Compound Description
| ID: C0374 | Common name: Rosmarinic Acid |
| IUPAC: (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid | CAS: CAS:20283-92-5 |
| Chembl ID: CHEMBL324842 | Pubchem ID: CID:5281792 |
| Formula: C18H16O8 | TCM-ID: TCMC2025 |
| Smiles: C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O | |
| Alias:
Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-, (αR)-;
Benzenepropanoic acid, α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-, [R-(E)]-; Cinnamic acid, 3,4-dihydroxy-, 2-ester with 3-(3,4-dihydroxyphenyl)lactic acid; Rosmarinic acid; (αR)-α-[[(2E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid; Labiatenic acid; Labiatic acid; Mamorekku RUH 2; Meiji Red Perilla Polyphenol; NPLC 0542; RM 21A; Rosemaric acid; Rosemary acid; SYL 001; trans-Rosmarinic acid |
Structure:
|
Related Targets (Total: 22)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T68XXK | 4-aminobutyrate aminotransferase, mitochondrial | ABAT |
P80404 |
A | 2 Reference(s) |
| T40NB1 | Ribosomal protein S6 kinase beta-1 | RPS6KB1 |
P23443 |
A | 1 Reference(s) |
| T16FZA | Prolyl endopeptidase | PREP |
P48147 |
A | 1 Reference(s) |
| T19YQS | Complement C3 | C3 |
P01024 |
B | 1 Reference(s) |
| T12WTT | Interleukin-5 | IL5 |
P05113 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T67HAF | Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
P42224 |
B | 1 Reference(s) |
| T80L9F | Complement C5 | C5 |
P01031 |
B | 1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
B | 2 Reference(s) |
| T92WFW | C-C motif chemokine 3 | CCL3 |
P10147 |
B | 2 Reference(s) |
| T23OTN | T-lymphocyte activation antigen CD80 | CD80 |
P33681 |
B | 2 Reference(s) |
| T47MPW | T-lymphocyte activation antigen CD86 | CD86 |
P42081 |
B | 2 Reference(s) |
| T68XO1 | Indoleamine 2,3-dioxygenase 1 | IDO1 |
P14902 |
B | 2 Reference(s) |
| T83P5X | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB |
O14920 |
B | 2 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
B | 1 Reference(s) |
| T70EJM | Eotaxin | CCL11 |
P51671 |
B | 3 Reference(s) |
| T34DZ7 | Interleukin-2 | IL2 |
P60568 |
B | 1 Reference(s) |
| T19CUN | Prothrombin | F2 |
P00734 |
B | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
B | 1 Reference(s) |
| T35KD8 | C-C chemokine receptor type 3 | CCR3 |
P51677 |
C | 2 Reference(s) |
| T80DCQ | Aurora kinase A | AURKA |
O14965 |
C | 2 Reference(s) |
| T83PO9 | Oligodendrocyte transcription factor 2 | OLIG2 |
Q13516 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 18)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0083 | Jiu Jie Cha | 九节茶 | Glabrous sarcandra | Sarcandra glabra |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H0632 | Xia Ku Cao | 夏枯草 | Common selfheal | Prunella vulgaris |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H0612 | Cao Shan Hu Jin Gao | 草珊瑚浸膏 | NA | Sarcandra glabra |
| H0496 | Shui Ze Lan | 水泽兰 | NA | Lycopus lucidus |
| H0002 | Hui Xiang | 茴香 | Fennel fruit | Foeniculum vulgare |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0614 | Wu Zhao Long | 五爪龙 | Cairo morningglory | Ipomoea cairica |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0673 | Xin Jiang Zi Cao | 新疆紫草 | Arnebia root | Arnebia euchroma |
| H0074 | Jing Jie Tan | 荆芥炭 | NA | Schizonepetae herba |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H0035 | Bai Su Zi | 白苏子 | Common perilla fruit | Perilla frutescens |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
Ckey description of the interaction between compound and target