Compound Description

ID:   C1225 Common name:   Cgmp
IUPAC:  9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-3H-purin-6-one CAS:  CAS:7665-99-8
Chembl ID:   CHEMBL395336 Pubchem ID:   CID:24316
Formula:  C10H12N5O7P TCM-ID:  TCMC888
Smiles:  O[C@@H]1[C@@H]2OP(=O)(O)OC[C@H]2O[C@H]1n1cnc2c1[nH]c(=N)nc2O
Alias:

Guanosine 3',5'-phosphate (cyclic);

4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, guanosine deriv.;

3',5'-Cyclic GMP;

3',5'-GMP;

Cyclic 3',5'-GMP;

Cyclic 3',5'-guanylic acid;

Cyclic GMP;

Cyclic guanosine 3',5'-monophosphate;

Cyclic guanosine monophosphate;

Guanosine 3',5'-monophosphate;

Guanosine 3',5'-phosphate;

Guanosine cyclic 3',5'-monophosphate;

Guanosine cyclic 3',5'-phosphate;

cGMP
Structure:

Related Targets  (Total: 20)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T99TRQ cGMP-dependent 3',5'-cyclic phosphodiesterasePDE2A O00408
A 1 Reference(s)
T09HVO Sodium/hydrogen exchanger 3SLC9A3 P48764
A 2 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
A 1 Reference(s)
T92P67 Vasodilator-stimulated phosphoproteinVASP P50552
B 1 Reference(s)
T68EUG Cyclic nucleotide-gated cation channel alpha-3CNGA3 Q16281
B 1 Reference(s)
T91XPP Beta-sarcoglycanSGCB Q16585
B 1 Reference(s)
T68CKY Tyrosine-protein kinase FynFYN P06241
B 1 Reference(s)
T68IZC Natriuretic peptides BNPPB P16860
B 1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
B 1 Reference(s)
T40Q3U Retinal guanylyl cyclase 1GUCY2D Q02846
B 1 Reference(s)
T10I26 Interferon betaIFNB1 P01574
B 1 Reference(s)
T53MV1 cGMP-dependent protein kinase 1PRKG1 Q13976
B 1 Reference(s)
T85K8L Forkhead box protein O1FOXO1 Q12778
B 1 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
B 1 Reference(s)
T78F9O Mucosal addressin cell adhesion molecule 1MADCAM1 Q13477
C 1 Reference(s)
T54G8J Protein kinase C delta typePRKCD Q05655
C 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
C 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
C 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
C 1 Reference(s)
T64P00 Metabotropic glutamate receptor 5GRM5 P41594
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 3)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens