HIT-result

Target id	Protein Name	Gene Symbol	Uniprot ID	No.of Literature Evidence
T52XO3	Cytochrome P450 2J2	CYP2J2	P51589	1 Reference(s)
T85NRC	Pyruvate kinase PKM	PKM	P14618	6 Reference(s)
T43N2D	Epidermal growth factor receptor	EGFR	P00533	1 Reference(s)
T67GDP	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	O00327	1 Reference(s)
T46K2X	Heat shock 70 kDa protein 4	HSPA4	P34932	1 Reference(s)
T05TS9	Cocaine esterase	CES2	O00748	1 Reference(s)
T36SOV	Plasminogen activator inhibitor 1	SERPINE1	P05121	2 Reference(s)
T40JZG	GPI-anchor transamidase	PIGK	Q92643	1 Reference(s)
T22NX4	Toll-like receptor 2	TLR2	O60603	1 Reference(s)
T76QBQ	CREB-regulated transcription coactivator 2	CRTC2	Q53ET0	1 Reference(s)
T49ORJ	Peroxisome proliferator-activated receptor alpha	PPARA	Q07869	8 Reference(s)
T37G49	Platelet-activating factor acetylhydrolase	PLA2G7	Q13093	1 Reference(s)
T56TXY	Polyunsaturated fatty acid 5-lipoxygenase	ALOX5	P09917	2 Reference(s)
T31U13	Cytochrome P450 2C19	CYP2C19	P33261	1 Reference(s)
T06RMZ	Nuclear factor NF-kappa-B p105 subunit	NFKB1	P19838	6 Reference(s)
T25Y64	Cholinesterase	BCHE	P06276	1 Reference(s)
T02QBS	Cytochrome P450 1A2	CYP1A2	P05177	2 Reference(s)
T11BI7	Toll-like receptor 4	TLR4	O00206	3 Reference(s)
T09BRP	NA	PKB_RS07820	NA	2 Reference(s)
T11ZYR	Cytochrome P450 2D6	CYP2D6	P10635	1 Reference(s)
T85AXP	Cytochrome P450 3A4	CYP3A4	P08684	1 Reference(s)
T54X6V	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	O15554	1 Reference(s)
T58XLK	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	P18031	1 Reference(s)
T90ZKN	Cathepsin B	CTSB	P07858	1 Reference(s)
T70OGQ	Sodium/potassium-transporting ATPase subunit alpha-1	ATP1A1	P05023	1 Reference(s)
T83YZD	Acetylcholinesterase	ACHE	P22303	2 Reference(s)
T63GUB	Proto-oncogene c-Fos	FOS	P01100	2 Reference(s)
T73EVE	Cyclic AMP-dependent transcription factor ATF-2	ATF2	P15336	1 Reference(s)
T75B9S	Cyclic AMP-responsive element-binding protein 1	CREB1	P16220	1 Reference(s)
T45G32	Proto-oncogene tyrosine-protein kinase Src	SRC	P12931	1 Reference(s)
T34FQX	Protein kinase C zeta type	PRKCZ	Q05513	1 Reference(s)
T74QOR	Tyrosine-protein kinase JAK3	JAK3	P52333	1 Reference(s)
T25NSJ	Mitogen-activated protein kinase 3	MAPK3	P27361	4 Reference(s)
T79WXA	Mitogen-activated protein kinase 1	MAPK1	P28482	4 Reference(s)
T04H8Y	Beta-secretase 1	BACE1	P56817	1 Reference(s)
T58J2Y	Peroxisome proliferator-activated receptor gamma	PPARG	P37231	2 Reference(s)
T57L0X	Oxysterols receptor LXR-alpha	NR1H3	Q13133	1 Reference(s)
T68XXK	4-aminobutyrate aminotransferase, mitochondrial	ABAT	P80404	1 Reference(s)
T01QLH	Estrogen receptor	ESR1	P03372	1 Reference(s)
T57HGP	Tumor necrosis factor receptor superfamily member 6	FAS	P25445	1 Reference(s)
T32KN9	Alpha-amylase 1A	AMY1A	P0DUB6	1 Reference(s)
T12PIB	Lysosomal alpha-glucosidase	GAA	P10253	1 Reference(s)
T50SX0	Nuclear receptor subfamily 1 group I member 2	NR1I2	O75469	1 Reference(s)
T30VNV	Myeloperoxidase	MPO	P05164	1 Reference(s)
T62P0D	Collagenase 3	MMP13	P45452	1 Reference(s)
T09H2Z	Nitric oxide synthase, inducible	NOS2	P35228	4 Reference(s)
T74WWP	Peroxisome proliferator-activated receptor delta	PPARD	Q03181	1 Reference(s)
T14JSX	Plasminogen	PLG	P00747	1 Reference(s)
T67LRH	RNA-binding protein Musashi homolog 1	MSI1	O43347	1 Reference(s)
T21DZX	Amine oxidase [flavin-containing] A	MAOA	P21397	2 Reference(s)
T25M2J	Anoctamin-1	ANO1	Q5XXA6	1 Reference(s)
T34DZ7	Interleukin-2	IL2	P60568	2 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	6 Reference(s)
T64BTV	Interleukin-1 beta	IL1B	P01584	2 Reference(s)
T38N69	Lymphokine-activated killer T-cell-originated protein kinase	PBK	Q96KB5	1 Reference(s)
T83P5X	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	O14920	1 Reference(s)
T08Q7W	Prostaglandin G/H synthase 2	PTGS2	P35354	7 Reference(s)
T74LFK	Neurogenic locus notch homolog protein 1	NOTCH1	P46531	1 Reference(s)
T70KPE	Transient receptor potential cation channel subfamily V member 3	TRPV3	Q8NET8	3 Reference(s)
T09INZ	Transient receptor potential cation channel subfamily A member 1	TRPA1	O75762	3 Reference(s)
T64X48	C-X-C chemokine receptor type 4	CXCR4	P61073	2 Reference(s)
T67ZT3	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTEN	P60484	3 Reference(s)
T15ZAV	Lymphocyte antigen 96	LY96	Q9Y6Y9	1 Reference(s)
T38OH4	Caspase-1	CASP1	P29466	2 Reference(s)
T77W6N	Thioredoxin reductase 1, cytoplasmic	TXNRD1	Q16881	3 Reference(s)
T88AJI	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	1 Reference(s)
T76TED	Pro-opiomelanocortin	POMC	P01189	1 Reference(s)
T37JN5	Neutrophil gelatinase-associated lipocalin	LCN2	P80188	1 Reference(s)
T17UP9	C-C motif chemokine 2	CCL2	P13500	1 Reference(s)
T00CXT	Prostaglandin G/H synthase 1	PTGS1	P23219	2 Reference(s)
T63BQU	Cytochrome P450 1A1	CYP1A1	P04798	2 Reference(s)
T99XQ3	DNA topoisomerase 1	TOP1	P11387	1 Reference(s)
T68BGR	Glial fibrillary acidic protein	GFAP	P14136	1 Reference(s)
T46YMA	Ras-related C3 botulinum toxin substrate 1	RAC1	P63000	1 Reference(s)
T86ROZ	Heme oxygenase 1	HMOX1	P09601	3 Reference(s)
T93R42	Dipeptidyl peptidase 1	CTSC	P53634	1 Reference(s)
T49TDM	Matrix metalloproteinase-9	MMP9	P14780	5 Reference(s)
T44LWL	Transcription factor p65	RELA	Q04206	12 Reference(s)
T79KQO	NF-kappa-B inhibitor alpha	NFKBIA	P25963	6 Reference(s)
T26KIE	Transcription factor AP-1	JUN	P05412	5 Reference(s)
T33OPP	Interleukin-6	IL6	P05231	1 Reference(s)
T24U57	E-selectin	SELE	P16581	1 Reference(s)
T72BXP	Platelet endothelial cell adhesion molecule	PECAM1	P16284	1 Reference(s)
T42EAZ	Vascular endothelial growth factor A	VEGFA	P15692	2 Reference(s)
T88QQE	Fibroblast growth factor 2	FGF2	P09038	1 Reference(s)
T96OOK	Signal transducer and activator of transcription 3	STAT3	P40763	2 Reference(s)
T71K92	Apoptosis regulator Bcl-2	BCL2	P10415	10 Reference(s)
T74I49	Bcl-2-like protein 1	BCL2L1	Q07817	4 Reference(s)
T39YUJ	Tyrosine-protein phosphatase non-receptor type 6	PTPN6	P29350	1 Reference(s)
T85U8U	Caspase-3	CASP3	P42574	6 Reference(s)
T80OJF	Interstitial collagenase	MMP1	P03956	1 Reference(s)
T80GUN	72 kDa type IV collagenase	MMP2	P08253	3 Reference(s)
T20H9F	Stromelysin-1	MMP3	P08254	2 Reference(s)
T95H9O	Stromelysin-2	MMP10	P09238	1 Reference(s)
T38T1U	Caspase-8	CASP8	Q14790	3 Reference(s)
T80TUC	Apoptosis regulator BAX	BAX	Q07812	5 Reference(s)
T23P74	Caspase-9	CASP9	P55211	3 Reference(s)
T82JWE	Cellular tumor antigen p53	TP53	P04637	2 Reference(s)
T39YFG	Trypsin-1	PRSS1	P07477	1 Reference(s)
T54WR0	Fatty acid-binding protein 5	FABP5	Q01469	1 Reference(s)
T21Q0D	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	P04035	1 Reference(s)
T12T4H	Brain-derived neurotrophic factor	BDNF	P23560	1 Reference(s)
T07S0E	BDNF/NT-3 growth factors receptor	NTRK2	Q16620	1 Reference(s)
T90XYZ	C-reactive protein	CRP	P02741	1 Reference(s)
T51WGR	Pancreas/duodenum homeobox protein 1	PDX1	P52945	1 Reference(s)
T43NBB	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	P11168	1 Reference(s)
T89L4V	Insulin	INS	P01308	1 Reference(s)
T38WWN	Serum paraoxonase/arylesterase 1	PON1	P27169	1 Reference(s)
T23YZF	Peptidyl-glycine alpha-amidating monooxygenase	PAM	P19021	1 Reference(s)
T77FOL	Neuromodulin	GAP43	P17677	2 Reference(s)
T93VFT	Endothelin-1	EDN1	P05305	1 Reference(s)
T02DEN	Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide	GCG	P01275	1 Reference(s)
T48UT8	Cholesteryl ester transfer protein	CETP	P11597	1 Reference(s)
T32HPO	Aspartyl aminopeptidase	DNPEP	Q9ULA0	1 Reference(s)
T02YLA	Alpha-lactalbumin	LALBA	P00709	1 Reference(s)
T73LPO	Poly [ADP-ribose] polymerase 1	PARP1	P09874	1 Reference(s)
T06Q1R	Amine oxidase [flavin-containing] B	MAOB	P27338	2 Reference(s)
T69XVX	Cytochrome P450 1B1	CYP1B1	Q16678	1 Reference(s)
T10HL8	Intercellular adhesion molecule 1	ICAM1	P05362	4 Reference(s)
T13KGH	Tyrosinase	TYR	P14679	1 Reference(s)
T75PC7	NA	MIR21	NA	1 Reference(s)
T66G0O	NA	MIR30A	NA	1 Reference(s)
T22OPB	Nuclear factor erythroid 2-related factor 2	NFE2L2	Q16236	2 Reference(s)
T67KTV	Transient receptor potential cation channel subfamily V member 1	TRPV1	Q8NER1	1 Reference(s)
T63FF5	Interferon regulatory factor 3	IRF3	Q14653	2 Reference(s)
T88TDZ	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	3 Reference(s)
T69NG6	Interleukin-10	IL10	P22301	1 Reference(s)
T51EKP	Apolipoprotein M	APOM	O95445	1 Reference(s)
T07VV7	Guanylin	GUCA2A	Q02747	1 Reference(s)
T80WPU	Protein ABHD15	ABHD15	Q6UXT9	1 Reference(s)
T56OUM	14-3-3 protein zeta/delta	YWHAZ	P63104	1 Reference(s)
T24YWQ	Insulin-degrading enzyme	IDE	P14735	1 Reference(s)
T34HYH	Interleukin-1 alpha	IL1A	P01583	1 Reference(s)
T98DNG	Natriuretic peptides A	NPPA	P01160	1 Reference(s)
T78ILO	Stearoyl-CoA desaturase	SCD	O00767	1 Reference(s)
T68IZC	Natriuretic peptides B	NPPB	P16860	1 Reference(s)
T02H9U	Nuclear factor of activated T-cells, cytoplasmic 4	NFATC4	Q14934	1 Reference(s)
T07NML	P-selectin	SELP	P16109	1 Reference(s)
T25H22	Protein kinase C beta type	PRKCB	P05771	1 Reference(s)
T69RXK	Cytochrome P450 2C9	CYP2C9	P11712	1 Reference(s)
T27U96	Granulocyte-macrophage colony-stimulating factor	CSF2	P04141	1 Reference(s)
T02GD4	Tumor necrosis factor ligand superfamily member 6	FASLG	P48023	1 Reference(s)
T10S5F	Cyclin-dependent kinase 4	CDK4	P11802	1 Reference(s)
T22IMH	Cyclin-dependent kinase 6	CDK6	Q00534	1 Reference(s)
T38BR0	G1/S-specific cyclin-D2	CCND2	P30279	1 Reference(s)
T75H3W	Cyclin-dependent kinase 2	CDK2	P24941	1 Reference(s)
T74JJN	Fatty acid synthase	FASN	P49327	1 Reference(s)
T64W2K	Cyclin-dependent kinase inhibitor 1	CDKN1A	P38936	1 Reference(s)
T93WZG	G1/S-specific cyclin-D1	CCND1	P24385	1 Reference(s)
T64UH1	Nitric oxide synthase, endothelial	NOS3	P29474	1 Reference(s)
T75HMM	Induced myeloid leukemia cell differentiation protein Mcl-1	MCL1	Q07820	1 Reference(s)
T04UTZ	G1/S-specific cyclin-E1	CCNE1	P24864	1 Reference(s)
T80OPZ	NADPH oxidase 4	NOX4	Q9NPH5	1 Reference(s)
T53ES3	Protein S100-A1	S100A1	P23297	1 Reference(s)
T04A6O	UDP-glucuronosyltransferase 1A3	UGT1A3	P35503	1 Reference(s)
T50WOV	ATP-dependent translocase ABCB1	ABCB1	P08183	1 Reference(s)
T92BZ2	Catenin beta-1	CTNNB1	P35222	1 Reference(s)
T14LSK	E3 ubiquitin-protein ligase XIAP	XIAP	P98170	1 Reference(s)
T91OUC	Mucin-5AC	MUC5AC	P98088	1 Reference(s)
T59IKQ	Vascular cell adhesion protein 1	VCAM1	P19320	1 Reference(s)
T61OY3	UDP-glucuronosyltransferase 1A1	UGT1A1	P22309	1 Reference(s)
T37WQE	Kallikrein-5	KLK5	Q9Y337	1 Reference(s)
T16DCZ	Twist-related protein 1	TWIST1	Q15672	1 Reference(s)
T67RBZ	Mitochondrial uncoupling protein 2	UCP2	P55851	1 Reference(s)
T67HYX	Mitochondrial uncoupling protein 3	UCP3	P55916	1 Reference(s)
T19EKF	Cholecystokinin	CCK	P06307	1 Reference(s)
T19XSL	Fatty acid-binding protein, liver	FABP1	P07148	1 Reference(s)
T23APZ	Retinol-binding protein 2	RBP2	P50120	1 Reference(s)
T38K2W	Receptor tyrosine-protein kinase erbB-2	ERBB2	P04626	1 Reference(s)
T03NWF	Sterol O-acyltransferase 1	SOAT1	P35610	1 Reference(s)
T48YPL	Aquaporin-3	AQP3	Q92482	1 Reference(s)
T53SLQ	Aquaporin-9	AQP9	O43315	1 Reference(s)
T75EH8	Glucagon-like peptide 1 receptor	GLP1R	P43220	1 Reference(s)
T52VL6	Signal transducer and activator of transcription 5A	STAT5A	P42229	1 Reference(s)
T19K8W	Signal transducer and activator of transcription 5B	STAT5B	P51692	1 Reference(s)
T39M6J	ATP-binding cassette sub-family C member 2	ABCC2	Q92887	1 Reference(s)
T42D4V	Histone deacetylase 1	HDAC1	Q13547	1 Reference(s)
T21UJU	Troponin I, cardiac muscle	TNNI3	P19429	1 Reference(s)
T10I26	Interferon beta	IFNB1	P01574	1 Reference(s)
T40EUL	Transient receptor potential cation channel subfamily V member 4	TRPV4	Q9HBA0	1 Reference(s)
T74QXI	Serine/threonine-protein kinase mTOR	MTOR	P42345	1 Reference(s)
T38EQ6	NAD(P)H dehydrogenase [quinone] 1	NQO1	P15559	1 Reference(s)

Herb ID: H0844	Chinese Character: 紫草
English Name: Redroot gromwell	Latin Name: Lithospermum erythrorhizon
Chinese Pin Yin : Zi Cao	TCM-ID: TCMH2706
Therapeutic Function in Chinese : 清热	Therapeutic Function in English: Heat clearence
Herb Function: Cool blood and invigorate blood, release toxins and bring the rash the surface, promote bowel movement and moisten the intestines

Herb Description

Related Targets (Total: 182)

Related Compounds (Total: 18)