HIT-result

Target Description

Type	Detail
Target ID	T84AR4
Protein Name	Smoothened homolog
Uniprot ID	Q99835
Protein Name Alias	SMO; Protein Gx
Gene ID	6608
Gene Symbol	SMO
Gene Alias	SMOH
TTD	T66505: Successful target
Pfam	PF01534 ; PF01392
GO	0021904:dorsal/ventral neural tube patterning 0090190:positive regulation of branching involved in ureteric bud morphogenesis 0035264:multicellular organism growth 0048741:skeletal muscle fiber development 0021910:smoothened signaling pathway involved in ventral spinal cord patterning 0060684:epithelial-mesenchymal cell signaling 0034504:protein localization to nucleus 0070062:extracellular exosome 2000036:regulation of stem cell population maintenance 0030425:dendrite 0048143:astrocyte activation 0048873:homeostasis of number of cells within a tissue 0030335:positive regulation of cell migration 0030666:endocytic vesicle membrane 0040018:positive regulation of multicellular organism growth 0001947:heart looping 0046622:positive regulation of organ growth 0051799:negative regulation of hair follicle development 0007494:midgut development 0060644:mammary gland epithelial cell differentiation 0003140:determination of left/right asymmetry in lateral mesoderm 0061053:somite development 0045880:positive regulation of smoothened signaling pathway 0048745:smooth muscle tissue development 0021987:cerebral cortex development 0050679:positive regulation of epithelial cell proliferation 0021953:central nervous system neuron differentiation 0021542:dentate gyrus development 0042307:positive regulation of protein import into nucleus 0007224:smoothened signaling pathway 0021794:thalamus development 0051451:myoblast migration 0010628:positive regulation of gene expression 0097731:9+0 non-motile cilium 0005886:plasma membrane 0002053:positive regulation of mesenchymal cell proliferation 0001570:vasculogenesis 0043231:intracellular membrane-bounded organelle 0043392:negative regulation of DNA binding 0016021:integral component of membrane 0060413:atrial septum morphogenesis 0001701:in utero embryonic development 0010629:negative regulation of gene expression 0009952:anterior/posterior pattern specification 0001649:osteoblast differentiation 0004930:G protein-coupled receptor activity 0050821:protein stabilization 0042475:odontogenesis of dentin-containing tooth 2000826:regulation of heart morphogenesis 0007417:central nervous system development 0071397:cellular response to cholesterol 0070986:left/right axis specification 0071679:commissural neuron axon guidance 0048853:forebrain morphogenesis 0021696:cerebellar cortex morphogenesis 0021938:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation 0001755:neural crest cell migration 0000122:negative regulation of transcription by RNA polymerase II 0005929:cilium 0060170:ciliary membrane 0031069:hair follicle morphogenesis 0072285:mesenchymal to epithelial transition involved in metanephric renal vesicle formation 0003323:type B pancreatic cell development 0060242:contact inhibition 0061113:pancreas morphogenesis 0030857:negative regulation of epithelial cell differentiation 0007228:positive regulation of hh target transcription factor activity 0097542:ciliary tip 0001708:cell fate specification 0002052:positive regulation of neuroblast proliferation 0045944:positive regulation of transcription by RNA polymerase II 0007371:ventral midline determination 0043066:negative regulation of apoptotic process 0005113:patched binding
PDB	5V56 ; 6OT0 ; 6XBK ; 4QIM ; 4N4W ; 4O9R ; 6XBJ ; 4QIN ; 6XBM ; 5L7D ; 5L7I ; 5V57 ; 4JKV ; 6XBL
Drugbank	DB01047 ; DB09143 ; DB11978 ; DB06786 ; DB08828
KEGG	hsa:6608

Type

Detail

Target ID

T84AR4

Protein Name

Smoothened homolog

Uniprot ID

Q99835

Protein Name Alias

SMO; Protein Gx

Gene ID

6608

Gene Symbol

SMO

Gene Alias

SMOH

TTD

T66505: Successful target

Pfam

PF01534 ; PF01392

0021904:dorsal/ventral neural tube patterning

0090190:positive regulation of branching involved in ureteric bud morphogenesis

0035264:multicellular organism growth

0048741:skeletal muscle fiber development

0021910:smoothened signaling pathway involved in ventral spinal cord patterning

0060684:epithelial-mesenchymal cell signaling

0034504:protein localization to nucleus

0070062:extracellular exosome

2000036:regulation of stem cell population maintenance

0030425:dendrite

0048143:astrocyte activation

0048873:homeostasis of number of cells within a tissue

0030335:positive regulation of cell migration

0030666:endocytic vesicle membrane

0040018:positive regulation of multicellular organism growth

0001947:heart looping

0046622:positive regulation of organ growth

0051799:negative regulation of hair follicle development

0007494:midgut development

0060644:mammary gland epithelial cell differentiation

0003140:determination of left/right asymmetry in lateral mesoderm

0061053:somite development

0045880:positive regulation of smoothened signaling pathway

0048745:smooth muscle tissue development

0021987:cerebral cortex development

0050679:positive regulation of epithelial cell proliferation

0021953:central nervous system neuron differentiation

0021542:dentate gyrus development

0042307:positive regulation of protein import into nucleus

0007224:smoothened signaling pathway

0021794:thalamus development

0051451:myoblast migration

0010628:positive regulation of gene expression

0097731:9+0 non-motile cilium

0005886:plasma membrane

0002053:positive regulation of mesenchymal cell proliferation

0001570:vasculogenesis

0043231:intracellular membrane-bounded organelle

0043392:negative regulation of DNA binding

0016021:integral component of membrane

0060413:atrial septum morphogenesis

0001701:in utero embryonic development

0010629:negative regulation of gene expression

0009952:anterior/posterior pattern specification

0001649:osteoblast differentiation

0004930:G protein-coupled receptor activity

0050821:protein stabilization

0042475:odontogenesis of dentin-containing tooth

2000826:regulation of heart morphogenesis

0007417:central nervous system development

0071397:cellular response to cholesterol

0070986:left/right axis specification

0071679:commissural neuron axon guidance

0048853:forebrain morphogenesis

0021696:cerebellar cortex morphogenesis

0021938:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

0001755:neural crest cell migration

0000122:negative regulation of transcription by RNA polymerase II

0005929:cilium

0060170:ciliary membrane

0031069:hair follicle morphogenesis

0072285:mesenchymal to epithelial transition involved in metanephric renal vesicle formation

0003323:type B pancreatic cell development

0060242:contact inhibition

0061113:pancreas morphogenesis

0030857:negative regulation of epithelial cell differentiation

0007228:positive regulation of hh target transcription factor activity

0097542:ciliary tip

0001708:cell fate specification

0002052:positive regulation of neuroblast proliferation

0045944:positive regulation of transcription by RNA polymerase II

0007371:ventral midline determination

0043066:negative regulation of apoptotic process

0005113:patched binding

PDB

5V56 ; 6OT0 ; 6XBK ; 4QIM ; 4N4W ; 4O9R ; 6XBJ ; 4QIN ; 6XBM ; 5L7D ; 5L7I ; 5V57 ; 4JKV ; 6XBL

Drugbank

DB01047 ; DB09143 ; DB11978 ; DB06786 ; DB08828

KEGG

hsa:6608

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H0194	Ma Bing Lang	马槟榔	Masaikai caper	Capparis masaikai
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0214	Bei He Huan	北合欢	Albizia	Albizia julibrissin
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0461	Shi Jun Zi Ren	使君子仁	NA	Combretum indicum
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0003	Huo Ma Ren	火麻仁	Hemp fimble seed	Cannabis sativa
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0919	Cui Yun Cao	翠云草	Hooked spikemoss	Selaginella uncinata
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0204	Ma Ren	麻仁	NA	Cannabis sativa

Target Description

Related Compounds (Total: 7)

Related Herbs (Total: 33)