HIT-result

Target id	Protein Name	Gene Symbol	Uniprot ID	No.of Literature Evidence
T43G0N	Cytochrome P450 2C8	CYP2C8	P10632	1 Reference(s)
T01FVG	DNA gyrase subunit B	gyrB	P0AES6	1 Reference(s)
T73LPO	Poly [ADP-ribose] polymerase 1	PARP1	P09874	3 Reference(s)
T43N2D	Epidermal growth factor receptor	EGFR	P00533	3 Reference(s)
T38K2W	Receptor tyrosine-protein kinase erbB-2	ERBB2	P04626	4 Reference(s)
T30VNV	Myeloperoxidase	MPO	P05164	2 Reference(s)
T67JR8	Heat shock factor protein 1	HSF1	Q00613	2 Reference(s)
T02QBS	Cytochrome P450 1A2	CYP1A2	P05177	2 Reference(s)
T51IKV	DNA topoisomerase 2-alpha	TOP2A	P11388	1 Reference(s)
T69XVX	Cytochrome P450 1B1	CYP1B1	Q16678	3 Reference(s)
T63BQU	Cytochrome P450 1A1	CYP1A1	P04798	2 Reference(s)
T25H22	Protein kinase C beta type	PRKCB	P05771	2 Reference(s)
T46AQJ	Glutathione S-transferase P	GSTP1	P09211	3 Reference(s)
T79WXA	Mitogen-activated protein kinase 1	MAPK1	P28482	7 Reference(s)
T85AXP	Cytochrome P450 3A4	CYP3A4	P08684	4 Reference(s)
T50SJ8	5'-AMP-activated protein kinase catalytic subunit alpha-2	PRKAA2	P54646	1 Reference(s)
T09DI4	Lysine-specific histone demethylase 1A	KDM1A	O60341	1 Reference(s)
T50SX0	Nuclear receptor subfamily 1 group I member 2	NR1I2	O75469	2 Reference(s)
T03YAI	Mitogen-activated protein kinase kinase kinase 5	MAP3K5	Q99683	1 Reference(s)
T39FBA	Thioredoxin-interacting protein	TXNIP	Q9H3M7	1 Reference(s)
T64BPL	Solute carrier family 23 member 1	SLC23A1	Q9UHI7	1 Reference(s)
T60KJ1	Putative endoplasmin-like protein	HSP90B2P	Q58FF3	2 Reference(s)
T47H3O	Heat shock protein HSP 90-alpha	HSP90AA1	P07900	2 Reference(s)
T13KGH	Tyrosinase	TYR	P14679	3 Reference(s)
T73LXA	Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1B	HSPA1A;HSPA1B	P0DMV8;P0DMV9	2 Reference(s)
T46K2X	Heat shock 70 kDa protein 4	HSPA4	P34932	10 Reference(s)
T31RKU	Glycerol kinase	GK	P32189	1 Reference(s)
T85JI5	Vitamin D3 receptor	VDR	P11473	3 Reference(s)
T81I4T	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	Q13131	2 Reference(s)
T74QXI	Serine/threonine-protein kinase mTOR	MTOR	P42345	4 Reference(s)
T54G8J	Protein kinase C delta type	PRKCD	Q05655	3 Reference(s)
T65S3S	Tyrosine-protein kinase JAK2	JAK2	O60674	2 Reference(s)
T68OIU	CREB-regulated transcription coactivator 1	CRTC1	Q6UUV9	1 Reference(s)
T88BCB	Glycerol-3-phosphate phosphatase	PGP	A6NDG6	1 Reference(s)
T01E7W	Aurora kinase B	AURKB	Q96GD4	1 Reference(s)
T42PUG	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	P11166	2 Reference(s)
T67MQU	Antileukoproteinase	SLPI	P03973	1 Reference(s)
T19CUN	Prothrombin	F2	P00734	2 Reference(s)
T01IGB	Serine/threonine-protein kinase/endoribonuclease IRE2	ERN2	Q76MJ5	1 Reference(s)
T94H37	Cadherin-1	CDH1	P12830	1 Reference(s)
T12PIB	Lysosomal alpha-glucosidase	GAA	P10253	1 Reference(s)
T31U13	Cytochrome P450 2C19	CYP2C19	P33261	1 Reference(s)
T70LAB	UDP-glucuronosyltransferase 1A9	UGT1A9	O60656	1 Reference(s)
T93SFQ	NAD-dependent protein deacetylase sirtuin-1	SIRT1	Q96EB6	2 Reference(s)
T01CL0	Tyrosine-protein kinase Lyn	LYN	P07948	1 Reference(s)
T21DZX	Amine oxidase [flavin-containing] A	MAOA	P21397	3 Reference(s)
T90QV5	Voltage-gated hydrogen channel 1	HVCN1	Q96D96	1 Reference(s)
T51K6D	Tyrosine-protein phosphatase non-receptor type 11	PTPN11	Q06124	1 Reference(s)
T70HTD	Cytochrome P450 2E1	CYP2E1	P05181	1 Reference(s)
T49PL1	Low-density lipoprotein receptor	LDLR	P01130	1 Reference(s)
T03CZ8	Catechol O-methyltransferase	COMT	P21964	2 Reference(s)
T61QXV	Nuclear respiratory factor 1	NRF1	Q16656	1 Reference(s)
T82JWE	Cellular tumor antigen p53	TP53	P04637	7 Reference(s)
T92BZ2	Catenin beta-1	CTNNB1	P35222	1 Reference(s)
T06RMZ	Nuclear factor NF-kappa-B p105 subunit	NFKB1	P19838	3 Reference(s)
T23P74	Caspase-9	CASP9	P55211	3 Reference(s)
T85U8U	Caspase-3	CASP3	P42574	19 Reference(s)
T80GUN	72 kDa type IV collagenase	MMP2	P08253	4 Reference(s)
T04H8Y	Beta-secretase 1	BACE1	P56817	1 Reference(s)
T06VX0	MAP/microtubule affinity-regulating kinase 4	MARK4	Q96L34	3 Reference(s)
T83YZD	Acetylcholinesterase	ACHE	P22303	2 Reference(s)
T20IHC	Diacylglycerol O-acyltransferase 1	DGAT1	O75907	1 Reference(s)
T16UZ4	Dipeptidyl peptidase 4	DPP4	P27487	1 Reference(s)
T70KPE	Transient receptor potential cation channel subfamily V member 3	TRPV3	Q8NET8	1 Reference(s)
T49TDM	Matrix metalloproteinase-9	MMP9	P14780	5 Reference(s)
T26KIE	Transcription factor AP-1	JUN	P05412	11 Reference(s)
T98QOA	DNA-dependent protein kinase catalytic subunit	PRKDC	P78527	2 Reference(s)
T67KTV	Transient receptor potential cation channel subfamily V member 1	TRPV1	Q8NER1	4 Reference(s)
T31EJG	Apoptotic protease-activating factor 1	APAF1	O14727	1 Reference(s)
T09INZ	Transient receptor potential cation channel subfamily A member 1	TRPA1	O75762	1 Reference(s)
T35QZO	Cytochrome c	CYCS	P99999	1 Reference(s)
T80TUC	Apoptosis regulator BAX	BAX	Q07812	9 Reference(s)
T01QLH	Estrogen receptor	ESR1	P03372	1 Reference(s)
T54VET	Protein tyrosine phosphatase type IVA 3	PTP4A3	O75365	2 Reference(s)
T11ZYR	Cytochrome P450 2D6	CYP2D6	P10635	1 Reference(s)
T88TDZ	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	10 Reference(s)
T50WOV	ATP-dependent translocase ABCB1	ABCB1	P08183	2 Reference(s)
T37BP1	Serine/threonine-protein kinase pim-1	PIM1	P11309	1 Reference(s)
T20VPX	Cyclin-dependent-like kinase 5	CDK5	Q00535	1 Reference(s)
T00RT4	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	P20839	1 Reference(s)
T68B5V	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	P12268	1 Reference(s)
T78C6N	Cathepsin K	CTSK	P43235	1 Reference(s)
T84W8G	Aryl hydrocarbon receptor	AHR	P35869	2 Reference(s)
T75EH8	Glucagon-like peptide 1 receptor	GLP1R	P43220	1 Reference(s)
T69RXK	Cytochrome P450 2C9	CYP2C9	P11712	1 Reference(s)
T25M2J	Anoctamin-1	ANO1	Q5XXA6	1 Reference(s)
T38T1U	Caspase-8	CASP8	Q14790	2 Reference(s)
T04TWI	CD40 ligand	CD40LG	P29965	1 Reference(s)
T94S85	Collagen alpha-1(I) chain	COL1A1	P02452	1 Reference(s)
T48XM4	Glutathione S-transferase Mu 2	GSTM2	P28161	1 Reference(s)
T87WYU	Glutathione S-transferase Mu 1	GSTM1	P09488	1 Reference(s)
T34DZ7	Interleukin-2	IL2	P60568	1 Reference(s)
T71GRQ	Hexokinase-2	HK2	P52789	1 Reference(s)
T99XQ3	DNA topoisomerase 1	TOP1	P11387	2 Reference(s)
T66BXF	Transcription factor E2F2	E2F2	Q14209	1 Reference(s)
T08Q7W	Prostaglandin G/H synthase 2	PTGS2	P35354	11 Reference(s)
T09H2Z	Nitric oxide synthase, inducible	NOS2	P35228	13 Reference(s)
T80OJF	Interstitial collagenase	MMP1	P03956	4 Reference(s)
T44LWL	Transcription factor p65	RELA	Q04206	9 Reference(s)
T65JYL	C-X-C motif chemokine 2	CXCL2	P19875	2 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	10 Reference(s)
T00CXT	Prostaglandin G/H synthase 1	PTGS1	P23219	3 Reference(s)
T10HL8	Intercellular adhesion molecule 1	ICAM1	P05362	5 Reference(s)
T97FEF	Broad substrate specificity ATP-binding cassette transporter ABCG2	ABCG2	Q9UNQ0	2 Reference(s)
T41INV	Nuclear receptor subfamily 1 group I member 3	NR1I3	Q14994	1 Reference(s)
T24LXT	G2/mitotic-specific cyclin-B1	CCNB1	P14635	4 Reference(s)
T07TMB	Cyclin-dependent kinase 1	CDK1	P06493	2 Reference(s)
T64W2K	Cyclin-dependent kinase inhibitor 1	CDKN1A	P38936	7 Reference(s)
T41TXS	Retinoblastoma-associated protein	RB1	P06400	2 Reference(s)
T28EY5	Serine/threonine-protein kinase Chk2	CHEK2	O96017	1 Reference(s)
T54SZZ	Endoplasmic reticulum chaperone BiP	HSPA5	P11021	1 Reference(s)
T59IKQ	Vascular cell adhesion protein 1	VCAM1	P19320	3 Reference(s)
T24U57	E-selectin	SELE	P16581	1 Reference(s)
T33OPP	Interleukin-6	IL6	P05231	3 Reference(s)
T64BTV	Interleukin-1 beta	IL1B	P01584	2 Reference(s)
T54CIF	Interleukin-8	CXCL8	P10145	2 Reference(s)
T71K92	Apoptosis regulator Bcl-2	BCL2	P10415	8 Reference(s)
T37VLU	Interferon gamma	IFNG	P01579	1 Reference(s)
T16A2X	Catalase	CAT	P04040	4 Reference(s)
T88B8X	Insulin receptor	INSR	P06213	1 Reference(s)
T68SE0	Solute carrier family 2, facilitated glucose transporter member 4	SLC2A4	P14672	3 Reference(s)
T74I49	Bcl-2-like protein 1	BCL2L1	Q07817	4 Reference(s)
T00EP2	Tissue-type plasminogen activator	PLAT	P00750	4 Reference(s)
T49ORJ	Peroxisome proliferator-activated receptor alpha	PPARA	Q07869	1 Reference(s)
T17UP9	C-C motif chemokine 2	CCL2	P13500	3 Reference(s)
T88AJI	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	2 Reference(s)
T93WZG	G1/S-specific cyclin-D1	CCND1	P24385	3 Reference(s)
T42EAZ	Vascular endothelial growth factor A	VEGFA	P15692	3 Reference(s)
T06MQM	Heat shock protein beta-1	HSPB1	P04792	2 Reference(s)
T22OPB	Nuclear factor erythroid 2-related factor 2	NFE2L2	Q16236	3 Reference(s)
T90XYZ	C-reactive protein	CRP	P02741	2 Reference(s)
T05RAA	Inhibitor of nuclear factor kappa-B kinase subunit alpha	CHUK	O15111	1 Reference(s)
T67HAF	Signal transducer and activator of transcription 1-alpha/beta	STAT1	P42224	2 Reference(s)
T69NG6	Interleukin-10	IL10	P22301	2 Reference(s)
T82ALJ	Glycogen synthase kinase-3 beta	GSK3B	P49841	1 Reference(s)
T26EZU	Myc proto-oncogene protein	MYC	P01106	1 Reference(s)
T54VQA	Cyclin-dependent kinase inhibitor 2A	CDKN2A	P42771	2 Reference(s)
T55EFK	Transcription factor E2F1	E2F1	Q01094	1 Reference(s)
T23WMS	Cathepsin D	CTSD	P07339	1 Reference(s)
T84P70	Urokinase-type plasminogen activator	PLAU	P00749	3 Reference(s)
T20JZ2	Androgen receptor	AR	P10275	2 Reference(s)
T91EAB	Insulin-like growth factor-binding protein 3	IGFBP3	P17936	2 Reference(s)
T94YOD	Interferon regulatory factor 1	IRF1	P10914	1 Reference(s)
T86ROZ	Heme oxygenase 1	HMOX1	P09601	3 Reference(s)
T09AAD	NADPH--cytochrome P450 reductase	POR	P16435	1 Reference(s)
T67ZT3	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTEN	P60484	1 Reference(s)
T78ZF2	Protein kinase C alpha type	PRKCA	P17252	1 Reference(s)
T14JZK	Receptor tyrosine-protein kinase erbB-3	ERBB3	P21860	2 Reference(s)
T64UH1	Nitric oxide synthase, endothelial	NOS3	P29474	2 Reference(s)
T38WWN	Serum paraoxonase/arylesterase 1	PON1	P27169	1 Reference(s)
T78VUO	RAF proto-oncogene serine/threonine-protein kinase	RAF1	P04049	1 Reference(s)
T57GP2	ETS domain-containing protein Elk-1	ELK1	P19419	1 Reference(s)
T79KQO	NF-kappa-B inhibitor alpha	NFKBIA	P25963	1 Reference(s)
T87DEX	Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	XDH	P47989	2 Reference(s)
T52CKD	Pro-epidermal growth factor	EGF	P01133	1 Reference(s)
T16OQ5	Puromycin-sensitive aminopeptidase	NPEPPS	P55786	1 Reference(s)
T08DOL	Sulfotransferase 1E1	SULT1E1	P49888	1 Reference(s)
T00H7Q	Neutrophil cytosol factor 1	NCF1	P14598	1 Reference(s)
T75HMM	Induced myeloid leukemia cell differentiation protein Mcl-1	MCL1	Q07820	1 Reference(s)
T37I29	NA	VIM2P	NA	1 Reference(s)
T77UWH	CCAAT/enhancer-binding protein beta	CEBPB	P17676	1 Reference(s)
T16MRU	NACHT, LRR and PYD domains-containing protein 3	NLRP3	Q96P20	1 Reference(s)
T54RF5	DnaJ homolog subfamily C member 5	DNAJC5	Q9H3Z4	1 Reference(s)
T63DP6	Heterogeneous nuclear ribonucleoprotein A1	HNRNPA1	P09651	1 Reference(s)
T25NSJ	Mitogen-activated protein kinase 3	MAPK3	P27361	2 Reference(s)
T54N7G	Fos-related antigen 1	FOSL1	P15407	1 Reference(s)
T91OUC	Mucin-5AC	MUC5AC	P98088	1 Reference(s)
T71BDH	Mitogen-activated protein kinase 14	MAPK14	Q16539	2 Reference(s)
T81MSV	Ubiquitin carboxyl-terminal hydrolase 10	USP10	Q14694	1 Reference(s)
T29MD1	Mitogen-activated protein kinase 8	MAPK8	P45983	3 Reference(s)
T03VS9	Protein-tyrosine kinase 2-beta	PTK2B	Q14289	1 Reference(s)
T02GD4	Tumor necrosis factor ligand superfamily member 6	FASLG	P48023	2 Reference(s)
T97KL5	Microsomal glutathione S-transferase 1	MGST1	P10620	2 Reference(s)
T81BH5	Sulfotransferase 1A1	SULT1A1	P50225	2 Reference(s)
T32SPJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	P48736	1 Reference(s)
T88LSZ	Aromatase	CYP19A1	P11511	1 Reference(s)
T48TW0	Platelet glycoprotein 4	CD36	P16671	1 Reference(s)
T31SX8	Bone morphogenetic protein 2	BMP2	P12643	2 Reference(s)
T36NQ9	Mothers against decapentaplegic homolog 1	SMAD1	Q15797	2 Reference(s)
T96OOK	Signal transducer and activator of transcription 3	STAT3	P40763	2 Reference(s)
T22J9V	Tyrosine-protein kinase JAK1	JAK1	P23458	1 Reference(s)
T68CKY	Tyrosine-protein kinase Fyn	FYN	P06241	1 Reference(s)
T37WY2	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	PCK1	P35558	1 Reference(s)
T68AKE	Zinc fingers and homeoboxes protein 2	ZHX2	Q9Y6X8	1 Reference(s)
T14DX3	Ribosomal protein S6 kinase alpha-3	RPS6KA3	P51812	1 Reference(s)
T06Q1R	Amine oxidase [flavin-containing] B	MAOB	P27338	1 Reference(s)
T53AOE	Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide	TGFB1	P01137	1 Reference(s)
T23LHE	Claudin-4	CLDN4	O14493	1 Reference(s)
T63YAO	Caveolin-1	CAV1	Q03135	1 Reference(s)
T31G6V	Ras association domain-containing protein 1	RASSF1	Q9NS23	1 Reference(s)
T34HYH	Interleukin-1 alpha	IL1A	P01583	1 Reference(s)
T79UQC	C-X-C motif chemokine 10	CXCL10	P02778	1 Reference(s)
T36SOV	Plasminogen activator inhibitor 1	SERPINE1	P05121	1 Reference(s)
T50VJF	Osteopontin	SPP1	P10451	1 Reference(s)
T91MKC	Runt-related transcription factor 2	RUNX2	Q13950	1 Reference(s)
T17CZC	Tissue factor	F3	P13726	1 Reference(s)
T84TJB	Homeobox protein Nkx-3.1	NKX3-1	Q99801	1 Reference(s)
T02WMA	Ornithine decarboxylase	ODC1	P11926	1 Reference(s)
T38EQ6	NAD(P)H dehydrogenase [quinone] 1	NQO1	P15559	1 Reference(s)
T63GUB	Proto-oncogene c-Fos	FOS	P01100	1 Reference(s)
T17CNB	Thioredoxin	TXN	P10599	2 Reference(s)
T09KPZ	Vimentin	VIM	P08670	1 Reference(s)
T43LYL	X-box-binding protein 1	XBP1	P17861	1 Reference(s)
T00T9M	Thrombospondin-1	THBS1	P07996	1 Reference(s)
T61DYZ	Phospholipid-transporting ATPase ABCA1	ABCA1	O95477	2 Reference(s)
T05WWN	Corticoliberin	CRH	P06850	1 Reference(s)
T47WT6	Breast cancer type 1 susceptibility protein	BRCA1	P38398	1 Reference(s)
T02M5I	Monocarboxylate transporter 1	SLC16A1	P53985	1 Reference(s)
T30L86	Tumor necrosis factor receptor superfamily member 10B	TNFRSF10B	O14763	1 Reference(s)
T34Y7V	Carbohydrate-responsive element-binding protein	MLXIPL	Q9NP71	1 Reference(s)
T12T4H	Brain-derived neurotrophic factor	BDNF	P23560	1 Reference(s)
T57L0X	Oxysterols receptor LXR-alpha	NR1H3	Q13133	1 Reference(s)
T76CGR	Pentraxin-related protein PTX3	PTX3	P26022	1 Reference(s)
T95IYZ	Adiponectin	ADIPOQ	Q15848	1 Reference(s)
T91KTQ	Methyl-CpG-binding protein 2	MECP2	P51608	1 Reference(s)
T04HXV	Cytochrome b-c1 complex subunit 1, mitochondrial	UQCRC1	P31930	1 Reference(s)
T86O9J	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	P19404	1 Reference(s)
T18DUA	Tight junction protein ZO-1	TJP1	Q07157	2 Reference(s)
T67JME	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	A8MPY1	1 Reference(s)
T67X1L	Eukaryotic translation initiation factor 2 subunit 1	EIF2S1	P05198	1 Reference(s)
T29JA7	P2X purinoceptor 4	P2RX4	Q99571	1 Reference(s)
T97ESI	Apolipoprotein E	APOE	P02649	1 Reference(s)
T93NTV	Ketohexokinase	KHK	P50053	1 Reference(s)
T82S6C	Hexokinase-4	GCK	P35557	1 Reference(s)
T74JJN	Fatty acid synthase	FASN	P49327	1 Reference(s)
T78ILO	Stearoyl-CoA desaturase	SCD	O00767	1 Reference(s)
T75B9S	Cyclic AMP-responsive element-binding protein 1	CREB1	P16220	1 Reference(s)
T37ADS	Early growth response protein 1	EGR1	P18146	1 Reference(s)
T84CEG	Claudin-5	CLDN5	O00501	1 Reference(s)
T60XS5	Lymphoid enhancer-binding factor 1	LEF1	Q9UJU2	1 Reference(s)
T52T5O	Axin-1	AXIN1	O15169	1 Reference(s)
T78EXU	Axin-2	AXIN2	Q9Y2T1	1 Reference(s)
T29B10	Interleukin-17A	IL17A	Q16552	1 Reference(s)
T23KDW	Cyclic AMP-dependent transcription factor ATF-4	ATF4	P18848	1 Reference(s)
T31JWV	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	PIK3CB	P42338	1 Reference(s)
T83QHM	Beta-nerve growth factor	NGF	P01138	1 Reference(s)
T08B2M	M-phase inducer phosphatase 1	CDC25A	P30304	1 Reference(s)
T33UEM	Lactoperoxidase	LPO	P22079	1 Reference(s)
T03TJ0	Interleukin-33	IL33	O95760	1 Reference(s)
T40G6B	Prostaglandin reductase 1	PTGR1	Q14914	1 Reference(s)
T31VDH	Myeloid differentiation primary response protein MyD88	MYD88	Q99836	1 Reference(s)
T58J2Y	Peroxisome proliferator-activated receptor gamma	PPARG	P37231	1 Reference(s)
T02JCT	Protein AATF	AATF	Q9NY61	1 Reference(s)
T08J6P	NA	MIR146B	NA	1 Reference(s)
T51WGR	Pancreas/duodenum homeobox protein 1	PDX1	P52945	1 Reference(s)
T90ORW	Bcl2-associated agonist of cell death	BAD	Q92934	1 Reference(s)
T39M6J	ATP-binding cassette sub-family C member 2	ABCC2	Q92887	1 Reference(s)

Herb ID: H0567	Chinese Character: 土大黄
English Name: NA	Latin Name: Rumex obtusifolius
Chinese Pin Yin : Tu Da Huang	TCM-ID: TCMH2130
Therapeutic Function in Chinese : NA	Therapeutic Function in English: NA
Herb Function: NA

Herb Description

Related Targets (Total: 247)

Related Compounds (Total: 6)