Herb Description
| Herb ID: H0495 | Chinese Character: 蚕砂 |
| English Name: Silkworm excrement | Latin Name: Bombyx mori |
| Chinese Pin Yin : Can Sha | TCM-ID: TCMH201 |
| Therapeutic Function in Chinese : 祛风湿 | Therapeutic Function in English: For dispelling wind-dampness |
| Herb Function: Dispel wind and dampness, harmonize the stomach and transform dampness | |
Related Targets (Total: 182)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
2 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
2 Reference(s) |
| T38EQ6 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 |
P15559 |
1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
2 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
4 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
4 Reference(s) |
| T36HAE | D-amino-acid oxidase | DAO |
P14920 |
1 Reference(s) |
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
| T89GFN | Macrophage migration inhibitory factor | MIF |
P14174 |
1 Reference(s) |
| T16X77 | Solute carrier family 15 member 1 | SLC15A1 |
P46059 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
4 Reference(s) |
| T28PHS | Angiotensin-converting enzyme | ACE |
P12821 |
2 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
4 Reference(s) |
| T69CTT | Acetyl-CoA acetyltransferase, mitochondrial | ACAT1 |
P24752 |
1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
1 Reference(s) |
| T61M4P | Nuclear receptor ROR-alpha | RORA |
P35398 |
1 Reference(s) |
| T77VME | ATP-binding cassette sub-family F member 3 | ABCF3 |
Q9NUQ8 |
1 Reference(s) |
| T80XW6 | Scavenger receptor class B member 1 | SCARB1 |
Q8WTV0 |
2 Reference(s) |
| T93AZS | NA | ECB2 |
NA |
1 Reference(s) |
| T38OH4 | Caspase-1 | CASP1 |
P29466 |
1 Reference(s) |
| T63KO8 | NA | MIR33A |
NA |
1 Reference(s) |
| T68OIU | CREB-regulated transcription coactivator 1 | CRTC1 |
Q6UUV9 |
1 Reference(s) |
| T40SWE | Glutamate carboxypeptidase 2 | FOLH1 |
Q04609 |
1 Reference(s) |
| T92ZDN | GTPase KRas | KRAS |
P01116 |
1 Reference(s) |
| T22H7B | Neuronal acetylcholine receptor subunit alpha-4 | CHRNA4 |
P43681 |
17 Reference(s) |
| T34I45 | Neuronal acetylcholine receptor subunit alpha-7 | CHRNA7 |
P36544 |
7 Reference(s) |
| T77PFO | Histone deacetylase 6 | HDAC6 |
Q9UBN7 |
2 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
1 Reference(s) |
| T47G3X | Glucocorticoid receptor | NR3C1 |
P04150 |
1 Reference(s) |
| T37B9N | UDP-glucuronosyltransferase 2B10 | UGT2B10 |
P36537 |
1 Reference(s) |
| T51HY5 | Signal transducer CD24 | CD24 |
P25063 |
1 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
3 Reference(s) |
| T09KMC | Solute carrier family 5 member 4 | SLC5A4 |
Q9NY91 |
1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
2 Reference(s) |
| T25M2J | Anoctamin-1 | ANO1 |
Q5XXA6 |
1 Reference(s) |
| T86J48 | Sodium/glucose cotransporter 1 | SLC5A1 |
P13866 |
1 Reference(s) |
| T34E5V | Endothelin-1 receptor | EDNRA |
P25101 |
10 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
4 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
| T45XTW | Retinoic acid receptor RXR-alpha | RXRA |
P19793 |
1 Reference(s) |
| T37BP1 | Serine/threonine-protein kinase pim-1 | PIM1 |
P11309 |
1 Reference(s) |
| T42K6K | M-phase inducer phosphatase 3 | CDC25C |
P30307 |
1 Reference(s) |
| T04A2Q | Serine/threonine-protein kinase PLK1 | PLK1 |
P53350 |
1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
1 Reference(s) |
| T75ZQD | Myelin proteolipid protein | PLP1 |
P60201 |
2 Reference(s) |
| T67U3B | Translocator protein | TSPO |
P30536 |
4 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
2 Reference(s) |
| T44AEN | NPC intracellular cholesterol transporter 1 | NPC1 |
O15118 |
2 Reference(s) |
| T01E8J | Amyloid-beta precursor protein | APP |
P05067 |
2 Reference(s) |
| T73S71 | Apolipoprotein B-100 | APOB |
P04114 |
3 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
| T13DVU | Conserved oligomeric Golgi complex subunit 2 | COG2 |
Q14746 |
1 Reference(s) |
| T37I8W | NA | MIR33B |
NA |
1 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
2 Reference(s) |
| T56FPY | CD81 antigen | CD81 |
P60033 |
1 Reference(s) |
| T89EW0 | Aquaporin-8 | AQP8 |
O94778 |
1 Reference(s) |
| T21K0F | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | ATP2A3 |
Q93084 |
1 Reference(s) |
| T92MGC | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SGMS2 |
Q8NHU3 |
1 Reference(s) |
| T81DYL | Cysteine-rich secretory protein 2 | CRISP2 |
P16562 |
1 Reference(s) |
| T90K33 | ATP-binding cassette sub-family G member 5 | ABCG5 |
Q9H222 |
2 Reference(s) |
| T75NEV | Aquaporin-1 | AQP1 |
P29972 |
1 Reference(s) |
| T91X8E | Sterol carrier protein 2 | SCP2 |
P22307 |
1 Reference(s) |
| T07VO1 | Steroid hormone receptor ERR1 | ESRRA |
P11474 |
1 Reference(s) |
| T47RAK | NA | MIR145 |
NA |
1 Reference(s) |
| T15ZAV | Lymphocyte antigen 96 | LY96 |
Q9Y6Y9 |
1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
| T84AR4 | Smoothened homolog | SMO |
Q99835 |
1 Reference(s) |
| T44GAO | 55 kDa erythrocyte membrane protein | MPP1 |
Q00013 |
1 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
1 Reference(s) |
| T08VQQ | Proprotein convertase subtilisin/kexin type 9 | PCSK9 |
Q8NBP7 |
1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T75SPS | Fibroblast growth factor 1 | FGF1 |
P05230 |
1 Reference(s) |
| T58CPZ | G-protein coupled receptor 55 | GPR55 |
Q9Y2T6 |
1 Reference(s) |
| T16CFE | Lysosome-associated membrane glycoprotein 1 | LAMP1 |
P11279 |
2 Reference(s) |
| T02GMU | Lysosome-associated membrane glycoprotein 2 | LAMP2 |
P13473 |
1 Reference(s) |
| T44X5B | Cholesterol 24-hydroxylase | CYP46A1 |
Q9Y6A2 |
2 Reference(s) |
| T35OPL | Sonic hedgehog protein | SHH |
Q15465 |
1 Reference(s) |
| T59L1E | Sterol regulatory element-binding protein cleavage-activating protein | SCAP |
Q12770 |
1 Reference(s) |
| T55TEP | Steroidogenic acute regulatory protein, mitochondrial | STAR |
P49675 |
1 Reference(s) |
| T24F1A | Pyruvate kinase PKLR | PKLR |
P30613 |
1 Reference(s) |
| T37VLU | Interferon gamma | IFNG |
P01579 |
2 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
2 Reference(s) |
| T61DYZ | Phospholipid-transporting ATPase ABCA1 | ABCA1 |
O95477 |
2 Reference(s) |
| T69VYP | ATP-binding cassette sub-family G member 1 | ABCG1 |
P45844 |
1 Reference(s) |
| T97K9N | Killer cell lectin-like receptor subfamily B member 1 | KLRB1 |
Q12918 |
1 Reference(s) |
| T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
1 Reference(s) |
| T62TXV | GTP-binding protein Rheb | RHEB |
Q15382 |
1 Reference(s) |
| T25UYT | Dual specificity mitogen-activated protein kinase kinase 4 | MAP2K4 |
P45985 |
2 Reference(s) |
| T74V1Z | Dual specificity mitogen-activated protein kinase kinase 7 | MAP2K7 |
O14733 |
2 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
1 Reference(s) |
| T95H9O | Stromelysin-2 | MMP10 |
P09238 |
1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
1 Reference(s) |
| T83TMF | Cytochrome P450 2B1 | Cyp2b1 |
P00176 |
1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
2 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
| T80PUR | Caspase-7 | CASP7 |
P55210 |
1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
1 Reference(s) |
| T94AGC | [F-actin]-monooxygenase MICAL1 | MICAL1 |
Q8TDZ2 |
1 Reference(s) |
| T48K08 | Procathepsin L | CTSL |
P07711 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
5 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
2 Reference(s) |
| T69X4A | 14-3-3 protein sigma | SFN |
P31947 |
1 Reference(s) |
| T58H37 | Perforin-1 | PRF1 |
P14222 |
1 Reference(s) |
| T80SD7 | Sterol regulatory element-binding protein 2 | SREBF2 |
Q12772 |
1 Reference(s) |
| T50MQN | NPC1-like intracellular cholesterol transporter 1 | NPC1L1 |
Q9UHC9 |
2 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
1 Reference(s) |
| T94H37 | Cadherin-1 | CDH1 |
P12830 |
2 Reference(s) |
| T79UHV | Prolow-density lipoprotein receptor-related protein 1 | LRP1 |
Q07954 |
1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
1 Reference(s) |
| T47HOW | NA | MIR185 |
NA |
1 Reference(s) |
| T90IQF | NA | HULC |
NA |
1 Reference(s) |
| T86TYE | Dehydrodolichyl diphosphate synthase complex subunit NUS1 | NUS1 |
Q96E22 |
1 Reference(s) |
| T26CFB | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638;P0DPQ6 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
| T30C1L | Sorting nexin-8 | SNX8 |
Q9Y5X2 |
1 Reference(s) |
| T17T4P | NA | MIR122 |
NA |
1 Reference(s) |
| T79TJS | Caveolin-3 | CAV3 |
P56539 |
1 Reference(s) |
| T66IUC | Homeobox protein Nkx-2.5 | NKX2-5 |
P52952 |
1 Reference(s) |
| T99EYH | Lipoprotein lipase | LPL |
P06858 |
1 Reference(s) |
| T95EU5 | ATP-binding cassette sub-family G member 8 | ABCG8 |
Q9H221 |
1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
1 Reference(s) |
| T92E71 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | HSD11B2 |
P80365 |
1 Reference(s) |
| T10KMJ | Insulin-like growth factor II | IGF2 |
P01344 |
1 Reference(s) |
| T29XZT | Pulmonary surfactant-associated protein A1 | SFTPA1 |
Q8IWL2 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
1 Reference(s) |
| T10RDU | Patatin-like phospholipase domain-containing protein 2 | PNPLA2 |
Q96AD5 |
1 Reference(s) |
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
1 Reference(s) |
| T05DRQ | Receptor tyrosine-protein kinase erbB-4 | ERBB4 |
Q15303 |
1 Reference(s) |
| T38CH0 | Tumor necrosis factor ligand superfamily member 9 | TNFSF9 |
P41273 |
1 Reference(s) |
| T68VQD | Excitatory amino acid transporter 1 | SLC1A3 |
P43003 |
1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
2 Reference(s) |
| T71V6E | Serine/threonine-protein kinase PAK 1 | PAK1 |
Q13153 |
1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
2 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T83QHM | Beta-nerve growth factor | NGF |
P01138 |
1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
| T69PZ6 | Protein phosphatase 1 regulatory subunit 12A | PPP1R12A |
O14974 |
1 Reference(s) |
| T85RZS | Corticotropin-releasing factor receptor 1 | CRHR1 |
P34998 |
1 Reference(s) |
| T83F6G | Corticotropin-releasing factor receptor 2 | CRHR2 |
Q13324 |
1 Reference(s) |
| T50JSQ | Corticotropin-releasing factor-binding protein | CRHBP |
P24387 |
1 Reference(s) |
| T76C5R | Parathyroid hormone-related protein | PTHLH |
P12272 |
1 Reference(s) |
| T43Y5O | D(3) dopamine receptor | DRD3 |
P35462 |
1 Reference(s) |
| T69ZRP | Appetite-regulating hormone | GHRL |
Q9UBU3 |
1 Reference(s) |
| T73QZ2 | Methylcytosine dioxygenase TET2 | TET2 |
Q6N021 |
1 Reference(s) |
| T91QMA | Histidine triad nucleotide-binding protein 1 | HINT1 |
P49773 |
1 Reference(s) |
| T64V6C | Glutamate decarboxylase 1 | GAD1 |
Q99259 |
1 Reference(s) |
| T09KPZ | Vimentin | VIM |
P08670 |
1 Reference(s) |
| T02DKV | Gastrin [Cleaved into: Gastrin-71 | GAST |
P01350 |
1 Reference(s) |
| T84Z2I | SHC-transforming protein 1 | SHC1 |
P29353 |
1 Reference(s) |
| T63V6Q | Cocaine- and amphetamine-regulated transcript protein | CARTPT |
Q16568 |
1 Reference(s) |
| T43IF3 | Chromogranin-A | CHGA |
P10645 |
1 Reference(s) |
| T33JS5 | CCN family member 2 | CCN2 |
P29279 |
1 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
| T12IEI | Cadherin-2 | CDH2 |
P19022 |
1 Reference(s) |
| T90Z3N | Filaggrin | FLG |
P20930 |
1 Reference(s) |
| T18C4B | Methylated-DNA--protein-cysteine methyltransferase | MGMT |
P16455 |
1 Reference(s) |
| T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
| T16R2S | Neuronal acetylcholine receptor subunit alpha-5 | CHRNA5 |
P30532 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
2 Reference(s) |
| T23A18 | Pro-neuregulin-3, membrane-bound isoform | NRG3 |
P56975 |
1 Reference(s) |
| T31JWV | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | PIK3CB |
P42338 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
2 Reference(s) |
| T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
1 Reference(s) |
| T76B0A | Gap junction alpha-1 protein | GJA1 |
P17302 |
2 Reference(s) |
| T94FQR | Fibroblast growth factor 7 | FGF7 |
P21781 |
1 Reference(s) |
| T56X9Z | Myeloid cell surface antigen CD33 | CD33 |
P20138 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
1 Reference(s) |
| T34X07 | CCAAT/enhancer-binding protein alpha | CEBPA |
P49715 |
1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
1 Reference(s) |
| T18YXD | Albumin | ALB |
P02768 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
Related Compounds (Total: 19)
C0653
Name: 20-Hydroxyecdysone
C0065
Name: Eupafolin
C0124
Name: Hispidulin
C0392
Name: Scopoletin
C1166
Name: Benzoic Acid
key description of the interaction between compound and target