Compound Description
| ID: C0808 | Common name: 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-2,3-Dihydrochromen-4-One |
| IUPAC: 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one | CAS: NA |
| Chembl ID: CHEMBL32571 | Pubchem ID: CID:932 |
| Formula: C15H12O5 | TCM-ID: TCMC525 |
| Smiles: C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O | |
| Alias:
NA
|
Structure:
|
Related Targets (Total: 31)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T48J1U | Aldo-keto reductase family 1 member C1 | AKR1C1 |
Q04828 |
A | 1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
A | 1 Reference(s) |
| T21EGX | Multidrug resistance-associated protein 1 | ABCC1 |
P33527 |
A | 1 Reference(s) |
| T88LSZ | Aromatase | CYP19A1 |
P11511 |
A | 1 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
A | 1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
B | 1 Reference(s) |
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
B | 1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
B | 1 Reference(s) |
| T23RXU | Glutathione reductase, mitochondrial | GSR |
P00390 |
B | 1 Reference(s) |
| T46AQJ | Glutathione S-transferase P | GSTP1 |
P09211 |
B | 1 Reference(s) |
| T59DDI | Liver carboxylesterase 1 | CES1 |
P23141 |
B | 1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
B | 1 Reference(s) |
| T03NWF | Sterol O-acyltransferase 1 | SOAT1 |
P35610 |
B | 1 Reference(s) |
| T95RKQ | Sterol O-acyltransferase 2 | SOAT2 |
O75908 |
B | 1 Reference(s) |
| T35FQV | Microsomal triglyceride transfer protein large subunit | MTTP |
P55157 |
B | 1 Reference(s) |
| T30TYH | Phospholipase A2 | PLA2G1B |
P04054 |
B | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
C | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
C | 1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
C | 1 Reference(s) |
| T90ORW | Bcl2-associated agonist of cell death | BAD |
Q92934 |
C | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
C | 1 Reference(s) |
| T33OSQ | Sterol regulatory element-binding protein 1 | SREBF1 |
P36956 |
C | 1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
C | 1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
C | 1 Reference(s) |
| T73S71 | Apolipoprotein B-100 | APOB |
P04114 |
C | 1 Reference(s) |
| T95IYZ | Adiponectin | ADIPOQ |
Q15848 |
C | 1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
C | 1 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
C | 1 Reference(s) |
| T84XYQ | Polycystin-2 | PKD2 |
Q13563 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 44)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0530 | Tao Ren Shuang | 桃仁霜 | Peach kernel | Prunus persica |
| H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1225 | Huai Mi | 槐米 | NA | Sophora japonica |
| H0663 | Xiao Ji | 小蓟 | Setose thistle | Cirsium setosum |
| H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1227 | Huai Zhi | 槐枝 | NA | Sophora japonica |
| H0965 | Deng Zhan Xi Xin | 灯盏细辛 | Shortscape fleabane | Erigeron breviscapus |
| H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0602 | Wu Mei Rou | 乌梅肉 | Ebony | Prunus mume |
| H1217 | Bai Mei Hua | 白梅花 | Japanese apricot flower | Prunus mume |
| H0529 | Tao Ren | 桃仁 | Peach kernel | Prunus persica |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0582 | Cao Dou Kou Ren | 草豆蔻仁 | Katsumada galangal | Alpinia katsumadai |
| H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0574 | Cao Dou Kou | 草豆蔻 | Katsumada galangal | Alpinia katsumadai |
| H0002 | Hui Xiang | 茴香 | Fennel fruit | Foeniculum vulgare |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1133 | Gui Jian Yu | 鬼箭羽 | Winged euonymus | Euonymus alatus |
| H0531 | Tao Zhi | 桃枝 | Peach juvenile branch | Prunus persica |
| H1222 | Huai Hua | 槐花 | flower bud of japanese pagodatree | Sophora japonica |
| H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1224 | Huai Jiao | 槐角 | pod of japanese pagodatree | Sophora japonica |
| H0802 | Zhi Geng | 枳梗 | NA | Citrus aurantium |
| H1240 | Huang Jing Zi | 黄荆子 | NA | Vitex negundo |
| H0527 | Tao | 桃 | Peach | Prunus persica |
| H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
| H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H0804 | Zhi Ke | 枳壳 | Seville ora nge unripe fruit | Citrus aurantium |
| H0446 | Sheng Jiang | 生姜 | Fresh common ginger | Zingiber officinale |
| H0601 | Wu Mei | 乌梅 | Japanese apricot | Prunus mume |
| H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
| H0705 | Yan Hu Lu Ba | 盐胡芦巴 | Fenugreek | Trigonella foenum-graecum |
| H0805 | Zhi Ke Gan Jin Gao | 枳壳干浸膏 | Seville ora nge unripe fruit | Citrus aurantium |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H0758 | Cheng Pi | 橙皮 | Bitter orange | Citrus aurantium |
| H0813 | Zhi Shi | 枳实 | Seville orange young fruit | Citrus aurantium |
| H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
Ckey description of the interaction between compound and target