HIT-result

Type	Detail
Target ID	T99TRQ
Protein Name	cGMP-dependent 3',5'-cyclic phosphodiesterase
Uniprot ID	O00408
Protein Name Alias	EC 3.1.4.17; Cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE
Gene ID	5138
Gene Symbol	PDE2A
Gene Alias	NA
TTD	T77400: Clinical Trial target
Pfam	PF00233 ; PF01590 ; PF13185
GO	0042802:identical protein binding 0005634:nucleus 0042301:phosphate ion binding 0010752:regulation of cGMP-mediated signaling 0004115:3',5'-cyclic-AMP phosphodiesterase activity 0061028:establishment of endothelial barrier 0003170:heart valve development 0035904:aorta development 0030911:TPR domain binding 0004118:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity 0097011:cellular response to granulocyte macrophage colony-stimulating factor stimulus 1904613:cellular response to 2,3,7,8-tetrachlorodibenzodioxine 0071260:cellular response to mechanical stimulus 0005829:cytosol 0036006:cellular response to macrophage colony-stimulating factor stimulus 0043117:positive regulation of vascular permeability 0019934:cGMP-mediated signaling 0035690:cellular response to drug 0043951:negative regulation of cAMP-mediated signaling 0043116:negative regulation of vascular permeability 0071560:cellular response to transforming growth factor beta stimulus 0004114:3',5'-cyclic-nucleotide phosphodiesterase activity 0030553:cGMP binding 0005759:mitochondrial matrix 0010628:positive regulation of gene expression 0005783:endoplasmic reticulum 0005886:plasma membrane 0048471:perinuclear region of cytoplasm 0000287:magnesium ion binding 0071320:cellular response to cAMP 0019933:cAMP-mediated signaling 0005741:mitochondrial outer membrane 0003281:ventricular septum development 0071321:cellular response to cGMP 0050729:positive regulation of inflammatory response 0010754:negative regulation of cGMP-mediated signaling 0030552:cAMP binding 0046069:cGMP catabolic process 0010821:regulation of mitochondrion organization 0005794:Golgi apparatus 0000122:negative regulation of transcription by RNA polymerase II 0008270:zinc ion binding 0042803:protein homodimerization activity 0005737:cytoplasm 0042734:presynaptic membrane 0007165:signal transduction 0007186:G protein-coupled receptor signaling pathway 0005743:mitochondrial inner membrane 0047555:3',5'-cyclic-GMP phosphodiesterase activity 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0030224:monocyte differentiation 0043949:regulation of cAMP-mediated signaling 0097060:synaptic membrane
PDB	3IBJ ; 5U7J ; 5TZZ ; 5U00 ; 4HTX ; 6B96 ; 4D09 ; 3ITM ; 6C7E ; 6CYD ; 5TZH ; 6B97 ; 6C7F ; 5TZC ; 1Z1L ; 5U7I ; 5TZ3 ; 6B98 ; 5TZA ; 5U7D ; 5TZW ; 4C1I ; 6CYB ; 4JIB ; 6C7D ; 5TZX ; 5U7L ; 6ZND ; 6C7G ; 6C7I ; 6CYC ; 5VP1 ; 5VP0 ; 6ZQZ ; 5U7K ; 6BLF ; 6C7J ; 3ITU ; 5XKM ; 4HTZ ; 4D08
Drugbank	DB05142 ; DB07954 ; DB09283 ; DB06246 ; DB08811 ; DB00201 ; DB02315
KEGG	hsa:5138

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Name: Cgmp

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens