Compound Description

ID:   C1234 Common name:   Cholesterol
IUPAC:  (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol CAS:  CAS:57-88-5
Chembl ID:   CHEMBL112570 Pubchem ID:   CID:5997
Formula:  C27H46O TCM-ID:  TCMC902
Smiles:  CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O)C)C
Alias:

Cholesterol;

(3β)-Cholest-5-en-3-ol;

(-)-Cholesterol;

3β-Hydroxycholest-5-ene
Structure:

Related Targets  (Total: 66)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T28PHS Angiotensin-converting enzymeACE P12821
A 2 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 2 Reference(s)
T69CTT Acetyl-CoA acetyltransferase, mitochondrialACAT1 P24752
A 1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
A 1 Reference(s)
T61M4P Nuclear receptor ROR-alphaRORA P35398
A 1 Reference(s)
T77VME ATP-binding cassette sub-family F member 3ABCF3 Q9NUQ8
A 1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
A 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
A 1 Reference(s)
T93AZS NAECB2 NA
A 1 Reference(s)
T38OH4 Caspase-1CASP1 P29466
A 1 Reference(s)
T63KO8 NAMIR33A NA
A 1 Reference(s)
T68OIU CREB-regulated transcription coactivator 1CRTC1 Q6UUV9
A 1 Reference(s)
T75ZQD Myelin proteolipid proteinPLP1 P60201
B 2 Reference(s)
T67U3B Translocator proteinTSPO P30536
B 4 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
B 2 Reference(s)
T44AEN NPC intracellular cholesterol transporter 1NPC1 O15118
B 2 Reference(s)
T01E8J Amyloid-beta precursor proteinAPP P05067
B 2 Reference(s)
T73S71 Apolipoprotein B-100APOB P04114
B 3 Reference(s)
T50V79 Interleukin-4IL4 P05112
B 1 Reference(s)
T13DVU Conserved oligomeric Golgi complex subunit 2COG2 Q14746
B 1 Reference(s)
T37I8W NAMIR33B NA
B 1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
B 1 Reference(s)
T56FPY CD81 antigenCD81 P60033
B 1 Reference(s)
T89EW0 Aquaporin-8AQP8 O94778
B 1 Reference(s)
T21K0F Sarcoplasmic/endoplasmic reticulum calcium ATPase 3ATP2A3 Q93084
B 1 Reference(s)
T92MGC Phosphatidylcholine:ceramide cholinephosphotransferase 2SGMS2 Q8NHU3
B 1 Reference(s)
T81DYL Cysteine-rich secretory protein 2CRISP2 P16562
B 1 Reference(s)
T90K33 ATP-binding cassette sub-family G member 5ABCG5 Q9H222
B 2 Reference(s)
T75NEV Aquaporin-1AQP1 P29972
B 1 Reference(s)
T91X8E Sterol carrier protein 2SCP2 P22307
B 1 Reference(s)
T07VO1 Steroid hormone receptor ERR1ESRRA P11474
B 1 Reference(s)
T47RAK NAMIR145 NA
B 1 Reference(s)
T15ZAV Lymphocyte antigen 96LY96 Q9Y6Y9
B 1 Reference(s)
T38WWN Serum paraoxonase/arylesterase 1PON1 P27169
B 1 Reference(s)
T84AR4 Smoothened homologSMO Q99835
B 1 Reference(s)
T44GAO 55 kDa erythrocyte membrane proteinMPP1 Q00013
B 1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
B 1 Reference(s)
T08VQQ Proprotein convertase subtilisin/kexin type 9PCSK9 Q8NBP7
B 1 Reference(s)
T04H8Y Beta-secretase 1BACE1 P56817
B 1 Reference(s)
T75SPS Fibroblast growth factor 1FGF1 P05230
B 1 Reference(s)
T58CPZ G-protein coupled receptor 55GPR55 Q9Y2T6
B 1 Reference(s)
T16CFE Lysosome-associated membrane glycoprotein 1LAMP1 P11279
B 1 Reference(s)
T02GMU Lysosome-associated membrane glycoprotein 2LAMP2 P13473
B 1 Reference(s)
T44X5B Cholesterol 24-hydroxylaseCYP46A1 Q9Y6A2
B 2 Reference(s)
T35OPL Sonic hedgehog proteinSHH Q15465
B 1 Reference(s)
T59L1E Sterol regulatory element-binding protein cleavage-activating proteinSCAP Q12770
B 1 Reference(s)
T55TEP Steroidogenic acute regulatory protein, mitochondrialSTAR P49675
B 1 Reference(s)
T80SD7 Sterol regulatory element-binding protein 2SREBF2 Q12772
C 1 Reference(s)
T50MQN NPC1-like intracellular cholesterol transporter 1NPC1L1 Q9UHC9
C 2 Reference(s)
T61DYZ Phospholipid-transporting ATPase ABCA1ABCA1 O95477
C 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
C 1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
C 1 Reference(s)
T79UHV Prolow-density lipoprotein receptor-related protein 1LRP1 Q07954
C 1 Reference(s)
T25H22 Protein kinase C beta typePRKCB P05771
C 1 Reference(s)
T47HOW NAMIR185 NA
C 1 Reference(s)
T90IQF NAHULC NA
C 1 Reference(s)
T86TYE Dehydrodolichyl diphosphate synthase complex subunit NUS1NUS1 Q96E22
C 1 Reference(s)
T26CFB DNA damage-inducible transcript 3 proteinDDIT3 P35638;P0DPQ6
C 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
C 1 Reference(s)
T30C1L Sorting nexin-8SNX8 Q9Y5X2
C 1 Reference(s)
T17T4P NAMIR122 NA
C 1 Reference(s)
T79TJS Caveolin-3CAV3 P56539
C 1 Reference(s)
T66IUC Homeobox protein Nkx-2.5NKX2-5 P52952
C 1 Reference(s)
T99EYH Lipoprotein lipaseLPL P06858
C 1 Reference(s)
T95EU5 ATP-binding cassette sub-family G member 8ABCG8 Q9H221
C 1 Reference(s)
T49PL1 Low-density lipoprotein receptorLDLR P01130
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 23)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0287 Nao Yang Hua闹羊花 Chinese azaleaRhododendron molle
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0476 Can E蚕蛾 SilkwormBombyx mori
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0735 Yi Bei Mu伊贝母 Siberian fritillary equivalent plant: fritillaria walujewiiFritillaria pallidiflora