Compound Description
| ID: C0047 | Common name: Epigalocatechin Gallate |
| IUPAC: [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate | CAS: NA |
| Chembl ID: CHEMBL297453 | Pubchem ID: CID:65064 |
| Formula: C22H18O11 | TCM-ID: TCMC1118 |
| Smiles: C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O | |
| Alias:
NA
|
Structure:
|
Related Targets (Total: 69)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T64T4I | Telomerase protein component 1 | TEP1 |
Q99973 |
A | 1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
A | 1 Reference(s) |
| T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
A | 1 Reference(s) |
| T68CKY | Tyrosine-protein kinase Fyn | FYN |
P06241 |
B | 1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
B | 1 Reference(s) |
| T97KFC | Transcription factor jun-B | JUNB |
P17275 |
B | 1 Reference(s) |
| T33BF9 | DNA | DNMT3B |
Q9UBC3 |
B | 1 Reference(s) |
| T02WMA | Ornithine decarboxylase | ODC1 |
P11926 |
B | 1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
B | 1 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
B | 1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
B | 1 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
B | 1 Reference(s) |
| T55JB4 | Fibroblast growth factor receptor 1 | FGFR1 |
P11362 |
B | 1 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
B | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
B | 1 Reference(s) |
| T22IMH | Cyclin-dependent kinase 6 | CDK6 |
Q00534 |
B | 1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
B | 1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
B | 1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
B | 1 Reference(s) |
| T33KFW | Matrilysin | MMP7 |
P09237 |
B | 1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
B | 1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T31P1D | Metalloproteinase inhibitor 1 | TIMP1 |
P01033 |
B | 1 Reference(s) |
| T53RK9 | T-cell surface glycoprotein CD4 | CD4 |
P01730 |
B | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
B | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
B | 1 Reference(s) |
| T02DYS | Protein fosB | FOSB |
P53539 |
B | 1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
B | 1 Reference(s) |
| T09KQF | Proliferating cell nuclear antigen | PCNA |
P12004 |
B | 1 Reference(s) |
| T56RMM | DNA | DNMT3A |
Q9Y6K1 |
B | 1 Reference(s) |
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
B | 1 Reference(s) |
| T63FF5 | Interferon regulatory factor 3 | IRF3 |
Q14653 |
B | 1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
B | 1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
B | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
B | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
B | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
B | 1 Reference(s) |
| T42XY2 | Insulin-like growth factor 1 receptor | IGF1R |
P08069 |
B | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
B | 1 Reference(s) |
| T71UHA | Transcription factor jun-D | JUND |
P17535 |
B | 1 Reference(s) |
| T34PRO | NADP-dependent malic enzyme | ME1 |
P48163 |
B | 1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
B | 1 Reference(s) |
| T78VUO | RAF proto-oncogene serine/threonine-protein kinase | RAF1 |
P04049 |
B | 1 Reference(s) |
| T94K7H | Cytochrome P450 7A1 | CYP7A1 |
P22680 |
C | 1 Reference(s) |
| T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
C | 1 Reference(s) |
| T88QQE | Fibroblast growth factor 2 | FGF2 |
P09038 |
C | 1 Reference(s) |
| T06URY | Transcription factor Sp1 | SP1 |
P08047 |
C | 1 Reference(s) |
| T57GP2 | ETS domain-containing protein Elk-1 | ELK1 |
P19419 |
C | 1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
C | 1 Reference(s) |
| T90ORW | Bcl2-associated agonist of cell death | BAD |
Q92934 |
C | 1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
C | 1 Reference(s) |
| T34X07 | CCAAT/enhancer-binding protein alpha | CEBPA |
P49715 |
C | 1 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
C | 1 Reference(s) |
| T60CG9 | MAP kinase-activating death domain protein | MADD |
Q8WXG6 |
C | 1 Reference(s) |
| T09KPZ | Vimentin | VIM |
P08670 |
C | 1 Reference(s) |
| T06PVX | E3 ubiquitin-protein ligase Mdm2 | MDM2 |
Q00987 |
C | 1 Reference(s) |
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
C | 1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
C | 1 Reference(s) |
| T67HAF | Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
P42224 |
C | 1 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
C | 1 Reference(s) |
| T36HB7 | Homeobox protein Hox-D1 | HOXD1 |
Q9GZZ0 |
C | 1 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
C | 1 Reference(s) |
| T84VZG | Ryanodine receptor 1 | RYR1 |
P21817 |
C | 1 Reference(s) |
| T62Y4H | Protein kinase C epsilon type | PRKCE |
Q02156 |
C | 1 Reference(s) |
| T84WE9 | Vascular endothelial growth factor receptor 1 | FLT1 |
P17948 |
C | 1 Reference(s) |
| T89S77 | Platelet-derived growth factor subunit B | PDGFB |
P01127 |
C | 1 Reference(s) |
| T41U5H | Cytochrome P450 3A7 | CYP3A7 |
P24462 |
C | 1 Reference(s) |
| T41WA8 | Ephrin type-A receptor 2 | EPHA2 |
P29317 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 14)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0637 | Cha Ye | 茶叶 | Common tea | Camellia sinensis |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0189 | Lv Cha | 绿茶 | Green tea | Folium camelliae sinensis |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H0721 | Yang Mei Gen | 杨梅根 | Myrica rubra sieb. et zucc | Myrica rubra |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H1029 | Fang Er Cha | 方儿茶 | khair in hindi | Senegalia catechu |
| H1004 | Bai Cha | 白茶 | White tea | Camellia sinensis |
| H0692 | Xue Ren Shen | 血人参 | NA | Lespedeza bicolor |
Ckey description of the interaction between compound and target