Target Description

Type Detail
Target ID T66IUC
Protein Name Homeobox protein Nkx-2.5
Uniprot ID P52952
Protein Name Alias Cardiac-specific homeobox;  Homeobox protein CSX;  Homeobox protein NK-2 homolog E
Gene ID 1482
Gene Symbol NKX2-5
Gene Alias CSX;  NKX2.5;  NKX2E
TTD NA
Pfam PF00046
GO
0003148:outflow tract septum morphogenesis

0003285:septum secundum development

0003682:chromatin binding

0030097:hemopoiesis

0043565:sequence-specific DNA binding

0000785:chromatin

0030878:thyroid gland development

0055008:cardiac muscle tissue morphogenesis

0051891:positive regulation of cardioblast differentiation

0030154:cell differentiation

0005667:transcription regulator complex

0003221:right ventricular cardiac muscle tissue morphogenesis

0008284:positive regulation of cell population proliferation

0055014:atrial cardiac muscle cell development

0043066:negative regulation of apoptotic process

0010765:positive regulation of sodium ion transport

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0006357:regulation of transcription by RNA polymerase II

0032993:protein-DNA complex

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0010832:negative regulation of myotube differentiation

0055117:regulation of cardiac muscle contraction

0003161:cardiac conduction system development

0060048:cardiac muscle contraction

0035050:embryonic heart tube development

0003700:DNA-binding transcription factor activity

0055007:cardiac muscle cell differentiation

1990837:sequence-specific double-stranded DNA binding

0045944:positive regulation of transcription by RNA polymerase II

0032991:protein-containing complex

0055013:cardiac muscle cell development

1903779:regulation of cardiac conduction

0003007:heart morphogenesis

0001570:vasculogenesis

0010667:negative regulation of cardiac muscle cell apoptotic process

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0003228:atrial cardiac muscle tissue development

0090090:negative regulation of canonical Wnt signaling pathway

0048536:spleen development

0045823:positive regulation of heart contraction

0010735:positive regulation of transcription via serum response element binding

0003180:aortic valve morphogenesis

0000976:transcription regulatory region sequence-specific DNA binding

0045893:positive regulation of transcription, DNA-templated

0090575:RNA polymerase II transcription regulator complex

0005634:nucleus

0060261:positive regulation of transcription initiation from RNA polymerase II promoter

0060413:atrial septum morphogenesis

0007512:adult heart development

0000122:negative regulation of transcription by RNA polymerase II

0060037:pharyngeal system development

0008134:transcription factor binding

0001947:heart looping

0055015:ventricular cardiac muscle cell development

0060412:ventricular septum morphogenesis

0003677:DNA binding

0045666:positive regulation of neuron differentiation

0045892:negative regulation of transcription, DNA-templated

0001216:DNA-binding transcription activator activity

PDB 6WC5 ; 3RKQ ; 6WC2 ; 4S0H
Drugbank NA
KEGG hsa:1482

Related Compounds  (Total: 2)

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C0554
Name: Cholesterol
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C1234
Name: Cholesterol


Related Herbs  (Total: 24)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0287 Nao Yang Hua闹羊花 Chinese azaleaRhododendron molle
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H0838 Zhu Zi Shen珠子参 Largeleaf japanese ginseng rhizomeRhizoma panacis majoris
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0476 Can E蚕蛾 SilkwormBombyx mori
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0735 Yi Bei Mu伊贝母 Siberian fritillary equivalent plant: fritillaria walujewiiFritillaria pallidiflora