Target Description

Type Detail
Target ID T38OH4
Protein Name Caspase-1
Uniprot ID P29466
Protein Name Alias CASP-1;  EC 3.4.22.36;  Interleukin-1 beta convertase;  IL-1BC;  Interleukin-1 beta-converting enzyme;  ICE;  IL-1 beta-converting enzyme;  p45
Gene ID 834
Gene Symbol CASP1
Gene Alias IL1BC;  IL1BCE
TTD T98269: Clinical Trial target
Pfam PF00619
GO
0019900:kinase binding

0050700:CARD domain binding

0019221:cytokine-mediated signaling pathway

0035590:purinergic nucleotide receptor signaling pathway

0005829:cytosol

0004175:endopeptidase activity

0050727:regulation of inflammatory response

0051882:mitochondrial depolarization

0032991:protein-containing complex

1901998:toxin transport

0071345:cellular response to cytokine stimulus

0008656:cysteine-type endopeptidase activator activity involved in apoptotic process

0004197:cysteine-type endopeptidase activity

0070269:pyroptosis

0010506:regulation of autophagy

0042802:identical protein binding

0032731:positive regulation of interleukin-1 beta production

0097179:protease inhibitor complex

0007165:signal transduction

0140448:signaling receptor ligand precursor processing

0071346:cellular response to interferon-gamma

0001666:response to hypoxia

0016540:protein autoprocessing

0006915:apoptotic process

0072559:NLRP3 inflammasome complex

1903265:positive regulation of tumor necrosis factor-mediated signaling pathway

0140447:cytokine precursor processing

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0005576:extracellular region

0097194:execution phase of apoptosis

0072557:IPAF inflammasome complex

0071222:cellular response to lipopolysaccharide

0072558:NLRP1 inflammasome complex

0032730:positive regulation of interleukin-1 alpha production

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0005886:plasma membrane

0097199:cysteine-type endopeptidase activity involved in apoptotic signaling pathway

0033198:response to ATP

0042981:regulation of apoptotic process

0097300:programmed necrotic cell death

0097169:AIM2 inflammasome complex

0071260:cellular response to mechanical stimulus

0005737:cytoplasm

0071310:cellular response to organic substance

0006508:proteolysis

0060081:membrane hyperpolarization

0005739:mitochondrion

PDB 6F6R ; 7KEU ; 2H4Y ; 1RWO ; 1IBC ; 5MMV ; 6KN0 ; 2H48 ; 6PZP ; 6BZ9 ; 1RWM ; 3D6F ; 2H51 ; 2HBR ; 2FQQ ; 2H4W ; 3D6H ; 3NS7 ; 1RWW ; 1RWK ; 1BMQ ; 6VIE ; 3E4C ; 1RWV ; 1RWX ; 5MTK ; 2HBZ ; 1SC3 ; 2HBQ ; 3D6M ; 1SC1 ; 1SC4 ; 1ICE ; 1RWP ; 1RWN ; 2HBY ; 2H54 ; 5FNA
Drugbank DB05301 ; DB07744 ; DB01017 ; DB00945 ; DB05408 ; DB07733 ; DB07916 ; DB05507 ; DB04875
KEGG hsa:834

Related Compounds  (Total: 12)

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C0104
Name: Ginsenoside Rh2
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C0281
Name: Paclitaxel
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C0401
Name: Shikonin
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C0476
Name: Ursolic Acid
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C0554
Name: Cholesterol


Related Herbs  (Total: 196)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0320 Qi Shu Gen漆树根 true lacquertree rootToxicodendron succedaneum
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0030 Jiang Pi姜皮 Ginger peelCortex zingiberis
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0177 Lu Lu Tong路路通 Beautiful sweetgumLiquidambar formosana
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0638 Xiang Bei象贝 FritillariaFritillaria thunbergii
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0503 Song Jie松节 Knotty pine wood, pine nodular branchLignum pini nodi
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0673 Xin Jiang Zi Cao新疆紫草 Arnebia rootArnebia euchroma
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0494 Shui Yang Mei Gen水杨梅根 Japanese avens rootGeum japonicum
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0938 Da Suan大蒜 GarlicAllium sativum
H0644 Xiang Mao香茅 LemongrassCymbopogon citratus
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0676 Xin Yi Hua Jin Gao Fen辛夷花浸膏粉 MagnoliaMagnolia liliflora
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0802 Zhi Geng枳梗 NACitrus aurantium
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0357 Ren Shen人参 GinsengPanax ginseng
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0656 Xiao Bo Gen小檗根 Barberry rootBerberis julianae
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0158 Liu Ling Ju六棱菊 NALaggera alata
H0470 Shi Ye柿叶 Persimmon leafDiospyros kaki
H0493 Shui Yang Mei水杨梅 Japanese avensGeum japonicum
H1178 Hei Jiang黑姜 Prepared gingerRhizoma zingiberis recens preparata
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0595 Wu Hua Guo无花果 FigFicus carica
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H0838 Zhu Zi Shen珠子参 Largeleaf japanese ginseng rhizomeRhizoma panacis majoris
H0646 Xiang Qing Lan香青兰 DragonheadDracocephalum moldavica
H0112 Ku Xing Ren苦杏仁 bitter apricot seedSemen armeniacae amarum
H1060 Fo Shou佛手 Fleshfingered citronCitrus medica var. sarcodactylis
H0986 Dian Zi Cao滇紫草 Paniculate onosmaOnosma paniculatum
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0403 Shan Cang Zi山苍子 NALitsea cubeba
H0674 Xin Yi辛夷 Lily magnolia budsMagnolia liliflora
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0844 Zi Cao紫草 Redroot gromwellLithospermum erythrorhizon
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0476 Can E蚕蛾 SilkwormBombyx mori
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0678 Xin Yi Ren辛夷仁 MagnoliaMagnolia liliflora
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0308 Pi Ba Ren枇杷仁 NAEriobotrya japonica
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H0675 Xin Yi Hua辛夷花 MagnoliaMagnolia liliflora
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0903 Ci Cai荠菜 ShepherdspurseCapsella bursa-pastoris
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H1109 Bai Hua She She Cao白花蛇舌草 Spreading hedyitisOldenlandia diffusa
H0735 Yi Bei Mu伊贝母 Siberian fritillary equivalent plant: fritillaria walujewiiFritillaria pallidiflora
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0390 Sang Ji Sheng桑寄生 Parasite scurrulaLoranthus parasiticus
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H1186 Hong Gen Cao红根草 Hispid sageSalvia prionitis
H0373 Bian Luo Bo卞萝卜 carrotDaucus carota var. sativa
H0747 An Xi Xiang安息香 Sumatra snowbelStyrax benzoin
H0416 Shan Shen山参 NAPanax ginseng
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0622 Xi He Liu西河柳 Chinese tamarisk twigCacumen tamaricis
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0604 Wu Wei Teng五味藤 NASecuridaca inappendiculata
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0854 Zi Wei Gen Pi紫葳根皮 NACampsis grandiflora
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H1004 Bai Cha白茶 White teaCamellia sinensis
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0287 Nao Yang Hua闹羊花 Chinese azaleaRhododendron molle
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H0715 Che Qian Zi车前子 seed of asiatic pantainPlantago asiatica
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H0719 Chen Pi陈皮 Dried tangerine peelPericarpium citri reticulatae
H0591 Wei Ling Cai委陵菜 Chinese cinquefoilPotentilla chinensis
H0453 Shi Di柿蒂 Persimmon persistent calyxDiospyros kaki
H0902 Chun Pi椿皮 Ailanthus bark, tree of heaven barkAilanthi cortex
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0132 Li Lu藜芦 Black falsehelleboreVeratrum nigrum
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0063 Jin Ye Zi金叶子 Yunnan craibiodendronCraibiodendron yunnanese
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0963 Dao Kou Cao倒扣草 NAAchyranthes aspera
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0577 Tu Niu Xi土牛膝 Common achyranthesAchyranthes aspera
H1232 Huang Cao Wu黄草乌 NAAconitum vilmorinianum
H1047 Feng Xiang Ye枫香叶 NALiquidambar formosana
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0303 Bi Cheng Qie毕澄茄 Cubeba pepperPiper cubeba
H0087 Ju Gu Ye枸骨叶 FOLIUM iLICIS cORNUTAEIlex cornuta
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H1215 Hua Ju Hong化橘红 Pummelo peelExocarpium citri grandis
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H0894 Chuan Xu Duan川续断 Himalayan teaselDipsacus asperoides
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0706 Yan Hu Suo延胡索 YanhusuoCorydalis yanhusuo
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H1165 He Shi鹤虱 Common carpesium fruitFructus carpesii
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0306 Pei Lan佩兰 FortuneEupatorium fortunei
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0701 Yan Bai岩柏 NAJuniperus formosana
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0801 Chong Bai La虫白蜡 Cera chinensis waxEricerus pela
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H0169 Lou Lu漏芦 Uniflower swisscentauryRhaponticum uniflorum
H0410 Shan Jiang Zi山姜子 NALitsea cubeba
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H1005 Dou Chi Jiang豆豉姜 Folium litseae cubebaeLitsea cubeba
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0560 Cao Bei Mu草贝母 Indian iphigeniaIphigenia indica
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H1049 Feng Xiang Zhi Chou Gao枫香脂稠膏 NALiquidambar formosana