HIT-result

Target Description

Type	Detail
Target ID	T94K7H
Protein Name	Cytochrome P450 7A1
Uniprot ID	P22680
Protein Name Alias	24-hydroxycholesterol 7-alpha-hydroxylase; EC 1.14.14.26; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; EC 1.14.14.23
Gene ID	1581
Gene Symbol	CYP7A1
Gene Alias	CYP7
TTD	NA
Pfam	PF00067
GO	0008395:steroid hydroxylase activity 0020037:heme binding 0045471:response to ethanol 0016125:sterol metabolic process 0043231:intracellular membrane-bounded organelle 0033782:24-hydroxycholesterol 7alpha-hydroxylase activity 0032966:negative regulation of collagen biosynthetic process 0016021:integral component of membrane 0005789:endoplasmic reticulum membrane 0005506:iron ion binding 0038183:bile acid signaling pathway 0071397:cellular response to cholesterol 0019222:regulation of metabolic process 0010468:regulation of gene expression 0006699:bile acid biosynthetic process 0015721:bile acid and bile salt transport 0045542:positive regulation of cholesterol biosynthetic process 0070857:regulation of bile acid biosynthetic process 0071333:cellular response to glucose stimulus 0006707:cholesterol catabolic process 0008123:cholesterol 7-alpha-monooxygenase activity 0042632:cholesterol homeostasis 0045717:negative regulation of fatty acid biosynthetic process
PDB	3V8D ; 3SN5 ; 3DAX
Drugbank	NA
KEGG	hsa:1581

Type

Detail

Target ID

T94K7H

Protein Name

Cytochrome P450 7A1

Uniprot ID

P22680

Protein Name Alias

24-hydroxycholesterol 7-alpha-hydroxylase; EC 1.14.14.26; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; EC 1.14.14.23

Gene ID

1581

Gene Symbol

CYP7A1

Gene Alias

CYP7

TTD

Pfam

PF00067

0008395:steroid hydroxylase activity

0020037:heme binding

0045471:response to ethanol

0016125:sterol metabolic process

0043231:intracellular membrane-bounded organelle

0033782:24-hydroxycholesterol 7alpha-hydroxylase activity

0032966:negative regulation of collagen biosynthetic process

0016021:integral component of membrane

0005789:endoplasmic reticulum membrane

0005506:iron ion binding

0038183:bile acid signaling pathway

0071397:cellular response to cholesterol

0019222:regulation of metabolic process

0010468:regulation of gene expression

0006699:bile acid biosynthetic process

0015721:bile acid and bile salt transport

0045542:positive regulation of cholesterol biosynthetic process

0070857:regulation of bile acid biosynthetic process

0071333:cellular response to glucose stimulus

0006707:cholesterol catabolic process

0008123:cholesterol 7-alpha-monooxygenase activity

0042632:cholesterol homeostasis

0045717:negative regulation of fatty acid biosynthetic process

PDB

3V8D ; 3SN5 ; 3DAX

Drugbank

KEGG

hsa:1581

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0189	Lv Cha	绿茶	Green tea	Folium camelliae sinensis
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0818	Zhi Zi	栀子	Cape jasmine fruit	Gardenia jasminoides
H0721	Yang Mei Gen	杨梅根	Myrica rubra sieb. et zucc	Myrica rubra
H0094	Gou Qi	枸杞	Chinese wolfberry fruit	Lycium chinense
H0692	Xue Ren Shen	血人参	NA	Lespedeza bicolor
H0424	Shan Zhi	山栀	Cape jasmine	Gardenia jasminoides
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0736	Yi Dian Hong	一点红	Sowthistle tasselflower	Emilia sonchifolia
H0849	Zi Su Geng	紫苏梗	Common perilla stem	Perilla frutescens var. arguta
H0819	Zhi Zi Jin Gao	栀子浸膏	Cape jasmine fruit	Gardenia jasminoides
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0943	Dan Cai	淡菜	Mussel	Mytilus edulis
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H0850	Zi Su Ye	紫苏叶	Common perilla leaf	Perilla frutescens var. arguta
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0352	Quan Xie	全蝎	Scorpion	Buthus martensi
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H1163	He Bao Cao	荷包草	NA	Lamprocapnos spectabilis
H1034	Fei Yang Cao	飞杨草	NA	Euphorbia hirta
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum

Target Description

Related Compounds (Total: 8)

Related Herbs (Total: 27)