Target Description

Type Detail
Target ID T27LA6
Protein Name DNA
Uniprot ID P26358
Protein Name Alias cytosine-5;  Dnmt1;  EC 2.1.1.37;  CXXC-type zinc finger protein 9;  DNA methyltransferase HsaI;  DNA MTase HsaI;  M.HsaI;  MCMT
Gene ID 1786
Gene Symbol DNMT1
Gene Alias AIM;  CXXC9;  DNMT
TTD T88304: Clinical Trial target
Pfam PF02008 ; PF06464 ; PF01426 ; PF12047 ; PF00145
GO
0006325:chromatin organization

0010629:negative regulation of gene expression

1905460:negative regulation of vascular associated smooth muscle cell apoptotic process

0051571:positive regulation of histone H3-K4 methylation

0003886:DNA (cytosine-5-)-methyltransferase activity

0007265:Ras protein signal transduction

0090309:positive regulation of DNA methylation-dependent heterochromatin assembly

1904707:positive regulation of vascular associated smooth muscle cell proliferation

0009008:DNA-methyltransferase activity

0006306:DNA methylation

1990841:promoter-specific chromatin binding

0003677:DNA binding

0010216:maintenance of DNA methylation

0008270:zinc ion binding

0051573:negative regulation of histone H3-K9 methylation

0005654:nucleoplasm

0005634:nucleus

1905931:negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

0010628:positive regulation of gene expression

0045814:negative regulation of gene expression, epigenetic

0000122:negative regulation of transcription by RNA polymerase II

PDB 3PTA ; 5WVO ; 3EPZ ; 4Z97 ; 4Z96 ; 6K3A ; 4YOC ; 5YDR ; 3SWR ; 4WXX
Drugbank DB05668 ; DB00721 ; DB01099 ; DB01035 ; DB01262 ; DB12116 ; DB00928
KEGG hsa:1786

Related Compounds  (Total: 12)

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C0046
Name: Epigallocatechin
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C0101
Name: Genistein
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C0363
Name: Resveratrol
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C0379
Name: S-Adenosyl Methionine
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C0380
Name: S-Adenosylhomocysteine


Related Herbs  (Total: 146)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0026 Jiang Soybean pasteGlycine max
H0142 Liang Jiang良姜 NAAlpinia officinarum
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H0416 Shan Shen山参 NAPanax ginseng
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0118 Kun Ming Shan Hai Tang昆明山海棠 Glaucousback threewingnutTripterygium hypoglaucum
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H1061 Bai He百合 LilyLilium brownii
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0357 Ren Shen人参 GinsengPanax ginseng
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H1227 Huai Zhi槐枝 NASophora japonica
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H1007 Dou You豆油 Soybean oilGlycine max
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H1225 Huai Mi槐米 NASophora japonica
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0342 Qing Hao青蒿 sweet wormwoodArtemisia carvifolia
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0721 Yang Mei Gen杨梅根 Myrica rubra sieb. et zuccMyrica rubra
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0408 Bing Lang槟榔 BetenutpalmAreca catechu
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H0343 Qing Hao Zi青蒿子 sweet wormwoodArtemisia carvifolia
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0633 Xia Tian Wu夏天无 Decumbent corydalisCorydalis decumbens
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1004 Bai Cha白茶 White teaCamellia sinensis
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0925 Da Fu Zi大腹子 Areca palmAreca catechu
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0181 Luo Bu Ma罗布麻 DogbaneApocynum venetum
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0706 Yan Hu Suo延胡索 YanhusuoCorydalis yanhusuo
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0827 Zhu Hong Jun竹红菌 Bambusa hypocrella*Hypocrella bambusae
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata