Target Description

Type Detail
Target ID T21EGX
Protein Name Multidrug resistance-associated protein 1
Uniprot ID P33527
Protein Name Alias EC 7.6.2.2;  ATP-binding cassette sub-family C member 1;  Glutathione-S-conjugate-translocating ATPase ABCC1;  EC 7.6.2.3;  Leukotriene C(4) transporter;  LTC4 transporter
Gene ID 4363
Gene Symbol ABCC1
Gene Alias MRP;  MRP1
TTD T11288: Successful target
Pfam PF00664 ; PF00005
GO
0070062:extracellular exosome

1904646:cellular response to amyloid-beta

0070633:transepithelial transport

0042493:response to drug

0005524:ATP binding

0150104:transport across blood-brain barrier

0009235:cobalamin metabolic process

0045332:phospholipid translocation

0016020:membrane

1990962:xenobiotic transport across blood-brain barrier

1905039:carboxylic acid transmembrane transport

0015431:ABC-type glutathione S-conjugate transporter activity

0099039:sphingolipid translocation

0140115:export across plasma membrane

0060326:cell chemotaxis

0042908:xenobiotic transport

0034040:ATPase-coupled lipid transmembrane transporter activity

0055085:transmembrane transport

0034634:glutathione transmembrane transporter activity

0006691:leukotriene metabolic process

0015562:efflux transmembrane transporter activity

0005886:plasma membrane

0034775:glutathione transmembrane transport

0042167:heme catabolic process

0005887:integral component of plasma membrane

0042910:xenobiotic transmembrane transporter activity

0016887:ATPase activity

0042626:ATPase-coupled transmembrane transporter activity

0046943:carboxylic acid transmembrane transporter activity

0016323:basolateral plasma membrane

0050729:positive regulation of inflammatory response

0009925:basal plasma membrane

0071716:leukotriene transport

0140359:ABC-type transporter activity

0015889:cobalamin transport

0008559:ABC-type xenobiotic transporter activity

0016328:lateral plasma membrane

0016324:apical plasma membrane

PDB 4C3Z ; 2CBZ
Drugbank DB04851 ; DB06335 ; DB00224 ; DB00694 ; DB00586 ; DB00541 ; DB01174 ; DB02375 ; DB03825 ; DB00345 ; DB01016 ; DB09213 ; DB01138 ; DB00115 ; DB09061 ; DB00845 ; DB05294 ; DB01072 ; DB00563 ; DB00396 ; DB04216 ; DB00445 ; DB00709 ; DB04348 ; DB01050 ; DB01708 ; DB01045 ; DB03467 ; DB08868 ; DB01165 ; DB00286 ; DB00762 ; DB00143 ; DB00570 ; DB01645 ; DB14011 ; DB00328 ; DB01032 ; DB00171 ; DB00997 ; DB01248 ; DB08881 ; DB00661 ; DB00399 ; DB01177 ; DB00773 ; DB00365 ; DB00503 ; DB02659 ; DB00693 ; DB08855 ; DB01204 ; DB09161 ; DB14962 ; DB14009 ; DB13783 ; DB00701 ; DB05812 ; DB00834 ; DB01076 ; DB00970 ; DB01232 ; DB01229 ; DB06176 ; DB00602 ; DB15719
KEGG hsa:4363

Related Compounds  (Total: 9)

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C0057
Name: Estrone
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C0390
Name: Schisandrin B
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C0481
Name: Verapamil
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C0627
Name: Matrine
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C0739
Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione


Related Herbs  (Total: 85)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0802 Zhi Geng枳梗 NACitrus aurantium
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H0357 Ren Shen人参 GinsengPanax ginseng
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0669 Xie Bai薤白 Longstamen onionAllium macrostemon
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1225 Huai Mi槐米 NASophora japonica
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0262 Bei Wu Wei北五味 fruit of chinese nmagnoliavineRosmarinus officinalis
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1227 Huai Zhi槐枝 NASophora japonica
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H0112 Ku Xing Ren苦杏仁 bitter apricot seedSemen armeniacae amarum
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0405 Shan Dou Gen山豆根 Tonkin sophora rootSophora subprostrata
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0601 Wu Mei乌梅 Japanese apricotPrunus mume
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0903 Ci Cai荠菜 ShepherdspurseCapsella bursa-pastoris
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1217 Bai Mei Hua白梅花 Japanese apricot flowerPrunus mume
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0602 Wu Mei Rou乌梅肉 EbonyPrunus mume
H0178 Lu Rong Jiao鹿茸胶 Gelatin of pilos deer hornColla cornus cervi
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0527 Tao PeachPrunus persica
H0610 Wu Xiang Xue Teng五香血藤 longpeduncle kadsura stemSchisandra sphenanthera
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0416 Shan Shen山参 NAPanax ginseng
H0919 Cui Yun Cao翠云草 Hooked spikemossSelaginella uncinata
H0204 Ma Ren麻仁 NACannabis sativa