HIT-result

Type	Detail
Target ID	T80DCQ
Protein Name	Aurora kinase A
Uniprot ID	O14965
Protein Name Alias	EC 2.7.11.1; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A
Gene ID	6790
Gene Symbol	AURKA
Gene Alias	AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6
TTD	T87675: Clinical Trial target
Pfam	PF00069
GO	0097431:mitotic spindle pole 0005634:nucleus 1900195:positive regulation of oocyte maturation 0106311:protein threonine kinase activity 0005829:cytosol 0000086:G2/M transition of mitotic cell cycle 0032091:negative regulation of protein binding 0005929:cilium 0097421:liver regeneration 0031625:ubiquitin protein ligase binding 0045840:positive regulation of mitotic nuclear division 0005813:centrosome 0004672:protein kinase activity 0031647:regulation of protein stability 0043203:axon hillock 0009611:response to wounding 0004712:protein serine/threonine/tyrosine kinase activity 0043066:negative regulation of apoptotic process 0005874:microtubule 0046982:protein heterodimerization activity 0032465:regulation of cytokinesis 0005814:centriole 0005654:nucleoplasm 0010629:negative regulation of gene expression 0045120:pronucleus 0106310:protein serine kinase activity 0009948:anterior/posterior axis specification 0006468:protein phosphorylation 0007052:mitotic spindle organization 0005524:ATP binding 0005819:spindle 0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process 0046605:regulation of centrosome cycle 0000278:mitotic cell cycle 0010972:negative regulation of G2/M transition of mitotic cell cycle 0071539:protein localization to centrosome 0032133:chromosome passenger complex 0051642:centrosome localization 0035174:histone serine kinase activity 0004674:protein serine/threonine kinase activity 0007100:mitotic centrosome separation 0010389:regulation of G2/M transition of mitotic cell cycle 0051301:cell division 0030496:midbody 0018105:peptidyl-serine phosphorylation 1901796:regulation of signal transduction by p53 class mediator 0046777:protein autophosphorylation 0051233:spindle midzone 1990138:neuron projection extension 0031145:anaphase-promoting complex-dependent catabolic process 0019901:protein kinase binding 0007057:spindle assembly involved in female meiosis I 0006511:ubiquitin-dependent protein catabolic process 0015630:microtubule cytoskeleton 0007051:spindle organization 0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 0031616:spindle pole centrosome 0048471:perinuclear region of cytoplasm 0072687:meiotic spindle 0042585:germinal vesicle
PDB	6CPE ; 3K5U ; 2J4Z ; 6HJJ ; 3VAP ; 4J8N ; 5AAD ; 3UP7 ; 5DRD ; 5L8J ; 7AYI ; 4JBP ; 3E5A ; 4O0W ; 4UYN ; 5OS1 ; 4UZH ; 5ORP ; 5DT3 ; 5G1X ; 5ORR ; 3R21 ; 5L8L ; 2XNG ; 6Z4Y ; 5ORX ; 4BYJ ; 3H0Y ; 3M11 ; 5AAE ; 4ZTR ; 6R4B ; 6CPF ; 2XRU ; 5DN3 ; 6R4A ; 2NP8 ; 5OBJ ; 6R49 ; 1MQ4 ; 5ORT ; 5ORN ; 3MYG ; 2C6D ; 6C2R ; 4DED ; 2W1D ; 3QBN ; 3H0Z ; 4DEB ; 4O0U ; 3UO6 ; 5ODT ; 6R4C ; 6R4D ; 4J8M ; 2XNE ; 3FDN ; 7AYH ; 6C2T ; 5DR9 ; 5DOS ; 2C6E ; 2J50 ; 5ONE ; 4UZD ; 4CEG ; 4DEA ; 2W1G ; 3NRM ; 5ORZ ; 5OSD ; 6I2U ; 6VPG ; 6CPG ; 4O0S ; 6XKA ; 6GRA ; 1MUO ; 4DEE ; 4BN1 ; 5OSE ; 3UNZ ; 4ZS0 ; 2X6D ; 2WTV ; 5DT0 ; 3H10 ; 5OS6 ; 5OS4 ; 4JBQ ; 5ORV ; 4C3R ; 5ZAN ; 3UO4 ; 3COH ; 4DHF ; 3UOL ; 3R22 ; 3UO5 ; 3UOK ; 6VPJ ; 5EW9 ; 3P9J ; 3LAU ; 5AAG ; 5LXM ; 6VPH ; 1OL7 ; 3UP2 ; 3O51 ; 6VPM ; 3HA6 ; 5DR6 ; 5DPV ; 3EFW ; 3W16 ; 5OS2 ; 2W1F ; 3UOJ ; 4JBO ; 5AAF ; 5OS5 ; 2X81 ; 5L8K ; 2W1E ; 2BMC ; 3UOH ; 5OSF ; 5DNR ; 3W2C ; 4ZTQ ; 2W1C ; 4JAI ; 6HJK ; 2X6E ; 5ORY ; 4C3P ; 2DWB ; 3O50 ; 6C83 ; 6VPL ; 4B0G ; 5ORW ; 1OL5 ; 5G15 ; 5ORL ; 6VPI ; 5OS0 ; 5ORS ; 4JAJ ; 1OL6 ; 4PRJ ; 5DR2 ; 5DT4 ; 5ORO ; 3W18 ; 2WTW ; 5OBR ; 3UOD ; 5OS3 ; 4ZTS ; 3W10 ; 2WQE ; 4BYI
Drugbank	DB06347 ; DB07362 ; DB06134 ; DB07545 ; DB02482 ; DB07266 ; DB07186 ; DB05198 ; DB08065 ; DB13061 ; DB05169 ; DB08066 ; DB12010 ; DB07360 ; DB06486 ; DB07801 ; DB05220
KEGG	hsa:6790

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H0140	Lian Zi	莲子	Hindu lotus seed	Nelumbo nucifera
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0614	Wu Zhao Long	五爪龙	Cairo morningglory	Ipomoea cairica
H0673	Xin Jiang Zi Cao	新疆紫草	Arnebia root	Arnebia euchroma
H0002	Hui Xiang	茴香	Fennel fruit	Foeniculum vulgare
H0074	Jing Jie Tan	荆芥炭	NA	Schizonepetae herba
H0496	Shui Ze Lan	水泽兰	NA	Lycopus lucidus
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H1164	He Geng	荷梗	Hindu lotus petiole	Nelumbo nucifera
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0302	Ou Fen	藕粉	Hindu lotus large rhizome	Nelumbo nucifera
H0612	Cao Shan Hu Jin Gao	草珊瑚浸膏	NA	Sarcandra glabra
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H0301	Ou	藕	Hindu lotus large rhizome	Nelumbo nucifera
H0632	Xia Ku Cao	夏枯草	Common selfheal	Prunella vulgaris
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0083	Jiu Jie Cha	九节茶	Glabrous sarcandra	Sarcandra glabra
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0141	Lian Zi Xin	莲子心	Hindu lotus plumule	Nelumbo nucifera
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H1169	He Ye	荷叶	Hindu lotus leaf	Nelumbo nucifera
H0304	Ou Pian	藕片	Hindu lotus large rhizome	Nelumbo nucifera
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 28)