Target Description

Type Detail
Target ID T68CKY
Protein Name Tyrosine-protein kinase Fyn
Uniprot ID P06241
Protein Name Alias EC 2.7.10.2;  Proto-oncogene Syn;  Proto-oncogene c-Fyn;  Src-like kinase;  SLK;  p59-Fyn
Gene ID 2534
Gene Symbol FYN
Gene Alias NA
TTD T17980: Successful target
Pfam PF00017 ; PF00018 ; PF07714
GO
2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

0070851:growth factor receptor binding

0099092:postsynaptic density, intracellular component

0010629:negative regulation of gene expression

0002862:negative regulation of inflammatory response to antigenic stimulus

0008360:regulation of cell shape

0071375:cellular response to peptide hormone stimulus

0007612:learning

0005102:signaling receptor binding

2001056:positive regulation of cysteine-type endopeptidase activity

0031397:negative regulation of protein ubiquitination

1903997:positive regulation of non-membrane spanning protein tyrosine kinase activity

1905477:positive regulation of protein localization to membrane

0046777:protein autophosphorylation

0097038:perinuclear endoplasmic reticulum

0046875:ephrin receptor binding

0002250:adaptive immune response

0043548:phosphatidylinositol 3-kinase binding

0097062:dendritic spine maintenance

0045087:innate immune response

0098978:glutamatergic synapse

1900449:regulation of glutamate receptor signaling pathway

0042610:CD8 receptor binding

0019221:cytokine-mediated signaling pathway

0005884:actin filament

0042609:CD4 receptor binding

1905232:cellular response to L-glutamate

1900182:positive regulation of protein localization to nucleus

0050690:regulation of defense response to virus by virus

0045471:response to ethanol

0031234:extrinsic component of cytoplasmic side of plasma membrane

0004713:protein tyrosine kinase activity

0035556:intracellular signal transduction

0005524:ATP binding

0042608:T cell receptor binding

0030425:dendrite

0050798:activated T cell proliferation

0007596:blood coagulation

0046872:metal ion binding

0002223:stimulatory C-type lectin receptor signaling pathway

0042802:identical protein binding

0030154:cell differentiation

0030900:forebrain development

0097386:glial cell projection

0050321:tau-protein kinase activity

0019899:enzyme binding

0043014:alpha-tubulin binding

0048471:perinuclear region of cytoplasm

1903202:negative regulation of oxidative stress-induced cell death

0010730:negative regulation of hydrogen peroxide biosynthetic process

0003015:heart process

0043524:negative regulation of neuron apoptotic process

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0071560:cellular response to transforming growth factor beta stimulus

0014069:postsynaptic density

0090314:positive regulation of protein targeting to membrane

0050852:T cell receptor signaling pathway

0051897:positive regulation of protein kinase B signaling

0048156:tau protein binding

0042177:negative regulation of protein catabolic process

0044297:cell body

1904646:cellular response to amyloid-beta

0004715:non-membrane spanning protein tyrosine kinase activity

0000165:MAPK cascade

1904645:response to amyloid-beta

0042493:response to drug

1905664:regulation of calcium ion import across plasma membrane

0051428:peptide hormone receptor binding

0006816:calcium ion transport

1905430:cellular response to glycine

0048010:vascular endothelial growth factor receptor signaling pathway

0005886:plasma membrane

0005768:endosome

0044325:ion channel binding

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0005739:mitochondrion

0005634:nucleus

0010976:positive regulation of neuron projection development

0007411:axon guidance

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0097718:disordered domain specific binding

0031802:type 5 metabotropic glutamate receptor binding

0030168:platelet activation

0038096:Fc-gamma receptor signaling pathway involved in phagocytosis

0007631:feeding behavior

0018108:peptidyl-tyrosine phosphorylation

0006468:protein phosphorylation

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0050900:leukocyte migration

0031295:T cell costimulation

0050804:modulation of chemical synaptic transmission

1902951:negative regulation of dendritic spine maintenance

0042542:response to hydrogen peroxide

0048813:dendrite morphogenesis

0005829:cytosol

0001764:neuron migration

0098685:Schaffer collateral - CA1 synapse

1901216:positive regulation of neuron death

0048013:ephrin receptor signaling pathway

0036120:cellular response to platelet-derived growth factor stimulus

0045121:membrane raft

0050730:regulation of peptidyl-tyrosine phosphorylation

0000304:response to singlet oxygen

0004714:transmembrane receptor protein tyrosine kinase activity

0050966:detection of mechanical stimulus involved in sensory perception of pain

PDB 4U1P ; 6IPY ; 1AVZ ; 3UA6 ; 2MRJ ; 6EDF ; 3UA7 ; 5ZAU ; 1G83 ; 1AZG ; 1AOT ; 6IPZ ; 1AOU ; 1NYF ; 1NYG ; 1A0N ; 1FYN ; 1SHF ; 4D8D ; 4EIK ; 2MQI ; 2DQ7 ; 3H0F ; 1ZBJ ; 4ZNX ; 4U17 ; 1EFN ; 3H0I ; 2MRK ; 3H0H ; 1M27
Drugbank DB02078 ; DB12010 ; DB01254
KEGG hsa:2534

Related Compounds  (Total: 5)

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C0047
Name: Epigalocatechin Gallate
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C0229
Name: Myricetin
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C0854
Name: Acetylcholine
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C0867
Name: Alcohol
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C1225
Name: Cgmp


Related Herbs  (Total: 96)

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H1040 Feng Mi蜂蜜 HoneyApis cerana
H1047 Feng Xiang Ye枫香叶 NALiquidambar formosana
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0357 Ren Shen人参 GinsengPanax ginseng
H0244 Mi La蜜蜡 Bee waxApis cerana
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0717 Yang Cong Tou洋葱头 Common onionAllium cepa
H0542 Tian Ma天麻 Tall gastrodiaGastrodia elata
H0158 Liu Ling Ju六棱菊 NALaggera alata
H1004 Bai Cha白茶 White teaCamellia sinensis
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0625 Ce Bai Tan侧柏炭 Oriental arbor-vitaePlatycladus orientalis
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0716 Yang Cong洋葱 Common onionAllium cepa
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0567 Tu Da Huang土大黄 NARumex obtusifolius
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0802 Zhi Geng枳梗 NACitrus aurantium
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0938 Da Suan大蒜 GarlicAllium sativum
H0320 Qi Shu Gen漆树根 true lacquertree rootToxicodendron succedaneum
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0425 Shan Zhi Ma山芝麻 Narrowleaf screwtreeHelicteres angustifolia
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H1061 Bai He百合 LilyLilium brownii
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0961 Dang Yao当药 Chinese swertiaSwertia chinensis
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
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H1049 Feng Xiang Zhi Chou Gao枫香脂稠膏 NALiquidambar formosana
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H1048 Feng Xiang Zhi枫香脂 Beautiful sweetgum resinResina liquidambaris
H0721 Yang Mei Gen杨梅根 Myrica rubra sieb. et zuccMyrica rubra
H1144 Bai Jiao Xiang白胶香 Beautiful sweetgum resinLiquidambar formosana
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0177 Lu Lu Tong路路通 Beautiful sweetgumLiquidambar formosana
H0379 Bian Xu萹蓄 Common knotgrassPolygonum aviculare
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0396 Sang Ye桑叶 White mulberry leafMorus alba
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H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0903 Ci Cai荠菜 ShepherdspurseCapsella bursa-pastoris
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0670 Chai Pi Zhang豺皮樟 Oblong-leaved litseaLitsea rotundifolia
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H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
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