Herb Description
| Herb ID: H1226 | Chinese Character: 淮山药 |
| English Name: rhizome of biglcaf yam | Latin Name: Rhizoma dioscoreae |
| Chinese Pin Yin : Huai Shan Yao | TCM-ID: TCMH943 |
| Therapeutic Function in Chinese : 补虚 | Therapeutic Function in English: For tonifying weakness |
| Herb Function: Replenish the spleen and stomach, promote fluid secretion and benefit the lung, and strengthen the kidney and restrain seminal discharge | |
Related Targets (Total: 109)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T30VNV | Myeloperoxidase | MPO |
P05164 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
3 Reference(s) |
| T64BED | 5-hydroxytryptamine receptor 2A | HTR2A |
P28223 |
1 Reference(s) |
| T48ZIG | D(2) dopamine receptor | DRD2 |
P14416 |
4 Reference(s) |
| T77RFX | Alpha-2A adrenergic receptor | ADRA2A |
P08913 |
1 Reference(s) |
| T09HVO | Sodium/hydrogen exchanger 3 | SLC9A3 |
P48764 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
1 Reference(s) |
| T28PHS | Angiotensin-converting enzyme | ACE |
P12821 |
2 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
2 Reference(s) |
| T69CTT | Acetyl-CoA acetyltransferase, mitochondrial | ACAT1 |
P24752 |
1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
1 Reference(s) |
| T61M4P | Nuclear receptor ROR-alpha | RORA |
P35398 |
1 Reference(s) |
| T77VME | ATP-binding cassette sub-family F member 3 | ABCF3 |
Q9NUQ8 |
1 Reference(s) |
| T80XW6 | Scavenger receptor class B member 1 | SCARB1 |
Q8WTV0 |
1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
1 Reference(s) |
| T93AZS | NA | ECB2 |
NA |
1 Reference(s) |
| T38OH4 | Caspase-1 | CASP1 |
P29466 |
1 Reference(s) |
| T63KO8 | NA | MIR33A |
NA |
1 Reference(s) |
| T68OIU | CREB-regulated transcription coactivator 1 | CRTC1 |
Q6UUV9 |
1 Reference(s) |
| T49FZB | Linker for activation of T-cells family member 1 | LAT |
O43561 |
1 Reference(s) |
| T09ICL | Transient receptor potential cation channel subfamily V member 6 | TRPV6 |
Q9H1D0 |
1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
2 Reference(s) |
| T64V6C | Glutamate decarboxylase 1 | GAD1 |
Q99259 |
1 Reference(s) |
| T83RKS | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | MGAT1 |
P26572 |
2 Reference(s) |
| T73PZA | Vesicular inhibitory amino acid transporter | SLC32A1 |
Q9H598 |
1 Reference(s) |
| T68XXK | 4-aminobutyrate aminotransferase, mitochondrial | ABAT |
P80404 |
4 Reference(s) |
| T35WLZ | Sodium- and chloride-dependent GABA transporter 3 | SLC6A11 |
P48066 |
2 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
1 Reference(s) |
| T41Z1X | Gamma-aminobutyric acid receptor-associated protein | GABARAP |
O95166 |
1 Reference(s) |
| T58K2N | Calmodulin-3;Calmodulin-1;Calmodulin-2 | CALM3;CALM1;CALM2 |
P0DP25;P0DP23;P0DP24 |
1 Reference(s) |
| T24LWC | Sodium-dependent dopamine transporter | SLC6A3 |
Q01959 |
1 Reference(s) |
| T42O1D | Delta-type opioid receptor | OPRD1 |
P41143 |
1 Reference(s) |
| T23TJV | Tyrosine 3-monooxygenase | TH |
P07101 |
2 Reference(s) |
| T81LOK | Nuclear receptor subfamily 4 group A member 2 | NR4A2 |
P43354 |
1 Reference(s) |
| T49IR9 | D(4) dopamine receptor | DRD4 |
P21917 |
1 Reference(s) |
| T27BN7 | Protachykinin-1 | TAC1 |
P20366 |
1 Reference(s) |
| T75ZQD | Myelin proteolipid protein | PLP1 |
P60201 |
2 Reference(s) |
| T67U3B | Translocator protein | TSPO |
P30536 |
4 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
2 Reference(s) |
| T44AEN | NPC intracellular cholesterol transporter 1 | NPC1 |
O15118 |
2 Reference(s) |
| T01E8J | Amyloid-beta precursor protein | APP |
P05067 |
2 Reference(s) |
| T73S71 | Apolipoprotein B-100 | APOB |
P04114 |
3 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
| T13DVU | Conserved oligomeric Golgi complex subunit 2 | COG2 |
Q14746 |
1 Reference(s) |
| T37I8W | NA | MIR33B |
NA |
1 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
1 Reference(s) |
| T56FPY | CD81 antigen | CD81 |
P60033 |
1 Reference(s) |
| T89EW0 | Aquaporin-8 | AQP8 |
O94778 |
1 Reference(s) |
| T21K0F | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | ATP2A3 |
Q93084 |
1 Reference(s) |
| T92MGC | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SGMS2 |
Q8NHU3 |
1 Reference(s) |
| T81DYL | Cysteine-rich secretory protein 2 | CRISP2 |
P16562 |
1 Reference(s) |
| T90K33 | ATP-binding cassette sub-family G member 5 | ABCG5 |
Q9H222 |
2 Reference(s) |
| T75NEV | Aquaporin-1 | AQP1 |
P29972 |
1 Reference(s) |
| T91X8E | Sterol carrier protein 2 | SCP2 |
P22307 |
1 Reference(s) |
| T07VO1 | Steroid hormone receptor ERR1 | ESRRA |
P11474 |
1 Reference(s) |
| T47RAK | NA | MIR145 |
NA |
1 Reference(s) |
| T15ZAV | Lymphocyte antigen 96 | LY96 |
Q9Y6Y9 |
1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
| T84AR4 | Smoothened homolog | SMO |
Q99835 |
1 Reference(s) |
| T44GAO | 55 kDa erythrocyte membrane protein | MPP1 |
Q00013 |
1 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
1 Reference(s) |
| T08VQQ | Proprotein convertase subtilisin/kexin type 9 | PCSK9 |
Q8NBP7 |
1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T75SPS | Fibroblast growth factor 1 | FGF1 |
P05230 |
1 Reference(s) |
| T58CPZ | G-protein coupled receptor 55 | GPR55 |
Q9Y2T6 |
1 Reference(s) |
| T16CFE | Lysosome-associated membrane glycoprotein 1 | LAMP1 |
P11279 |
1 Reference(s) |
| T02GMU | Lysosome-associated membrane glycoprotein 2 | LAMP2 |
P13473 |
1 Reference(s) |
| T44X5B | Cholesterol 24-hydroxylase | CYP46A1 |
Q9Y6A2 |
2 Reference(s) |
| T35OPL | Sonic hedgehog protein | SHH |
Q15465 |
1 Reference(s) |
| T59L1E | Sterol regulatory element-binding protein cleavage-activating protein | SCAP |
Q12770 |
1 Reference(s) |
| T55TEP | Steroidogenic acute regulatory protein, mitochondrial | STAR |
P49675 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
1 Reference(s) |
| T71B0A | Cytosolic phospholipase A2 | PLA2G4A |
P47712 |
1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
2 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
1 Reference(s) |
| T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
1 Reference(s) |
| T51WGR | Pancreas/duodenum homeobox protein 1 | PDX1 |
P52945 |
1 Reference(s) |
| T82S6C | Hexokinase-4 | GCK |
P35557 |
1 Reference(s) |
| T18CPB | Choline O-acetyltransferase | CHAT |
P28329 |
1 Reference(s) |
| T31SX8 | Bone morphogenetic protein 2 | BMP2 |
P12643 |
1 Reference(s) |
| T74WWP | Peroxisome proliferator-activated receptor delta | PPARD |
Q03181 |
2 Reference(s) |
| T58CAO | Alpha-synuclein | SNCA |
P37840 |
1 Reference(s) |
| T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T80SD7 | Sterol regulatory element-binding protein 2 | SREBF2 |
Q12772 |
1 Reference(s) |
| T50MQN | NPC1-like intracellular cholesterol transporter 1 | NPC1L1 |
Q9UHC9 |
2 Reference(s) |
| T61DYZ | Phospholipid-transporting ATPase ABCA1 | ABCA1 |
O95477 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
1 Reference(s) |
| T94H37 | Cadherin-1 | CDH1 |
P12830 |
1 Reference(s) |
| T79UHV | Prolow-density lipoprotein receptor-related protein 1 | LRP1 |
Q07954 |
1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
1 Reference(s) |
| T47HOW | NA | MIR185 |
NA |
1 Reference(s) |
| T90IQF | NA | HULC |
NA |
1 Reference(s) |
| T86TYE | Dehydrodolichyl diphosphate synthase complex subunit NUS1 | NUS1 |
Q96E22 |
1 Reference(s) |
| T26CFB | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638;P0DPQ6 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
| T30C1L | Sorting nexin-8 | SNX8 |
Q9Y5X2 |
1 Reference(s) |
| T17T4P | NA | MIR122 |
NA |
1 Reference(s) |
| T79TJS | Caveolin-3 | CAV3 |
P56539 |
1 Reference(s) |
| T66IUC | Homeobox protein Nkx-2.5 | NKX2-5 |
P52952 |
1 Reference(s) |
| T99EYH | Lipoprotein lipase | LPL |
P06858 |
1 Reference(s) |
| T95EU5 | ATP-binding cassette sub-family G member 8 | ABCG8 |
Q9H221 |
1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
1 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
1 Reference(s) |
Related Compounds (Total: 6)
C0931
Name: Aspartic Acid
C0049
Name: Ergosterol
C0094
Name: Gamma-Aminobutyric Acid
C0034
Name: Dopamine
C1234
Name: Cholesterol
key description of the interaction between compound and target