HIT-result

Type	Detail
Target ID	T27LA6
Protein Name	DNA
Uniprot ID	P26358
Protein Name Alias	cytosine-5; Dnmt1; EC 2.1.1.37; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; MCMT
Gene ID	1786
Gene Symbol	DNMT1
Gene Alias	AIM; CXXC9; DNMT
TTD	T88304: Clinical Trial target
Pfam	PF02008 ; PF06464 ; PF01426 ; PF12047 ; PF00145
GO	0006325:chromatin organization 0010629:negative regulation of gene expression 1905460:negative regulation of vascular associated smooth muscle cell apoptotic process 0051571:positive regulation of histone H3-K4 methylation 0003886:DNA (cytosine-5-)-methyltransferase activity 0007265:Ras protein signal transduction 0090309:positive regulation of DNA methylation-dependent heterochromatin assembly 1904707:positive regulation of vascular associated smooth muscle cell proliferation 0009008:DNA-methyltransferase activity 0006306:DNA methylation 1990841:promoter-specific chromatin binding 0003677:DNA binding 0010216:maintenance of DNA methylation 0008270:zinc ion binding 0051573:negative regulation of histone H3-K9 methylation 0005654:nucleoplasm 0005634:nucleus 1905931:negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching 0010628:positive regulation of gene expression 0045814:negative regulation of gene expression, epigenetic 0000122:negative regulation of transcription by RNA polymerase II
PDB	3PTA ; 5WVO ; 3EPZ ; 4Z97 ; 4Z96 ; 6K3A ; 4YOC ; 5YDR ; 3SWR ; 4WXX
Drugbank	DB05668 ; DB00721 ; DB01099 ; DB01035 ; DB01262 ; DB12116 ; DB00928
KEGG	hsa:1786

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H1228	Huang Bai	黄柏	Amur corktree	Phellodendron amurense
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0342	Qing Hao	青蒿	sweet wormwood	Artemisia carvifolia
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0118	Kun Ming Shan Hai Tang	昆明山海棠	Glaucousback threewingnut	Tripterygium hypoglaucum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H1127	Guang Shan Zha	广山楂	Chinese hawthorn	Crataegus pinnatifida
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H1231	Huang Bai Tan	黄柏炭	Amur corktree	Phellodendron amurense
H1140	Guo Gang Long	过岗龙	NA	Entada phaseoloides
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H0181	Luo Bu Ma	罗布麻	Dogbane	Apocynum venetum
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H1115	Guan Huang Bai	关黄柏	Amur cork tree	Phellodendron amurense
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0818	Zhi Zi	栀子	Cape jasmine fruit	Gardenia jasminoides
H1068	Bai He Liu Jin Gao	百合流浸膏	Lily	Lilium brownii
H0416	Shan Shen	山参	NA	Panax ginseng
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H1230	Huang Bai Fen	黄柏粉	Amur corktree	Phellodendron amurense
H0422	Shan Zha Tan	山楂炭	Chinese hawthorn	Crataegus pinnatifida
H0419	Shan Zha	山楂	Chinese hawthorn	Crataegus pinnatifida
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0020	Ji Yan Cao	鸡眼草	Striate kummerowia	Kummerowia striata
H0229	Mao Da Ding Cao	毛大丁草	Pilose gerbera	Gerbera piloselloides
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0026	Jiang	姜	Soybean paste	Glycine max
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0424	Shan Zhi	山栀	Cape jasmine	Gardenia jasminoides
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0420	Shan Zha Chou Gao	山楂稠膏	Chinese hawthorn	Crataegus pinnatifida
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0704	Yan Guan Huang Bai	盐关黄柏	Amur cork tree	Phellodendron amurense
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1225	Huai Mi	槐米	NA	Sophora japonica
H0343	Qing Hao Zi	青蒿子	sweet wormwood	Artemisia carvifolia
H1007	Dou You	豆油	Soybean oil	Glycine max
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum
H0989	Ding Kui Cao	丁葵草	Herb of twinleaf zornia	Kummerowia striata
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0361	Ren Zi Cao	人字草	Herb of twinleaf zornia	Kummerowia striata
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0094	Gou Qi	枸杞	Chinese wolfberry fruit	Lycium chinense
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0692	Xue Ren Shen	血人参	NA	Lespedeza bicolor
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H0721	Yang Mei Gen	杨梅根	Myrica rubra sieb. et zucc	Myrica rubra
H0733	Ye Shan Zha	野山楂	nippon bawthorn	Crataegus pinnatifida
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0053	Jin Lian Hua	金莲花	Chinese globeflower	Trollius chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1141	Guo Gang Long Jin Gao	过岗龙浸膏	NA	Entada phaseoloides
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H1211	Bai Mei	白眉	pilose gerbera herb	Gerbera piloselloides
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H0421	Shan Zha Qing Gao	山楂清膏	Chinese hawthorn	Crataegus pinnatifida
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0827	Zhu Hong Jun	竹红菌	Bambusa hypocrella*	Hypocrella bambusae
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0819	Zhi Zi Jin Gao	栀子浸膏	Cape jasmine fruit	Gardenia jasminoides
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H1061	Bai He	百合	Lily	Lilium brownii
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0457	Shi Er	石耳	Rock-Ears	Umbilicaria esculenta

Target Description

Related Compounds (Total: 12)

Related Herbs (Total: 146)