Target Description

Type Detail
Target ID T84XYQ
Protein Name Polycystin-2
Uniprot ID Q13563
Protein Name Alias PC2;  Autosomal dominant polycystic kidney disease type II protein;  Polycystic kidney disease 2 protein;  Polycystwin;  R48321;  Transient receptor potential cation channel subfamily P member 2
Gene ID 5311
Gene Symbol PKD2
Gene Alias TRPP2
TTD NA
Pfam PF08016
GO
0090279:regulation of calcium ion import

0060170:ciliary membrane

0060674:placenta blood vessel development

0071458:integral component of cytoplasmic side of endoplasmic reticulum membrane

0072218:metanephric ascending thin limb development

0005267:potassium channel activity

0072075:metanephric mesenchyme development

0005102:signaling receptor binding

0098662:inorganic cation transmembrane transport

0072686:mitotic spindle

0071556:integral component of lumenal side of endoplasmic reticulum membrane

0048763:calcium-induced calcium release activity

0071320:cellular response to cAMP

0060315:negative regulation of ryanodine-sensitive calcium-release channel activity

0072177:mesonephric duct development

0036064:ciliary basal body

0051117:ATPase binding

0003127:detection of nodal flow

0044782:cilium organization

0001947:heart looping

0042803:protein homodimerization activity

0072208:metanephric smooth muscle tissue development

0001889:liver development

0015271:outward rectifier potassium channel activity

0035904:aorta development

0061441:renal artery morphogenesis

0072235:metanephric distal tubule development

0045429:positive regulation of nitric oxide biosynthetic process

0005249:voltage-gated potassium channel activity

0042805:actinin binding

0035502:metanephric part of ureteric bud development

2000134:negative regulation of G1/S transition of mitotic cell cycle

0072284:metanephric S-shaped body morphogenesis

0002133:polycystin complex

0071910:determination of liver left/right asymmetry

0051290:protein heterotetramerization

0016055:Wnt signaling pathway

0042802:identical protein binding

0021915:neural tube development

0005783:endoplasmic reticulum

0001892:embryonic placenta development

0071158:positive regulation of cell cycle arrest

0031514:motile cilium

0051298:centrosome duplication

0070588:calcium ion transmembrane transport

0005509:calcium ion binding

0009925:basal plasma membrane

0034703:cation channel complex

0008092:cytoskeletal protein binding

0034614:cellular response to reactive oxygen species

0198738:cell-cell signaling by wnt

0007368:determination of left/right symmetry

0072164:mesonephric tubule development

0071805:potassium ion transmembrane transport

0005244:voltage-gated ion channel activity

0016020:membrane

0007507:heart development

0005261:cation channel activity

0005248:voltage-gated sodium channel activity

0005245:voltage-gated calcium channel activity

0007050:cell cycle arrest

0006816:calcium ion transport

0072214:metanephric cortex development

0043398:HLH domain binding

0005929:cilium

0005886:plasma membrane

0001658:branching involved in ureteric bud morphogenesis

0030659:cytoplasmic vesicle membrane

0044325:ion channel binding

0045180:basal cortex

0051289:protein homotetramerization

0045944:positive regulation of transcription by RNA polymerase II

0035725:sodium ion transmembrane transport

0045737:positive regulation of cyclin-dependent protein serine/threonine kinase activity

0042127:regulation of cell population proliferation

0007259:receptor signaling pathway via JAK-STAT

0071464:cellular response to hydrostatic pressure

0008285:negative regulation of cell population proliferation

0070062:extracellular exosome

0042994:cytoplasmic sequestering of transcription factor

0005789:endoplasmic reticulum membrane

0050982:detection of mechanical stimulus

0072219:metanephric cortical collecting duct development

0051371:muscle alpha-actinin binding

0022843:voltage-gated cation channel activity

0051209:release of sequestered calcium ion into cytosol

0071470:cellular response to osmotic stress

0051219:phosphoprotein binding

0005794:Golgi apparatus

0005911:cell-cell junction

0021510:spinal cord development

0071498:cellular response to fluid shear stress

0005887:integral component of plasma membrane

0005737:cytoplasm

0031587:positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

0071277:cellular response to calcium ion

0061333:renal tubule morphogenesis

0097730:non-motile cilium

0051262:protein tetramerization

0030027:lamellipodium

PDB 2KQ6 ; 2KLE ; 5MKE ; 2KLD ; 6D1W ; 5T4D ; 6A70 ; 2Y4Q ; 3HRO ; 5K47 ; 6T9N ; 3HRN ; 5MKF ; 6WB8 ; 6T9O
Drugbank NA
KEGG hsa:5311

Related Compounds  (Total: 2)

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C0281
Name: Paclitaxel
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C0808
Name: 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-2,3-Dihydrochromen-4-One


Related Herbs  (Total: 50)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0802 Zhi Geng枳梗 NACitrus aurantium
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1227 Huai Zhi槐枝 NASophora japonica
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0601 Wu Mei乌梅 Japanese apricotPrunus mume
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0602 Wu Mei Rou乌梅肉 EbonyPrunus mume
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H1217 Bai Mei Hua白梅花 Japanese apricot flowerPrunus mume
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0527 Tao PeachPrunus persica
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1225 Huai Mi槐米 NASophora japonica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis