Target Description

Type Detail
Target ID T83P5X
Protein Name Inhibitor of nuclear factor kappa-B kinase subunit beta
Uniprot ID O14920
Protein Name Alias I-kappa-B-kinase beta;  IKK-B;  IKK-beta;  IkBKB;  EC 2.7.11.10;  I-kappa-B kinase 2;  IKK2;  Nuclear factor NF-kappa-B inhibitor kinase beta;  NFKBIKB;  Serine/threonine protein kinase IKBKB;  EC 2.7.11.1
Gene ID 3551
Gene Symbol IKBKB
Gene Alias IKKB
TTD T78429: Clinical Trial target
Pfam PF12179 ; PF00069 ; PF18397
GO
1903347:negative regulation of bicellular tight junction assembly

0005634:nucleus

0010803:regulation of tumor necrosis factor-mediated signaling pathway

0106311:protein threonine kinase activity

0005829:cytosol

0097110:scaffold protein binding

0002756:MyD88-independent toll-like receptor signaling pathway

0050852:T cell receptor signaling pathway

0035666:TRIF-dependent toll-like receptor signaling pathway

0004672:protein kinase activity

0009898:cytoplasmic side of plasma membrane

0006954:inflammatory response

0009615:response to virus

0042803:protein homodimerization activity

0007249:I-kappaB kinase/NF-kappaB signaling

0046982:protein heterodimerization activity

0070498:interleukin-1-mediated signaling pathway

0043066:negative regulation of apoptotic process

0051403:stress-activated MAPK cascade

0042802:identical protein binding

0035509:negative regulation of myosin-light-chain-phosphatase activity

0045893:positive regulation of transcription, DNA-templated

0002223:stimulatory C-type lectin receptor signaling pathway

0106310:protein serine kinase activity

0045944:positive regulation of transcription by RNA polymerase II

1903140:regulation of establishment of endothelial barrier

0006468:protein phosphorylation

0005524:ATP binding

0002479:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

0045121:membrane raft

0072659:protein localization to plasma membrane

1990459:transferrin receptor binding

0004674:protein serine/threonine kinase activity

0071356:cellular response to tumor necrosis factor

0038095:Fc-epsilon receptor signaling pathway

0008385:IkappaB kinase complex

0018105:peptidyl-serine phosphorylation

0042325:regulation of phosphorylation

0045087:innate immune response

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0035631:CD40 receptor complex

0051092:positive regulation of NF-kappaB transcription factor activity

0019901:protein kinase binding

0033209:tumor necrosis factor-mediated signaling pathway

0030866:cortical actin cytoskeleton organization

0005737:cytoplasm

0008384:IkappaB kinase activity

0016032:viral process

PDB 4KIK ; 4E3C ; 3BRV ; 3BRT
Drugbank DB00795 ; DB00244 ; DB00945 ; DB05183 ; DB06521 ; DB06151 ; DB01169 ; DB12010 ; DB00995
KEGG hsa:3551

Related Compounds  (Total: 13)

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C0100
Name: Gefitinib
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C0127
Name: Humulone
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C0232
Name: (R)-Cysteine
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C0283
Name: Paeonol
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C0374
Name: Rosmarinic Acid


Related Herbs  (Total: 99)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H1162 Hang Shao杭芍 White peony rootPaeonia albiflora
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H1061 Bai He百合 LilyLilium brownii
H0338 Qing Ban Xia清半夏 Ternate pinelliaPinellia ternata
H0357 Ren Shen人参 GinsengPanax ginseng
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0630 Ce Bai Ye侧柏叶 Chinese arborvitae leafThuja orientalis
H0238 Mei Hua梅花 Plum flowerFlos mume
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0036 Jie Geng桔梗 BalloonflowerPlatycodon grandiflorum
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0083 Jiu Jie Cha九节茶 Glabrous sarcandraSarcandra glabra
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H1167 He Tao核桃 English walnut seedSemen juglandis
H1036 Fen Dan Pi粉丹皮 Tree peony barkPaeonia suffruticosa
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0120 Ban Bian Qi半边旗 pinnated brake herbPteris semipinnata
H1157 Han Lian Cao旱莲草 ecliptaHerba ecliptae prostratae
H0968 Di Feng Pi地枫皮 Difengpi anisetreeIllicium difengpi
H0625 Ce Bai Tan侧柏炭 Oriental arbor-vitaePlatycladus orientalis
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0021 Bai Shao白芍 Common peonyPaeonia lactiflora
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1188 Hong Hua红花 SafflowerCarthamus tinctorius
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H0266 Mu Dan Pi牡丹皮 Subshrubby peony barkPaeonia moutan
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0706 Yan Hu Suo延胡索 YanhusuoCorydalis yanhusuo
H0684 Xu Chang Qing徐长卿 Paniculate swallowwortCynanchum paniculatum
H0456 Bu Gu Zhi补骨脂 Malaytea scurfpeaPsoralea corylifolia
H0151 Ling Yang Jiao羚羊角 Antelope hornCornu saigae tataricae
H1184 Bai Lian白蔹 Japanese ampelopsisAmpelopsis japonica
H0612 Cao Shan Hu Jin Gao草珊瑚浸膏 NASarcandra glabra
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0827 Zhu Hong Jun竹红菌 Bambusa hypocrella*Hypocrella bambusae
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0439 Sheng Ban Xia生半夏 Ternate pinelliaPinellia ternata
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0159 Ban Xia Qu半夏曲 Pinellia tuber leavenPinellia ternata
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H0673 Xin Jiang Zi Cao新疆紫草 Arnebia rootArnebia euchroma
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H1168 He Tao Ren核桃仁 English walnut seedSemen juglandis
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0023 Bai Shao Gan Jin Gao白芍干浸膏 Common peonyPaeonia lactiflora
H0629 Xi Xin细辛 Siebold wildgingerAsarum sieboldii
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0273 Mu Tong木通 Fiveleaf akebiaAkebia quinata
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0642 Xiang Jia Pi香加皮 Chinese silkvine root-barkPeriploca sepium
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0155 Ban Xia半夏 Ternate pinelliaPinellia ternata
H1110 Gua Lou Zi瓜蒌子 mongolian snakegourd seedTrichosanthes kirilowii maxim
H0844 Zi Cao紫草 Redroot gromwellLithospermum erythrorhizon
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii
H0416 Shan Shen山参 NAPanax ginseng
H0633 Xia Tian Wu夏天无 Decumbent corydalisCorydalis decumbens
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H0204 Ma Ren麻仁 NACannabis sativa