 Reference(s) |
T35OPL | Sonic hedgehog protein | SHH |
Q15465 |
1 Reference(s) |
T59L1E | Sterol regulatory element-binding protein cleavage-activating protein | SCAP |
Q12770 |
1 Reference(s) |
T55TEP | Steroidogenic acute regulatory protein, mitochondrial | STAR |
P49675 |
1 Reference(s) |
T92MFC | Phosphomannomutase 2 | PMM2 |
O15305 |
1 Reference(s) |
T07NML | P-selectin | SELP |
P16109 |
1 Reference(s) |
T23VMI | Tumor necrosis factor | TNF |
P01375 |
6 Reference(s) |
T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
3 Reference(s) |
T33OPP | Interleukin-6 | IL6 |
P05231 |
1 Reference(s) |
T36BW3 | Cathepsin G | CTSG |
P08311 |
1 Reference(s) |
T57MP0 | Chymase | CMA1 |
P23946 |
1 Reference(s) |
T31P1D | Metalloproteinase inhibitor 1 | TIMP1 |
P01033 |
1 Reference(s) |
T80OJF | Interstitial collagenase | MMP1 |
P03956 |
2 Reference(s) |
T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
1 Reference(s) |
T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
T16A2X | Catalase | CAT |
P04040 |
3 Reference(s) |
T64BTV | Interleukin-1 beta | IL1B |
P01584 |
5 Reference(s) |
T26KIE | Transcription factor AP-1 | JUN |
P05412 |
3 Reference(s) |
T33VZN | Retinoic acid receptor beta | RARB |
P10826 |
1 Reference(s) |
T84P70 | Urokinase-type plasminogen activator | PLAU |
P00749 |
1 Reference(s) |
T58FWN | Tyrosine-protein kinase BTK | BTK |
Q06187 |
1 Reference(s) |
T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
1 Reference(s) |
T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
3 Reference(s) |
T01QLH | Estrogen receptor | ESR1 |
P03372 |
1 Reference(s) |
T27U96 | Granulocyte-macrophage colony-stimulating factor | CSF2 |
P04141 |
1 Reference(s) |
T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
2 Reference(s) |
T84WE9 | Vascular endothelial growth factor receptor 1 | FLT1 |
P17948 |
1 Reference(s) |
T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
1 Reference(s) |
T29JZ3 | Vascular endothelial growth factor receptor 3 | FLT4 |
P35916 |
1 Reference(s) |
T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
2 Reference(s) |
T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
1 Reference(s) |
T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
T32UNL | Lens fiber major intrinsic protein | MIP |
P30301 |
1 Reference(s) |
T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
1 Reference(s) |
T44LWL | Transcription factor p65 | RELA |
Q04206 |
2 Reference(s) |
T27F5B | Interleukin-1 receptor-associated kinase 1 | IRAK1 |
P51617 |
1 Reference(s) |
T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
T71B0A | Cytosolic phospholipase A2 | PLA2G4A |
P47712 |
1 Reference(s) |
T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
2 Reference(s) |
T52UTG | Haptoglobin | HP |
P00738 |
1 Reference(s) |
T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
1 Reference(s) |
T95IYZ | Adiponectin | ADIPOQ |
Q15848 |
3 Reference(s) |
T48UT8 | Cholesteryl ester transfer protein | CETP |
P11597 |
1 Reference(s) |
T55IIP | CDGSH iron-sulfur domain-containing protein 1 | CISD1 |
Q9NZ45 |
1 Reference(s) |
T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
2 Reference(s) |
T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
2 Reference(s) |
T97XMW | NA | MIR374A |
NA |
1 Reference(s) |
T69NG6 | Interleukin-10 | IL10 |
P22301 |
1 Reference(s) |
T51EKP | Apolipoprotein M | APOM |
O95445 |
1 Reference(s) |
T07VV7 | Guanylin | GUCA2A |
Q02747 |
1 Reference(s) |
T80WPU | Protein ABHD15 | ABHD15 |
Q6UXT9 |
1 Reference(s) |
T56OUM | 14-3-3 protein zeta/delta | YWHAZ |
P63104 |
1 Reference(s) |
T24YWQ | Insulin-degrading enzyme | IDE |
P14735 |
1 Reference(s) |
T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
1 Reference(s) |
T16O4B | CCAAT/enhancer-binding protein epsilon | CEBPE |
Q15744 |
1 Reference(s) |
T10WEJ | Betaine--homocysteine S-methyltransferase 1 | BHMT |
Q93088 |
1 Reference(s) |
T99HGY | Ubiquitin-protein ligase E3A | UBE3A |
Q05086 |
1 Reference(s) |
T80SD7 | Sterol regulatory element-binding protein 2 | SREBF2 |
Q12772 |
1 Reference(s) |
T50MQN | NPC1-like intracellular cholesterol transporter 1 | NPC1L1 |
Q9UHC9 |
2 Reference(s) |
T61DYZ | Phospholipid-transporting ATPase ABCA1 | ABCA1 |
O95477 |
1 Reference(s) |
T94H37 | Cadherin-1 | CDH1 |
P12830 |
1 Reference(s) |
T79UHV | Prolow-density lipoprotein receptor-related protein 1 | LRP1 |
Q07954 |
1 Reference(s) |
T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
2 Reference(s) |
T47HOW | NA | MIR185 |
NA |
1 Reference(s) |
T90IQF | NA | HULC |
NA |
1 Reference(s) |
T86TYE | Dehydrodolichyl diphosphate synthase complex subunit NUS1 | NUS1 |
Q96E22 |
1 Reference(s) |
T26CFB | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638;P0DPQ6 |
2 Reference(s) |
T30C1L | Sorting nexin-8 | SNX8 |
Q9Y5X2 |
1 Reference(s) |
T17T4P | NA | MIR122 |
NA |
1 Reference(s) |
T79TJS | Caveolin-3 | CAV3 |
P56539 |
1 Reference(s) |
T66IUC | Homeobox protein Nkx-2.5 | NKX2-5 |
P52952 |
1 Reference(s) |
T95EU5 | ATP-binding cassette sub-family G member 8 | ABCG8 |
Q9H221 |
1 Reference(s) |
T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
1 Reference(s) |
T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
2 Reference(s) |
T51P5Q | DNA replication factor Cdt1 | CDT1 |
Q9H211 |
1 Reference(s) |
T26UPI | Collagen alpha-1(VII) chain | COL7A1 |
Q02388 |
1 Reference(s) |
T17FIA | Angiotensinogen | AGT |
P01019 |
1 Reference(s) |
T65DBI | Beta-galactoside alpha-2,6-sialyltransferase 2 | ST6GAL2 |
Q96JF0 |
1 Reference(s) |
T39WPZ | Mitogen-activated protein kinase 9 | MAPK9 |
P45984 |
1 Reference(s) |
T05JUS | Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin | PENK |
P01210 |
1 Reference(s) |
T43DMF | Kappa-type opioid receptor | OPRK1 |
P41145 |
1 Reference(s) |
T76TED | Pro-opiomelanocortin | POMC |
P01189 |
1 Reference(s) |
T36I66 | Metallothionein-2 | MT2A |
P02795 |
1 Reference(s) |
T01S8U | Metalloproteinase inhibitor 2 | TIMP2 |
P16035 |
1 Reference(s) |
T26PDJ | CUGBP Elav-like family member 1 | CELF1 |
Q92879 |
1 Reference(s) |
T77UWH | CCAAT/enhancer-binding protein beta | CEBPB |
P17676 |
1 Reference(s) |
T30VA7 | Stromelysin-3 | MMP11 |
P24347 |
1 Reference(s) |
T94S85 | Collagen alpha-1(I) chain | COL1A1 |
P02452 |
2 Reference(s) |
T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
1 Reference(s) |
T04WT7 | Fibronectin | FN1 |
P02751 |
1 Reference(s) |
T32ECR | Collagen alpha-2(I) chain | COL1A2 |
P08123 |
1 Reference(s) |
T48K08 | Procathepsin L | CTSL |
P07711 |
1 Reference(s) |
T49M04 | Rap guanine nucleotide exchange factor 4 | RAPGEF4 |
Q8WZA2 |
1 Reference(s) |
T02HZD | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | JMJD6 |
Q6NYC1 |
1 Reference(s) |
T70SFS | Superoxide dismutase [Mn], mitochondrial | SOD2 |
P04179 |
1 Reference(s) |
T90W59 | Histone deacetylase 11 | HDAC11 |
Q96DB2 |
1 Reference(s) |
T52CKD | Pro-epidermal growth factor | EGF |
P01133 |
1 Reference(s) |
T42PUG | Solute carrier family 2, facilitated glucose transporter member 1 | SLC2A1 |
P11166 |
1 Reference(s) |
T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
1 Reference(s) |
T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
1 Reference(s) |
T95K0K | Interferon alpha-1/13 | IFNA1; IFNA13 |
P01562 |
1 Reference(s) |
T64LKA | Bile salt export pump | ABCB11 |
O95342 |
2 Reference(s) |
T78O6C | Mothers against decapentaplegic homolog 3 | SMAD3 |
P84022 |
1 Reference(s) |
T84CEG | Claudin-5 | CLDN5 |
O00501 |
1 Reference(s) |
T30AEN | Aquaporin-5 | AQP5 |
P55064 |
1 Reference(s) |
T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
1 Reference(s) |
T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
1 Reference(s) |
T37SV3 | Occludin | OCLN |
Q16625 |
1 Reference(s) |
T69F5W | Forkhead box protein D3 | FOXD3 |
Q9UJU5 |
1 Reference(s) |
T13I7C | Transforming growth factor beta-2 proprotein | TGFB2 |
P61812 |
1 Reference(s) |
T44EUX | Fragile X mental retardation syndrome-related protein 1 | FXR1 |
P51114 |
1 Reference(s) |
T92LK2 | Tumor necrosis factor ligand superfamily member 10 | TNFSF10 |
P50591 |
1 Reference(s) |
T64X48 | C-X-C chemokine receptor type 4 | CXCR4 |
P61073 |
1 Reference(s) |
T04V7K | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | ENPP7 |
Q6UWV6 |
1 Reference(s) |
T51U9M | Carnitine O-palmitoyltransferase 1, muscle isoform | CPT1B |
Q92523 |
1 Reference(s) |
T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
1 Reference(s) |
T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
T20W8R | NA | MIR182 |
NA |
1 Reference(s) |
T13YN2 | Bcl-2-like protein 1 | Bcl2l1 |
Q64373 |
1 Reference(s) |
T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
1 Reference(s) |