Target Description

Type Detail
Target ID T84VZG
Protein Name Ryanodine receptor 1
Uniprot ID P21817
Protein Name Alias RYR-1;  RyR1;  Skeletal muscle calcium release channel;  Skeletal muscle ryanodine receptor;  Skeletal muscle-type ryanodine receptor;  Type 1 ryanodine receptor
Gene ID 6261
Gene Symbol RYR1
Gene Alias RYDR
TTD T92328: Discontinued target
Pfam PF08454 ; PF00520 ; PF00622 ; PF02026 ; PF06459 ; PF08709 ; PF02815 ; PF01365
GO
0070062:extracellular exosome

0031301:integral component of organelle membrane

0014808:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

0006936:muscle contraction

0030018:Z disc

0034220:ion transmembrane transport

0043588:skin development

0005524:ATP binding

0001666:response to hypoxia

0016529:sarcoplasmic reticulum

0015278:calcium-release channel activity

0051209:release of sequestered calcium ion into cytosol

0005245:voltage-gated calcium channel activity

1990425:ryanodine receptor complex

0005516:calmodulin binding

0033017:sarcoplasmic reticulum membrane

0006816:calcium ion transport

0005886:plasma membrane

1903779:regulation of cardiac conduction

0048763:calcium-induced calcium release activity

0031674:I band

0005790:smooth endoplasmic reticulum

0030659:cytoplasmic vesicle membrane

0042383:sarcolemma

0005887:integral component of plasma membrane

0005219:ryanodine-sensitive calcium-release channel activity

0005737:cytoplasm

0014701:junctional sarcoplasmic reticulum membrane

0051289:protein homotetramerization

0031000:response to caffeine

0005938:cell cortex

0051480:regulation of cytosolic calcium ion concentration

0034704:calcium channel complex

0071277:cellular response to calcium ion

0005509:calcium ion binding

0014802:terminal cisterna

0043931:ossification involved in bone maturation

0003151:outflow tract morphogenesis

0071313:cellular response to caffeine

0048741:skeletal muscle fiber development

0005262:calcium channel activity

PDB 6UHS ; 6UHI
Drugbank DB04786 ; DB11093 ; DB00201 ; DB14481 ; DB09085 ; DB01219 ; DB11348
KEGG hsa:6261

Related Compounds  (Total: 5)

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C0046
Name: Epigallocatechin
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C0047
Name: Epigalocatechin Gallate
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C0114
Name: (-)-Epicatechin
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C0710
Name: Ribose
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C1205
Name: Caffeine


Related Herbs  (Total: 119)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0351 Quan Shen拳参 BistortPolygonum bistorta
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1217 Bai Mei Hua白梅花 Japanese apricot flowerPrunus mume
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0925 Da Fu Zi大腹子 Areca palmAreca catechu
H1033 Fang Ji防己 Fourstamen stephaniaStephania tetrandra
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0779 Zao Jiao Zhen皂角针 Chinese honeylocust spineGleditsia sinensis
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H1009 Du Huo独活 Doubleteeth pubescent angelicaAngelica pubescens
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0777 Zao Jia皂荚 Chinese honeylocustGleditsia sinensis
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H1061 Bai He百合 LilyLilium brownii
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0362 Rong Shu Xu榕树须 BanyanFicus microcarpa
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H0118 Kun Ming Shan Hai Tang昆明山海棠 Glaucousback threewingnutTripterygium hypoglaucum
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H0615 Wu Zhi Mao Tao五指毛桃 five-finger fig rootFicus simplicissima
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0793 Zhao Shan Bai照山白 Manchurian rhododendronRhododendron micranthum
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0698 Ya Zao牙皂 Chinese honeylocust abnormal fruitGleditsia sinensis
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0120 Ban Bian Qi半边旗 pinnated brake herbPteris semipinnata
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H0939 Da Xue Teng大血藤 SargentgloryvineSargentodoxa cuneata
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0602 Wu Mei Rou乌梅肉 EbonyPrunus mume
H1004 Bai Cha白茶 White teaCamellia sinensis
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0007 Huo Xue Teng活血藤 NASargentodoxa cuneata
H0534 Teng Li Gen藤梨根 NAActinidia arguta
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0868 Chuan Du Huo川独活 Doubleteeth pubescent angelicaAngelica pubescens
H0284 Nan She Teng南蛇藤 Oriental bittersweetCelastrus orbiculatus
H0220 Man Shan Hong You满山红油 Daurian rhododendron oilOleum rhododendri daurici
H0342 Qing Hao青蒿 sweet wormwoodArtemisia carvifolia
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0363 Rong Shu Ye榕树叶 BanyanFicus microcarpa
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0343 Qing Hao Zi青蒿子 sweet wormwoodArtemisia carvifolia
H0601 Wu Mei乌梅 Japanese apricotPrunus mume
H0341 Qing Feng Teng青风藤 OrientvineSinomenium acutum
H0408 Bing Lang槟榔 BetenutpalmAreca catechu
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0087 Ju Gu Ye枸骨叶 FOLIUM iLICIS cORNUTAEIlex cornuta
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0189 Lv Cha绿茶 Green teaFolium camelliae sinensis
H1212 Hu Ye Gan Jin Gao槲叶干浸膏 NAQuercus dentata
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0532 Teng Huang藤黄 Gamboge tree resinGarcinia morella
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0181 Luo Bu Ma罗布麻 DogbaneApocynum venetum
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0603 Wu Tong Ye Jin Gao梧桐叶浸膏 Parasol treesFirmiana simplex
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0721 Yang Mei Gen杨梅根 Myrica rubra sieb. et zuccMyrica rubra
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis