Herb Description

Herb ID:   H1204 Chinese Character:   胡椒
English Name:  Black pepper Latin Name:  Piper nigrum
Chinese Pin Yin :  Hu Jiao TCM-ID:  TCMH907
Therapeutic Function in Chinese :  温里 Therapeutic Function in English:  For warming interior
Herb Function:  Dispel cold from the stomach, and eliminate phlegm

Related Targets  (Total: 210)

Target idProtein NameGene SymbolUniprot IDNo.of Literature Evidence
T06Q1R Amine oxidase [flavin-containing] BMAOB P27338
2 Reference(s)
T21DZX Amine oxidase [flavin-containing] AMAOA P21397
2 Reference(s)
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
3 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
4 Reference(s)
T73EVE Cyclic AMP-dependent transcription factor ATF-2ATF2 P15336
1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
2 Reference(s)
T50SX0 Nuclear receptor subfamily 1 group I member 2NR1I2 O75469
2 Reference(s)
T68NCI Aldo-keto reductase family 1 member B1AKR1B1 P15121
1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
6 Reference(s)
T77W6N Thioredoxin reductase 1, cytoplasmicTXNRD1 Q16881
1 Reference(s)
T22NX4 Toll-like receptor 2TLR2 O60603
1 Reference(s)
T76QBQ CREB-regulated transcription coactivator 2CRTC2 Q53ET0
1 Reference(s)
T37CIB ATP-binding cassette sub-family B member 6, mitochondrialABCB6 Q9NP58
2 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
54 Reference(s)
T88BCB Glycerol-3-phosphate phosphatasePGP A6NDG6
4 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
5 Reference(s)
T60A9R NACYP3A NA
1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
4 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
1 Reference(s)
T39FBA Thioredoxin-interacting proteinTXNIP Q9H3M7
1 Reference(s)
T21EGX Multidrug resistance-associated protein 1ABCC1 P33527
2 Reference(s)
T25M2J Anoctamin-1ANO1 Q5XXA6
1 Reference(s)
T58XLK Tyrosine-protein phosphatase non-receptor type 1PTPN1 P18031
2 Reference(s)
T77PFO Histone deacetylase 6HDAC6 Q9UBN7
3 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
4 Reference(s)
T22H7B Neuronal acetylcholine receptor subunit alpha-4CHRNA4 P43681
17 Reference(s)
T34I45 Neuronal acetylcholine receptor subunit alpha-7CHRNA7 P36544
8 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
4 Reference(s)
T37ADS Early growth response protein 1EGR1 P18146
2 Reference(s)
T47G3X Glucocorticoid receptorNR3C1 P04150
1 Reference(s)
T37B9N UDP-glucuronosyltransferase 2B10UGT2B10 P36537
1 Reference(s)
T51HY5 Signal transducer CD24CD24 P25063
1 Reference(s)
T22XGJ Alpha-1A adrenergic receptorADRA1A P35348
7 Reference(s)
T71QVU Alpha-1D adrenergic receptorADRA1D P25100
1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
2 Reference(s)
T62P0D Collagenase 3MMP13 P45452
2 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
4 Reference(s)
T74WWP Peroxisome proliferator-activated receptor deltaPPARD Q03181
1 Reference(s)
T14JSX PlasminogenPLG P00747
1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
1 Reference(s)
T67LRH RNA-binding protein Musashi homolog 1MSI1 O43347
1 Reference(s)
T37G49 Platelet-activating factor acetylhydrolasePLA2G7 Q13093
1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
5 Reference(s)
T53YWQ Pro-neuropeptide Y [Cleaved into: Neuropeptide YNPY P01303
2 Reference(s)
T69RXK Cytochrome P450 2C9CYP2C9 P11712
1 Reference(s)
T16QQC Cytochrome P450 3A5CYP3A5 P20815
1 Reference(s)
T16A2X CatalaseCAT P04040
1 Reference(s)
T70HTD Cytochrome P450 2E1CYP2E1 P05181
1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
2 Reference(s)
T95RKQ Sterol O-acyltransferase 2SOAT2 O75908
1 Reference(s)
T85U8U Caspase-3CASP3 P42574
5 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
3 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
5 Reference(s)
T36B1Q Baculoviral IAP repeat-containing protein 5BIRC5 O15392
2 Reference(s)
T18YXD AlbuminALB P02768
1 Reference(s)
T54KVP Protein regulator of cytokinesis 1PRC1 O43663
1 Reference(s)
T69XVX Cytochrome P450 1B1CYP1B1 Q16678
1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
4 Reference(s)
T61DYZ Phospholipid-transporting ATPase ABCA1ABCA1 O95477
1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
2 Reference(s)
T69VYP ATP-binding cassette sub-family G member 1ABCG1 P45844
1 Reference(s)
T39YFG Trypsin-1PRSS1 P07477
1 Reference(s)
T54WR0 Fatty acid-binding protein 5FABP5 Q01469
1 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
3 Reference(s)
T07S0E BDNF/NT-3 growth factors receptorNTRK2 Q16620
1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
2 Reference(s)
T51WGR Pancreas/duodenum homeobox protein 1PDX1 P52945
1 Reference(s)
T43NBB Solute carrier family 2, facilitated glucose transporter member 2SLC2A2 P11168
1 Reference(s)
T89L4V InsulinINS P01308
1 Reference(s)
T38WWN Serum paraoxonase/arylesterase 1PON1 P27169
1 Reference(s)
T23YZF Peptidyl-glycine alpha-amidating monooxygenasePAM P19021
1 Reference(s)
T77FOL NeuromodulinGAP43 P17677
1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
1 Reference(s)
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
1 Reference(s)
T02DEN Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptideGCG P01275
2 Reference(s)
T48UT8 Cholesteryl ester transfer proteinCETP P11597
1 Reference(s)
T32HPO Aspartyl aminopeptidaseDNPEP Q9ULA0
1 Reference(s)
T20H9F Stromelysin-1MMP3 P08254
2 Reference(s)
T02YLA Alpha-lactalbuminLALBA P00709
1 Reference(s)
T76TED Pro-opiomelanocortinPOMC P01189
1 Reference(s)
T37JN5 Neutrophil gelatinase-associated lipocalinLCN2 P80188
1 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
2 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
1 Reference(s)
T77M4W Adenosine receptor A2aADORA2A P29274
1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
4 Reference(s)
T33OPP Interleukin-6IL6 P05231
2 Reference(s)
T84G6T Interleukin-12 subunit betaIL12B P29460
1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
2 Reference(s)
T51EKP Apolipoprotein MAPOM O95445
1 Reference(s)
T07VV7 GuanylinGUCA2A Q02747
1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
1 Reference(s)
T80WPU Protein ABHD15ABHD15 Q6UXT9
1 Reference(s)
T56OUM 14-3-3 protein zeta/deltaYWHAZ P63104
1 Reference(s)
T24YWQ Insulin-degrading enzymeIDE P14735
1 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
1 Reference(s)
T39M6J ATP-binding cassette sub-family C member 2ABCC2 Q92887
1 Reference(s)
T04V7K Ectonucleotide pyrophosphatase/phosphodiesterase family member 7ENPP7 Q6UWV6
1 Reference(s)
T51U9M Carnitine O-palmitoyltransferase 1, muscle isoformCPT1B Q92523
1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
1 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
1 Reference(s)
T10RDU Patatin-like phospholipase domain-containing protein 2PNPLA2 Q96AD5
1 Reference(s)
T57L0X Oxysterols receptor LXR-alphaNR1H3 Q13133
1 Reference(s)
T05DRQ Receptor tyrosine-protein kinase erbB-4ERBB4 Q15303
1 Reference(s)
T38CH0 Tumor necrosis factor ligand superfamily member 9TNFSF9 P41273
1 Reference(s)
T68VQD Excitatory amino acid transporter 1SLC1A3 P43003
1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
2 Reference(s)
T71V6E Serine/threonine-protein kinase PAK 1PAK1 Q13153
1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
2 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
1 Reference(s)
T83QHM Beta-nerve growth factorNGF P01138
1 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
2 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
1 Reference(s)
T69PZ6 Protein phosphatase 1 regulatory subunit 12APPP1R12A O14974
1 Reference(s)
T85RZS Corticotropin-releasing factor receptor 1CRHR1 P34998
1 Reference(s)
T83F6G Corticotropin-releasing factor receptor 2CRHR2 Q13324
1 Reference(s)
T50JSQ Corticotropin-releasing factor-binding proteinCRHBP P24387
1 Reference(s)
T76C5R Parathyroid hormone-related proteinPTHLH P12272
1 Reference(s)
T43Y5O D(3) dopamine receptorDRD3 P35462
1 Reference(s)
T69ZRP Appetite-regulating hormoneGHRL Q9UBU3
1 Reference(s)
T73QZ2 Methylcytosine dioxygenase TET2TET2 Q6N021
1 Reference(s)
T91QMA Histidine triad nucleotide-binding protein 1HINT1 P49773
1 Reference(s)
T64V6C Glutamate decarboxylase 1GAD1 Q99259
2 Reference(s)
T09KPZ VimentinVIM P08670
1 Reference(s)
T02DKV Gastrin [Cleaved into: Gastrin-71GAST P01350
1 Reference(s)
T84Z2I SHC-transforming protein 1SHC1 P29353
1 Reference(s)
T63V6Q Cocaine- and amphetamine-regulated transcript proteinCARTPT Q16568
1 Reference(s)
T43IF3 Chromogranin-ACHGA P10645
1 Reference(s)
T33JS5 CCN family member 2CCN2 P29279
1 Reference(s)
T75HMM Induced myeloid leukemia cell differentiation protein Mcl-1MCL1 Q07820
1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
1 Reference(s)
T12IEI Cadherin-2CDH2 P19022
1 Reference(s)
T90Z3N FilaggrinFLG P20930
1 Reference(s)
T18C4B Methylated-DNA--protein-cysteine methyltransferaseMGMT P16455
1 Reference(s)
T16R2S Neuronal acetylcholine receptor subunit alpha-5CHRNA5 P30532
1 Reference(s)
T23A18 Pro-neuregulin-3, membrane-bound isoformNRG3 P56975
1 Reference(s)
T31JWV Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPIK3CB P42338
1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
2 Reference(s)
T67RBZ Mitochondrial uncoupling protein 2UCP2 P55851
2 Reference(s)
T67HYX Mitochondrial uncoupling protein 3UCP3 P55916
1 Reference(s)
T19EKF CholecystokininCCK P06307
1 Reference(s)
T19XSL Fatty acid-binding protein, liverFABP1 P07148
1 Reference(s)
T23APZ Retinol-binding protein 2RBP2 P50120
1 Reference(s)
T38K2W Receptor tyrosine-protein kinase erbB-2ERBB2 P04626
1 Reference(s)
T03NWF Sterol O-acyltransferase 1SOAT1 P35610
1 Reference(s)
T48YPL Aquaporin-3AQP3 Q92482
1 Reference(s)
T53SLQ Aquaporin-9AQP9 O43315
1 Reference(s)
T75EH8 Glucagon-like peptide 1 receptorGLP1R P43220
1 Reference(s)
T52VL6 Signal transducer and activator of transcription 5ASTAT5A P42229
1 Reference(s)
T19K8W Signal transducer and activator of transcription 5BSTAT5B P51692
1 Reference(s)
T98DNG Natriuretic peptides ANPPA P01160
1 Reference(s)
T78ILO Stearoyl-CoA desaturaseSCD O00767
1 Reference(s)
T68IZC Natriuretic peptides BNPPB P16860
1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
2 Reference(s)
T02H9U Nuclear factor of activated T-cells, cytoplasmic 4NFATC4 Q14934
1 Reference(s)
T70HC9 Hepatocyte nuclear factor 1-alphaHNF1A P20823
1 Reference(s)
T49J7I Hepatocyte nuclear factor 4-alphaHNF4A P41235
1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
1 Reference(s)
T23P74 Caspase-9CASP9 P55211
1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
2 Reference(s)
T42O1D Delta-type opioid receptorOPRD1 P41143
1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
1 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
1 Reference(s)
T85IZ0 Opioid-binding protein/cell adhesion moleculeOPCML Q14982
1 Reference(s)
T95IYZ AdiponectinADIPOQ Q15848
1 Reference(s)
T04WT7 FibronectinFN1 P02751
1 Reference(s)
T52GFD Neuronal acetylcholine receptor subunit alpha-6CHRNA6 Q15825
1 Reference(s)
T78IOY Telomerase reverse transcriptaseTERT O14746
1 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
1 Reference(s)
T78KL2 Collagen alpha-1(III) chainCOL3A1 P02461
1 Reference(s)
T56TXY Polyunsaturated fatty acid 5-lipoxygenaseALOX5 P09917
1 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
1 Reference(s)
T15VAS Integrin beta-1ITGB1 P05556
1 Reference(s)
T27LA6 DNADNMT1 P26358
1 Reference(s)
T25H22 Protein kinase C beta typePRKCB P05771
1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
1 Reference(s)
T02DYS Protein fosBFOSB P53539
1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
1 Reference(s)
T17CZC Tissue factorF3 P13726
1 Reference(s)
T14LSK E3 ubiquitin-protein ligase XIAPXIAP P98170
1 Reference(s)
T32IXS Integrin alpha-MITGAM P11215
1 Reference(s)
T91F6Z Integrin alpha-LITGAL P20701
1 Reference(s)
T25C2G Nuclear receptor subfamily 4 group A member 1NR4A1 P22736
1 Reference(s)
T50V79 Interleukin-4IL4 P05112
1 Reference(s)
T03O7G OrexinHCRT O43612
1 Reference(s)
T82RFG P2Y purinoceptor 12P2RY12 Q9H244
1 Reference(s)
T73WJH Calcium/calmodulin-dependent protein kinase kinase 2CAMKK2 Q96RR4
1 Reference(s)
T45G32 Proto-oncogene tyrosine-protein kinase SrcSRC P12931
1 Reference(s)
T01P7T Retinoic acid receptor RXR-betaRXRB P28702
1 Reference(s)
T02P7Q Dihydrofolate reductaseDHFR P00374
1 Reference(s)
T75OVL High affinity nerve growth factor receptorNTRK1 P04629
2 Reference(s)
T00EP2 Tissue-type plasminogen activatorPLAT P00750
1 Reference(s)
T31P1D Metalloproteinase inhibitor 1TIMP1 P01033
1 Reference(s)
T85AB0 Metalloproteinase inhibitor 4TIMP4 Q99727
1 Reference(s)
T85HMF Metalloproteinase inhibitor 3TIMP3 P35625
1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
1 Reference(s)
T64T6J Beta-1 adrenergic receptorADRB1 P08588
1 Reference(s)
T63M1G Integrin alpha-2ITGA2 P17301
1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
1 Reference(s)
T01E8J Amyloid-beta precursor proteinAPP P05067
1 Reference(s)
T56G7O Acyl-CoA-binding proteinDBI P07108
1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
1 Reference(s)
T28HOM LeptinLEP P41159
1 Reference(s)
T24U57 E-selectinSELE P16581
1 Reference(s)
T13HLX cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32)PDE4B Q07343
1 Reference(s)
T18CPB Choline O-acetyltransferaseCHAT P28329
1 Reference(s)

Related Compounds  (Total: 18)

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C0315
Name: Piperine
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C0316
Name: Piplartine
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C0285
Name: Palmitic Acid
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C0481
Name: Verapamil
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C0064
Name: Eugenol