HIT-result

Target Description

Type	Detail
Target ID	T58K2N
Protein Name	Calmodulin-3;Calmodulin-1;Calmodulin-2
Uniprot ID	P0DP25 ; P0DP23 ; P0DP24
Protein Name Alias	NA
Gene ID	801
Gene Symbol	CALM3;CALM1;CALM2
Gene Alias	NA
TTD
Pfam	PF13499
GO	0022400:regulation of rhodopsin mediated signaling pathway 0010880:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 0019904:protein domain specific binding 0007223:Wnt signaling pathway, calcium modulating pathway 0002027:regulation of heart rate 0005513:detection of calcium ion 0001975:response to amphetamine 0005980:glycogen catabolic process 0055117:regulation of cardiac muscle contraction 0030017:sarcomere 0060315:negative regulation of ryanodine-sensitive calcium-release channel activity 0051592:response to calcium ion 0030672:synaptic vesicle membrane 0034704:calcium channel complex 0000165:MAPK cascade 0019901:protein kinase binding 0005876:spindle microtubule 0043209:myelin sheath 1900242:regulation of synaptic vesicle endocytosis 0005576:extracellular region 0010800:positive regulation of peptidyl-threonine phosphorylation 0007186:G protein-coupled receptor signaling pathway 0000086:G2/M transition of mitotic cell cycle 0098901:regulation of cardiac muscle cell action potential 0043539:protein serine/threonine kinase activator activity 0051000:positive regulation of nitric-oxide synthase activity 0005813:centrosome 1901842:negative regulation of high voltage-gated calcium channel activity 0097718:disordered domain specific binding 0030235:nitric-oxide synthase regulator activity 0005829:cytosol 0050998:nitric-oxide synthase binding 0060316:positive regulation of ryanodine-sensitive calcium-release channel activity 2000300:regulation of synaptic vesicle exocytosis 0005737:cytoplasm 0005509:calcium ion binding 0038095:Fc-epsilon receptor signaling pathway 0010856:adenylate cyclase activator activity 0032465:regulation of cytokinesis 0007190:activation of adenylate cyclase activity 0046146:tetrahydrobiopterin metabolic process 0031800:type 3 metabotropic glutamate receptor binding 0043548:phosphatidylinositol 3-kinase binding 0016240:autophagosome membrane docking 0071902:positive regulation of protein serine/threonine kinase activity 0016032:viral process 0021762:substantia nigra development 0043647:inositol phosphate metabolic process 0002576:platelet degranulation 0030426:growth cone 0050999:regulation of nitric-oxide synthase activity 0005634:nucleus 0043388:positive regulation of DNA binding 0007268:chemical synaptic transmission 0008179:adenylate cyclase binding 0032516:positive regulation of phosphoprotein phosphatase activity 0010881:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 1901844:regulation of cell communication by electrical coupling involved in cardiac conduction 0031966:mitochondrial membrane 0140056:organelle localization by membrane tethering 0031432:titin binding 0048306:calcium-dependent protein binding 0006936:muscle contraction 1990456:mitochondrion-endoplasmic reticulum membrane tethering 0010801:negative regulation of peptidyl-threonine phosphorylation 0060314:regulation of ryanodine-sensitive calcium-release channel activity 0035307:positive regulation of protein dephosphorylation 0072542:protein phosphatase activator activity 0000922:spindle pole 0090151:establishment of protein localization to mitochondrial membrane 0005886:plasma membrane 0031954:positive regulation of protein autophosphorylation 0031982:vesicle 1902494:catalytic complex 0008076:voltage-gated potassium channel complex 0031997:N-terminal myristoylation domain binding 0032991:protein-containing complex 0044325:ion channel binding 0019855:calcium channel inhibitor activity 0005654:nucleoplasm 0030234:enzyme regulator activity 0051343:positive regulation of cyclic-nucleotide phosphodiesterase activity 0051412:response to corticosterone
PDB	4OVN ; 4UMO ; 1SK6 ; 1CTR ; 3DVK ; 3OXQ ; 6BUT ; 6CNN ; 1XFV ; 6PBX ; 7CR4 ; 1ZUZ ; 6JI8 ; 1AJI ; 6MUE ; 6X35 ; 6U39 ; 5WSU ; 3SUI ; 6B8L ; 4BYF ; 5JTH ; 6U3A ; 4BW7 ; 2X0G ; 6K4L ; 2M55 ; 6B8N ; 6HR1 ; 2W73 ; 6DAE ; 5JQA ; 6M7H ; 2K0F ; 5I0I ; 6FEH ; 6Y95 ; 6Y4O ; 6UZZ ; 4BW8 ; 5V02 ; 6JIU ; 2K0E ; 5VMS ; 6OS4 ; 6X32 ; 7BYL ; 1LVC ; 1YR5 ; 5NIN ; 2R28 ; 1K90 ; 1J7P ; 5DSU ; 5J03 ; 3DVJ ; 2L7L ; 6GDK ; 5V7X ; 2LL7 ; 4LZX ; 2HF5 ; 3BYA ; 3UCY ; 6HCS ; 4GOW ; 3O77 ; 2K61 ; 1NKF ; 1UP5 ; 4DJC ; 2JZI ; 6PLM ; 4Q5U ; 6E2G ; 1SW8 ; 1Y6W ; 6K4K ; 5K7L ; 6N5W ; 1XFU ; 6B8P ; 2Y4V ; 4V0C ; 6JIY ; 2F3Z ; 2K0J ; 6X36 ; 2WEL ; 6CNO ; 7BYM ; 2KUG ; 5GGM ; 5K8Q ; 5V03 ; 6C1H ; 1PK0 ; 6PBY ; 2MG5 ; 6K67 ; 2LGF ; 6MUD ; 2N27 ; 7BYN ; 6JII ; 2I08 ; 3EWT ; 1XFW ; 2V01 ; 4JQ0 ; 1XFX ; 2L53 ; 2V02 ; 5DBR ; 1CLL ; 4L79 ; 3HR4 ; 6E2F ; 6C1D ; 2KNE ; 6EEB ; 2N77 ; 1XFY ; 5J8H ; 6U3B ; 3G43 ; 4UPU ; 2BE6 ; 6B8Q ; 6SZ5 ; 5TP6 ; 2KUH ; 6B8M ; 5WSV ; 2LQC ; 4DCK ; 5WC5 ; 6GDL ; 6JV2 ; 7CR3 ; 6M2W ; 1YRU ; 6O5G ; 2M0J ; 1CDL ; 2LL6 ; 1XFZ ; 3J41 ; 6JRS ; 1WRZ ; 6V00 ; 6XYR ; 6FEG ; 4Q57 ; 6V01 ; 6Y94 ; 5TP5 ; 6DAF ; 6S5T ; 1S26 ; 2VAY ; 6X33 ; 5WBX ; 7CR7 ; 3DVM ; 1L7Z ; 3UCT ; 6Y4P ; 6PAW ; 2F3Y ; 2N8J ; 1J7O ; 2M0K ; 3O78 ; 6DAD ; 6DAH ; 4M1L ; 1ZOT ; 6CNM ; 1IWQ ; 1YRT ; 2LQP ; 5COC ; 1K93 ; 4JPZ ; 3DVE ; 3UCW ; 6C1G ; 3EWV ; 6K4R ; 5DOW ; 6U3D ; 2LV6 ; 5OEO ; 2N6A
Drugbank	DB03977 ; DB11093 ; DB00850 ; DB04841 ; DB08231 ; DB01069 ; DB01100 ; DB01023 ; DB13800 ; DB00753 ; DB00623 ; DB00836 ; DB01065 ; DB04825 ; DB01115 ; DB11348 ; DB00527 ; DB00831 ; DB03900 ; DB14481 ; DB04513 ; DB00622 ; DB08039 ; DB00477 ; DB02868 ; DB01244 ; DB00925 ; DB01429 ; DB01373
KEGG	hsa:808 ; hsa:805 ; hsa:801

Type

Detail

Target ID

T58K2N

Protein Name

Calmodulin-3;Calmodulin-1;Calmodulin-2

Uniprot ID

P0DP25
; P0DP23
; P0DP24

Protein Name Alias

Gene ID

801

Gene Symbol

CALM3;CALM1;CALM2

Gene Alias

TTD

Pfam

PF13499

0022400:regulation of rhodopsin mediated signaling pathway

0010880:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

0019904:protein domain specific binding

0007223:Wnt signaling pathway, calcium modulating pathway

0002027:regulation of heart rate

0005513:detection of calcium ion

0001975:response to amphetamine

0005980:glycogen catabolic process

0055117:regulation of cardiac muscle contraction

0030017:sarcomere

0060315:negative regulation of ryanodine-sensitive calcium-release channel activity

0051592:response to calcium ion

0030672:synaptic vesicle membrane

0034704:calcium channel complex

0000165:MAPK cascade

0019901:protein kinase binding

0005876:spindle microtubule

0043209:myelin sheath

1900242:regulation of synaptic vesicle endocytosis

0005576:extracellular region

0010800:positive regulation of peptidyl-threonine phosphorylation

0007186:G protein-coupled receptor signaling pathway

0000086:G2/M transition of mitotic cell cycle

0098901:regulation of cardiac muscle cell action potential

0043539:protein serine/threonine kinase activator activity

0051000:positive regulation of nitric-oxide synthase activity

0005813:centrosome

1901842:negative regulation of high voltage-gated calcium channel activity

0097718:disordered domain specific binding

0030235:nitric-oxide synthase regulator activity

0005829:cytosol

0050998:nitric-oxide synthase binding

0060316:positive regulation of ryanodine-sensitive calcium-release channel activity

2000300:regulation of synaptic vesicle exocytosis

0005737:cytoplasm

0005509:calcium ion binding

0038095:Fc-epsilon receptor signaling pathway

0010856:adenylate cyclase activator activity

0032465:regulation of cytokinesis

0007190:activation of adenylate cyclase activity

0046146:tetrahydrobiopterin metabolic process

0031800:type 3 metabotropic glutamate receptor binding

0043548:phosphatidylinositol 3-kinase binding

0016240:autophagosome membrane docking

0071902:positive regulation of protein serine/threonine kinase activity

0016032:viral process

0021762:substantia nigra development

0043647:inositol phosphate metabolic process

0002576:platelet degranulation

0030426:growth cone

0050999:regulation of nitric-oxide synthase activity

0005634:nucleus

0043388:positive regulation of DNA binding

0007268:chemical synaptic transmission

0008179:adenylate cyclase binding

0032516:positive regulation of phosphoprotein phosphatase activity

0010881:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

1901844:regulation of cell communication by electrical coupling involved in cardiac conduction

0031966:mitochondrial membrane

0140056:organelle localization by membrane tethering

0031432:titin binding

0048306:calcium-dependent protein binding

0006936:muscle contraction

1990456:mitochondrion-endoplasmic reticulum membrane tethering

0010801:negative regulation of peptidyl-threonine phosphorylation

0060314:regulation of ryanodine-sensitive calcium-release channel activity

0035307:positive regulation of protein dephosphorylation

0072542:protein phosphatase activator activity

0000922:spindle pole

0090151:establishment of protein localization to mitochondrial membrane

0005886:plasma membrane

0031954:positive regulation of protein autophosphorylation

0031982:vesicle

1902494:catalytic complex

0008076:voltage-gated potassium channel complex

0031997:N-terminal myristoylation domain binding

0032991:protein-containing complex

0044325:ion channel binding

0019855:calcium channel inhibitor activity

0005654:nucleoplasm

0030234:enzyme regulator activity

0051343:positive regulation of cyclic-nucleotide phosphodiesterase activity

0051412:response to corticosterone

PDB

4OVN ; 4UMO ; 1SK6 ; 1CTR ; 3DVK ; 3OXQ ; 6BUT ; 6CNN ; 1XFV ; 6PBX ; 7CR4 ; 1ZUZ ; 6JI8 ; 1AJI ; 6MUE ; 6X35 ; 6U39 ; 5WSU ; 3SUI ; 6B8L ; 4BYF ; 5JTH ; 6U3A ; 4BW7 ; 2X0G ; 6K4L ; 2M55 ; 6B8N ; 6HR1 ; 2W73 ; 6DAE ; 5JQA ; 6M7H ; 2K0F ; 5I0I ; 6FEH ; 6Y95 ; 6Y4O ; 6UZZ ; 4BW8 ; 5V02 ; 6JIU ; 2K0E ; 5VMS ; 6OS4 ; 6X32 ; 7BYL ; 1LVC ; 1YR5 ; 5NIN ; 2R28 ; 1K90 ; 1J7P ; 5DSU ; 5J03 ; 3DVJ ; 2L7L ; 6GDK ; 5V7X ; 2LL7 ; 4LZX ; 2HF5 ; 3BYA ; 3UCY ; 6HCS ; 4GOW ; 3O77 ; 2K61 ; 1NKF ; 1UP5 ; 4DJC ; 2JZI ; 6PLM ; 4Q5U ; 6E2G ; 1SW8 ; 1Y6W ; 6K4K ; 5K7L ; 6N5W ; 1XFU ; 6B8P ; 2Y4V ; 4V0C ; 6JIY ; 2F3Z ; 2K0J ; 6X36 ; 2WEL ; 6CNO ; 7BYM ; 2KUG ; 5GGM ; 5K8Q ; 5V03 ; 6C1H ; 1PK0 ; 6PBY ; 2MG5 ; 6K67 ; 2LGF ; 6MUD ; 2N27 ; 7BYN ; 6JII ; 2I08 ; 3EWT ; 1XFW ; 2V01 ; 4JQ0 ; 1XFX ; 2L53 ; 2V02 ; 5DBR ; 1CLL ; 4L79 ; 3HR4 ; 6E2F ; 6C1D ; 2KNE ; 6EEB ; 2N77 ; 1XFY ; 5J8H ; 6U3B ; 3G43 ; 4UPU ; 2BE6 ; 6B8Q ; 6SZ5 ; 5TP6 ; 2KUH ; 6B8M ; 5WSV ; 2LQC ; 4DCK ; 5WC5 ; 6GDL ; 6JV2 ; 7CR3 ; 6M2W ; 1YRU ; 6O5G ; 2M0J ; 1CDL ; 2LL6 ; 1XFZ ; 3J41 ; 6JRS ; 1WRZ ; 6V00 ; 6XYR ; 6FEG ; 4Q57 ; 6V01 ; 6Y94 ; 5TP5 ; 6DAF ; 6S5T ; 1S26 ; 2VAY ; 6X33 ; 5WBX ; 7CR7 ; 3DVM ; 1L7Z ; 3UCT ; 6Y4P ; 6PAW ; 2F3Y ; 2N8J ; 1J7O ; 2M0K ; 3O78 ; 6DAD ; 6DAH ; 4M1L ; 1ZOT ; 6CNM ; 1IWQ ; 1YRT ; 2LQP ; 5COC ; 1K93 ; 4JPZ ; 3DVE ; 3UCW ; 6C1G ; 3EWV ; 6K4R ; 5DOW ; 6U3D ; 2LV6 ; 5OEO ; 2N6A

Drugbank

DB03977 ; DB11093 ; DB00850 ; DB04841 ; DB08231 ; DB01069 ; DB01100 ; DB01023 ; DB13800 ; DB00753 ; DB00623 ; DB00836 ; DB01065 ; DB04825 ; DB01115 ; DB11348 ; DB00527 ; DB00831 ; DB03900 ; DB14481 ; DB04513 ; DB00622 ; DB08039 ; DB00477 ; DB02868 ; DB01244 ; DB00925 ; DB01429 ; DB01373

KEGG

hsa:808 ; hsa:805 ; hsa:801

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis
H1230	Huang Bai Fen	黄柏粉	Amur corktree	Phellodendron amurense
H0629	Xi Xin	细辛	Siebold wildginger	Asarum sieboldii
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H1061	Bai He	百合	Lily	Lilium brownii
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H0704	Yan Guan Huang Bai	盐关黄柏	Amur cork tree	Phellodendron amurense
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1231	Huang Bai Tan	黄柏炭	Amur corktree	Phellodendron amurense
H1228	Huang Bai	黄柏	Amur corktree	Phellodendron amurense
H1068	Bai He Liu Jin Gao	百合流浸膏	Lily	Lilium brownii
H1115	Guan Huang Bai	关黄柏	Amur cork tree	Phellodendron amurense
H0827	Zhu Hong Jun	竹红菌	Bambusa hypocrella*	Hypocrella bambusae
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H0620	Xi Gua	西瓜	Watermelon	Citrullus vulgaris
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 29)