Compound Description
| ID: C0046 | Common name: Epigallocatechin |
| IUPAC: (2R,3R)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol | CAS: CAS:970-74-1 |
| Chembl ID: CHEMBL47386 | Pubchem ID: CID:72277 |
| Formula: C15H14O7 | TCM-ID: TCMC1117 |
| Smiles: C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O | |
| Alias:
2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R-cis)-;
Epigallocatechol; Gallocatechol, l-; (2R,3R)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol; (-)-3,3',4',5,5',7-Flavanhexol; (-)-Epigallocatechin; (-)-Epigallocatechol; (-)-epi-Gallocatechin; (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,5,7-trihydroxychroman; 1-epi-3',4',5',5,7-Pentahydroxy-3-flavanol; 3,3',4',5,5',7-Flavanhexol; Antiscurvy factor C2; EGC; Epigallocatechin; Factor C2 (antiscurvy); Galloepicatechin; L-Epigallocatechin; NSC 674039; Sunphenon EGC; epi-Gallocatechin; l-Epigallocatechin; l-Epigallocatechol |
Structure:
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Related Targets (Total: 20)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T27LA6 | DNA | DNMT1 |
P26358 |
A | 1 Reference(s) |
| T01JSX | Carbonyl reductase [NADPH] 1 | CBR1 |
P16152 |
A | 1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
A | 1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
A | 1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
A | 1 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
A | 1 Reference(s) |
| T69ESY | Ras GTPase-activating protein-binding protein 1 | G3BP1 |
Q13283 |
A | 1 Reference(s) |
| T18LX5 | Neutrophil elastase | ELANE |
P08246 |
A | 1 Reference(s) |
| T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
A | 1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
B | 1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
B | 1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
B | 1 Reference(s) |
| T81BH5 | Sulfotransferase 1A1 | SULT1A1 |
P50225 |
B | 1 Reference(s) |
| T84VZG | Ryanodine receptor 1 | RYR1 |
P21817 |
C | 1 Reference(s) |
| T84P70 | Urokinase-type plasminogen activator | PLAU |
P00749 |
C | 1 Reference(s) |
| T60A9R | NA | CYP3A |
NA |
C | 1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
C | 1 Reference(s) |
| T06MXL | Neprilysin | MME |
P08473 |
C | 1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
C | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 34)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H1055 | Bai Guo Ren | 白果仁 | ginkgo | Ginkgo biloba |
| H0342 | Qing Hao | 青蒿 | sweet wormwood | Artemisia carvifolia |
| H0422 | Shan Zha Tan | 山楂炭 | Chinese hawthorn | Crataegus pinnatifida |
| H0419 | Shan Zha | 山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H1051 | Bai Guo | 白果 | Ginkgo nut | Ginkgo biloba |
| H0020 | Ji Yan Cao | 鸡眼草 | Striate kummerowia | Kummerowia striata |
| H0053 | Jin Lian Hua | 金莲花 | Chinese globeflower | Trollius chinensis |
| H0118 | Kun Ming Shan Hai Tang | 昆明山海棠 | Glaucousback threewingnut | Tripterygium hypoglaucum |
| H1141 | Guo Gang Long Jin Gao | 过岗龙浸膏 | NA | Entada phaseoloides |
| H0229 | Mao Da Ding Cao | 毛大丁草 | Pilose gerbera | Gerbera piloselloides |
| H1211 | Bai Mei | 白眉 | pilose gerbera herb | Gerbera piloselloides |
| H0361 | Ren Zi Cao | 人字草 | Herb of twinleaf zornia | Kummerowia striata |
| H0421 | Shan Zha Qing Gao | 山楂清膏 | Chinese hawthorn | Crataegus pinnatifida |
| H1127 | Guang Shan Zha | 广山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H1140 | Guo Gang Long | 过岗龙 | NA | Entada phaseoloides |
| H1029 | Fang Er Cha | 方儿茶 | khair in hindi | Senegalia catechu |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H0750 | Yin Xing Ye | 银杏叶 | Folium ginkgo | Ginkgo biloba |
| H0420 | Shan Zha Chou Gao | 山楂稠膏 | Chinese hawthorn | Crataegus pinnatifida |
| H0181 | Luo Bu Ma | 罗布麻 | Dogbane | Apocynum venetum |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0692 | Xue Ren Shen | 血人参 | NA | Lespedeza bicolor |
| H1004 | Bai Cha | 白茶 | White tea | Camellia sinensis |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H0343 | Qing Hao Zi | 青蒿子 | sweet wormwood | Artemisia carvifolia |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0637 | Cha Ye | 茶叶 | Common tea | Camellia sinensis |
| H0721 | Yang Mei Gen | 杨梅根 | Myrica rubra sieb. et zucc | Myrica rubra |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H0733 | Ye Shan Zha | 野山楂 | nippon bawthorn | Crataegus pinnatifida |
| H0989 | Ding Kui Cao | 丁葵草 | Herb of twinleaf zornia | Kummerowia striata |
| H0457 | Shi Er | 石耳 | Rock-Ears | Umbilicaria esculenta |
Ckey description of the interaction between compound and target