Compound Description

ID:   C0554 Common name:   Cholesterol
IUPAC:  10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol CAS:  CAS:57-88-5
Chembl ID:   CHEMBL3184306 Pubchem ID:   CID:304
Formula:  C27H46O TCM-ID:  TCMC2837
Smiles:  CC(CCCC(C1CCC2C1(C)CCC1C2CC=C2C1(C)CCC(C2)O)C)C
Alias:

Cholesterol;

(3β)-Cholest-5-en-3-ol;

(-)-Cholesterol;

3β-Hydroxycholest-5-ene
Structure:

Related Targets  (Total: 54)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T61DYZ Phospholipid-transporting ATPase ABCA1ABCA1 O95477
A 3 Reference(s)
T28PHS Angiotensin-converting enzymeACE P12821
A 2 Reference(s)
T69CTT Acetyl-CoA acetyltransferase, mitochondrialACAT1 P24752
A 1 Reference(s)
T50V79 Interleukin-4IL4 P05112
A 1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
A 1 Reference(s)
T77VME ATP-binding cassette sub-family F member 3ABCF3 Q9NUQ8
A 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 1 Reference(s)
T44BA7 Tripeptidyl-peptidase 2TPP2 P29144
A 1 Reference(s)
T84AR4 Smoothened homologSMO Q99835
A 1 Reference(s)
T17JU3 Keratin, type I cytoskeletal 20KRT20 P35900
A 1 Reference(s)
T99EYH Lipoprotein lipaseLPL P06858
A 1 Reference(s)
T68OIU CREB-regulated transcription coactivator 1CRTC1 Q6UUV9
A 1 Reference(s)
T67U3B Translocator proteinTSPO P30536
B 1 Reference(s)
T44S1A Apolipoprotein A-IAPOA1 P02647
B 1 Reference(s)
T49PL1 Low-density lipoprotein receptorLDLR P01130
B 1 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
B 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
C 1 Reference(s)
T80SD7 Sterol regulatory element-binding protein 2SREBF2 Q12772
C 1 Reference(s)
T79TJS Caveolin-3CAV3 P56539
C 1 Reference(s)
T50MQN NPC1-like intracellular cholesterol transporter 1NPC1L1 Q9UHC9
C 3 Reference(s)
T25H22 Protein kinase C beta typePRKCB P05771
C 2 Reference(s)
T90K33 ATP-binding cassette sub-family G member 5ABCG5 Q9H222
C 1 Reference(s)
T61M4P Nuclear receptor ROR-alphaRORA P35398
C 1 Reference(s)
T79UHV Prolow-density lipoprotein receptor-related protein 1LRP1 Q07954
C 1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
C 1 Reference(s)
T56FPY CD81 antigenCD81 P60033
C 1 Reference(s)
T89EW0 Aquaporin-8AQP8 O94778
C 1 Reference(s)
T21K0F Sarcoplasmic/endoplasmic reticulum calcium ATPase 3ATP2A3 Q93084
C 1 Reference(s)
T20JZ2 Androgen receptorAR P10275
C 1 Reference(s)
T07S6X Sulfotransferase 1C2SULT1C2 O00338
C 1 Reference(s)
T92MGC Phosphatidylcholine:ceramide cholinephosphotransferase 2SGMS2 Q8NHU3
C 1 Reference(s)
T89GCM Inward rectifier potassium channel 2KCNJ2 P63252
C 1 Reference(s)
T47HOW NAMIR185 NA
C 1 Reference(s)
T90IQF NAHULC NA
C 1 Reference(s)
T75NEV Aquaporin-1AQP1 P29972
C 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
C 1 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
C 1 Reference(s)
T86TYE Dehydrodolichyl diphosphate synthase complex subunit NUS1NUS1 Q96E22
C 1 Reference(s)
T93AZS NAECB2 NA
C 1 Reference(s)
T01E8J Amyloid-beta precursor proteinAPP P05067
C 1 Reference(s)
T38OH4 Caspase-1CASP1 P29466
C 1 Reference(s)
T30C1L Sorting nexin-8SNX8 Q9Y5X2
C 1 Reference(s)
T02Z3O Low-density lipoprotein receptor-related protein 6LRP6 O75581
C 1 Reference(s)
T97ESI Apolipoprotein EAPOE P02649
C 1 Reference(s)
T91DA5 StAR-related lipid transfer protein 5STARD5 Q9NSY2
C 1 Reference(s)
T17T4P NAMIR122 NA
C 1 Reference(s)
T08VQQ Proprotein convertase subtilisin/kexin type 9PCSK9 Q8NBP7
C 1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
C 1 Reference(s)
T04H8Y Beta-secretase 1BACE1 P56817
C 1 Reference(s)
T75SPS Fibroblast growth factor 1FGF1 P05230
C 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
C 1 Reference(s)
T94K7H Cytochrome P450 7A1CYP7A1 P22680
C 1 Reference(s)
T66IUC Homeobox protein Nkx-2.5NKX2-5 P52952
C 1 Reference(s)
T95EU5 ATP-binding cassette sub-family G member 8ABCG8 Q9H221
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 1)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0838 Zhu Zi Shen珠子参 Largeleaf japanese ginseng rhizomeRhizoma panacis majoris