Home
Search
Target-mining
My-Target curation
Browse
Help

Compound Description

ID:   C0247 Common name:   Nicotine
IUPAC:  3-[(2S)-1-methylpyrrolidin-2-yl]pyridine CAS:  CAS:54-11-5
Chembl ID:   CHEMBL3 Pubchem ID:   CID:89594
Formula:  C10H14N2 TCM-ID:  TCMC1743
Smiles:  CN1CCC[C@H]1c1cccnc1
Alias:

Nicotine;

Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-;

3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine;

(-)-(S)-Nicotine;

(-)-3-(1-Methyl-2-pyrrolidyl)pyridine;

(-)-Nicotine;

(-)-β-Pyridyl-α-N-methylpyrrolidine;

(S)-(-)-Nicotine;

(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine;

(S)-Nicotine;

Exodus;

Flux Maag;

Habitrol;

L-Nicotine;

NSC 5065;

Nicabate;

Nicoderm;

Nicolan;

Niconil;

Nicopatch;

Nicorette;

Nicotell TTS;

Nicotin;

Nicotinell;

Nicotrol;

Nikofrenon;

Niquitin;

Tabazur;

XL All Insecticide;

l-Nicotine
Structure:

Related Targets  (Total: 56)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T22H7B Neuronal acetylcholine receptor subunit alpha-4CHRNA4 P43681
 A 17 Reference(s)
T34I45 Neuronal acetylcholine receptor subunit alpha-7CHRNA7 P36544
 A 7 Reference(s)
T77PFO Histone deacetylase 6HDAC6 Q9UBN7
 A 2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
 A 2 Reference(s)
T37ADS Early growth response protein 1EGR1 P18146
 A 1 Reference(s)
T47G3X Glucocorticoid receptorNR3C1 P04150
 A 1 Reference(s)
T37B9N UDP-glucuronosyltransferase 2B10UGT2B10 P36537
 A 1 Reference(s)
T51HY5 Signal transducer CD24CD24 P25063
 A 1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
 B 1 Reference(s)
T61DYZ Phospholipid-transporting ATPase ABCA1ABCA1 O95477
 B 1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
 B 1 Reference(s)
T69VYP ATP-binding cassette sub-family G member 1ABCG1 P45844
 B 1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
 C 1 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
 C 1 Reference(s)
T10RDU Patatin-like phospholipase domain-containing protein 2PNPLA2 Q96AD5
 C 1 Reference(s)
T57L0X Oxysterols receptor LXR-alphaNR1H3 Q13133
 C 1 Reference(s)
T05DRQ Receptor tyrosine-protein kinase erbB-4ERBB4 Q15303
 C 1 Reference(s)
T38CH0 Tumor necrosis factor ligand superfamily member 9TNFSF9 P41273
 C 1 Reference(s)
T68VQD Excitatory amino acid transporter 1SLC1A3 P43003
 C 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
 C 1 Reference(s)
T71V6E Serine/threonine-protein kinase PAK 1PAK1 Q13153
 C 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
 C 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
 C 1 Reference(s)
T83QHM Beta-nerve growth factorNGF P01138
 C 1 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
 C 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
 C 1 Reference(s)
T69PZ6 Protein phosphatase 1 regulatory subunit 12APPP1R12A O14974
 C 1 Reference(s)
T85RZS Corticotropin-releasing factor receptor 1CRHR1 P34998
 C 1 Reference(s)
T83F6G Corticotropin-releasing factor receptor 2CRHR2 Q13324
 C 1 Reference(s)
T50JSQ Corticotropin-releasing factor-binding proteinCRHBP P24387
 C 1 Reference(s)
T76C5R Parathyroid hormone-related proteinPTHLH P12272
 C 1 Reference(s)
T43Y5O D(3) dopamine receptorDRD3 P35462
 C 1 Reference(s)
T69ZRP Appetite-regulating hormoneGHRL Q9UBU3
 C 1 Reference(s)
T73QZ2 Methylcytosine dioxygenase TET2TET2 Q6N021
 C 1 Reference(s)
T91QMA Histidine triad nucleotide-binding protein 1HINT1 P49773
 C 1 Reference(s)
T64V6C Glutamate decarboxylase 1GAD1 Q99259
 C 1 Reference(s)
T09KPZ VimentinVIM P08670
 C 1 Reference(s)
T02DKV Gastrin [Cleaved into: Gastrin-71GAST P01350
 C 1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
 C 1 Reference(s)
T84Z2I SHC-transforming protein 1SHC1 P29353
 C 1 Reference(s)
T63V6Q Cocaine- and amphetamine-regulated transcript proteinCARTPT Q16568
 C 1 Reference(s)
T43IF3 Chromogranin-ACHGA P10645
 C 1 Reference(s)
T33JS5 CCN family member 2CCN2 P29279
 C 1 Reference(s)
T75HMM Induced myeloid leukemia cell differentiation protein Mcl-1MCL1 Q07820
 C 1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
 C 1 Reference(s)
T12IEI Cadherin-2CDH2 P19022
 C 1 Reference(s)
T90Z3N FilaggrinFLG P20930
 C 1 Reference(s)
T18C4B Methylated-DNA--protein-cysteine methyltransferaseMGMT P16455
 C 1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
 C 1 Reference(s)
T16R2S Neuronal acetylcholine receptor subunit alpha-5CHRNA5 P30532
 C 1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
 C 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
 C 1 Reference(s)
T23A18 Pro-neuregulin-3, membrane-bound isoformNRG3 P56975
 C 1 Reference(s)
T31JWV Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPIK3CB P42338
 C 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
 C 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 11)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0476 Can E蚕蛾 SilkwormBombyx mori
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens

Ckey description of the interaction between compound and target


Site Map Contact Us Terms and Conditions Privacy Policy