HIT-result

Target Description

Type	Detail
Target ID	T61M4P
Protein Name	Nuclear receptor ROR-alpha
Uniprot ID	P35398
Protein Name Alias	Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
Gene ID	6095
Gene Symbol	RORA
Gene Alias	NR1F1; RZRA
TTD	T43206: Preclinical target
Pfam	PF00105 ; PF00104
GO	0003677:DNA binding 0008134:transcription factor binding 0005634:nucleus 0010906:regulation of glucose metabolic process 0071347:cellular response to interleukin-1 0043124:negative regulation of I-kappaB kinase/NF-kappaB signaling 0043565:sequence-specific DNA binding 0046068:cGMP metabolic process 0071456:cellular response to hypoxia 0006355:regulation of transcription, DNA-templated 0021930:cerebellar granule cell precursor proliferation 0006809:nitric oxide biosynthetic process 0098531:ligand-activated transcription factor activity 0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding 0001223:transcription coactivator binding 0008589:regulation of smoothened signaling pathway 0042753:positive regulation of circadian rhythm 0071356:cellular response to tumor necrosis factor 0036315:cellular response to sterol 0006805:xenobiotic metabolic process 0001222:transcription corepressor binding 0021702:cerebellar Purkinje cell differentiation 0000785:chromatin 0032922:circadian regulation of gene expression 0010575:positive regulation of vascular endothelial growth factor production 0008142:oxysterol binding 0050728:negative regulation of inflammatory response 0042632:cholesterol homeostasis 0042692:muscle cell differentiation 0070328:triglyceride homeostasis 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0045893:positive regulation of transcription, DNA-templated 0008270:zinc ion binding 0003700:DNA-binding transcription factor activity 0001525:angiogenesis 0006357:regulation of transcription by RNA polymerase II 0006367:transcription initiation from RNA polymerase II promoter 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0005654:nucleoplasm 0019221:cytokine-mediated signaling pathway 0045599:negative regulation of fat cell differentiation 0045944:positive regulation of transcription by RNA polymerase II 0004879:nuclear receptor activity 0072539:T-helper 17 cell differentiation 0008013:beta-catenin binding 0019218:regulation of steroid metabolic process 0043030:regulation of macrophage activation 0030522:intracellular receptor signaling pathway
PDB	1S0X ; 4S15 ; 1N83
Drugbank	DB04540 ; DB01990
KEGG	hsa:6095

Type

Detail

Target ID

T61M4P

Protein Name

Nuclear receptor ROR-alpha

Uniprot ID

P35398

Protein Name Alias

Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha

Gene ID

6095

Gene Symbol

RORA

Gene Alias

NR1F1; RZRA

TTD

T43206: Preclinical target

Pfam

PF00105 ; PF00104

0003677:DNA binding

0008134:transcription factor binding

0005634:nucleus

0010906:regulation of glucose metabolic process

0071347:cellular response to interleukin-1

0043124:negative regulation of I-kappaB kinase/NF-kappaB signaling

0043565:sequence-specific DNA binding

0046068:cGMP metabolic process

0071456:cellular response to hypoxia

0006355:regulation of transcription, DNA-templated

0021930:cerebellar granule cell precursor proliferation

0006809:nitric oxide biosynthetic process

0098531:ligand-activated transcription factor activity

0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding

0001223:transcription coactivator binding

0008589:regulation of smoothened signaling pathway

0042753:positive regulation of circadian rhythm

0071356:cellular response to tumor necrosis factor

0036315:cellular response to sterol

0006805:xenobiotic metabolic process

0001222:transcription corepressor binding

0021702:cerebellar Purkinje cell differentiation

0000785:chromatin

0032922:circadian regulation of gene expression

0010575:positive regulation of vascular endothelial growth factor production

0008142:oxysterol binding

0050728:negative regulation of inflammatory response

0042632:cholesterol homeostasis

0042692:muscle cell differentiation

0070328:triglyceride homeostasis

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0045893:positive regulation of transcription, DNA-templated

0008270:zinc ion binding

0003700:DNA-binding transcription factor activity

0001525:angiogenesis

0006357:regulation of transcription by RNA polymerase II

0006367:transcription initiation from RNA polymerase II promoter

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0005654:nucleoplasm

0019221:cytokine-mediated signaling pathway

0045599:negative regulation of fat cell differentiation

0045944:positive regulation of transcription by RNA polymerase II

0004879:nuclear receptor activity

0072539:T-helper 17 cell differentiation

0008013:beta-catenin binding

0019218:regulation of steroid metabolic process

0043030:regulation of macrophage activation

0030522:intracellular receptor signaling pathway

PDB

1S0X ; 4S15 ; 1N83

Drugbank

DB04540 ; DB01990

KEGG

hsa:6095

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0476	Can E	蚕蛾	Silkworm	Bombyx mori

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 24)