Target Description

Type Detail
Target ID T05DRQ
Protein Name Receptor tyrosine-protein kinase erbB-4
Uniprot ID Q15303
Protein Name Alias EC 2.7.10.1;  Proto-oncogene-like protein c-ErbB-4;  Tyrosine kinase-type cell surface receptor HER4;  p180erbB4
Gene ID 2066
Gene Symbol ERBB4
Gene Alias HER4
TTD T92057: Successful target
Pfam PF01030 ; PF07714 ; PF00757 ; PF14843
GO
0098982:GABA-ergic synapse

0021551:central nervous system morphogenesis

0005634:nucleus

0043235:receptor complex

0038128:ERBB2 signaling pathway

0007275:multicellular organism development

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0046777:protein autophosphorylation

0018108:peptidyl-tyrosine phosphorylation

2001223:negative regulation of neuron migration

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0005829:cytosol

0030334:regulation of cell migration

0099061:integral component of postsynaptic density membrane

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0007399:nervous system development

0071364:cellular response to epidermal growth factor stimulus

0098978:glutamatergic synapse

0060749:mammary gland alveolus development

0004713:protein tyrosine kinase activity

0008284:positive regulation of cell population proliferation

0060644:mammary gland epithelial cell differentiation

0051897:positive regulation of protein kinase B signaling

0007416:synapse assembly

0008285:negative regulation of cell population proliferation

0061026:cardiac muscle tissue regeneration

0045211:postsynaptic membrane

0005759:mitochondrial matrix

0007507:heart development

0000165:MAPK cascade

0005887:integral component of plasma membrane

0005524:ATP binding

0045165:cell fate commitment

0005886:plasma membrane

0001934:positive regulation of protein phosphorylation

0009880:embryonic pattern specification

0007595:lactation

0060045:positive regulation of cardiac muscle cell proliferation

0000976:transcription regulatory region sequence-specific DNA binding

0009925:basal plasma membrane

0070374:positive regulation of ERK1 and ERK2 cascade

0043653:mitochondrial fragmentation involved in apoptotic process

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0021889:olfactory bulb interneuron differentiation

0099056:integral component of presynaptic membrane

0005576:extracellular region

0001755:neural crest cell migration

0045893:positive regulation of transcription, DNA-templated

0004714:transmembrane receptor protein tyrosine kinase activity

0005739:mitochondrion

0042803:protein homodimerization activity

0007165:signal transduction

0033674:positive regulation of kinase activity

0016477:cell migration

0005654:nucleoplasm

0005154:epidermal growth factor receptor binding

0046427:positive regulation of receptor signaling pathway via JAK-STAT

0016323:basolateral plasma membrane

2000145:regulation of cell motility

2000010:positive regulation of protein localization to cell surface

0043066:negative regulation of apoptotic process

PDB 3U2P ; 2R4B ; 3U7U ; 2AHX ; 2LCX ; 3BBT ; 3BCE ; 3BBW ; 2L2T ; 3U9U
Drugbank DB12267 ; DB15035 ; DB12010 ; DB08916
KEGG hsa:2066

Related Compounds  (Total: 2)

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C0247
Name: Nicotine
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C1207
Name: Calcitriol


Related Herbs  (Total: 11)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0476 Can E蚕蛾 SilkwormBombyx mori
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus