HIT-result

Target Description

Type	Detail
Target ID	T85RZS
Protein Name	Corticotropin-releasing factor receptor 1
Uniprot ID	P34998
Protein Name Alias	CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
Gene ID	1394
Gene Symbol	CRHR1
Gene Alias	CRFR; CRFR1; CRHR
TTD	T45262: Successful target
Pfam	PF00002 ; PF02793
GO	0008528:G protein-coupled peptide receptor activity 0015056:corticotrophin-releasing factor receptor activity 0016021:integral component of membrane 1901386:negative regulation of voltage-gated calcium channel activity 0002862:negative regulation of inflammatory response to antigenic stimulus 0051424:corticotropin-releasing hormone binding 0043404:corticotropin-releasing hormone receptor activity 0051458:corticotropin secretion 0007186:G protein-coupled receptor signaling pathway 0017046:peptide hormone binding 0007166:cell surface receptor signaling pathway 0071376:cellular response to corticotropin-releasing hormone stimulus 0005886:plasma membrane 0010578:regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway 0043005:neuron projection 0005887:integral component of plasma membrane 0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway 0005768:endosome 0031226:intrinsic component of plasma membrane 0006955:immune response 0007567:parturition 0007190:activation of adenylate cyclase activity 2000852:regulation of corticosterone secretion 0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway 0007565:female pregnancy
PDB	6P9X ; 2L27 ; 3EHU ; 3EHS ; 4Z9G ; 6PB0 ; 4K5Y ; 3EHT
Drugbank	DB09067
KEGG	hsa:104909134 ; hsa:1394

Type

Detail

Target ID

T85RZS

Protein Name

Corticotropin-releasing factor receptor 1

Uniprot ID

P34998

Protein Name Alias

CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1

Gene ID

1394

Gene Symbol

CRHR1

Gene Alias

CRFR; CRFR1; CRHR

TTD

T45262: Successful target

Pfam

PF00002 ; PF02793

0008528:G protein-coupled peptide receptor activity

0015056:corticotrophin-releasing factor receptor activity

0016021:integral component of membrane

1901386:negative regulation of voltage-gated calcium channel activity

0002862:negative regulation of inflammatory response to antigenic stimulus

0051424:corticotropin-releasing hormone binding

0043404:corticotropin-releasing hormone receptor activity

0051458:corticotropin secretion

0007186:G protein-coupled receptor signaling pathway

0017046:peptide hormone binding

0007166:cell surface receptor signaling pathway

0071376:cellular response to corticotropin-releasing hormone stimulus

0005886:plasma membrane

0010578:regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway

0043005:neuron projection

0005887:integral component of plasma membrane

0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway

0005768:endosome

0031226:intrinsic component of plasma membrane

0006955:immune response

0007567:parturition

0007190:activation of adenylate cyclase activity

2000852:regulation of corticosterone secretion

0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway

0007565:female pregnancy

PDB

6P9X ; 2L27 ; 3EHU ; 3EHS ; 4Z9G ; 6PB0 ; 4K5Y ; 3EHT

Drugbank

DB09067

KEGG

hsa:104909134 ; hsa:1394

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H1040	Feng Mi	蜂蜜	Honey	Apis cerana
H0713	Che Qian Cao	车前草	all-grass of rippleseed plantain	Plantago depressa
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0244	Mi La	蜜蜡	Bee wax	Apis cerana
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H1133	Gui Jian Yu	鬼箭羽	Winged euonymus	Euonymus alatus
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0133	Li Yu	鲤鱼	Carp	Cyprinus carpio
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 16)