Herb Description
| Herb ID: H1243 | Chinese Character: 黄连须 |
| English Name: Coptis deltoidea | Latin Name: Coptis chinensis |
| Chinese Pin Yin : Huang Lian Xu | TCM-ID: TCMH975 |
| Therapeutic Function in Chinese : NA | Therapeutic Function in English: NA |
| Herb Function: NA | |
Related Targets (Total: 141)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
2 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
7 Reference(s) |
| T08DOL | Sulfotransferase 1E1 | SULT1E1 |
P49888 |
1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
2 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
4 Reference(s) |
| T91T8I | Glucose-6-phosphatase catalytic subunit 1 | G6PC1 |
P35575 |
1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
2 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
2 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
10 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
3 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
3 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
2 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
11 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
1 Reference(s) |
| T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
3 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
4 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
3 Reference(s) |
| T34I45 | Neuronal acetylcholine receptor subunit alpha-7 | CHRNA7 |
P36544 |
5 Reference(s) |
| T22H7B | Neuronal acetylcholine receptor subunit alpha-4 | CHRNA4 |
P43681 |
1 Reference(s) |
| T83P5X | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB |
O14920 |
1 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
3 Reference(s) |
| T70HTD | Cytochrome P450 2E1 | CYP2E1 |
P05181 |
1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T33OSQ | Sterol regulatory element-binding protein 1 | SREBF1 |
P36956 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
3 Reference(s) |
| T76SUY | Solute carrier family 22 member 2 | SLC22A2 |
O15244 |
3 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
3 Reference(s) |
| T57FUN | Beclin-1 | BECN1 |
Q14457 |
1 Reference(s) |
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
3 Reference(s) |
| T98RXH | Focal adhesion kinase 1 | PTK2 |
Q05397 |
1 Reference(s) |
| T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
1 Reference(s) |
| T83ENN | Solute carrier family 22 member 3 | SLC22A3 |
O75751 |
1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
4 Reference(s) |
| T25M2J | Anoctamin-1 | ANO1 |
Q5XXA6 |
1 Reference(s) |
| T31MUM | 5,6-dihydroxyindole-2-carboxylic acid oxidase | TYRP1 |
P17643 |
1 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
2 Reference(s) |
| T74QOR | Tyrosine-protein kinase JAK3 | JAK3 |
P52333 |
1 Reference(s) |
| T85C8T | Serine/threonine-protein kinase PAK 4 | PAK4 |
O96013 |
1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
4 Reference(s) |
| T50SJ8 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | PRKAA2 |
P54646 |
1 Reference(s) |
| T23TJV | Tyrosine 3-monooxygenase | TH |
P07101 |
1 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
4 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
3 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
4 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
1 Reference(s) |
| T32R5L | Cyclin-dependent kinase 9 | CDK9 |
P50750 |
1 Reference(s) |
| T25S8M | Phosphatidylethanolamine N-methyltransferase | PEMT |
Q9UBM1 |
1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
1 Reference(s) |
| T92P67 | Vasodilator-stimulated phosphoprotein | VASP |
P50552 |
2 Reference(s) |
| T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
1 Reference(s) |
| T45XTW | Retinoic acid receptor RXR-alpha | RXRA |
P19793 |
1 Reference(s) |
| T52XO3 | Cytochrome P450 2J2 | CYP2J2 |
P51589 |
1 Reference(s) |
| T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
2 Reference(s) |
| T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
| T22H8P | Carbonic anhydrase 3 | CA3 |
P07451 |
1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
7 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
4 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
1 Reference(s) |
| T62ERY | Interleukin-1 receptor-associated kinase 4 | IRAK4 |
Q9NWZ3 |
1 Reference(s) |
| T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
1 Reference(s) |
| T76AZQ | Histidine decarboxylase | HDC |
P19113 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
2 Reference(s) |
| T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
2 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
| T73HMK | Bcl-2-binding component 3, isoforms 1/2 | BBC3 |
Q9BXH1 |
1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
2 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
2 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
2 Reference(s) |
| T04WT7 | Fibronectin | FN1 |
P02751 |
1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
1 Reference(s) |
| T67UWO | C-C motif chemokine 26 | CCL26 |
Q9Y258 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
| T02IOG | Cyclin-dependent kinase inhibitor 1B | CDKN1B |
P46527 |
1 Reference(s) |
| T67LQK | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | MAPK11 |
Q15759 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
2 Reference(s) |
| T93PLN | Serine/threonine-protein kinase/endoribonuclease IRE1 | ERN1 |
O75460 |
1 Reference(s) |
| T74D4Y | CASP8 and FADD-like apoptosis regulator | CFLAR |
O15519 |
1 Reference(s) |
| T50VJF | Osteopontin | SPP1 |
P10451 |
1 Reference(s) |
| T53KRS | E3 ubiquitin-protein ligase NEDD4-like | NEDD4L |
Q96PU5 |
1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
1 Reference(s) |
| T38G9K | TNF receptor-associated factor 2 | TRAF2 |
Q12933 |
1 Reference(s) |
| T60UPF | Parvalbumin alpha | PVALB |
P20472 |
2 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
1 Reference(s) |
| T18CUI | Neuron-specific calcium-binding protein hippocalcin | HPCA |
P84074 |
1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
1 Reference(s) |
| T39RV3 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
Q02750 |
1 Reference(s) |
| T66S13 | Dual specificity mitogen-activated protein kinase kinase 2 | MAP2K2 |
P36507 |
1 Reference(s) |
| T08SJX | Astrocytic phosphoprotein PEA-15 | PEA15 |
Q15121 |
1 Reference(s) |
| T38OQ4 | Peroxiredoxin-2 | PRDX2 |
P32119 |
1 Reference(s) |
| T38J3Y | Gamma-enolase | ENO2 |
P09104 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
1 Reference(s) |
| T93W1J | Vascular endothelial growth factor C | VEGFC |
P49767 |
1 Reference(s) |
| T32GWR | Ephrin-B2 | EFNB2 |
P52799 |
3 Reference(s) |
| T95IYZ | Adiponectin | ADIPOQ |
Q15848 |
1 Reference(s) |
| T38H79 | Membrane protein MLC1 | MLC1 |
Q15049 |
1 Reference(s) |
| T62R6K | Myosin light chain kinase 3 | MYLK3 |
Q32MK0 |
1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
1 Reference(s) |
| T78OTS | APC membrane recruitment protein 1 | AMER1 |
Q5JTC6 |
1 Reference(s) |
| T27LA6 | DNA | DNMT1 |
P26358 |
1 Reference(s) |
| T28HOM | Leptin | LEP |
P41159 |
1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
| T28K6X | Insulin receptor substrate 1 | IRS1 |
P35568 |
1 Reference(s) |
| T70VB4 | Cortistatin | CORT |
O00230 |
1 Reference(s) |
| T20E5P | Cytochrome b-245 heavy chain | CYBB |
P04839 |
1 Reference(s) |
| T09HVO | Sodium/hydrogen exchanger 3 | SLC9A3 |
P48764 |
1 Reference(s) |
| T94H37 | Cadherin-1 | CDH1 |
P12830 |
1 Reference(s) |
| T10ICM | Oxidized low-density lipoprotein receptor 1 | OLR1 |
P78380 |
1 Reference(s) |
| T80XW6 | Scavenger receptor class B member 1 | SCARB1 |
Q8WTV0 |
1 Reference(s) |
| T75PC7 | NA | MIR21 |
NA |
2 Reference(s) |
| T38JCD | DNA-binding protein inhibitor ID-1 | ID1 |
P41134 |
1 Reference(s) |
| T58K2N | Calmodulin-3;Calmodulin-1;Calmodulin-2 | CALM3;CALM1;CALM2 |
P0DP25;P0DP23;P0DP24 |
1 Reference(s) |
| T40W2M | NA | MIR93 |
NA |
1 Reference(s) |
| T90HSB | NA | MIR373 |
NA |
1 Reference(s) |
| T29C6N | Ezrin | EZR |
P15311 |
1 Reference(s) |
| T31P1D | Metalloproteinase inhibitor 1 | TIMP1 |
P01033 |
1 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
2 Reference(s) |
| T26CFB | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638;P0DPQ6 |
1 Reference(s) |
| T33BF9 | DNA | DNMT3B |
Q9UBC3 |
1 Reference(s) |
| T34WFL | Proto-oncogene tyrosine-protein kinase receptor Ret | RET |
P07949 |
1 Reference(s) |
| T25YP8 | Aquaporin-4 | AQP4 |
P55087 |
1 Reference(s) |
| T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
2 Reference(s) |
| T14ENF | Microtubule-associated protein 2 | MAP2 |
P11137 |
1 Reference(s) |
| T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
1 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
1 Reference(s) |
Related Compounds (Total: 18)
C0457
Name: Tricin
C1231
Name: Chlorogenic Acid
C0187
Name: Limonin
C0485
Name: Wogonin
C0073
Name: Ferulic Acid
key description of the interaction between compound and target