Herb ID: H0844 | Chinese Character: 紫草 |
English Name: Redroot gromwell | Latin Name: Lithospermum erythrorhizon |
Chinese Pin Yin : Zi Cao | TCM-ID: TCMH2706 |
Therapeutic Function in Chinese : 清热 | Therapeutic Function in English: Heat clearence |
Herb Function: Cool blood and invigorate blood, release toxins and bring the rash the surface, promote bowel movement and moisten the intestines |
Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
---|---|---|---|---|
T52XO3 | Cytochrome P450 2J2 | CYP2J2 |
P51589 |
1 Reference(s) |
T85NRC | Pyruvate kinase PKM | PKM |
P14618 |
6 Reference(s) |
T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
1 Reference(s) |
T67GDP | Aryl hydrocarbon receptor nuclear translocator-like protein 1 | ARNTL |
O00327 |
1 Reference(s) |
T46K2X | Heat shock 70 kDa protein 4 | HSPA4 |
P34932 |
1 Reference(s) |
T05TS9 | Cocaine esterase | CES2 |
O00748 |
1 Reference(s) |
T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
2 Reference(s) |
T40JZG | GPI-anchor transamidase | PIGK |
Q92643 |
1 Reference(s) |
T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
1 Reference(s) |
T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
8 Reference(s) |
T37G49 | Platelet-activating factor acetylhydrolase | PLA2G7 |
Q13093 |
1 Reference(s) |
T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
2 Reference(s) |
T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
1 Reference(s) |
T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
6 Reference(s) |
T25Y64 | Cholinesterase | BCHE |
P06276 |
1 Reference(s) |
T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
2 Reference(s) |
T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
3 Reference(s) |
T09BRP | NA | PKB_RS07820 |
NA |
2 Reference(s) |
T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
1 Reference(s) |
T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
1 Reference(s) |
T54X6V | Intermediate conductance calcium-activated potassium channel protein 4 | KCNN4 |
O15554 |
1 Reference(s) |
T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
1 Reference(s) |
T90ZKN | Cathepsin B | CTSB |
P07858 |
1 Reference(s) |
T70OGQ | Sodium/potassium-transporting ATPase subunit alpha-1 | ATP1A1 |
P05023 |
1 Reference(s) |
T83YZD | Acetylcholinesterase | ACHE |
P22303 |
2 Reference(s) |
T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
2 Reference(s) |
T73EVE | Cyclic AMP-dependent transcription factor ATF-2 | ATF2 |
P15336 |
1 Reference(s) |
T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
1 Reference(s) |
T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
1 Reference(s) |
T34FQX | Protein kinase C zeta type | PRKCZ |
Q05513 |
1 Reference(s) |
T74QOR | Tyrosine-protein kinase JAK3 | JAK3 |
P52333 |
1 Reference(s) |
T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
4 Reference(s) |
T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
4 Reference(s) |
T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
2 Reference(s) |
T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
1 Reference(s) |
T68XXK | 4-aminobutyrate aminotransferase, mitochondrial | ABAT |
P80404 |
1 Reference(s) |
T01QLH | Estrogen receptor | ESR1 |
P03372 |
1 Reference(s) |
T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
1 Reference(s) |
T32KN9 | Alpha-amylase 1A | AMY1A |
P0DUB6 |
1 Reference(s) |
T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
1 Reference(s) |
T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
1 Reference(s) |
T30VNV | Myeloperoxidase | MPO |
P05164 |
1 Reference(s) |
T62P0D | Collagenase 3 | MMP13 |
P45452 |
1 Reference(s) |
T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
4 Reference(s) |
T74WWP | Peroxisome proliferator-activated receptor delta | PPARD |
Q03181 |
1 Reference(s) |
T14JSX | Plasminogen | PLG |
P00747 |
1 Reference(s) |
T67LRH | RNA-binding protein Musashi homolog 1 | MSI1 |
O43347 |
1 Reference(s) |
T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
2 Reference(s) |
T25M2J | Anoctamin-1 | ANO1 |
Q5XXA6 |
1 Reference(s) |
T34DZ7 | Interleukin-2 | IL2 |
P60568 |
2 Reference(s) |
T23VMI | Tumor necrosis factor | TNF |
P01375 |
6 Reference(s) |
T64BTV | Interleukin-1 beta | IL1B |
P01584 |
2 Reference(s) |
T38N69 | Lymphokine-activated killer T-cell-originated protein kinase | PBK |
Q96KB5 |
1 Reference(s) |
T83P5X | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB |
O14920 |
1 Reference(s) |
T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
7 Reference(s) |
T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
1 Reference(s) |
T70KPE | Transient receptor potential cation channel subfamily V member 3 | TRPV3 |
Q8NET8 |
3 Reference(s) |
T09INZ | Transient receptor potential cation channel subfamily A member 1 | TRPA1 |
O75762 |
3 Reference(s) |
T64X48 | C-X-C chemokine receptor type 4 | CXCR4 |
P61073 |
2 Reference(s) |
T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
3 Reference(s) |
T15ZAV | Lymphocyte antigen 96 | LY96 |
Q9Y6Y9 |
1 Reference(s) |
T38OH4 | Caspase-1 | CASP1 |
P29466 |
2 Reference(s) |
T77W6N | Thioredoxin reductase 1, cytoplasmic | TXNRD1 |
Q16881 |
3 Reference(s) |
T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
1 Reference(s) |
T76TED | Pro-opiomelanocortin | POMC |
P01189 |
1 Reference(s) |
T37JN5 | Neutrophil gelatinase-associated lipocalin | LCN2 |
P80188 |
1 Reference(s) |
T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
1 Reference(s) |
T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
2 Reference(s) |
T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
2 Reference(s) |
T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
1 Reference(s) |
T68BGR | Glial fibrillary acidic protein | GFAP |
P14136 |
1 Reference(s) |
T46YMA | Ras-related C3 botulinum toxin substrate 1 | RAC1 |
P63000 |
1 Reference(s) |
T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
3 Reference(s) |
T93R42 | Dipeptidyl peptidase 1 | CTSC |
P53634 |
1 Reference(s) |
T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
5 Reference(s) |
T44LWL | Transcription factor p65 | RELA |
Q04206 |
12 Reference(s) |
T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
6 Reference(s) |
T26KIE | Transcription factor AP-1 | JUN |
P05412 |
5 Reference(s) |
T33OPP | Interleukin-6 | IL6 |
P05231 |
1 Reference(s) |
T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
T72BXP | Platelet endothelial cell adhesion molecule | PECAM1 |
P16284 |
1 Reference(s) |
T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
2 Reference(s) |
T88QQE | Fibroblast growth factor 2 | FGF2 |
P09038 |
1 Reference(s) |
T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
2 Reference(s) |
T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
10 Reference(s) |
T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
4 Reference(s) |
T39YUJ | Tyrosine-protein phosphatase non-receptor type 6 | PTPN6 |
P29350 |
1 Reference(s) |
T85U8U | Caspase-3 | CASP3 |
P42574 |
6 Reference(s) |
T80OJF | Interstitial collagenase | MMP1 |
P03956 |
1 Reference(s) |
T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
3 Reference(s) |
T20H9F | Stromelysin-1 | MMP3 |
P08254 |
2 Reference(s) |
T95H9O | Stromelysin-2 | MMP10 |
P09238 |
1 Reference(s) |
T38T1U | Caspase-8 | CASP8 |
Q14790 |
3 Reference(s) |
T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
5 Reference(s) |
T23P74 | Caspase-9 | CASP9 |
P55211 |
3 Reference(s) |
T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
2 Reference(s) |
T39YFG | Trypsin-1 | PRSS1 |
P07477 |
1 Reference(s) |
T54WR0 | Fatty acid-binding protein 5 | FABP5 |
Q01469 |
1 Reference(s) |
T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
1 Reference(s) |
T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
T07S0E | BDNF/NT-3 growth factors receptor | NTRK2 |
Q16620 |
1 Reference(s) |
T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
T51WGR | Pancreas/duodenum homeobox protein 1 | PDX1 |
P52945 |
1 Reference(s) |
T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
1 Reference(s) |
T89L4V | Insulin | INS |
P01308 |
1 Reference(s) |
T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
T23YZF | Peptidyl-glycine alpha-amidating monooxygenase | PAM |
P19021 |
1 Reference(s) |
T77FOL | Neuromodulin | GAP43 |
P17677 |
2 Reference(s) |
T93VFT | Endothelin-1 | EDN1 |
P05305 |
1 Reference(s) |
T02DEN | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide | GCG |
P01275 |
1 Reference(s) |
T48UT8 | Cholesteryl ester transfer protein | CETP |
P11597 |
1 Reference(s) |
T32HPO | Aspartyl aminopeptidase | DNPEP |
Q9ULA0 |
1 Reference(s) |
T02YLA | Alpha-lactalbumin | LALBA |
P00709 |
1 Reference(s) |
T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
1 Reference(s) |
T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
2 Reference(s) |
T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
1 Reference(s) |
T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
4 Reference(s) |
T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
T75PC7 | NA | MIR21 |
NA |
1 Reference(s) |
T66G0O | NA | MIR30A |
NA |
1 Reference(s) |
T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
2 Reference(s) |
T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
1 Reference(s) |
T63FF5 | Interferon regulatory factor 3 | IRF3 |
Q14653 |
2 Reference(s) |
T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
3 Reference(s) |
T69NG6 | Interleukin-10 | IL10 |
P22301 |
1 Reference(s) |
T51EKP | Apolipoprotein M | APOM |
O95445 |
1 Reference(s) |
T07VV7 | Guanylin | GUCA2A |
Q02747 |
1 Reference(s) |
T80WPU | Protein ABHD15 | ABHD15 |
Q6UXT9 |
1 Reference(s) |
T56OUM | 14-3-3 protein zeta/delta | YWHAZ |
P63104 |
1 Reference(s) |
T24YWQ | Insulin-degrading enzyme | IDE |
P14735 |
1 Reference(s) |
T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
1 Reference(s) |
T98DNG | Natriuretic peptides A | NPPA |
P01160 |
1 Reference(s) |
T78ILO | Stearoyl-CoA desaturase | SCD |
O00767 |
1 Reference(s) |
T68IZC | Natriuretic peptides B | NPPB |
P16860 |
1 Reference(s) |
T02H9U | Nuclear factor of activated T-cells, cytoplasmic 4 | NFATC4 |
Q14934 |
1 Reference(s) |
T07NML | P-selectin | SELP |
P16109 |
1 Reference(s) |
T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
1 Reference(s) |
T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
1 Reference(s) |
T27U96 | Granulocyte-macrophage colony-stimulating factor | CSF2 |
P04141 |
1 Reference(s) |
T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
1 Reference(s) |
T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
1 Reference(s) |
T22IMH | Cyclin-dependent kinase 6 | CDK6 |
Q00534 |
1 Reference(s) |
T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
1 Reference(s) |
T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
1 Reference(s) |
T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
T04UTZ | G1/S-specific cyclin-E1 | CCNE1 |
P24864 |
1 Reference(s) |
T80OPZ | NADPH oxidase 4 | NOX4 |
Q9NPH5 |
1 Reference(s) |
T53ES3 | Protein S100-A1 | S100A1 |
P23297 |
1 Reference(s) |
T04A6O | UDP-glucuronosyltransferase 1A3 | UGT1A3 |
P35503 |
1 Reference(s) |
T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
1 Reference(s) |
T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
1 Reference(s) |
T91OUC | Mucin-5AC | MUC5AC |
P98088 |
1 Reference(s) |
T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
T61OY3 | UDP-glucuronosyltransferase 1A1 | UGT1A1 |
P22309 |
1 Reference(s) |
T37WQE | Kallikrein-5 | KLK5 |
Q9Y337 |
1 Reference(s) |
T16DCZ | Twist-related protein 1 | TWIST1 |
Q15672 |
1 Reference(s) |
T67RBZ | Mitochondrial uncoupling protein 2 | UCP2 |
P55851 |
1 Reference(s) |
T67HYX | Mitochondrial uncoupling protein 3 | UCP3 |
P55916 |
1 Reference(s) |
T19EKF | Cholecystokinin | CCK |
P06307 |
1 Reference(s) |
T19XSL | Fatty acid-binding protein, liver | FABP1 |
P07148 |
1 Reference(s) |
T23APZ | Retinol-binding protein 2 | RBP2 |
P50120 |
1 Reference(s) |
T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
1 Reference(s) |
T03NWF | Sterol O-acyltransferase 1 | SOAT1 |
P35610 |
1 Reference(s) |
T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
1 Reference(s) |
T53SLQ | Aquaporin-9 | AQP9 |
O43315 |
1 Reference(s) |
T75EH8 | Glucagon-like peptide 1 receptor | GLP1R |
P43220 |
1 Reference(s) |
T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
1 Reference(s) |
T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
1 Reference(s) |
T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
1 Reference(s) |
T42D4V | Histone deacetylase 1 | HDAC1 |
Q13547 |
1 Reference(s) |
T21UJU | Troponin I, cardiac muscle | TNNI3 |
P19429 |
1 Reference(s) |
T10I26 | Interferon beta | IFNB1 |
P01574 |
1 Reference(s) |
T40EUL | Transient receptor potential cation channel subfamily V member 4 | TRPV4 |
Q9HBA0 |
1 Reference(s) |
T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
T38EQ6 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 |
P15559 |
1 Reference(s) |