HIT-result

Type	Detail
Target ID	T44X5B
Protein Name	Cholesterol 24-hydroxylase
Uniprot ID	Q9Y6A2
Protein Name Alias	CH24H; EC 1.14.14.25; Cholesterol 24-monooxygenase; Cholesterol 24S-hydroxylase; Cytochrome P450 46A1
Gene ID	10858
Gene Symbol	CYP46A1
Gene Alias	CYP46
TTD	T33641: Clinical Trial target
Pfam	PF00067
GO	1900271:regulation of long-term synaptic potentiation 0006805:xenobiotic metabolic process 0042448:progesterone metabolic process 0006707:cholesterol catabolic process 0030425:dendrite 0098793:presynapse 0006699:bile acid biosynthetic process 0005506:iron ion binding 0016125:sterol metabolic process 1903044:protein localization to membrane raft 0033781:cholesterol 24-hydroxylase activity 0008395:steroid hydroxylase activity 0020037:heme binding 0016021:integral component of membrane 0062184:testosterone 16-beta-hydroxylase activity 0098794:postsynapse 0005783:endoplasmic reticulum 0005789:endoplasmic reticulum membrane 0007399:nervous system development
PDB	3MDR ; 3MDM ; 3MDV ; 4J14 ; 3MDT ; 2Q9F ; 4ENH ; 2Q9G ; 4FIA
Drugbank	NA
KEGG	hsa:10858

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0476	Can E	蚕蛾	Silkworm	Bombyx mori

Target Description