Target Description

Type Detail
Target ID T99TRQ
Protein Name cGMP-dependent 3',5'-cyclic phosphodiesterase
Uniprot ID O00408
Protein Name Alias EC;  Cyclic GMP-stimulated phosphodiesterase;  CGS-PDE;  cGSPDE
Gene ID 5138
Gene Symbol PDE2A
Gene Alias NA
TTD T77400: Clinical Trial target
Pfam PF00233 ; PF01590 ; PF13185
0042802:identical protein binding


0042301:phosphate ion binding

0010752:regulation of cGMP-mediated signaling

0004115:3',5'-cyclic-AMP phosphodiesterase activity

0061028:establishment of endothelial barrier

0003170:heart valve development

0035904:aorta development

0030911:TPR domain binding

0004118:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity

0097011:cellular response to granulocyte macrophage colony-stimulating factor stimulus

1904613:cellular response to 2,3,7,8-tetrachlorodibenzodioxine

0071260:cellular response to mechanical stimulus


0036006:cellular response to macrophage colony-stimulating factor stimulus

0043117:positive regulation of vascular permeability

0019934:cGMP-mediated signaling

0035690:cellular response to drug

0043951:negative regulation of cAMP-mediated signaling

0043116:negative regulation of vascular permeability

0071560:cellular response to transforming growth factor beta stimulus

0004114:3',5'-cyclic-nucleotide phosphodiesterase activity

0030553:cGMP binding

0005759:mitochondrial matrix

0010628:positive regulation of gene expression

0005783:endoplasmic reticulum

0005886:plasma membrane

0048471:perinuclear region of cytoplasm

0000287:magnesium ion binding

0071320:cellular response to cAMP

0019933:cAMP-mediated signaling

0005741:mitochondrial outer membrane

0003281:ventricular septum development

0071321:cellular response to cGMP

0050729:positive regulation of inflammatory response

0010754:negative regulation of cGMP-mediated signaling

0030552:cAMP binding

0046069:cGMP catabolic process

0010821:regulation of mitochondrion organization

0005794:Golgi apparatus

0000122:negative regulation of transcription by RNA polymerase II

0008270:zinc ion binding

0042803:protein homodimerization activity


0042734:presynaptic membrane

0007165:signal transduction

0007186:G protein-coupled receptor signaling pathway

0005743:mitochondrial inner membrane

0047555:3',5'-cyclic-GMP phosphodiesterase activity

0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

0030224:monocyte differentiation

0043949:regulation of cAMP-mediated signaling

0097060:synaptic membrane

PDB 3IBJ ; 5U7J ; 5TZZ ; 5U00 ; 4HTX ; 6B96 ; 4D09 ; 3ITM ; 6C7E ; 6CYD ; 5TZH ; 6B97 ; 6C7F ; 5TZC ; 1Z1L ; 5U7I ; 5TZ3 ; 6B98 ; 5TZA ; 5U7D ; 5TZW ; 4C1I ; 6CYB ; 4JIB ; 6C7D ; 5TZX ; 5U7L ; 6ZND ; 6C7G ; 6C7I ; 6CYC ; 5VP1 ; 5VP0 ; 6ZQZ ; 5U7K ; 6BLF ; 6C7J ; 3ITU ; 5XKM ; 4HTZ ; 4D08
Drugbank DB05142 ; DB07954 ; DB09283 ; DB06246 ; DB08811 ; DB00201 ; DB02315
KEGG hsa:5138

Related Compounds  (Total: 1)

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Name: Cgmp

Related Herbs  (Total: 3)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens