HIT-result

Target Description

Type	Detail
Target ID	T44AEN
Protein Name	NPC intracellular cholesterol transporter 1
Uniprot ID	O15118
Protein Name Alias	Niemann-Pick C1 protein
Gene ID	4864
Gene Symbol	NPC1
Gene Alias	NA
TTD	NA
Pfam	PF02460 ; PF16414 ; PF12349
GO	0038023:signaling receptor activity 0015248:sterol transporter activity 0070062:extracellular exosome 0090150:establishment of protein localization to membrane 0005783:endoplasmic reticulum 0034383:low-density lipoprotein particle clearance 0033344:cholesterol efflux 0016242:negative regulation of macroautophagy 0046686:response to cadmium ion 0007628:adult walking behavior 1905103:integral component of lysosomal membrane 0071404:cellular response to low-density lipoprotein particle stimulus 0004888:transmembrane signaling receptor activity 0060548:negative regulation of cell death 0005765:lysosomal membrane 0005635:nuclear envelope 0005887:integral component of plasma membrane 0032367:intracellular cholesterol transport 0048471:perinuclear region of cytoplasm 0006914:autophagy 0006486:protein glycosylation 0005764:lysosome 0045121:membrane raft 0016021:integral component of membrane 0007041:lysosomal transport 0015485:cholesterol binding 0042493:response to drug 0046718:viral entry into host cell 0016020:membrane 0042632:cholesterol homeostasis 0010467:gene expression 0005576:extracellular region 0005794:Golgi apparatus 0031902:late endosome membrane 0031579:membrane raft organization 0008206:bile acid metabolic process 0006897:endocytosis 0001618:virus receptor activity 0008203:cholesterol metabolic process 0030301:cholesterol transport 0071383:cellular response to steroid hormone stimulus
PDB	6W5R ; 5KWY ; 5U73 ; 3JD8 ; 5F18 ; 6W5S ; 6W5T ; 6W5U ; 5U74 ; 3GKI ; 6W5V ; 5JNX ; 3GKH ; 3GKJ ; 5F1B ; 5HNS ; 6UOX
Drugbank	NA
KEGG	hsa:4864

Type

Detail

Target ID

T44AEN

Protein Name

NPC intracellular cholesterol transporter 1

Uniprot ID

O15118

Protein Name Alias

Niemann-Pick C1 protein

Gene ID

4864

Gene Symbol

NPC1

Gene Alias

TTD

Pfam

PF02460 ; PF16414 ; PF12349

0038023:signaling receptor activity

0015248:sterol transporter activity

0070062:extracellular exosome

0090150:establishment of protein localization to membrane

0005783:endoplasmic reticulum

0034383:low-density lipoprotein particle clearance

0033344:cholesterol efflux

0016242:negative regulation of macroautophagy

0046686:response to cadmium ion

0007628:adult walking behavior

1905103:integral component of lysosomal membrane

0071404:cellular response to low-density lipoprotein particle stimulus

0004888:transmembrane signaling receptor activity

0060548:negative regulation of cell death

0005765:lysosomal membrane

0005635:nuclear envelope

0005887:integral component of plasma membrane

0032367:intracellular cholesterol transport

0048471:perinuclear region of cytoplasm

0006914:autophagy

0006486:protein glycosylation

0005764:lysosome

0045121:membrane raft

0016021:integral component of membrane

0007041:lysosomal transport

0015485:cholesterol binding

0042493:response to drug

0046718:viral entry into host cell

0016020:membrane

0042632:cholesterol homeostasis

0010467:gene expression

0005576:extracellular region

0005794:Golgi apparatus

0031902:late endosome membrane

0031579:membrane raft organization

0008206:bile acid metabolic process

0006897:endocytosis

0001618:virus receptor activity

0008203:cholesterol metabolic process

0030301:cholesterol transport

0071383:cellular response to steroid hormone stimulus

PDB

6W5R ; 5KWY ; 5U73 ; 3JD8 ; 5F18 ; 6W5S ; 6W5T ; 6W5U ; 5U74 ; 3GKI ; 6W5V ; 5JNX ; 3GKH ; 3GKJ ; 5F1B ; 5HNS ; 6UOX

Drugbank

KEGG

hsa:4864

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 23)