Target Description

Type Detail
Target ID T92WFW
Protein Name C-C motif chemokine 3
Uniprot ID P10147
Protein Name Alias G0/G1 switch regulatory protein 19-1;  Macrophage inflammatory protein 1-alpha;  MIP-1-alpha;  PAT 464.1;  SIS-beta;  Small-inducible cytokine A3;  Tonsillar lymphocyte LD78 alpha protein
Gene ID 6348
Gene Symbol CCL3
Gene Alias G0S19-1;  MIP1A;  SCYA3
TTD T97765: Clinical Trial target
Pfam PF00048
GO
0042056:chemoattractant activity

0014808:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

0002548:monocyte chemotaxis

0001775:cell activation

0070098:chemokine-mediated signaling pathway

0006887:exocytosis

0031726:CCR1 chemokine receptor binding

0032731:positive regulation of interleukin-1 beta production

0000165:MAPK cascade

0010629:negative regulation of gene expression

0005615:extracellular space

0009636:response to toxic substance

0023052:signaling

0045671:negative regulation of osteoclast differentiation

0043491:protein kinase B signaling

0008360:regulation of cell shape

0031663:lipopolysaccharide-mediated signaling pathway

0032760:positive regulation of tumor necrosis factor production

0043922:negative regulation by host of viral transcription

0007186:G protein-coupled receptor signaling pathway

0050850:positive regulation of calcium-mediated signaling

0043547:positive regulation of GTPase activity

0048246:macrophage chemotaxis

0048020:CCR chemokine receptor binding

0071346:cellular response to interferon-gamma

0051928:positive regulation of calcium ion transport

0005829:cytosol

1903980:positive regulation of microglial cell activation

0042802:identical protein binding

0050795:regulation of behavior

0048247:lymphocyte chemotaxis

0005576:extracellular region

0006816:calcium ion transport

1904141:positive regulation of microglial cell migration

0007267:cell-cell signaling

0007010:cytoskeleton organization

0008009:chemokine activity

0005737:cytoplasm

0071347:cellular response to interleukin-1

0031730:CCR5 chemokine receptor binding

0071407:cellular response to organic cyclic compound

0001649:osteoblast differentiation

0043308:eosinophil degranulation

0043525:positive regulation of neuron apoptotic process

0048245:eosinophil chemotaxis

0030335:positive regulation of cell migration

0004672:protein kinase activity

0004698:calcium-dependent protein kinase C activity

0050729:positive regulation of inflammatory response

0043615:astrocyte cell migration

0051930:regulation of sensory perception of pain

0016004:phospholipase activator activity

0019221:cytokine-mediated signaling pathway

0006874:cellular calcium ion homeostasis

2000503:positive regulation of natural killer cell chemotaxis

0070374:positive regulation of ERK1 and ERK2 cascade

0030502:negative regulation of bone mineralization

0006935:chemotaxis

0071621:granulocyte chemotaxis

0071356:cellular response to tumor necrosis factor

0006954:inflammatory response

0010628:positive regulation of gene expression

0010818:T cell chemotaxis

0090280:positive regulation of calcium ion import

0070723:response to cholesterol

0030593:neutrophil chemotaxis

0051897:positive regulation of protein kinase B signaling

0019722:calcium-mediated signaling

0016301:kinase activity

PDB 3FPU ; 1B50 ; 3H44 ; 2X6G ; 5COR ; 5D65 ; 1B53 ; 4RA8 ; 3KBX ; 2X69 ; 4ZKB
Drugbank DB05364
KEGG hsa:6348

Related Compounds  (Total: 3)

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C0374
Name: Rosmarinic Acid
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C0450
Name: Toluene
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C1106
Name: shikonin


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H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0398 Sha Ren砂仁 Villous amomumAmomum villosum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0673 Xin Jiang Zi Cao新疆紫草 Arnebia rootArnebia euchroma
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0357 Ren Shen人参 GinsengPanax ginseng
H0518 Suo Sha Ren缩砂仁 Villous amomum fruitFructus amomi
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H1198 Hou Tou Jun猴头菌 Bearded tooth carpophoreHericium erinaceus
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0399 Sha Ren Ye砂仁叶 NAAmomum villosum
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
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H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0612 Cao Shan Hu Jin Gao草珊瑚浸膏 NASarcandra glabra
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
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H0083 Jiu Jie Cha九节茶 Glabrous sarcandraSarcandra glabra
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0524 Tan Xiang檀香 SandalwoodSantalum album
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0416 Shan Shen山参 NAPanax ginseng
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
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