HIT-result

Target Description

Type	Detail
Target ID	T27F5B
Protein Name	Interleukin-1 receptor-associated kinase 1
Uniprot ID	P51617
Protein Name Alias	IRAK-1; EC 2.7.11.1
Gene ID	3654
Gene Symbol	IRAK1
Gene Alias	IRAK
TTD	T63846: Patented target
Pfam	PF00069 ; PF00531
GO	0042802:identical protein binding 0005634:nucleus 0007568:aging 0046777:protein autophosphorylation 0034142:toll-like receptor 4 signaling pathway 0034162:toll-like receptor 9 signaling pathway 0035556:intracellular signal transduction 0004672:protein kinase activity 0070498:interleukin-1-mediated signaling pathway 0106310:protein serine kinase activity 0005829:cytosol 0004674:protein serine/threonine kinase activity 0007250:activation of NF-kappaB-inducing kinase activity 0071456:cellular response to hypoxia 1901224:positive regulation of NIK/NF-kappaB signaling 0106311:protein threonine kinase activity 0045087:innate immune response 0071222:cellular response to lipopolysaccharide 0060337:type I interferon signaling pathway 0016301:kinase activity 0000187:activation of MAPK activity 0051092:positive regulation of NF-kappaB transcription factor activity 0070555:response to interleukin-1 0002224:toll-like receptor signaling pathway 0005524:ATP binding 0005886:plasma membrane 0048661:positive regulation of smooth muscle cell proliferation 0007254:JNK cascade 0032088:negative regulation of NF-kappaB transcription factor activity 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0070423:nucleotide-binding oligomerization domain containing signaling pathway 0032991:protein-containing complex 0031072:heat shock protein binding 0034134:toll-like receptor 2 signaling pathway 0032481:positive regulation of type I interferon production 0006468:protein phosphorylation 0043406:positive regulation of MAP kinase activity 0042803:protein homodimerization activity 0005737:cytoplasm 0002755:MyD88-dependent toll-like receptor signaling pathway 0016032:viral process 0046982:protein heterodimerization activity 0004704:NF-kappaB-inducing kinase activity 0005811:lipid droplet 0005654:nucleoplasm 0032496:response to lipopolysaccharide 0034605:cellular response to heat 0019221:cytokine-mediated signaling pathway 0031663:lipopolysaccharide-mediated signaling pathway 1904996:positive regulation of leukocyte adhesion to vascular endothelial cell 0043066:negative regulation of apoptotic process 0010008:endosome membrane 0001959:regulation of cytokine-mediated signaling pathway
PDB	6BFN
Drugbank	DB12010
KEGG	hsa:3654

Type

Detail

Target ID

T27F5B

Protein Name

Interleukin-1 receptor-associated kinase 1

Uniprot ID

P51617

Protein Name Alias

IRAK-1; EC 2.7.11.1

Gene ID

3654

Gene Symbol

IRAK1

Gene Alias

IRAK

TTD

T63846: Patented target

Pfam

PF00069 ; PF00531

0042802:identical protein binding

0005634:nucleus

0007568:aging

0046777:protein autophosphorylation

0034142:toll-like receptor 4 signaling pathway

0034162:toll-like receptor 9 signaling pathway

0035556:intracellular signal transduction

0004672:protein kinase activity

0070498:interleukin-1-mediated signaling pathway

0106310:protein serine kinase activity

0005829:cytosol

0004674:protein serine/threonine kinase activity

0007250:activation of NF-kappaB-inducing kinase activity

0071456:cellular response to hypoxia

1901224:positive regulation of NIK/NF-kappaB signaling

0106311:protein threonine kinase activity

0045087:innate immune response

0071222:cellular response to lipopolysaccharide

0060337:type I interferon signaling pathway

0016301:kinase activity

0000187:activation of MAPK activity

0051092:positive regulation of NF-kappaB transcription factor activity

0070555:response to interleukin-1

0002224:toll-like receptor signaling pathway

0005524:ATP binding

0005886:plasma membrane

0048661:positive regulation of smooth muscle cell proliferation

0007254:JNK cascade

0032088:negative regulation of NF-kappaB transcription factor activity

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0070423:nucleotide-binding oligomerization domain containing signaling pathway

0032991:protein-containing complex

0031072:heat shock protein binding

0034134:toll-like receptor 2 signaling pathway

0032481:positive regulation of type I interferon production

0006468:protein phosphorylation

0043406:positive regulation of MAP kinase activity

0042803:protein homodimerization activity

0005737:cytoplasm

0002755:MyD88-dependent toll-like receptor signaling pathway

0016032:viral process

0046982:protein heterodimerization activity

0004704:NF-kappaB-inducing kinase activity

0005811:lipid droplet

0005654:nucleoplasm

0032496:response to lipopolysaccharide

0034605:cellular response to heat

0019221:cytokine-mediated signaling pathway

0031663:lipopolysaccharide-mediated signaling pathway

1904996:positive regulation of leukocyte adhesion to vascular endothelial cell

0043066:negative regulation of apoptotic process

0010008:endosome membrane

0001959:regulation of cytokine-mediated signaling pathway

PDB

6BFN

Drugbank

DB12010

KEGG

hsa:3654

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Name: Paclitaxel

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Name: Paeoniflorin

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Name: Mangiferin

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Name: Ginsenoside Rb1

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Name: Ginsenoside Rb1

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0631	Xi Yang Shen	西洋参	American ginseng	Panax quinquefolium
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0468	Shi Wei	石韦	Japanese felt fern frond	Pyrrosia lingua
H0378	San Qi	三七	Sanchi	Panax notoginseng
H1191	Hong Shen	红参	Red ginseng	Radix ginseng rubra
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0464	Shi Liu Zi	石榴子	NA	Punica granatum

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 15)