HIT-result

Target Description

Type	Detail
Target ID	T64P00
Protein Name	Metabotropic glutamate receptor 5
Uniprot ID	P41594
Protein Name Alias	mGluR5
Gene ID	2915
Gene Symbol	GRM5
Gene Alias	GPRC1E; MGLUR5
TTD	T99347: Clinical Trial target
Pfam	PF10606 ; PF01094 ; PF00003 ; PF07562
GO	0090647:modulation of age-related behavioral decline 0001932:regulation of protein phosphorylation 0007626:locomotory behavior 0035584:calcium-mediated signaling using intracellular calcium source 0007612:learning 1902938:regulation of intracellular calcium activated chloride channel activity 0006448:regulation of translational elongation 1990782:protein tyrosine kinase binding 0099170:postsynaptic modulation of chemical synaptic transmission 0099583:neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 0099553:trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 0048169:regulation of long-term neuronal synaptic plasticity 0007611:learning or memory 0042802:identical protein binding 1904646:cellular response to amyloid-beta 0051966:regulation of synaptic transmission, glutamatergic 0061098:positive regulation of protein tyrosine kinase activity 0098839:postsynaptic density membrane 0008066:glutamate receptor activity 0050808:synapse organization 0050890:cognition 0007216:G protein-coupled glutamate receptor signaling pathway 0001640:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 0004930:G protein-coupled receptor activity 0005886:plasma membrane 0007186:G protein-coupled receptor signaling pathway 0007206:phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 0030296:protein tyrosine kinase activator activity 0098685:Schaffer collateral - CA1 synapse 0005887:integral component of plasma membrane 0006417:regulation of translation 0099530:G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 0043005:neuron projection 0005737:cytoplasm 0007268:chemical synaptic transmission
PDB	6N50 ; 6N51 ; 5CGD ; 6N52 ; 3LMK ; 4OO9 ; 6N4X ; 6N4Y ; 5CGC
Drugbank	DB05070 ; DB06201 ; DB00659 ; DB12733
KEGG	hsa:2915

Type

Detail

Target ID

T64P00

Protein Name

Metabotropic glutamate receptor 5

Uniprot ID

P41594

Protein Name Alias

mGluR5

Gene ID

2915

Gene Symbol

GRM5

Gene Alias

GPRC1E; MGLUR5

TTD

T99347: Clinical Trial target

Pfam

PF10606 ; PF01094 ; PF00003 ; PF07562

0090647:modulation of age-related behavioral decline

0001932:regulation of protein phosphorylation

0007626:locomotory behavior

0035584:calcium-mediated signaling using intracellular calcium source

0007612:learning

1902938:regulation of intracellular calcium activated chloride channel activity

0006448:regulation of translational elongation

1990782:protein tyrosine kinase binding

0099170:postsynaptic modulation of chemical synaptic transmission

0099583:neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

0099553:trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

0048169:regulation of long-term neuronal synaptic plasticity

0007611:learning or memory

0042802:identical protein binding

1904646:cellular response to amyloid-beta

0051966:regulation of synaptic transmission, glutamatergic

0061098:positive regulation of protein tyrosine kinase activity

0098839:postsynaptic density membrane

0008066:glutamate receptor activity

0050808:synapse organization

0050890:cognition

0007216:G protein-coupled glutamate receptor signaling pathway

0001640:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

0004930:G protein-coupled receptor activity

0005886:plasma membrane

0007186:G protein-coupled receptor signaling pathway

0007206:phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

0030296:protein tyrosine kinase activator activity

0098685:Schaffer collateral - CA1 synapse

0005887:integral component of plasma membrane

0006417:regulation of translation

0099530:G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

0043005:neuron projection

0005737:cytoplasm

0007268:chemical synaptic transmission

PDB

6N50 ; 6N51 ; 5CGD ; 6N52 ; 3LMK ; 4OO9 ; 6N4X ; 6N4Y ; 5CGC

Drugbank

DB05070 ; DB06201 ; DB00659 ; DB12733

KEGG

hsa:2915

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H0334	Bi Ma Ren	蓖麻仁	Ricinus	Ricinus communis
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0326	Bi Ma Gen	蓖麻根	Castorbean root	Ricinus communis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0340	Bi Ma Zi	蓖麻子	Castorbean seed	Ricinus communis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0321	Bi Ma	蓖麻	castor oil plant	Ricinus communis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0416	Shan Shen	山参	NA	Panax ginseng
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 18)