HIT-result

Type	Detail
Target ID	T41WA8
Protein Name	Ephrin type-A receptor 2
Uniprot ID	P29317
Protein Name Alias	EC 2.7.10.1; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK
Gene ID	1969
Gene Symbol	EPHA2
Gene Alias	ECK
TTD	T57278: Clinical Trial target
Pfam	PF00041 ; PF01404 ; PF14575 ; PF07714 ; PF00536
GO	0030316:osteoclast differentiation 0051898:negative regulation of protein kinase B signaling 1901491:negative regulation of lymphangiogenesis 0043535:regulation of blood vessel endothelial cell migration 0045765:regulation of angiogenesis 0005524:ATP binding 0033628:regulation of cell adhesion mediated by integrin 0002043:blood vessel endothelial cell proliferation involved in sprouting angiogenesis 0070309:lens fiber cell morphogenesis 1904238:pericyte cell differentiation 0043491:protein kinase B signaling 0016477:cell migration 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0009986:cell surface 0008630:intrinsic apoptotic signaling pathway in response to DNA damage 0005925:focal adhesion 0019838:growth factor binding 0060326:cell chemotaxis 0007275:multicellular organism development 0001618:virus receptor activity 0001501:skeletal system development 0031258:lamellipodium membrane 0048320:axial mesoderm formation 0030216:keratinocyte differentiation 0060444:branching involved in mammary gland duct morphogenesis 0046058:cAMP metabolic process 0090630:activation of GTPase activity 0050830:defense response to Gram-positive bacterium 0033598:mammary gland epithelial cell proliferation 0001570:vasculogenesis 0005886:plasma membrane 0033674:positive regulation of kinase activity 1903348:positive regulation of bicellular tight junction assembly 0046849:bone remodeling 0043005:neuron projection 0005887:integral component of plasma membrane 0030027:lamellipodium 0005005:transmembrane-ephrin receptor activity 0032587:ruffle membrane 0016525:negative regulation of angiogenesis 0032682:negative regulation of chemokine production 0021915:neural tube development 0001649:osteoblast differentiation 0036342:post-anal tail morphogenesis 0014028:notochord formation 0072659:protein localization to plasma membrane 0070848:response to growth factor 0043235:receptor complex 0048013:ephrin receptor signaling pathway 0031256:leading edge membrane 0007411:axon guidance 1903078:positive regulation of protein localization to plasma membrane 0045296:cadherin binding 0006954:inflammatory response 0070372:regulation of ERK1 and ERK2 cascade 0010591:regulation of lamellipodium assembly 0007155:cell adhesion 0060035:notochord cell development 0004714:transmembrane receptor protein tyrosine kinase activity 0048870:cell motility 0070160:tight junction
PDB	3MX0 ; 7B7N ; 6NJZ ; 5IA4 ; 6NK2 ; 1MQB ; 5IA2 ; 5NKB ; 4PDO ; 2KSO ; 5I9V ; 6HEW ; 5IA5 ; 6Q7E ; 5I9X ; 2K9Y ; 6FNG ; 6Q7G ; 6HET ; 5NK7 ; 4TRL ; 6NK1 ; 6NK0 ; 3HEI ; 5EK7 ; 3MBW ; 5NKG ; 6HEU ; 5NK8 ; 6Q7C ; 5NK4 ; 3SKJ ; 5NK6 ; 6FNF ; 5IA0 ; 5NKH ; 5I9W ; 5NK9 ; 3HPN ; 5NK2 ; 6HEY ; 6B9L ; 6HEV ; 3FL7 ; 3KKA ; 2X11 ; 6HEX ; 6FNH ; 2E8N ; 4P2K ; 5IA1 ; 5NKA ; 5NKC ; 6Q7D ; 6Q7F ; 5NKF ; 5NK1 ; 6HES ; 3C8X ; 6F7M ; 7CZF ; 6F7N ; 5I9Z ; 7CZE ; 2X10 ; 5NJZ ; 6Q7B ; 5NKI ; 5IA3 ; 3CZU ; 5I9Y ; 5I9U ; 5NK3 ; 5NKD ; 5NZ9 ; 6RW2 ; 6NKP ; 5NK0 ; 5NK5 ; 5NKE
Drugbank	DB04395 ; DB01254 ; DB08896 ; DB12010
KEGG	hsa:1969

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0919	Cui Yun Cao	翠云草	Hooked spikemoss	Selaginella uncinata
H0189	Lv Cha	绿茶	Green tea	Folium camelliae sinensis
H0461	Shi Jun Zi Ren	使君子仁	NA	Combretum indicum
H0424	Shan Zhi	山栀	Cape jasmine	Gardenia jasminoides
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0204	Ma Ren	麻仁	NA	Cannabis sativa
H1034	Fei Yang Cao	飞杨草	NA	Euphorbia hirta
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0819	Zhi Zi Jin Gao	栀子浸膏	Cape jasmine fruit	Gardenia jasminoides
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0003	Huo Ma Ren	火麻仁	Hemp fimble seed	Cannabis sativa
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0818	Zhi Zi	栀子	Cape jasmine fruit	Gardenia jasminoides
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0721	Yang Mei Gen	杨梅根	Myrica rubra sieb. et zucc	Myrica rubra
H0692	Xue Ren Shen	血人参	NA	Lespedeza bicolor

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 24)