HIT-result

Type	Detail
Target ID	T83P5X
Protein Name	Inhibitor of nuclear factor kappa-B kinase subunit beta
Uniprot ID	O14920
Protein Name Alias	I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; EC 2.7.11.10; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB; EC 2.7.11.1
Gene ID	3551
Gene Symbol	IKBKB
Gene Alias	IKKB
TTD	T78429: Clinical Trial target
Pfam	PF12179 ; PF00069 ; PF18397
GO	1903347:negative regulation of bicellular tight junction assembly 0005634:nucleus 0010803:regulation of tumor necrosis factor-mediated signaling pathway 0106311:protein threonine kinase activity 0005829:cytosol 0097110:scaffold protein binding 0002756:MyD88-independent toll-like receptor signaling pathway 0050852:T cell receptor signaling pathway 0035666:TRIF-dependent toll-like receptor signaling pathway 0004672:protein kinase activity 0009898:cytoplasmic side of plasma membrane 0006954:inflammatory response 0009615:response to virus 0042803:protein homodimerization activity 0007249:I-kappaB kinase/NF-kappaB signaling 0046982:protein heterodimerization activity 0070498:interleukin-1-mediated signaling pathway 0043066:negative regulation of apoptotic process 0051403:stress-activated MAPK cascade 0042802:identical protein binding 0035509:negative regulation of myosin-light-chain-phosphatase activity 0045893:positive regulation of transcription, DNA-templated 0002223:stimulatory C-type lectin receptor signaling pathway 0106310:protein serine kinase activity 0045944:positive regulation of transcription by RNA polymerase II 1903140:regulation of establishment of endothelial barrier 0006468:protein phosphorylation 0005524:ATP binding 0002479:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 0045121:membrane raft 0072659:protein localization to plasma membrane 1990459:transferrin receptor binding 0004674:protein serine/threonine kinase activity 0071356:cellular response to tumor necrosis factor 0038095:Fc-epsilon receptor signaling pathway 0008385:IkappaB kinase complex 0018105:peptidyl-serine phosphorylation 0042325:regulation of phosphorylation 0045087:innate immune response 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0035631:CD40 receptor complex 0051092:positive regulation of NF-kappaB transcription factor activity 0019901:protein kinase binding 0033209:tumor necrosis factor-mediated signaling pathway 0030866:cortical actin cytoskeleton organization 0005737:cytoplasm 0008384:IkappaB kinase activity 0016032:viral process
PDB	4KIK ; 4E3C ; 3BRV ; 3BRT
Drugbank	DB00795 ; DB00244 ; DB00945 ; DB05183 ; DB06521 ; DB06151 ; DB01169 ; DB12010 ; DB00995
KEGG	hsa:3551

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Name: Gefitinib

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Name: Humulone

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Name: (R)-Cysteine

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Name: Paeonol

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Name: Rosmarinic Acid

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H1162	Hang Shao	杭芍	White peony root	Paeonia albiflora
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0071	Bai Ye	柏叶	Chinese arborvitae twig	Platycladus orientalis
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0043	Jie Zi	芥子	India mustard seed	Brassica juncea
H1061	Bai He	百合	Lily	Lilium brownii
H0338	Qing Ban Xia	清半夏	Ternate pinellia	Pinellia ternata
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0002	Hui Xiang	茴香	Fennel fruit	Foeniculum vulgare
H0630	Ce Bai Ye	侧柏叶	Chinese arborvitae leaf	Thuja orientalis
H0238	Mei Hua	梅花	Plum flower	Flos mume
H0074	Jing Jie Tan	荆芥炭	NA	Schizonepetae herba
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0036	Jie Geng	桔梗	Balloonflower	Platycodon grandiflorum
H0784	Chi Shao	赤芍	Red peony root	Paeonia obovata
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0083	Jiu Jie Cha	九节茶	Glabrous sarcandra	Sarcandra glabra
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H1068	Bai He Liu Jin Gao	百合流浸膏	Lily	Lilium brownii
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H1036	Fen Dan Pi	粉丹皮	Tree peony bark	Paeonia suffruticosa
H0429	Shao Yao	芍药	Red peony root	Paeonia obovata
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0120	Ban Bian Qi	半边旗	pinnated brake herb	Pteris semipinnata
H1157	Han Lian Cao	旱莲草	eclipta	Herba ecliptae prostratae
H0968	Di Feng Pi	地枫皮	Difengpi anisetree	Illicium difengpi
H0625	Ce Bai Tan	侧柏炭	Oriental arbor-vitae	Platycladus orientalis
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H0021	Bai Shao	白芍	Common peony	Paeonia lactiflora
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H1188	Hong Hua	红花	Safflower	Carthamus tinctorius
H0450	Shi Chang Pu	石菖蒲	Grassleaved sweetflag	Acorus tatarinowii
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H1231	Huang Bai Tan	黄柏炭	Amur corktree	Phellodendron amurense
H0266	Mu Dan Pi	牡丹皮	Subshrubby peony bark	Paeonia moutan
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0614	Wu Zhao Long	五爪龙	Cairo morningglory	Ipomoea cairica
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H0684	Xu Chang Qing	徐长卿	Paniculate swallowwort	Cynanchum paniculatum
H0456	Bu Gu Zhi	补骨脂	Malaytea scurfpea	Psoralea corylifolia
H0151	Ling Yang Jiao	羚羊角	Antelope horn	Cornu saigae tataricae
H1184	Bai Lian	白蔹	Japanese ampelopsis	Ampelopsis japonica
H0612	Cao Shan Hu Jin Gao	草珊瑚浸膏	NA	Sarcandra glabra
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H0827	Zhu Hong Jun	竹红菌	Bambusa hypocrella*	Hypocrella bambusae
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis
H0632	Xia Ku Cao	夏枯草	Common selfheal	Prunella vulgaris
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H0439	Sheng Ban Xia	生半夏	Ternate pinellia	Pinellia ternata
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H0159	Ban Xia Qu	半夏曲	Pinellia tuber leaven	Pinellia ternata
H1115	Guan Huang Bai	关黄柏	Amur cork tree	Phellodendron amurense
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0673	Xin Jiang Zi Cao	新疆紫草	Arnebia root	Arnebia euchroma
H1230	Huang Bai Fen	黄柏粉	Amur corktree	Phellodendron amurense
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0496	Shui Ze Lan	水泽兰	NA	Lycopus lucidus
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H0023	Bai Shao Gan Jin Gao	白芍干浸膏	Common peony	Paeonia lactiflora
H0629	Xi Xin	细辛	Siebold wildginger	Asarum sieboldii
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0704	Yan Guan Huang Bai	盐关黄柏	Amur cork tree	Phellodendron amurense
H0273	Mu Tong	木通	Fiveleaf akebia	Akebia quinata
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0642	Xiang Jia Pi	香加皮	Chinese silkvine root-bark	Periploca sepium
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1228	Huang Bai	黄柏	Amur corktree	Phellodendron amurense
H0155	Ban Xia	半夏	Ternate pinellia	Pinellia ternata
H1110	Gua Lou Zi	瓜蒌子	mongolian snakegourd seed	Trichosanthes kirilowii maxim
H0844	Zi Cao	紫草	Redroot gromwell	Lithospermum erythrorhizon
H0003	Huo Ma Ren	火麻仁	Hemp fimble seed	Cannabis sativa
H0451	Shi Chang Pu Jin Gao	石菖蒲浸膏	Grassleaved sweetflag	Acorus tatarinowii
H0452	Shi Chang Pu Qing Gao	石菖蒲清膏	Grassleaved sweetflag	Acorus tatarinowii
H0416	Shan Shen	山参	NA	Panax ginseng
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H0204	Ma Ren	麻仁	NA	Cannabis sativa

Target Description

Related Compounds (Total: 13)

Related Herbs (Total: 99)