Compound Description

ID:   C0281 Common name:   Paclitaxel
IUPAC:  NA CAS:  CAS:33069-62-4
Chembl ID:   CHEMBL428647 Pubchem ID:   CID:36314
Formula:  C47H51NO14 TCM-ID:  TCMC1824
Smiles:  CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Alias:

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-;

Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine;

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.;

(-)-Paclitaxel;

5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine;

ABI 007;

Abraxane;

Anzatax;

BMS 181339-01;

Capxol;

Coroflex Please;

Cremophor-free paclitaxel;

Cyclopax;

Cynviloq;

Cypher select;

DHP 107;

Ebetaxel;

EmPAC;

EndoTAG 1;

Genaxol;

Genetaxyl;

Genexol;

Genexol-PM;

IG 001;

IG 002;

Infinnium;

Intaxel;

LEP-ETU;

Liposome-entrapped paclitaxel easy-to-use;

MBT 0206;

Mitotax;

NK 105;

NSC 125973;

Nab-paclitaxel;

Nanotax;

Nanoxel;

OncoGel;

Onxal;

Oraxol;

PTX;

Pacitaxel;

Pacliex;

Paclitaxel;

Padexol;

Paxene;

Plaxicel;

QW 8184;

Sindaxel;

TAXUS Express;

TAXUS stent;

TaxAlbin;

Taxol;

Taxol A;

Taxus;

Taxus Liberte;

Tocosol Paclitaxel;

Yewtaxan;

Zisu
Structure:

Related Targets  (Total: 53)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
A 1 Reference(s)
T69NWB Selenoprotein SSELENOS Q9BQE4
A 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 1 Reference(s)
T20MBF SerotransferrinTF P02787
A 1 Reference(s)
T27F5B Interleukin-1 receptor-associated kinase 1IRAK1 P51617
A 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
A 1 Reference(s)
T10R1D Copper-transporting ATPase 1ATP7A Q04656
A 1 Reference(s)
T84EOF NAMIR197 NA
A 1 Reference(s)
T50HKY cAMP-dependent protein kinase type I-alpha regulatory subunitPRKAR1A P10644
A 1 Reference(s)
T77A47 Eukaryotic translation initiation factor 4EEIF4E P06730
B 1 Reference(s)
T72QH0 Eukaryotic translation initiation factor 4E-binding protein 1EIF4EBP1 Q13541
B 1 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
B 1 Reference(s)
T50SX0 Nuclear receptor subfamily 1 group I member 2NR1I2 O75469
B 1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
B 1 Reference(s)
T64UH1 Nitric oxide synthase, endothelialNOS3 P29474
B 1 Reference(s)
T42FMQ Mitogen-activated protein kinase kinase kinase 1MAP3K1 Q13233
B 1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
B 1 Reference(s)
T35E0A Tubulin alpha-1B chainTUBA1B P68363
B 1 Reference(s)
T73HTV ThrombomodulinTHBD P07204
B 1 Reference(s)
T09INZ Transient receptor potential cation channel subfamily A member 1TRPA1 O75762
B 1 Reference(s)
T34HD8 Steroidogenic factor 1NR5A1 Q13285
B 1 Reference(s)
T38T1U Caspase-8CASP8 Q14790
B 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
C 3 Reference(s)
T53OZE Cytidine deaminaseCDA P32320
C 1 Reference(s)
T61KGI NAMIR143 NA
C 1 Reference(s)
T55LCD POU domain, class 5, transcription factor 1POU5F1 Q01860
C 2 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
C 1 Reference(s)
T13E59 Centromere-associated protein ECENPE Q02224
C 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
C 4 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
C 1 Reference(s)
T83F53 Forkhead box protein M1FOXM1 Q08050
C 1 Reference(s)
T92P67 Vasodilator-stimulated phosphoproteinVASP P50552
C 1 Reference(s)
T62HEE H(+)/Cl(-) exchange transporter 3CLCN3 P51790
C 1 Reference(s)
T96T89 Serine/arginine-rich splicing factor 3SRSF3 P84103
C 1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
C 1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
C 1 Reference(s)
T32PI2 Programmed cell death 1 ligand 1CD274 Q9NZQ7
C 1 Reference(s)
T38OH4 Caspase-1CASP1 P29466
C 1 Reference(s)
T55K84 Thioredoxin domain-containing protein 17TXNDC17 Q9BRA2
C 1 Reference(s)
T23P74 Caspase-9CASP9 P55211
C 1 Reference(s)
T54KVP Protein regulator of cytokinesis 1PRC1 O43663
C 1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
C 1 Reference(s)
T39M65 NAMIR216B NA
C 1 Reference(s)
T84XYQ Polycystin-2PKD2 Q13563
C 1 Reference(s)
T26QPN Maternal embryonic leucine zipper kinaseMELK Q14680
C 1 Reference(s)
T74RBE Inositol 1,4,5-trisphosphate receptor type 1ITPR1 Q14643
C 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
C 1 Reference(s)
T47RAK NAMIR145 NA
C 1 Reference(s)
T42GML NAMIR183 NA
C 1 Reference(s)
T72CRD NAMIR96 NA
C 1 Reference(s)
T20W8R NAMIR182 NA
C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 6)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
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H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0464 Shi Liu Zi石榴子 NAPunica granatum