Compound Description
| ID: C1234 | Common name: Cholesterol |
| IUPAC: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | CAS: CAS:57-88-5 |
| Chembl ID: CHEMBL112570 | Pubchem ID: CID:5997 |
| Formula: C27H46O | TCM-ID: TCMC902 |
| Smiles: CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O)C)C | |
| Alias:
Cholesterol;
(3β)-Cholest-5-en-3-ol; (-)-Cholesterol; 3β-Hydroxycholest-5-ene |
Structure:
|
Related Targets (Total: 66)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T28PHS | Angiotensin-converting enzyme | ACE |
P12821 |
A | 2 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 2 Reference(s) |
| T69CTT | Acetyl-CoA acetyltransferase, mitochondrial | ACAT1 |
P24752 |
A | 1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
A | 1 Reference(s) |
| T61M4P | Nuclear receptor ROR-alpha | RORA |
P35398 |
A | 1 Reference(s) |
| T77VME | ATP-binding cassette sub-family F member 3 | ABCF3 |
Q9NUQ8 |
A | 1 Reference(s) |
| T80XW6 | Scavenger receptor class B member 1 | SCARB1 |
Q8WTV0 |
A | 1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
A | 1 Reference(s) |
| T93AZS | NA | ECB2 |
NA |
A | 1 Reference(s) |
| T38OH4 | Caspase-1 | CASP1 |
P29466 |
A | 1 Reference(s) |
| T63KO8 | NA | MIR33A |
NA |
A | 1 Reference(s) |
| T68OIU | CREB-regulated transcription coactivator 1 | CRTC1 |
Q6UUV9 |
A | 1 Reference(s) |
| T75ZQD | Myelin proteolipid protein | PLP1 |
P60201 |
B | 2 Reference(s) |
| T67U3B | Translocator protein | TSPO |
P30536 |
B | 4 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
B | 2 Reference(s) |
| T44AEN | NPC intracellular cholesterol transporter 1 | NPC1 |
O15118 |
B | 2 Reference(s) |
| T01E8J | Amyloid-beta precursor protein | APP |
P05067 |
B | 2 Reference(s) |
| T73S71 | Apolipoprotein B-100 | APOB |
P04114 |
B | 3 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
B | 1 Reference(s) |
| T13DVU | Conserved oligomeric Golgi complex subunit 2 | COG2 |
Q14746 |
B | 1 Reference(s) |
| T37I8W | NA | MIR33B |
NA |
B | 1 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
B | 1 Reference(s) |
| T56FPY | CD81 antigen | CD81 |
P60033 |
B | 1 Reference(s) |
| T89EW0 | Aquaporin-8 | AQP8 |
O94778 |
B | 1 Reference(s) |
| T21K0F | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | ATP2A3 |
Q93084 |
B | 1 Reference(s) |
| T92MGC | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SGMS2 |
Q8NHU3 |
B | 1 Reference(s) |
| T81DYL | Cysteine-rich secretory protein 2 | CRISP2 |
P16562 |
B | 1 Reference(s) |
| T90K33 | ATP-binding cassette sub-family G member 5 | ABCG5 |
Q9H222 |
B | 2 Reference(s) |
| T75NEV | Aquaporin-1 | AQP1 |
P29972 |
B | 1 Reference(s) |
| T91X8E | Sterol carrier protein 2 | SCP2 |
P22307 |
B | 1 Reference(s) |
| T07VO1 | Steroid hormone receptor ERR1 | ESRRA |
P11474 |
B | 1 Reference(s) |
| T47RAK | NA | MIR145 |
NA |
B | 1 Reference(s) |
| T15ZAV | Lymphocyte antigen 96 | LY96 |
Q9Y6Y9 |
B | 1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
B | 1 Reference(s) |
| T84AR4 | Smoothened homolog | SMO |
Q99835 |
B | 1 Reference(s) |
| T44GAO | 55 kDa erythrocyte membrane protein | MPP1 |
Q00013 |
B | 1 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
B | 1 Reference(s) |
| T08VQQ | Proprotein convertase subtilisin/kexin type 9 | PCSK9 |
Q8NBP7 |
B | 1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
B | 1 Reference(s) |
| T75SPS | Fibroblast growth factor 1 | FGF1 |
P05230 |
B | 1 Reference(s) |
| T58CPZ | G-protein coupled receptor 55 | GPR55 |
Q9Y2T6 |
B | 1 Reference(s) |
| T16CFE | Lysosome-associated membrane glycoprotein 1 | LAMP1 |
P11279 |
B | 1 Reference(s) |
| T02GMU | Lysosome-associated membrane glycoprotein 2 | LAMP2 |
P13473 |
B | 1 Reference(s) |
| T44X5B | Cholesterol 24-hydroxylase | CYP46A1 |
Q9Y6A2 |
B | 2 Reference(s) |
| T35OPL | Sonic hedgehog protein | SHH |
Q15465 |
B | 1 Reference(s) |
| T59L1E | Sterol regulatory element-binding protein cleavage-activating protein | SCAP |
Q12770 |
B | 1 Reference(s) |
| T55TEP | Steroidogenic acute regulatory protein, mitochondrial | STAR |
P49675 |
B | 1 Reference(s) |
| T80SD7 | Sterol regulatory element-binding protein 2 | SREBF2 |
Q12772 |
C | 1 Reference(s) |
| T50MQN | NPC1-like intracellular cholesterol transporter 1 | NPC1L1 |
Q9UHC9 |
C | 2 Reference(s) |
| T61DYZ | Phospholipid-transporting ATPase ABCA1 | ABCA1 |
O95477 |
C | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
C | 1 Reference(s) |
| T94H37 | Cadherin-1 | CDH1 |
P12830 |
C | 1 Reference(s) |
| T79UHV | Prolow-density lipoprotein receptor-related protein 1 | LRP1 |
Q07954 |
C | 1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
C | 1 Reference(s) |
| T47HOW | NA | MIR185 |
NA |
C | 1 Reference(s) |
| T90IQF | NA | HULC |
NA |
C | 1 Reference(s) |
| T86TYE | Dehydrodolichyl diphosphate synthase complex subunit NUS1 | NUS1 |
Q96E22 |
C | 1 Reference(s) |
| T26CFB | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638;P0DPQ6 |
C | 1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
C | 1 Reference(s) |
| T30C1L | Sorting nexin-8 | SNX8 |
Q9Y5X2 |
C | 1 Reference(s) |
| T17T4P | NA | MIR122 |
NA |
C | 1 Reference(s) |
| T79TJS | Caveolin-3 | CAV3 |
P56539 |
C | 1 Reference(s) |
| T66IUC | Homeobox protein Nkx-2.5 | NKX2-5 |
P52952 |
C | 1 Reference(s) |
| T99EYH | Lipoprotein lipase | LPL |
P06858 |
C | 1 Reference(s) |
| T95EU5 | ATP-binding cassette sub-family G member 8 | ABCG8 |
Q9H221 |
C | 1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 23)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0809 | Zhi Mu | 知母 | Common anemarrhena | Anemarrhena asphodeloides |
| H0609 | Wu Wei Zi Liu Jin Gao | 五味子流浸膏 | Five-flavor berry | Schisandra chinensis |
| H0648 | Xiang Si Teng | 相思藤 | Coralhead plant vine | Abrus precatorius |
| H0605 | Wu Wei Zi | 五味子 | Chinese magnoliavine | Schisandra chinensis |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0606 | Wu Wei Zi Chun Jin Gao | 五味子醇浸膏 | Five-flavor berry | Schisandra chinensis |
| H1226 | Huai Shan Yao | 淮山药 | rhizome of biglcaf yam | Rhizoma dioscoreae |
| H0500 | Can Yong | 蚕蛹 | Silkworm chrysalis | Bombyx mori |
| H0608 | Wu Wei Zi Jin Gao | 五味子浸膏 | Five-flavor berry | Schisandra chinensis |
| H0735 | Yi Bei Mu | 伊贝母 | Siberian fritillary equivalent plant: fritillaria walujewii | Fritillaria pallidiflora |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0490 | Can Jian | 蚕茧 | Silk cocoon | Bombyx mori |
| H0227 | Mang Guo Ye | 芒果叶 | Mango leaf | Mangifera indica |
| H0495 | Can Sha | 蚕砂 | Silkworm excrement | Bombyx mori |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0607 | Wu Wei Zi Jin Chu Wu | 五味子浸出物 | Five-flavor berry | Schisandra chinensis |
| H1134 | Bai Jiang Can | 白僵蚕 | Silkworm larva | Bombyx mori |
| H0697 | Ya Ma Zi | 亚麻子 | Common flax seed | Linum usitatissimum |
| H0476 | Can E | 蚕蛾 | Silkworm | Bombyx mori |
| H0484 | Shui Fei Ji | 水飞蓟 | St marys | Silybum marianum |
| H0649 | Xiang Si Zi | 相思子 | Coralhead plant | Abrus precatorius |
| H0287 | Nao Yang Hua | 闹羊花 | Chinese azalea | Rhododendron molle |
Ckey description of the interaction between compound and target